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| 1 | Drug resistance mechanisms and novel drug targets for tuberculosis therapy显示文摘Drug-resistant tuberculosis(TB) poses a significant challenge to the successful treatment and control of TB worldwide.Resistance to anti-TB drugs has existed since the beginning of the chemotherapy era.New insights into the resistant mechanisms of anti-TB drugs have been provided.Better understanding of drug resistance mechanisms helps in the development of new tools for the rapid diagnosis of drugresistant TB.There is also a pressing need in the development of new drugs with novel targets to improve the current treatment of TB and to prevent the emergence of drug resistance in Mycobacterium tuberculosis.This review summarizes the anti-TB drug resistance mechanisms,furnishes some possible novel drug targets in the development of new agents for TB therapy and discusses the usefulness using known targets to develop new anti-TB drugs.Whole genome sequencing is currently an advanced technology to uncover drug resistance mechanisms in M.tuberculosis.However,further research is required to unravel the significance of some newly discovered gene mutations in their contribution to drug resistance. | Md Mahmudul Islam H.M. Adnan Hameed Julius Mugweru Chiranjibi Chhotaray Changwei Wang Yaoju Tan Jianxiong Liu Xinjie Li Shouyong Tan Iwao Ojima Wing Wai Yew Eric Nuermberger Gyanu Lamichhane Tianyu Zhang | 2017 | Journal of Genetics and Genomics2017，44，1： | 15 |
| 2 | An experimental study on thermal characteristics of nanofluid with graphene and multi-wall carbon nanotubes显示文摘High-thermal conductivity enhancement of nanofluid is one of the promising topics of the nanoscience research field. This work reports the experimental study on the preparation of graphene(GN) and multi-walled carbon nanotubes(MWCNTs) based nanofluids with the assistance of sodium dodecyl benzene sulfonate(SDBS) and sodium dodecyl sulfate(SDS) surfactants, and their thermal behaviors. The present work suggests not a solution, but a solution approach and deduces a new conclusion by trying to resolve the agglomeration problem and improve the dispersibility of nanoparticles in the base fluid. The analysis results of FESEM, thermal conductivity, diffusivity, effusivity and heat transfer coefficient enhancement ratio of nanofluid with surfactants SDS and SDBS expose strong evidence of the dispersing effect of surfactant on the making of nanofluid. | A.K.M Mahmudul Haque Sunghyun Kwon Junhyo Kim Jungpil Noh Sunchul Huh Hanshik Chung Hyomin Jeong | 2015 | Journal of Central South University2015，22，8： | 5 |
| 3 | Fisheries resources of Bangladesh:Present status and future direction显示文摘Bangladesh is considered one of the most suitable regions for fisheries in the world,with the world's largest flooded wetland and the third largest aquatic biodiversity in Asia after China and India.This paper reviews the performance of fisheries in Bangladesh using data collected from the Bangladesh Department of Fisheries,and related un-published grey literatures.The findings within describe recent growth within Bangladeshi inland fisheries,primarily in the inland aquaculture sector(2014e2015).This increase in the aquaculture production has been made possible with the implementation of scientific and technological modernization.From 2000 and 2016,aquaculture production increased from 712,640 and 2,060,408 metric t,a much larger quantity than wild capture production(1.023 million t)in 2016.There has also been a recent increase in the value of fishery exports,with more than US$34.08 billion in 2010 rising to more than US$46.60 billion in 2015.However,fisheries production is well below production targets despite the large gains seen in the aquaculture sector. | Md.Mostafa Shamsuzzaman Mohammad Mahmudul Islam Nusrat Jahan Tania Md.Abdullah Al-Mamun Partho Protim Barman Xiangmin Xu | 2017 | Aquaculture and Fisheries2017，2，4： | 4 |
| 4 | Predictive car-following scheme for improving traffic flows on urban road networks显示文摘Driving behavior is one of the main reasons that causes bottleneck on the freeway or restricts the capacity of signalized intersections.This paper proposes a car-following scheme in a model predictive control(MPC)framework to improve the traffic flow behavior,particularly in stopping and speeding up of individual vehicles in dense urban traffic under a connected vehicle(CV)environment.Using information received through vehicle-to-vehicle(V2V)communication,the scheme predicts the future states of the preceding vehicle and computes the control input by solving a constrained optimization problem considering a finite future horizon.The objective function is to minimize the weighted costs due to speed deviation,control input,and unsafe gaps.The scheme shares the planned driving information with the following vehicles so that they can make better cooperative driving decision.The proposed car-following scheme is simulated in a typical driving scenario with multiple vehicles in dense traffic that has to stop at red signals in multiple intersections.The speeding up or queue clearing and stopping characteristics of the traffic using the proposed scheme is compared with the existing car-following scheme through numerical simulation. | A.S.M.BAKIBILLAH Mahmudul HASAN Md Mustafijur RAHMAN Md Abdus Samad KAMAL | 2019 | Control Theory and Technology2019，17，4： | 3 |
| 5 | Advances in the development of molecular genetic tools for Mycobacterium tuberculosis显示文摘Mycobacterium tuberculosis, a Gram-positive bacterium of great clinical relevance, is a lethal pathogen owing to its complex physiological characteristics and development of drug resistance. Several molecular genetic tools have been developed in the past few decades to study this microorganism. These tools have been instrumental in understanding how M. tuberculosis became a successful pathogen. Advanced molecular genetic tools have played a significant role in exploring the complex pathways involved in M. tuberculosis pathogenesis. Here, we review various molecular genetic tools used in the study of M. tuberculosis. Further, we discuss the applications of clustered regularly interspaced short palindromic repeat interference(CRISPRi), a novel technology recently applied in M. tuberculosis research to study target gene functions. Finally, prospective outcomes of the applications of molecular techniques in the field of M. tuberculosis genetic research are also discussed. | Chiranjibi Chhotaray Yaoju Tan Julius Mugweru Md Mahmudul Islam H.M.Adnan Hameed Shuai Wang Zhili Lu Changwei Wang Xinjie Li Shouyong Tan Jianxiong Liu Tianyu Zhang | 2018 | Journal of Genetics and Genomics2018，45，6： | 2 |
| 6 | ISSR as new markers for identification of homokaryotic protoclones of Agaricus bisporus显示文摘 | Mahmudul I N Bian Y B | 2010 | Curr Microbiol2010，60，2： | 1 |
| 7 | ISSR as new markers for identifica-tion of homokaryotic protoclones ofAgaricus bisporus显示文摘 | MAHMUDUL I N BIAN Yinbing | 2010 | Curr Microbiol2010，60，2： | 1 |
| 8 | ISSR as New Markers for Identification of Homokaryotic Protoclones of Agaricus bisporus显示文摘 | Mahmudul Islam Nazrul Bian Yin-Bing | | 0，，02： | 1 |
| 9 | Phosphoramidon, an endothelin coverting enzyme inhibitor attenuate local gastric ischemia -reperfusion injury in rat显示文摘 | Mahmudul hassan Hiromasa Kashimura | 1997 | Life Sei1997，61，10： | 1 |
| 10 | Export market correlation and strategic trade policy显示文摘 | Mahmudul A Chiang S H | 2001 | Canadian Journal of Economics2001，33，1： | 1 |
| 11 | Differentiation of homokaryons and heterokaryons of Agaricus bisporus with inter-simple sequence repeat markers 显示文摘 | MAHMUDUL IN BIAN YB | 2011 | Microbiol Res2011，166，： | 1 |
| 12 | Price discrimination and social welfare with correlated demand显示文摘 | Anam Mahmudul Chiang S H | 2006 | J of Economic Behavior & Organization2006，61，1： | 1 |
| 13 | Pancreaticoduodenal artery aneurysms associated with celiac axis stenosis due to compression by median arcuate ligament and celiac plexus显示文摘 | Kaori Suzuki Hiromasa Kashimura Mikio Sato Mahmudul Hassan Hikaru Yokota Akira Nakahara Hiroshi Muto Kenji Yuzawa Katashi Fukao Naomi Tanaka | 1998 | Journal of Gastroenterology1998，，3： | 1 |
| 14 | Advances and perspectives in discovery and functional analysis of small secreted proteins in plants显示文摘Small secreted proteins(SSPs)are less than 250 amino acids in length and are actively transported out of cells through conventional protein secretion pathways or unconventional protein secretion pathways.In plants,SSPs have been found to play important roles in various processes,including plant growth and development,plant response to abiotic and biotic stresses,and beneficial plant–microbe interactions.Over the past 10 years,substantial progress has been made in the identification and functional characterization of SSPs in several plant species relevant to agriculture,bioenergy,and horticulture.Yet,there are potentially a lot of SSPs that have not been discovered in plant genomes,which is largely due to limitations of existing computational algorithms.Recent advances in genomics,transcriptomics,and proteomics research,as well as the development of new computational algorithms based on machine learning,provide unprecedented capabilities for genome-wide discovery of novel SSPs in plants.In this review,we summarize known SSPs and their functions in various plant species.Then we provide an update on the computational and experimental approaches that can be used to discover new SSPs.Finally,we discuss strategies for elucidating the biological functions of SSPs in plants. | Xiao-Li Hu Haiwei Lu Md Mahmudul Hassan Jin Zhang Guoliang Yuan Paul E.Abraham Him K.Shrestha Manuel I.Villalobos Solis Jin-Gui Chen Timothy J.Tschaplinski Mitchel J.Doktycz Gerald A.Tuskan Zong-Ming(Max)Cheng Xiaohan Yang | 2021 | Horticulture Research2021，8，1： | 1 |
| 15 | Expanding the application of a UV-visible reporter for transient gene expression and stable transformation in plants显示文摘Green fl uorescent protein(GFP)has been widely used for monitoring gene expression and protein localization in diverse organisms.However,highly sensitive imaging equipment,like fl uorescence microscope,is usually required for the visualization of GFP,limitings its application to fi xed locations in samples.A reporter that can be visualized in realtime regardless the shape,size and location of the target samples will increase the fl exibility and ef fi ciency of research work.Here,we report the application of a GFP-like protein,called eYGFPuv,in both transient expression and stable transformation,in two herbaceous plant species(Arabidopsis and tobacco)and two woody plant species(poplar and citrus).We observed bright fl uorescence under UV light in all of the four plant species without any effects on plant growth or development.eYGFPuv was shown to be effective for imaging transient expression in leaf and root tissues.With a focus on in vitro transformation,we demonstrated that the transgenic events expressing 1x eYGFPuv could be easily identi fi ed visually during the callus stage and the shoot stage,enabling early and ef fi cient selection of transformants.Furthermore,whole-plant level visualization of eYGFPuv revealed its ubiquitous stability in transgenic plants.In addition,our transformation experiments showed that eYGFPuv can also be used to select transgenic plants without antibiotics.This work demonstrates the feasibility of utilizing 1x eYGFPuv in studies of gene expression and plant transformation in diverse plants. | Guoliang Yuan Haiwei Lu Dan Tang Md Mahmudul Hassan Yi Li Jin-Gui Chen Gerald A.Tuskan Xiaohan Yang | 2021 | Horticulture Research2021，8，1： | 1 |
| 16 | Nonwo-ven Polylactic Acid and Flax Biocomposites显示文摘 | Shah Alimuzzaman K Hugh Gong Mahmudul Akonda | 2013 | Polymer Compos-ites2013，10，： | 1 |
| 17 | ISSR as new markers for identification of homokaryotic protoclones of Agaricus bisporus 显示文摘 | Mahmudul I N Bian Y B | 2010 | Current Microbiology2010，60，： | 1 |
| 18 | Efficient approaches for de- signing reversible binary coded decimal adders 显示文摘 | ASHIS KUMER BISWAS MAHMUDUL MD HASAN AHSAN RAJA CHOWDHURY | 2008 | Microelectronics Journal2008，，39： | 1 |
| 19 | Dumping with correlated demand 显示文摘 | Anam Mahmudul Chiang Shin-Hwan | 1996 | Southern Economic Journal1996，62，4： | 1 |
| 20 | Export market correlation and strategic trade policy显示文摘 | Anam Mahmudul Shin-Hwan Chiang | 2000 | Canadian Journal of Economics2000，33，1： | 1 |
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