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| 1 | Real time endoscopic ultrasound elastography and strain ratio in the diagnosis of solid pancreatic lesions显示文摘AIM To evaluate the accuracy of the elastography score combined to the strain ratio in the diagnosis of solid pancreatic lesions(SPL). METHODS A total of 172 patients with SPL identified by endoscopic ultrasound were enrolled in the study to evaluate the efficacy of elastography and strain ratio in differentiating malignant from benign lesions. The semi quantitative score of elastography was represented by the strain ratio method. Two areas were selected, area(A) representing the region of interest and area(B) representing the normal area. Area(B) was then divided by area(A). Sensitivity, specificity, positive predictive value(PPV), negative predictive value(NPV), and accuracy were calculated by comparing diagnoses made by elastography, strain ratio and final diagnoses.RESULTS SPL were shown to be benign in 49 patients and malignant in 123 patients. Elastography alone had a sensitivity of 99%, a specificity of 63%, and an accuracy of 88%, a PPV of 87% and an NPV of 96%. The best cut-off level of strain ratio to obtain the maximal area under the curve was 7.8 with a sensitivity of 92%, specificity of 77%, PPV of 91%, NPV of 80% and an accuracy of 88%. Another estimated cut off strain ratio level of 3.8 had a higher sensitivity of 99% and NPV of 96%, but with less specificity, PPV and accuracy 53%, 84% and 86%, respectively. Adding both elastography to strain ratio resulted in a sensitivity of 98%, specificity of 77%, PPV of 91%, NPV of 95% and accuracy of 92% for the diagnosis of SPL. CONCLUSION Combining elastography to strain ratio increases the accuracy of the differentiation of benign from malignant SPL. | Hussein Okasha Shaimaa Elkholy Ramy El-Sayed Mohamed-Naguib Wifi Mohamed El-Nady Walid El-Nabawi Waleed A El-Dayem Mohamed I Radwan Ali Farag Yahya El-sherif Emad Al-Gemeie Ahmed Salman Mohamed El-Sherbiny Ahmed El-Mazny Reem E Mahdy | 2017 | World Journal of Gastroenterology2017，23，32： | 11 |
| 2 | Association between low molecular polypeptide 7 single nucleotide polymorphism and response to therapy in hepatitis C virus infection显示文摘AIM: To investigate the relationship between low molecular polypeptide-7 (LMP-7) gene polymorphism and response to interferon (IFN) therapy in chronic hepatitis C virus (HCV) patients. METHODS: LMP-7 polymorphism at codon 49 with nucleotide substitution from A to C was amplified in 104 chronic HCV patients of genotype 4. The amplicons were digested with restriction endonuclease Bsm I and the produced restriction fragment length polymorphism was analyzed. Patients received IFN + regional blood volume therapy for 48 wk and the frequency of thissingle nucleotide polymorphism (SNP) was statistically correlated with treatment response. The exclusion criteria for these patients were stated by the national health program for treating viral hepatitis. Main exclusion criteria included co-infection with hepatitis B virus or schistosomiasis, thyroid dysfunction, uncontrolled diabetes mellitus, history of long term drug or alcohol intake and autoimmune hepatitis. Multivariate analyses were done to correlate LMP-7 SNP plus several factors such as age, gender, weight, serum alpha-fetoprotein (AFP) and alanine aminotransferase levels, liver activity, fibrosis score and viral load with response to therapy. RESULTS: The data presented in this study clearly demonstrated statistically significant differences between sustained virological response (SVR) (defined as the absence of HCV RNA levels in the patient's sera at least 6 mo after discontinuation of treatment) and non-response (NR) (where HCV RNA levels in the patient's sera never become undetectable for 6 mo during or after treatment). Variables were described as odds ratio with 95%CI. The data were considered significant if P values were ≤ 0.05; highly significant if P < 0.01 and very highly significant if P < 0.001. Current data showed that 91.7% of patients carrying LMP-7 C/C allele were associated with SVR, while the other two genotypes C/A and A/A were associated with NR patients, 83.3% and 64.3% respectively, showing that genotype CC was strongly associated with response to interferon (95%CI: 12.0719-134.6572, P = 0.0001). The majority of parameters recorded in SVR and NR patients included higher values of mean age (P = 0.004), alanine aminotransferase (P = 0.001), AFP (P = 0.001), body weight (P = 0.025), viral load (P = 0.025), higher fibrosis and histological activity index indices among NR vs SVR patients. Also, the multivariate statistical analysis of the different factors of fibro-sis score, liver activity grade, genotypes and alleles of LMP-7 gene polymorphism in responders and NRs of HCV patients in this study showed that HCV patients with A allele had a very highly significant association with the NRs, high fibrosis and higher liver activity, while the C allele had a very highly significant association with the responders, low fibrosis and lower liver activity (95%CI: 3.5800-13.2519, P = 0.0001).CONCLUSION: LMP-7 SNP is a candidate gene that should be considered when designing a mathematical model for predicting response to therapy and disease progression in HCV patients. | Moataza H Omran Basma E Fotouh Samar S Youssef Noha E Ibrahim Wael Nabil EL-Sayed M Mahdy Wafaa G Shosha Mostafa K El-Awady | 2013 | World Journal of Hepatology2013，5，3： | 4 |
| 3 | Effect of temperature and ero- sion on pitting corrosion of XlOO steel in aqueous silica slur- ries containing bicarbonate and chloride content显示文摘 | Mahdi E Rauf A Eltai E 0 | 2014 | Corro- sion Science2014，83，6： | 1 |
| 4 | Effects of preparation conditions on the monodispersity of albumin microspheres 显示文摘 | Ibrahim E - S Safwat S | 1998 | Journal of Microencapsulation1998，15，5： | 1 |
| 5 | PLL-based ASIC system for DSP real-timeanalogue interface显示文摘 | Mahdi A E Grout I A | 2003 | Microprocessors and Microsystems2003，27，1： | 1 |
| 6 | Towards linking libraires and Wikipedia: automatic subject indexing of library records with Wikipedia concepts显示文摘 | Joorabchi A Mahdi A E | 2014 | Journal of Information Science2014，40，2： | 1 |
| 7 | Crushing response of composite corrugated tubes to quasi-static axial loading显示文摘 | Elgalai A M Mahdi E Hamouda A M S | 2004 | Composite Structures2004，66，14： | 1 |
| 8 | An investigation into hybrid carbon/glass fiber reinforced epoxy composite automotive drive shaft显示文摘 | Badle M A Mahdi E Hamouda A M S | | 0，，03： | 1 |
| 9 | Study of the mechanical and thermal properties of Sn-5 wt% Sb solder alloy at two annealing temperatures 显示文摘 | Bahay M M E Mossalamy M E E Mahdy M | 2003 | Phys Status Solidi A2003，198，1： | 1 |
| 10 | Monitoring the virus load can predict the emergence of drug-resistant hepatitis B virus strains in renal transplantation patients during lamivudine therapy显示文摘 | Puchhammer-Stockl E Mahdi CW Kletzmayr J | | 0，，： | 1 |
| 11 | AC impedance study on the atmospheric corrosion of aluminum under peri- odic wet-dry conditions显示文摘 | Gamal A Mahdy E L Kim K B | 2004 | Electrochimica Acta2004，49，： | 1 |
| 12 | Malaria infection by sporozoite challenge induces high functional antibody titres against blood stage antigens after a DNA prime, poxvirus boost vaccination strategy in Rhesus macaques 显示文摘 | Mahdi Abdel Hamid M Remarque E J E1 Hassan IM | 2011 | Malar J2011，10，1： | 1 |
| 13 | Familial associations in women with polycystic ovary syndrome 显示文摘 | Atiomo WU E1 - Mahdi E Hardiman P | 2003 | Fertil Steril2003，80，1： | 1 |
| 14 | An investigation into hybrid carbon/glass fiber reinforced epoxy composite automotive drive shaft 显示文摘 | BADIEH M A MAHDI E HAMOUDA A M S | 2011 | Materials and Designs2011，32，： | 1 |
| 15 | Effect of Nitrogen Fertilizer Application on Growing Season Soil Carbon Dioxide Emission in a Corn-Soybean Rotation显示文摘 | Al-Kaisi Mahdi M Kruse Marc L Sawyer John E | 2008 | Journal of Environmental Quality2008，，2： | 1 |
| 16 | Localization of the equine major histocompatibility complex (ELA) to chromosome 20 by in situ hybridization显示文摘 | Makinen A Chowdhary B Mahdy E | 1989 | Hereditas1989，110，1： | 1 |
| 17 | Effect of temperature and erosion on pitting corrosion of XIOO steel in aqueous silica slurries containing bicarbonate and chloride content显示文摘 | MAHDI E RAUF A ELTAI E O | 2014 | Corrosion Science2014，83，： | 1 |
| 18 | Synthesis of C 2-chlorophenyl)(phenyl) methanones and 2- (2-chlorophenyl )-1- phenylethanonesby Friedel-Crafts acylation of 2-chlorobenzoic acids and 2-(2-chiorophenyI ) acetic acids using microwave heating显示文摘 | Mahdi J Ankati H Biehl E R | 2011 | Tetrahedron Letters2011，52，： | 1 |
| 19 | Localization of the equine major histocompatibility complex(ELA) to chromosome 20 by in situ hybridization显示文摘 | Makinen A Chowdhary B Mahdy E | 1989 | Hereditas1989，110，1： | 1 |
| 20 | Chro- mosomal localization of the ovine major histocompati- bility complex (OLA) by in situ hybridization显示文摘 | Mahdy E A Makinen A Chowdhary B P | 1989 | Hereditas1989，111，： | 1 |
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