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您的检索式：作者名="Mahmoud Torabi"
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| 1 | Paroxetine vs pregabalin for the management of neuropathic pain in multiple sclerosis显示文摘AIM: To compare the effectiveness and tolerability of paroxetine vs pregabalin for the management of multiple sclerosis(MS)-induced neuropathic pain(NPP).METHODS: A randomized, flexible-dose open-label 8-wk study involving 21 relapsing-remitting MS patients with MS-induced NPP was conducted to evaluate the effectiveness and tolerability of pregabalin versus paroxetine for pain management. The trial included a 3-wk dose titration phase followed by a 5-wk stable dose phase. Primary outcome measures included daily patient-reported pain intensity as measured using a 100 mm visual analogue scale(VAS pain) and daily impact of pain on daily activities(VAS impact). Hierarchical regression modeling was conducted on each outcome to determine if within person VAS trajectory for pain and impact differed across study groups, during 56 d follow-up. RESULTS: Attrition rates were significantly greater(P < 0.001) in the paroxetine versus pregabalin study group(70% vs 18.2%, respectively). Average study duration between study groups also significantly differed(P < 0.001). Paroxetine participants completed an average of 27.3 d of treatment vs 49.5 d in the pregabalin group, with the majority of patients withdrawing due to adverse events. Due to the high attrition rates in the paroxetine study arm, the investigators stopped the study prior to achieving complete recruitment. As such, no significant differences between pregabalin and paroxetine study arms were noted for the primary outcome measures(VAS pain, VAS impact). Comparative assessment of baseline patient characteristics also revealed no significant differences between the study arms. CONCLUSION: High attrition rates associated with paroxetine use suggest that it be used with caution for MS-induced NPP. Efficacy outcomes could not be assessed due to attrition. | Dana A Turcotte Malcolm Doupe Mahmoud Torabi Andrew J Gomori Karen Ethans Farid Esfahani Katie Galloway Michael P Namaka | 2014 | World Journal of Anesthesiology2014，3，2： | 1 |
| 2 | Application of Three Focused Cluster Detection Methods to Study Geographic Variation in the Incidence of Multiple Sclerosis in Manitoba, Canada显示文摘 | Torabi Mahmoud Green Chris Yu Nancy Marrie Ruth Ann | 2014 | Neuroepidemiology2014，，1： | 1 |
| 3 | A discrete-time susceptible-infectious-recovered-susceptible model for the analysis of influenza data显示文摘We develop a discrete time compartmental model to describe the spread of seasonal influenza virus.As time and disease state variables are assumed to be discrete,this model is considered to be a discrete time,stochastic,Susceptible-Infectious-RecoveredSusceptible(DT-SIRS)model,where weekly counts of disease are assumed to follow a Poisson distribution.We allow the disease transmission rate to also vary over time,and the disease can only be reintroduced after extinction if there is a contact with infected individuals from other host populations.To capture the variability of influenza activities from one season to the next,we define the seasonality with a 4-week period effect that may change over years.We examine three different transmission rates and compare their performance to that of existing approaches.Even though there is limited information for susceptible and recovered individuals,we demonstrate that the simple models for transmission rates effectively capture the behaviour of the disease dynamics.We use a Bayesian approach for inference.The framework is applied in an analysis of the temporal spread of influenza in the province of Manitoba,Canada,2012e2015. | Georges Bucyibaruta C.B.Dean Mahmoud Torabi | 2023 | Infectious Disease Modelling2023，8，2： | 0 |
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