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| 1 | Anti-bacterial activity and brine shrimp lethality bioassay of methanolic extracts of fourteen different edible vegetables from Bangladesh显示文摘Objective:To investigate the antibacterial and cytotoxic activity of fourteen different edible vegetables methanolic extract from Bangladesh.Methods:The antibacterial activity was evaluated using disc diffusion assay method against 12 bacteria(both gram positive and gram negative).The plant extracts were also screened for cytotoxic activity using the brine shrimp lethality bioassay method and the lethal concentrations(LC_(50))were determined at confidence intervals by analyzing the data on a computer loaded with'Finney Programme??Results:All the vegetable extracts showed low to elevated levels of antibacterial activity against most of the tested strains(zone of inhibition=5-28 mm).The most active extract against all bacterial strains was from Xanthium indicum which showed remarkable antibacterial activity having the diameter of growth inhibition zone ranging from 12 to 28 mm followed by Alternanthera sessilis(zone of inhibition=6-21 mm).All extracts exhibited considerable general toxicity towards brine shrimps.The LC_(50)value of the tested extracts was within the range of 8.447 to 60.323μg/mL with respect to the positive control(vincristine sulphate)which was 0.91μg/mL.Among all studied extracts,Xanthium indicum displayed the highest cytotoxic effect with LC_(50)value of 8.447μg/mL.Conclusions:The results of the present investigation suggest that most of the studied plants are potentially good source of antibacterial and anticancer agents. | M.Obayed Ullah Mahmuda Haque Kaniz Fatima Urmi Abu Hasanat Md.Zulfiker Elichea Synthi Anita Momtaj Begum Kaiser Hamid | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，1： | 5 |
| 2 | Analysis of immune responses against H pylori in rabbits显示文摘AIM: To investigate the immunogenicity of H pylori proteins, to evaluate the production rate of anti H pylori IgG antibodies in relation to time and to demonstrate the fidelity of newly optimized in-house enzyme- linked immunosorbent assay (ELISA) technique as an alternative for H pylori infection assay. METHODS: In the present study, 100 μg of formalin- fixed H pylori whole cell antigens was injected into an experimental animal (New Zealand white female rabbit) intramuscularly on d 0, 16, 27 and 36. The first two doses were injected with adjuvants. On d 0, a serum sample was collected from the rabbit before immunization and this pre-immunized serum was used as a negative control for the whole study. To evaluate the immunogenic responses of the injected antigen, serum samples were collected from the rabbit at regular intervals up to d 42. The sera were analyzed using in- house ELISA and Western blot techniques. RESULTS: The production of anti H pylori IgG antibodies in the rabbit in response to the injected antigen increased almost exponentially up to d 14 and after that it was maintained at the same level until the last day (d 42). By analyzing the immune profiles of immunized sera, 11 proteins were identified to be immunogenic, among them 2 (approximately 100 kDa and 85 kDa) were most prominent. CONCLUSION: Analysis of the immune responses against pathogenic microorganisms like H pylori is necessary for the development of various diagnostic and preventive approaches. The results of this experiment reveal that the formalin-fixed H pylori whole cell antigens injected into the rabbit are highly immunogenic. These prominent proteins (approximately 100 kDa and 85 kDa) might have higher immunogenic effects among humansinfected with H pylori and some of these immunogenic proteins can be included in diagnostic approaches based on serology and also for vaccine formulation. The in- house ELISA is a promising alternative compared to invasive techniques. | Khademul Islam Ibrahim Khalil Chowdhury Rafiqul Ahsan Mahmuda Yasmin Jamalun Nessa | 2007 | World Journal of Gastroenterology2007，13，4： | 4 |
| 3 | Development of Epstein-Barr virus-associated gastric cancer:Infection,inflammation,and oncogenesis显示文摘Epstein-Barr virus(EBV)-associated gastric cancer(EBVaGC)cells originate from a single-cell clone infected with EBV.However,more than 95%of patients with gastric cancer have a history of Helicobacter pylori(H.pylori)infection,and H.pylori is a major causative agent of gastric cancer.Therefore,it has long been argued that H.pylori infection may affect the development of EBVaGC,a subtype of gastric cancer.Atrophic gastrointestinal inflammation,a symptom of H.pylori infection,is observed in the gastric mucosa of EBVaGC.Therefore,it remains unclear whether H.pylori infection is a cofactor for gastric carcinogenesis caused by EBV infection or whether H.pylori and EBV infections act independently on gastric cancer formation.It has been reported that EBV infection assists in the oncogenesis of gastric cancer caused by H.pylori infection.In contrast,several studies have reported that H.pylori infection accelerates tumorigenesis initiated by EBV infection.By reviewing both clinical epidemiological and experimental data,we reorganized the role of H.pylori and EBV infections in gastric cancer formation. | Hisashi Iizasa Andy Visi Kartika Sintayehu Fekadu Shunpei Okada Daichi Onomura Afifah Fatimah Azzahra Ahmad Wadi Mosammat Mahmuda Khatun Thin Myat Moe Jun Nishikawa Hironori Yoshiyama | 2022 | World Journal of Gastroenterology2022，28，44： | 3 |
| 4 | Single nucleotide polymorphisms in candidate genes are significantly associated with resistance to Haemonchus contortus infection in goats显示文摘Background: Haemonchosis is a major economic problem in goat production in humid, tropical and subtropical regions. The disease is caused by an abomasal nematode, Haemonchus contortus, which is highly pathogenic in small ruminants. The aim of this study was to identifying single-nucleotide polymorphisms(SNP) that were associated with fecal egg counts(FEC) and could be used as markers to identify resistance to H. contortus in goats.Results: Ten novel variants in the CI TA, ATP2 A3, HSPA8, STAT5 B, ESYT1, and SERPING1 genes were associated with FEC in goats with a nominal significance level of P < 0.05. Two missense mutation in the exon region of the caprine CI TA gene resulted in replacement of arginine with cysteine at position 9473550(R9473550 C) and aspartic acid with glutamic acid at position 9473870(D9473870 E). Chinese goat breeds had significantly higher FEC than Bangladeshi goat breeds within their respective genotypes. Polymorphism information content(PIC), effective al ele number(Ne), and heterozygosity(He)were greatest for the STAT5 B197A > G SNP locus in al goat breeds. Pairwise coefficients of linkage disequilibrium(D′, r2)revealed complete LD(r2= 1) between significant SNP polymorphisms in CI TA and SERPING1 and strong LD(r2= 0.93 and0.98) between polymorphisms in HSPA8 and ATP2 A3, respectively. Correlation coefficient(r) between FEC and body weight(BW) was significantly positive(r = 0.56***, P < 0.001) but that between FEC and packed cel volume(PCV) was negatively significant(r =-0.47**, P < 0.01) in the total population of goats. On the other hand, correlation coefficient(r)between BW and PCV was not significant in total population of goats. Association analysis revealed that haplotypes within ATP2 A3, HSPA8, and SERPING1 were significantly associated with FEC. Quantitative real-time PCR revealed that the relative expression of m RNA was higher(P < 0.001) for resistant, compared to susceptible, groups of goats for al candidate genes except CI TA.Conclusions: This study identified SNP markers that can potential y be used in marker-assisted selection programs to develop goat breeds that are resistant to H. contortus. | Mahmuda Bilkis Bintee Alam Abdullah Ibne Omar Md.Omar Faruque David Russell Notter Kathiravan Periasamy Md.Motahar Hussain Mondal Md.Jalal Uddin Sarder Md.Shamsuddin Jianhua Cao Xiaoyong Du Zhenyang Wu Shuhong Zhao | 2019 | Journal of Animal Science and Biotechnology2019，10，2： | 2 |
| 5 | Women Em- powerment through Participation in Micro- Credit Pro- gramme: A Case Study from Bangladesh 显示文摘 | Mahmuda Hoque Yoshihito Itohara | 2009 | Journal of So- cial Sciences2009，，03： | 1 |
| 6 | Phytochemical screening and in vitro bioactivities of the extracts of aerial part of Boerhavia diffusa Linn.显示文摘Objective:To investigate the bioactivities of crude n-hexane,ethyl acetate and methanol extracts of aerial part of Boerhavia diffusa Linn.(B.diffusa) and its phytochemical analysis.Methods: the identification of phyloconstituents and assay of antioxidant,thrombolytic,cytotoxic, antimicrobial activities were conducted using specific standard in vitro procedures.Results:The results showed that the plant extracts were a rich source of phytoconstituents.Methanol extract showed higher antioxidant,thrombolytic activity and less cytotoxic activity than those of n-hexane and ethyl acetate extracts of A diffusa.Among the bioactivities,antioxidant activity was the most notable compared to the positive control and thus could be a potential rich source of natural antioxidant.In case of antimicrobial screening,crude extracts of the plant showed remarkable antibacterial activity against tested microorganisms.All the extracts showed significant inhibitory activity against Candida albicuns,at a concentration of 1000 μg/disc.Conclusions:The present findings suggest that,the plant widely available in Bangladesh,could be a prominent source of medicinally important natural compounds. | Apurba Sarker Apu Mahmuda Sultana Liza A.T.M.Jamaluddin Md.Amran Howlader Repon Kumer Saha Farhana Rizwan Nishat Nasrin | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，9： | 1 |
| 7 | Measure- ments and modelling of free-surface turbulent flows induced by a magnetic stirrer in an unbaffled stirred tank reactor 显示文摘 | MAHMUDA T HAQUEA J N ROBERTSA K J | 2009 | Chem Eng Sci2009，64，20： | 1 |
| 8 | Minimizing Distance Using Just-in-Time Teaching and Flipped Classroom显示文摘 | Mahmuda Akhter | 2015 | Sino-US English Teaching2015，12，1： | 1 |
| 9 | Evaluation of multiplex PCR system for simultaneous detection of Escherichia coli 0157 : H7, Listeria monocytogenes and Salmonella enteritidis in shrimp samples 显示文摘 | Mahmuda Yasmin Susumu Kawasaki Shinichi Kawamoto | 2007 | Bangladesh Journal of Microbiology2007，24，1： | 1 |
| 10 | Anaemia and vita- min A deficiency in poor urban pregnant women of Bangla desh 显示文摘 | Ahmed F Mahmuda I Sattar A | 2003 | AsiaPacJ ClinNutr2003，12，46： | 1 |
| 11 | Xenon Mitigates Isoflurane-induced Neuronal Apoptosis in the Developing Rodent Brain显示文摘 | Daqing Ma Peter Williamson Adam Januszewski Marie-Caroline Nogaro Mahmuda Hossain Lay Ping Ong Yi Shu Nicholas P. Franks Mervyn Maze | 2007 | Anesthesiology2007，，4： | 1 |
| 12 | Portable and secure multimedia data transfer in mobile phones using record management store显示文摘 | Shahiduzzaman MM Mahmuda Naznin Akond Rahman | 2010 | Computer Science and Information Technology2010，，5： | 1 |
| 13 | 3D part inspection path planning of a laser scanner with control on the uncertainty 显示文摘 | Mussa Mahmuda David Joannic | 2011 | 43:345 - 3552011，43，： | 1 |
| 14 | Role of cyanobacteria in the persistence of Vibrio choterae O139 in saline microcosms显示文摘 | Islam MS Mahmuda S Morshed MG | 2004 | Can J Micro2004，50，2： | 1 |
| 15 | A study of mass transfer in the membrane air - stripping processusing microporous polyproplylene hollow fibers 显示文摘 | Mahmuda H Kumarb A Roberto M | 2000 | J Membr Sci2000，179，： | 1 |
| 16 | Xenon Mitigates Isoflurane-induced Neuronal Apoptosis in the Developing Rodent Brain显示文摘 | Daqing Ma Peter Williamson Adam Januszewski Marie-Caroline Nogaro Mahmuda Hossain Lay Ping Ong Yi Shu Nicholas P. Franks Mervyn Maze | 2007 | Anesthesiology2007，，4： | 1 |
| 17 | 基于槟榔叶农林复合系统的经济活力和保护作用:孟加拉Khasia部落原有的农耕系统显示文摘在孟加拉锡尔赫特地区Khasia部落家庭园地或其周围,对基于槟榔叶农林复合系统的文化产业与经济管理技术进行了调查研究。Khasia是一个受教育较普及的社区;该区家庭平均大小为7.68人,男女比率为141:100;家庭园地里物种丰富。在槟榔农林复合系统中共有15个木材品种,22个园艺种,6个药用植物种,以及13个一年生作物种(包括一些叶用蔬菜),7个香味料植物种和5个竹类种。Khasia也是一个经济繁荣区,最小家庭月收入57美元。槟榔收益是当地居民收入的重要来源。该区95.45%的家庭涉及槟榔农事。槟榔人工林年平均收入约为1157美元/公顷,此农林复合生产项目的收益.投入比率为4.47。槟榔人工林区内物种丰富度较高,对维持农林复合系统可持续性以及系统内生物多样性保护具有重要意义。图2表3参19。 | Mizanur Rahman Mohammad Mahfuzur Rahman Mahmuda Islam | 2009 | Journal of Forestry Research2009，20，2： | 1 |
| 18 | Dexmedetomidine Attenuates Isoflurane-induced Neurocognitive Impairment in Neonatal Rats显示文摘 | Robert D. Sanders Jing Xu Yi Shu Adam Januszewski Sunil Halder Antonio Fidalgo Pamela Sun Mahmuda Hossain Daqing Ma Mervyn Maze | 2009 | Anesthesiology2009，，5： | 1 |
| 19 | Association study and autism spectrum disorders in a Japanese population显示文摘 | okoyama S A1 Mahmuda N Munesue T | 2015 | between the UDIOI/Dbll gefle Brain Science2015，5，2： | 1 |
| 20 | Improved Eating and Cooking Quality of indica Rice Cultivar YK17 via Adenine Base Editing of Wx^(a)Allele of Granule-Bound Starch Synthase I(GBSS I)显示文摘Amylose content(AC)is the key determinant of eating and cooking quality(ECQ)of rice.The major Wxa allele of granule-bound starch synthase I(GBSS I)in indica rice produces higher AC,making rice hard and dry after cooking.Recent work has improved ECQ of japonica rice via clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9(CRISPR/Cas9)or cytosine base editing(CBE)techniques. | Mahmuda Binte Monsur Cao Ni Wei Xiangjin Xie Lihong Jiao Guiai TAng Shaoqing Nese Sreeniwsulu Shao Gaoneng Hu Peisong | 2021 | Rice science2021，28，5： | 1 |
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