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| 1 | Autologous mobilized peripheral blood CD34^+ cell infusion in non-viral decompensated liver cirrhosis显示文摘AIM: To study the effect of mobilized peripheral blood autologous CD34 positive(CD34+) cell infusion in patients with non-viral decompensated cirrhosis.METHODS: Cirrhotic patients of non-viral etiology were divided into 2 groups based on their willingness to be listed for deceased donor liver transplant(DDLT)(control, n = 23) or to receive autologous CD34+ cell infusion through the hepatic artery(study group, n= 22). Patients in the study group were admitted to hospital and received granulocyte colony stimulating factor injections 520 μg/d for 3 consecutive days to mobilize CD34+ cells from the bone marrow. On day 4,leukapheresis was done and CD34+ cells were isolated using CliniMAC magnetic cell sorter. The isolated CD34+ cells were infused into the hepatic artery under radiological guidance. The patients were discharged within 48 h. The control group received standard of care treatment for liver cirrhosis and were worked up for DDLT as per protocol of the institute. Both groups were followed up every week for 4 wk and then every month for 3 mo.RESULTS: In the control and the study group, the cause of cirrhosis was cryptogenic in 18(78.2%) and16(72.72%) and alcohol related in 5(21.7%) and6(27.27%), respectively. The mean day 3 cell count(cells/μL) was 27.00 ± 20.43 with a viability of 81.84± 11.99%. and purity of 80%-90%. Primary end point analysis revealed that at 4 wk, the mean serum albumin in the study group increased significantly(2.83± 0.36 vs 2.43 ± 0.42, P = 0.001) when compared with controls. This improvement in albumin was,however, not sustained at 3 mo. However, at the end of3 mo there was a statistically significant improvement in serum creatinine in the study group(0.96 ± 0.33 vs 1.42 ± 0.70, P = 0.01) which translated into a significant improvement in the Model for End-Stage Liver Disease score(15.75 ± 5.13 vs 19.94 ± 6.68,P = 0.04). On statistical analysis of secondary end points, the transplant free survival at the end of 1 mo and 3 mo did not show any significant difference(P =0.60) when compared to the control group. There was no improvement in aspartate transaminase, alanine transaminase, and bilirubin at any point in the study population. There was no mortality benefit in the study group. The procedure was safe with no procedural or treatment related complications.CONCLUSION: Autologous CD 34+ cell infusion is safe and effectively improves liver function in the short term and may serve as a bridge to liver transplantation. | Mithun Sharma Padaki Nagaraja Rao Mitnala Sasikala Mamata Reddy Kuncharam Chimpa Reddy Vardaraj Gokak BPSS Raju Jagdeesh R Singh Piyal Nag D Nageshwar Reddy | 2015 | World Journal of Gastroenterology2015，21，23： | 9 |
| 2 | High-resolution line scan diffusion tensor MR imaging of white matter fiber tract anatomy显示文摘 | Mamata H Mamata Y Westin CF | 2002 | Am J Neuroradiol2002，23，1： | 1 |
| 3 | Characterization of Plasmids encoding CTX-M β-lactamase and their Addiction Systems in Escherichia coli isolates from Animals显示文摘 | Migma Dorji Tamang Mamata Gurung Min-Su Kang Hyang-Mi Nam Dong Chan Moon Geum-Chan Jang Suk-Chan Jung Yong Ho Park Suk-Kyung Lim | 2014 | Veterinary Microbiology2014，，： | 1 |
| 4 | Online customized index synthesis in commercial web sites显示文摘 | Mamata Jenamani Pratap K J Mohapatra Sujoy Ghose | 2002 | IEEE Intelligent Systems2002，，1112： | 1 |
| 5 | Apparent diffusion coefficient and fractional anisotropy in spinal cord: age and cervical spondylosis-related changes显示文摘 | Mamata H Jolesz FA Maier SE | 2005 | J Magn Reson Imaging2005，22，1： | 1 |
| 6 | Processing and vi- sualization for diffusion tensor MRI 显示文摘 | Westin CF Maier SE Mamata H etal | 2002 | Med Image Anal JT-Medical image analysis2002，6，2： | 1 |
| 7 | Characterization of central nervous system structures by magnetic resonance diffusion anisotropy显示文摘 | Jolesz FA Maier SE | 2004 | Neurochem hat2004，45，： | 1 |
| 8 | An efficient reverse auction mechanism for limited supplier base显示文摘 | Arun K R Mamata J Pratap K J M | 2011 | Electronic Commerce Research and Applications2011，10，2： | 1 |
| 9 | Vulnerability to Agricultural Drought in Western Orissa:A Case Study of Representative Blocks显示文摘 | Mrutyunjay Swain Mamata Swain | 2011 | Agricultural Economics Research Review2011，，24： | 1 |
| 10 | Supplier behavior modeling and winner determination using parallel MDP显示文摘 | Arun K R Mamata J Pratap K J M | 2011 | Expert Systems with Applications2011，38，5： | 1 |
| 11 | Surgical indications in patients with an intra cerebral hemorrhage due to ruptured middle cerebral artery aneurysm显示文摘 | Shimoda M Oda S Mamata Y | 1997 | J Neurusurg1997，87，2： | 1 |
| 12 | Apparent diffusion coefficient and fractional anisotropy in spinal cord: age and cervical spondylosis related changes显示文摘 | Mamata H Jolesz F A Maier S E | 2005 | J Magn Reson Imaging2005，22，1： | 1 |
| 13 | Characterization of central nervous system structures by magnetic resonance diffusion anisotropy显示文摘 | Mamata H Jolesz FA Maier SE | 2004 | Neurochem Int2004，45，4： | 1 |
| 14 | Towards understanding the roles of social capital in knowledge integration : A case study of a collaborative information systems project 显示文摘 | Mamata B Pan S L Tan B C Y | 2007 | Journal of the American Society for Information Science and Technology2007，58，2： | 1 |
| 15 | Biexponential dif- fusion tensor analysis of human brain diffusion data 显示文摘 | Maier SE vajapeyam S Mamata H | 2004 | Mag- netic Resonance in Medicine2004，51，2： | 1 |
| 16 | Dielectric Properties of Vanadium Substituted Lithium ZincTitanium Ferrite显示文摘 | Mamata M Sumitra P Sarma H N K | 2003 | Intern J of Modern Physics B2003，17，21： | 1 |
| 17 | High-resolution line scan diffusion tensor MR imaging of white matter fiber tract anatomy 显示文摘 | Mamaata H Mamata Y Westin CF | 2002 | AJNR2002，23，1： | 1 |
| 18 | High - resolution line scan difusion tensor MRI maging of white mater fiber tract anatomy显示文摘 | MAMATA H MAMATA Y WESTIN C F | 2002 | Am J Neuorradiol2002，23，1： | 1 |
| 19 | Generation of cytotoxic immune response against a rat glioma by in vivo primary and secondary in vitro stimulation with tumor cells显示文摘 | Holladay FP Lopez G Mamata de | 1992 | Neurosurgery1992，30，： | 1 |
| 20 | Characterization of central nervous system structures by magnetic resonance diffusion anisotropy 显示文摘 | Mamata FI Jolesz FA Maier SE | 2004 | Neurochem Int2004，45，4： | 1 |
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