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| 1 | Evaluation of enterochromaffin cells and melatonin secretion exponents in ulcerative colitis显示文摘AIM: To study an assessment of the number of enterochromaffin cells and expression of hydroxyindole-Omethyltransferase in colonic mucosa and urine excretion of 6-sulfatoxymelatonin in patients with ulcerative colitis. METHODS: The study included 30 healthy subjects (groupⅠ-C), 30 patients with ulcerative proctitis [group Ⅱ-ulcerative proctitis (UP)] and 30 patients with ulcerative colitis [group Ⅲ-ulcerative colitis (UC)] in acute phases of these diseases. The number of enterochromaffin cells (EC) was estimated in rectal and colonic mucosa. Bioptates were assembled from many different parts of the large intestine. Immunorective cells collected from various parts of the colon were counted according to the Eurovision DAKO (Dako A/S, Copenhagen, Denmark) System in the range of 10 fields in each bioptate at × 200 magnification. The level of mRNA expression of hydroxyindole-O-methyltransferase (HIOMT) in colonic mucosa was estimated with RT-PCR. Urine 6-sulfatoxymelatonin (6-HMS) excretion was determined immunoenzymatically using an IBL (IBL International GmbH, Hamburg, Germany) kit (RE 54031). RESULTS: The number of EC cells in healthy subjects (C) was 132.40 ± 31.26. In patients of group Ⅱ (UP) and group Ⅲ (UC) the number of these cells was higher 225.40 ± 37.35 (P < 0.001) and 225.24 ± 40.50 (P < 0.001) respectively. Similar differences were related to HIOMT expression, which was 1.04 ± 0.36 in group C, 1.56 ± 0.56 (P < 0.01) in group UP and 2.00 ± 0.35 (P < 0.001) in group UC. Twenty-four hour 6-HMS urinary excretion was as follows: C 16.32 ± 4.95 μg/24 h, UP 26.30 ± 7.29 μg/24 h (P < 0.01), UC 42.30 ± 12.56 μg/24h (P < 0.001). A correlation between number of EC cells and 6-HMS excretion was noted in all groups: r = 0.766 in patients with UP, r = 0.703 with UC and r = 0.8551 in the control group; the correlation between the results is statistically significant. CONCLUSION: In the acute phases of both UP and UC, proliferation of EC cells and high expression of HIOMT and urine excretion of 6-HMS is noted. These changes may represent a beneficial response in the anti-inflammatory and defense mechanism. | Cezary Chojnacki Maria Wisniewska-Jarosińska Grazyna Kulig Ireneusz Majsterek Russel J Reiter Jan Chojnacki | 2013 | World Journal of Gastroenterology2013，19，23： | 5 |
| 2 | Evaluation of oxidative stress markers in pathogenesis of primary open-angle glaucoma显示文摘 | Majsterek I Malinowska K Stanczyk M | 2011 | Exp Mol Pathol2011，90，2： | 1 |
| 3 | A comparison of the action of amifostine and melatonin on DNA-damaging effects and apoptosis induced by idarubicin in normal and cancer cells 显示文摘 | Majsterek I Gloc E Blasiak J | 2005 | J Pineal Res2005，38，4： | 1 |
| 4 | Gene polymorphisms of the MMP1, MMP9, MMP12,IL-113 and TIMP1 and the risk of primary open-angle glaucoma 显示文摘 | Markiewicz L Majsterek I Przybylowska K Dziki L Waszczyk M Gacek M | 2013 | Acta Ophtholmol2013，91，7： | 1 |
| 5 | ABL-fusion oncoproteins activate multi-pathway of DNA repair: role in drug resistance? 显示文摘 | MAJSTEREK I SLUPIANEK A HOSER G | 2004 | Biochimie2004，86，1： | 1 |
| 6 | Toxicity of microcystin from cyanobacteria growing in a source of drinking water显示文摘 | Majsterek I Sicinska P Tarczynska M | 2004 | Comparative Biochemistry and Physiology Part C2004，139，13： | 1 |
| 7 | Angiogenesis markers quantification in breast cancer and their correlation with clinicopathological prognostic variables 显示文摘 | Rykala J Przybylowska K Majsterek I et ol | 2011 | Pathol Oncol Res2011，17，4： | 1 |
| 8 | Evaluation of oxidative stress markers in pathogenesis of diabetic neuropathy显示文摘 | Jacek Kasznicki Marcin Kosmalski Agnieszka Sliwinska Malgorzata Mrowicka Malgorzata Stanczyk Ireneusz Majsterek Jozef Drzewoski | 2012 | Molecular Biology Reports2012，，9： | 1 |
| 9 | Phonological awareness and beginning reading: evaluation of a school-based srecning procedure 显示文摘 | Majsterek DJ Ellenwood AE | 1995 | J Learn Disabil1995，28，： | 1 |
| 10 | Fusion tyrosine kinases induce drug resistance by stimulation of homology-dependent recombination repair,prolongation of G(2)/M phase,and protection from apoptosis显示文摘 | Slupianek A Hoser G Majsterek I | 2002 | Mol Cell Biol2002，22，12： | 1 |
| 11 | Comparative study of DNA damage,cell cycle and apoptosis in human K562 and CCRF-CEM leukemia cells:role of BCR/ABL in therapeutic resistance显示文摘 | Dariusz Pyte Tomasz Wysocki Ireneusz Majsterek | 2006 | Gomparative Biochemistry and Physiology Part C:Toxicology & Pharmacology2006，144，1： | 1 |
| 12 | The Trp64Arg beta3-adrenergic receptor amino-acid variant is not associated with overweight and type 2 diabetes mellitus in Polish population显示文摘 | Kasznicki J Blasiak J Majsterek I | 2005 | Exp Clin Endocrinol Diabetes2005，113，10： | 1 |
| 13 | Prospects and limitations of the rational engineering of fibrillar collagens显示文摘 | Majsterek I Mc Adams E Adachi E | 2003 | Protein Sci2003，12，9： | 1 |
| 14 | Fusion tyrosine kinases induce drug resistance by stimulation of homology-dependent recombination repair,prolongation of G(2)/M phase,and protection from apoptosis显示文摘 | Slupianek A Hoser G Majsterek I | 2002 | Mol Cell Biol2002，22，12： | 1 |
| 15 | Toxicity of micro-cystin from cyanobacteria growing in a source of drinking water显示文摘 | MAJSTEREK I SICINSKA P TARCZYNSKA M | 2004 | CompBiochem Physiol C Toxicol Pharmacol2004，139，13： | 1 |
| 16 | The Trp64Arg beta3-adrenergic receptor amino-acid variant is not associated with overweight and type 2 diabetes mellitns in Polish population显示文摘 | Kasznicki J Blasiak J Majsterek I | | 0，，10： | 1 |
| 17 | Angiogenesis Markers Quantification in Breast Cancer and Their Correla- tion with Clinicopathological Prognostic Variables 显示文摘 | Rykala J Przybylowska K Majsterek I | 2011 | Patho Oncol Res2011，17，4： | 1 |
| 18 | Fusion tyrosine kinases Induce drug resistance by stimulation of homology-dependent recombination repair,prolongation of G2/M phase,and protection from apoptosis显示文摘 | Slupianek A Hoser G Majsterek I | 2002 | Mol Cell Biol2002，22，12： | 1 |
| 19 | Angiogenesis markers quan-tification in breast cancer and their correlation with clinicopathological prognostic variables显示文摘 | Rykala J Przybylowska K Majsterek I | | 0，，04： | 1 |
| 20 | Association of MMPI-1607 IG/2G and TIMP1 372 T/C gene polymorphisms with risk of primary open angle glaucoma in a Polish popula- tion显示文摘 | Majsterek I Markiewicz L Przybylowska K | 2011 | Med Sci Monit2011，17，7： | 1 |
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