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| 1 | Convergence of neuro-endocrine-immune pathways in the pathophysiology of irritable bowel syndrome显示文摘Disordered signalling between the brain and the gut are generally accepted to underlie the functional bowel disorder, irritable bowel syndrome(IBS). However, partly due to the lack of disease-defining biomarkers, understanding the aetiology of this complex and multifactorial disease remains elusive. This common gastrointestinal disorder is characterised by alterations in bowel habit such as diarrhoea and/or constipation, bloating and abdominal pain, and symptom exacerbation has been linked with periods of stress, both psychosocial and infection-related. Indeed, a high level of comorbidity exists between IBS and stress-related mood disorders such as anxiety and depression. Moreover, studies have observed alterations in autonomic output and neuro-endocrine signalling in IBS patients. Accumulating evidence indicates that a maladaptive stress response, probably mediated by the stress hormone, corticotropin-releasing factor contributes to the initiation, persistence and severity of symptom flares.Other risk factors for developing IBS include a positive family history, childhood trauma, dietary factors and prior gastrointestinal infection. An emerging role has been attributed to the importance of immune factors in the pathophysiology of IBS with evidence of altered cytokine profiles and increased levels of mucosal immune cells. These factors have also been shown to have direct effects on neural signalling. This review discusses how pathological changes in neural, immune and endocrine pathways, and communication between these systems, contribute to symptom flares in IBS. | Maria M Buckley Siobhain M O'Mahony Dervla O'Malley | 2014 | World Journal of Gastroenterology2014，20，27： | 24 |
| 2 | Chemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS2): an open-label, randomised factorial trial显示文摘 | Matthew T Seymour Lindsay C Thompson Harpreet S Wasan Gary Middleton Alison E Brewster Stephen F Shepherd M Sinead O’Mahony Timothy S Maughan Mahesh Parmar Ruth E Langley | 2011 | The Lancet2011，，9779： | 2 |
| 3 | R&D, knowledge spillovers and company productivity performance 显示文摘 | O'Mahony M Vecchi M | 2009 | Research Policy2009，38，1： | 1 |
| 4 | If we get too much to your bones they'll go brittle': women's initial fears about radiotherapy for early brest cancer显示文摘 | O'Mahony M | 2008 | Psycho-oncology2008，17，： | 1 |
| 5 | Toxicity of cadmium in sediments: the role of acid volatile sulfide 显示文摘 | Di Toro D M Mahony J D Hansen D J | 1990 | Environmental Toxicology and Chemistry1990，9，12： | 1 |
| 6 | Toxicity of cadmium in sediments: the role of acid volatile sulfide 显示文摘 | DI TORO D M MAHONY J D HANSEN D J | 1990 | Environmental Toxicology and Chemistry1990，9，12： | 1 |
| 7 | Estrogen receptor-beta prevents cardiac fibrosis显示文摘 | Pedram A Razandi M O'Mahony F | 2010 | Mol Endocrinol2010，24，11： | 1 |
| 8 | Multivariate short- term traffic flow forecasting using time-series analysis 显示文摘 | Ghosh B Basu B O'Mahony M | 2009 | Intelligent Transportation Systems IEEE Trans- actions on2009，10，2： | 1 |
| 9 | Probiotic impact on microbial flora,inflammation and tumour development in IL-10 knockout mice显示文摘 | O'MAHONY L FEENEY M O'HALLORAN S | | 0，，08： | 1 |
| 10 | A Model for Development of Optimized Feeder Routes and Coordinated Schedules:A Genetic Algorithms Approach显示文摘 | Shrivastava P O' Mahony M | 2006 | Transport Policy2006，13，5： | 1 |
| 11 | Anisotropic elastic properties of cancellous bone from a hJaman edentulous mandible显示文摘 | Mahony A M Williams J L Katz J O | 2000 | Clin Oral Implants Res2000，11，5： | 1 |
| 12 | Development of Sport Interest Inventory (SII): Implications for measuring unique consumer motives at sporting events 显示文摘 | Funk D C Mahony D F Nakazawa M | 2001 | Internatianal Journal of Sports Marketing and Sponsorship2001，3，： | 1 |
| 13 | AVS predicts the actte toxicity of Cd and Ni in sediments 显示文摘 | DI TORO D M MAHONY J D HANSEN D L | 1992 | Environmental Science & Technology1992，26，1： | 1 |
| 14 | Parti- tioning of metals to sediment organic carbon 显示文摘 | MAHONY J D DITORO D M GONZALEZ A M | 1996 | Environmen- tal Toxicology and Chemistry1996，15，12： | 1 |
| 15 | Recurrence of fetal macrosomia in non-diabetic pregnancies显示文摘 | Walsh C A Mahony R T Foley M E | 2012 | J Obstet Gynecol2012，27，4： | 1 |
| 16 | Manual of lecture notes for Food Sensory Science显示文摘 | M O'Mahony | 2005 | Food Science & Technology2005，，6： | 1 |
| 17 | Collaborative rec?ommendation, a robustness analysis显示文摘 | O'Mahony M P Hurley NJ Kushmerick N | 2004 | ACM Transactions on In?ternet Technology2004，4，4： | 1 |
| 18 | NF- kappaB/Rel regulates inhibitory and excitatory neuronal function and synaptic plasticity显示文摘 | O'Mahony A Raber J Montano M | 2006 | Mol Cell Biol2006，26，： | 1 |
| 19 | Chemical Senses and Flavor显示文摘 | O'Mahony M | 1976 | Food Science & Technology1976，，2： | 1 |
| 20 | Toxicity of cadmium in sediments:the role of acid volatile sulfide显示文摘 | Di Toro D M Mahony J D Hansen D J | 1990 | Environ Toxicol Chem1990，9，： | 1 |
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