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| 1 | Correlation between the proportion of breast volume involved by locally advanced tumors and invasion of the skin and posterior structures显示文摘AIM: To evaluate any differences between the percentages of involved breast volume, pathologic attributes,and tumor marker expression of T3 and T4a-c tumors in locally advanced breast cancers(BC).METHODS: All patients with T3 N > 0 and T4a-c BC without evidence of distant metastasis(M0), presenting to the Breast Clinic from 1980 to 2010, were examinedto determine whether their BC's involved ≥ 50% of their breast volumes, defined by gross replacement of at least one hemisphere. Core needle biopsy or postmastectomy specimens from tumors involving a known percent of breast volume were evaluated for:(1)pathological grades and lympho-vascular invasion(LVI);(2) hormone receptor(ER/PR) expression > 0; and(3)epidermoid growth factor 2(her2) over-expression(3+)by immune-histochemical staining or fluorescent in situ hybridization.RESULTS: The data base included 98 patients with T3N> 0 M0 and 120 with T4a-c, any N disease, M0 disease. T3 tumor masses involved 50% or more of the breast in 23/98(24%), and T4a-c tumors 65/120(54%)(P < 0.001). Only 1% of T3 tumors and 23% of T4a-c tumors presented with total breast replacement. There were no significant differences between the pathological attributes and marker expression of the T3 and T4a-c tumors.CONCLUSION: These data suggest that erosion of the overlying skin or underlying chest wall by some BC may be due to neglect and delay, rather than inherent biological aggressiveness. | Parastoo B Dahi Komal P Dhiran Constantine A Axiotis Jeremy Weedon Mahmoud El-Tamer Gurinder Sidhu Albert S Braverman | 2012 | World Journal of Clinical Oncology2012，3，3： | 2 |
| 2 | Celastrol blocks neuronal cell death and extends life in transgenic mouse model of amyotrophic lateral sclerosis 显示文摘 | MAHMOUD K KHATUNA K SUSANNE P | 2005 | Neurodegener Dis2005，2，5： | 1 |
| 3 | Longer time inter val between completion of neoadjuvant ehemoradiation and sur- gical resection does not improve downstaging of rectal carcino- ma显示文摘 | Stein D E Mahmoud N N Anne P R | 2003 | Dis Colon Rectum2003，46，： | 1 |
| 4 | Application of Fenton's reagent to remediate diesel contaminated soils显示文摘 | Xu P Achari G Mahmoud M | 2006 | Practice Periodical of Hazardous Toxic and Radioactive Waste Management2006，10，： | 1 |
| 5 | A change point method for linear profile data 显示文摘 | Mahmoud M A Parker P A WoodaU W H Hawkins D M | 2007 | Quality and Reliability Engineering International2007，23，2： | 1 |
| 6 | Mechanical properties of and wa- ter vapor transferability through whey protein films显示文摘 | MAHMOUD R SAVELLO P A | 1992 | J Dairy Sci1992，75，4： | 1 |
| 7 | Solubility and hydrolysability of films produced by transglutaminase catalytic crosslinking of whey protein显示文摘 | Mahmoud R Savello P A | 1993 | J Dairy Sci1993，76，： | 1 |
| 8 | Pharmacological characterization of the chemokine receptor, CCR5显示文摘 | Mueller A Mahmoud N G Goedecke M C Mckeating J A Strange P G | 2002 | Br J Pharmacol2002，135，： | 1 |
| 9 | CEO compensa'tion, firm performance and operational characteristics 显示文摘 | Mahmoud M N Frank P D | 2008 | Managerial Finance2008，34，8： | 1 |
| 10 | Evaluation of water quality using acceptance sampling by variables 显示文摘 | Smith E P Zahran A Mahmoud M | 2003 | Environmetrics2003，14，4： | 1 |
| 11 | Effects of Different Or- ganic and Inorganic Fertilizers on Cucumber Yield and Some Soil Properties 显示文摘 | Mahmoud E EL-Kader N A Robin P | 2009 | World Journal of Agricultural Sciences2009，5，4： | 1 |
| 12 | 查看详情显示文摘 | RUSHMAN P GILBERT N V MAHMOUD S | | 0，，05： | 1 |
| 13 | Effieient search and design procedures for robust multistage VQ of LPC parameters for 4 kb/s speech coding显示文摘 | LeBlanc W P Bhattacharya B Mahmoud S A | 1993 | IEEE Trans on Speech and Audio Pro- cessing1993，1，4： | 1 |
| 14 | A new semi-analytical modeling of steam-assisted gravity drainage in heavy oil reservoirs 显示文摘 | Najeh A Mahmoud R P Hadi J | 2009 | J Petrol Sci Eng2009，69，： | 1 |
| 15 | Mineral trioxide aggregate: a comprehensive literature review-part II: leakage and biocompatibility investigations 显示文摘 | Mahmoud T Masoud P | 2010 | J Endod2010，36，2： | 1 |
| 16 | Fermentation pre- treatment of landfill leachate for enhanced electron recovery in a microbial electrolysis cell 显示文摘 | Mahmoud M Parameswaran P Torres C l | 2014 | Bioresource Technology2014，151，： | 1 |
| 17 | Efficient search and design procedures for robust multi-stage VQ of LPC parameters for 4 Kb/s speech coding 显示文摘 | Leblanc W P Bhattacharya B Mahmoud S A | 1993 | IEEE Trans on speech and audio processing1993，1，4： | 1 |
| 18 | Solubility and hydrolysability of films produced by transglutaminase catalytic crosslinking of whey protein显示文摘 | Mahmoud R Savello P A | 1993 | J Dairy Sci1993，76，： | 1 |
| 19 | A change point method for linear profile data显示文摘 | MAHMOUD M A PARKER P A WOODALL W H | 2007 | Quality and Reliability Engineering Intetnational2007，23，2： | 1 |
| 20 | Profitability analysis of a femtosecond laser system for cataract surgery using a fuzzy logic approach显示文摘AIM:To define the financial and management conditions required to introduce a femtosecond laser system for cataract surgery in a clinic using a fuzzy logic approach.METHODS:In the simulation performed in the current study,the costs associated to the acquisition and use of a commercially available femtosecond laser platform for cataract surgery(VICTUS,TECHNOLAS Perfect Vision GmbH,Bausch & Lomb,Munich,Germany) during a period of 5y were considered.A sensitivity analysis was performed considering such costs and the countable amortization of the system during this 5y period.Furthermore,a fuzzy logic analysis was used to obtain an estimation of the money income associated to each femtosecond laser-assisted cataract surgery(G). RESULTS:According to the sensitivity analysis,the femtosecond laser system under evaluation can be profitable if 1400 cataract surgeries are performed per year and if each surgery can be invoiced more than $500.In contrast,the fuzzy logic analysis confirmed that the patient had to pay more per surgery,between $661.8 and $667.4 per surgery,without considering the cost of the intraocular lens(IOL).CONCLUSION:A profitability of femtosecond laser systems for cataract surgery can be obtained after a detailed financial analysis,especially in those centers with large volumes of patients.The cost of the surgery for patients should be adapted to the real flow of patients with the ability of paying a reasonable range of cost. | Jose Antonio Trigueros David P Pinero Mahmoud M Ismail | 2016 | International Journal of Ophthalmology(English edition)2016，9，7： | 1 |
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