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| 1 | Capecitabine and irinotecan with and without bevacizumab for advanced colorectal cancer patients显示文摘AIM:To investigate the efficacy and safety of capecitabine plus irinotecan±bevacizumab in advanced or metastatic colorectal cancer patients. METHODS:Forty six patients with previously untreated,locally-advanced or metastatic colorectal cancer(mCRC) were recruited between 2001-2006 in a prospective open-label phaseⅡtrial,in German community-based outpatient clinics.Patients received a standard capecitabine plus irinotecan(CAPIRI) or CAPIRI plus bevacizumab(CAPIRI-BEV) regimen every 3 wk. Dose reductions were mandatory from the first cycle in cases of>grade 2 toxicity.The treatment choice of bevacizumab was at the discretion of the physician.Theprimary endpoints were response and toxicity and secondary endpoints included progression-free survival and overall survival. RESULTS:In the CAPIRI group vs the CAPRI-Bev group there were more female than male patients(47% vs 24%) ,and more patients had colon as the primary tumor site(58.8%vs 48.2%) with fewer patients having sigmoid colon as primary tumor site(5.9%vs 20.7%) .Grade 3/4 toxicity was higher with CAPIRI than CAPIRI-Bev:82%vs 58.6%.Partial response rates were 29.4%and 34.5%,and tumor control rates were 70.6%and 75.9%,respectively.No complete responses were observed.The median progression-free survival was 11.4 mo and 12.8 mo for CAPIRI and CAPIRI-Bev,respectively.The median overall survival for CAPIRI was 15 mo(458 d) and for CAPIRI-Bev 24 mo(733 d) .These differences were not statistically different.In the CAPIRI-Bev,group,two patients underwent a full secondary tumor resection after treatment,whereas in the CAPIRI group no cases underwent this procedure. CONCLUSION:Both regimens were well tolerated and offered effective tumor growth control in this outpatient setting.Severe gastrointestinal toxicities and thromboembolic events were rare and if observed were never fatal. | Markus Moehler Martin F Sprinzl Murad Abdelfattah Carl C Schimanski Bernd Adami Werner Godderz Klaus Majer Dimitri Flieger Andreas Teufel Juergen Siebler Thomas Hoehler Peter R Galle Stephan Kanzler | 2009 | World Journal of Gastroenterology2009，15，4： | 10 |
| 2 | Solubilities of oxygen and carbon dioxide in butyl methyl imidazolium tetrafluoroborate as a function of temperature and at pressures close to atmospheric pressure显示文摘 | Husson-Borg P Majer V Comes M F C | 2003 | J Chem Eng Data2003，48，3： | 1 |
| 3 | Determination of an optimal pitfall trap size for sampling spiders in a western Australian Jarrah forest 显示文摘 | Brennan K E C Majer J D Reygaert N | 1999 | Journal of Insect Conservation1999，3，： | 1 |
| 4 | Use of flow calorimetry for determining enthalpies of absorption and the solubility of CO2 in aqueous monoethanolamine solutions 显示文摘 | Mathonat C Majer V Mather A E Orolier J P E | 1998 | Industrial and Engineering Chemistry Research1998，37，： | 1 |
| 5 | The role of ants in degraded soils within dry andra state forest显示文摘 | Majer J D Walker T C Berlandier F | 1987 | Mulga Res Ctre J1987，9，： | 1 |
| 6 | Seasonal performance of a wetland constructed to process dairymilkhouse wastewater in Connecticut 显示文摘 | Majer N J Clausen J C Neafsey J A | 2000 | Ecological Engineering2000，14，12： | 1 |
| 7 | Seasonal performance of a wetland constructed to process dairy milkhouse wastewater in Connecticut 显示文摘 | Majer Newman J Clausen J C Neafsey J A | 2000 | Ecological Engineering2000，14，12： | 1 |
| 8 | Wave propagation through elastic porous media containing two immiscible fluids 显示文摘 | Lo W C Sposito G Majer E | 2005 | Water Resources Research2005，41，02： | 1 |
| 9 | Use of flow calorimetry for determining enthalpies of absorption and the solubility of CO2 in aqueous monoethanolamine solutions显示文摘 | Mathonat C Majer V Mather A E Grolier J P E | | 0，，10： | 1 |
| 10 | The Erlangen Slot Machine: A Dynamically Reconfigurable FPGA-based Computer显示文摘 | Bobda C Majer M Ahmadinia A | 2007 | VLSI Signal Processing2007，47，1： | 1 |
| 11 | Enthalpies of absorption and solubility of CO2 in aqueous solutions of methyldiethanolamine显示文摘 | Mathonat C Majer V Mather A E Grolier J P E | | 0，，1： | 1 |
| 12 | Defining the boundaries:structure and function of LOB domain proteins显示文摘 | Majer C Hochholdinger F | 2011 | Trends Plant Sci2011，16，： | 1 |
| 13 | Wave propagation through elastic porous media containing two immiscible fluids显示文摘 | LO W C SPOSITO G MAJER E | | 0，，： | 1 |
| 14 | Scleroderma (systemic sclerosis): classification, subsets and pathogenesis显示文摘 | LEROY E C BLACK C FLEISCH MAJER R | 1988 | J Rheumatol1988，15，2： | 1 |
| 15 | Reinitialization of DAE's after discontinuities显示文摘 | Majer C Marquardt W Gilles E D | 1995 | Computers and Chemical Engineering1995，，： | 1 |
| 16 | The use of artificial neural networks for the prediction of water quality parameters 显示文摘 | Majer H R Dandy G C | 1996 | Water Resource Research1996，32，4： | 1 |
| 17 | Determination of an optimal pitfall trap size for sampling spiders in a western Australian Jarrah Forest显示文摘 | Brennan K E C Majer J D Reygaert N | 1999 | Journal of Insect Conservation1999，3，： | 1 |
| 18 | Wave propagation through elastic porous media containing two immiscible fluids显示文摘 | Lo W C Majer E Sposito G | 2005 | Water Resources Research2005，41，2： | 1 |
| 19 | Solubilities of Oxygen and Carbon Dioxide in Butyl Methyl imidazolium Tetrafluoroborate as a Function of Temperature and at Pressures Close to Atmospheric Pressures显示文摘 | Majer V Gomes M F C | 2003 | J Chem Eng Data2003，48，： | 1 |
| 20 | Low-frequency diIatational wave propagation through unsaturat- ed porous media containing two immiscible fluids显示文摘 | Lo W C Sposito G Majer E | 2007 | Transport in Porous Media2007，，： | 1 |
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