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| 1 | Open label trial of granulocyte apheresis suggests therapeutic efficacy in chronically active steroid refractory ulcerative colitis显示文摘AIM:To study the efficacy, safety, and feasibility of a granulocyte adsorptive type apheresis system for the treatment of patients with chronically active ulcerative colitis despite standard therapy.METHODS: An open label multicenter study was carried out in 39 patients with active ulcerative colitis (CAI6-8) despite continuous use of steroids (a minimum total dose of 400 mg prednisone within the last 4 wk).Patients received a total of five aphereses using a granulocyte adsorptive technique (Adacolumn(R), Otsuka Pharmaceutical Europe, UK). Assessments at wk 6 and during follow-up until 4 mo comprised clinical (CAI) and endoscopic (EI) activity index, histology, quality of life(IBDQ), and laboratory tests.RESULTS: Thirty-five out of thirty-nine patients were qualified for intent-to-treat analysis. After the apheresis treatment at wk 6, 13/35 (37.1%) patients achieved clinical remission and 10/35 (28.6%) patients had endoscopic remission (CAI<4, EI<4). Quality of life (IBDQ) increased significantly (24 points, P<0.01)at wk 6. Apheresis could be performed in all but one patient. Aphereses were well tolerated, only one patient experienced anemia.CONCLUSION: In patients with steroid refractory ulcerative colitis, five aphereses with a granulocyte/monocyte depleting filter show potential short-term efficacy. Tolerability and technical feasibility of the procedure are excellent. | Wolfgang Kruis Axel Dignass Elisabeth Steinhagen-Thiessen Julia Morgenstern Joachim M(o|¨)ssner Stephan Schreiber Maurizio Vecchi Alberto Malesci Max Reinshagen Robert L(o|¨)fberg | 2005 | World Journal of Gastroenterology2005，11，44： | 4 |
| 2 | Optimisation by simulated annealing显示文摘 | Kirkpatrick S Gelatt C D Vecchi M P | 1983 | Science1983，220，： | 1 |
| 3 | R&D, knowledge spillovers and company productivity performance 显示文摘 | O'Mahony M Vecchi M | 2009 | Research Policy2009，38，1： | 1 |
| 4 | Optimization by Simulated Annealing 显示文摘 | Kirkpatrick S Gelatt C D Vecchi M P | 1983 | Science1983，220，： | 1 |
| 5 | Optimization by simulated annealing显示文摘 | Kirkpatrick S Gelatt Jr C D Vecchi M P | 1983 | Science1983，220，4598： | 1 |
| 6 | Optimization by simulated annealing 显示文摘 | Kirkpatrick S Gelartt C D Vecchi M P | 1983 | Science1983，220，11： | 1 |
| 7 | Optimization by simulated annealing显示文摘 | Kirpatric S Gelatt Jr C D Vecchi M P | 1983 | Science1983，220，： | 1 |
| 8 | Evidence that the interaction between circulating IgA and fibronectin is a normal process enhanced in primary IgA nephropathy显示文摘 | DAVIN J C Li VECCHI M NAGY J | 1991 | J Clin Immunol1991，11，2： | 1 |
| 9 | Optimization by simulated annealing显示文摘 | KIRKPATRICK S GELATT C D VECCHI M P | 1983 | Science1983，220，4598： | 1 |
| 10 | High rate of posi- tive anti-tissue transglutaminase antibodies in chronic liver dis- ease, Role of liver decompensafion and of the antigen source显示文摘 | VECCHI M FOLLI C DONATO MF | 2003 | Scand J Gastroenterol2003，38，1： | 1 |
| 11 | Optimization by simulated annealing 显示文摘 | Kirkpatrick S Gelatt Jr C D Vecchi M P | 1983 | Science1983，220，： | 1 |
| 12 | Optimization by Simulated Annealing显示文摘 | Kirkpatrick S Gelatt C D Vecchi M P | | 0，，： | 1 |
| 13 | Gene expres- sion analysis of early and advanced gastric cancers 显示文摘 | Vecchi M Nuciforo P Romagnoli S | 2007 | Oncogene2007，26，： | 1 |
| 14 | Global wiring by simulated annealing 显示文摘 | Vecchi M P Kirkpatrick S | 1983 | IEEE Transactions on Computer-Aided Design of Integrated Circuites and Systems1983，4，： | 1 |
| 15 | Optimization by simulated annealing显示文摘 | Kirkpatrick S Gelatt C D Vecchi M P | 1983 | Science1983，220，： | 1 |
| 16 | Optimization by simulated annealing显示文摘 | Kirkpatrick S Gelatt C D Vecchi M P | 1983 | Science1983，220，： | 1 |
| 17 | Optimization by simulated annealing 显示文摘 | Kirkpatrick S Gelatt Jr C D Vecchi M P | 1983 | Science1983，220，5： | 1 |
| 18 | Prophage association of reef( A )dements encoding efflux-mediated erythromycin resistance in Streptococcus pyogenes 显示文摘 | Giovanetti E Brenciani A Vecchi M | 2005 | J Antimicrob Chemother2005，55，4： | 1 |
| 19 | Genetic ele- ments carrying erm (B) in Streptococcus pyogenes and association with tet tetracycline resistance gene显示文摘 | BRENCIANI A BACCIAGLIA A VECCHI M | 2007 | Antimicrob Agents Chemother2007，51，： | 1 |
| 20 | Optimization by Simulated Annealing 显示文摘 | Kirkpatrick S Gelatt C D Vecchi M P | 1983 | Science1983，220，4598： | 1 |
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