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| 1 | Hepatitis B genotypes: Relation to clinical outcome in patients with chronic hepatitis B in Saudi Arabia显示文摘AIM: To identify the most common hepatitis B virus (HBV) genotype in Saudi Arabia, and correlate the prevailing genotypes with the clinical outcome of patients. METHODS: Patients were consecutively recruited from the hepatology clinics of two tertiary care referral cen- ters. Patients were categorized into 4 different groups: group 1, patients with hepatitis B and normal liver en- zymes; group 2, patients with hepatitis B and abnormal liver enzymes but without cirrhosis; group 3, patients with hepatitis B and liver cirrhosis; group 4, patients with hepatitis B and hepatocellular carcinoma. All patients had a positive hepatitis B surface antigen (HBsAg). Ge- notyping of HBV was performed by nested PCR-mediated amplification of the target sequence and hybridization with sequence-specific oligonucleotides. RESULTS: Seventy patients were enrolled in this study. They were predominantly male (72.9%) in their mid- forty’s (mean age 47 years). Forty-nine (70%) patients were hepatitis B envelope antigen (HBeAg) negative. The majority of patients (64%) acquired HBV through unknown risk factors. Hepatitis B genotyping revealed that 57 patients (81.4%) were genotype D, 1 patient (1.4%) had genotype A, 1 patient (1.4%) had geno- type C, and 4 patients (5.7%) had genotype E, while 7 patients (10%) had mixed genotype (4 patients ADG, 1 patient DE, 1 patient DF, and 1 patient ADFG). Based on univariate analysis of genotype D patients, significant predictors of advanced liver disease were age, gender, aspartate transaminase, alanine transaminase, albumin,bilirubin, and alkaline phosphatase (all P < 0.001). In multivariate analysis decreased hemoglobin (r = -0.05; 95% CI: -0.08 to -0.03; P = 0.001) and albumin levels (r = -0.004; 95% CI: -0.007 to -0.001; P = 0.002) were highly significant predictors of advanced liver disease. In patients with HBV genotype D, HBeAg negativity was found to increase across advancing stages of liver dis- ease (P = 0.024). CONCLUSION: This study highlights that the vast ma- jority of Saudi patients with chronic hepatitis B have genotype D. No correlation could be observed between the different genotypes and epidemiological or clinical factors. The relationship between genotype D and HBeAg status in terms of disease severity needs to be further elucidated in larger longitudinal studies. | Ayman A Abdo Badr M Al-Jarallah Faisal M Sanai Ahmad S Hersi Khalid Al-Swat Nahla A Azzam Manal Al-Dukhayil Amira Al-Maarik Faleh Z Al-Faleh | 2006 | World Journal of Gastroenterology2006，12，43： | 7 |
| 2 | Six Minute Walk Test to assess functional capacity in chronic liver disease patients显示文摘AIM: To examine the utility of Six Minute Walk Test (6MWT) in patients with chronic liver disease (CLD). METHODS: Two hundred and fifty subjects between the ages of 18 and 80 (mean 47) years performed 6MWT and the Six Minute Walk Distance (6MWD) was measured. RESULTS: The subjects were categorized into four groups. Group A (n = 45) healthy subjects (control); group B (n = 49) chronic hepatitis B patients; group C (n = 54) chronic hepatitis C patients; group D (n = 98) liver cirrhosis patients. The four groups differed in terms of 6MWDs (P < 0.001). The longest distance walked was 421 ± 47 m by group A, then group B (390 ± 53 m), group C (357 ± 72 m) and group D (306 ± 111 m). The 6MWD correlated with age (r = -0.482, P < 0.01), hemoglobin (r = +0.373, P < 0.001) and albumin (r = +0.311, P < 0.001) levels. The Child-Pugh classification was negatively correlated with the 6MWD in cirrhosis (group D) patients (r = -0.328, P < 0.01). At the end of a 12 mo follow-up period, 15 of the 98 cirrhosis patients had died from disease complications. The 6MWD for the surviving cirrhotic patients was longer than for non-survivors (317 ± 101 vs 245 ± 145 m, P = 0.021; 95% CI 11-132). The 6MWD was found to be an independent predictor of survival (P = 0.024). CONCLUSION: 6MWT is a useful tool for assessing physical function in CLD patients. We suggest that 6MWD may serve as a prognostic indicator in patients with liver cirrhosis. | Hatem F Alameri Faisal M Sanai Manal Al Dukhayil Nahla A Azzam Khalid A Al-Swat Ahmad S Hersi Ayman A Abdo | 2007 | World Journal of Gastroenterology2007，13，29： | 5 |
| 3 | Effectiveness of hepatitis B virus vaccination program in Egypt:Multicenter national project显示文摘AIM:To assess the effectiveness of hepatitis B virus(HBV) vaccination program among fully vaccinated children.METHODS:A national community based crosssectional study was carried out in 6 governorates representing Egypt. A total of 3600 children aged from 9 mo to 16 years who were fully vaccinated with HBV vaccine during infancy were recruited. Face to face interviews were carried out and sera were evaluated for hepatitis B surface antigen(HBsA g),anti-HBV core antibodies(total) and quantitative detection of hepatitis B surface antibody using enzyme linked immunoassays techniques. Samples positive to HBs Ag/anti-HBV core antibodies were subjected to quantitative HBV-DNA detection by real time polymerase chain reaction with 3.8 IU/L detection limit. RESULTS:Sero-protection was detected among 2059 children(57.2%) with geometric mean titers 75.4 ± 3.6 IU/L compared to 3.1 ± 2.1 IU/L among nonseroprotected children. Multivariate logistic analysis revealed that older age and female gender were the significant predicting variables for having non seroprotective level,with adjusted odds ratio 3.3,9.1and 14.2 among children aged 5 to < 10,10 to < 15 and ≥ 15 years respectively compared to those < 5 years and 1.1 among girls compared to boys with P < 0.01. HBs Ag was positive in 0.11% and breakthrough infection was 0.36% and 0.39% depending on positivity of anti-HBc and DNA detection respectively. The prevalence of HBV infection was significantly higher among children aged ≥ 7 years(0.59%) compared to 0.07% among younger children with odds ratio equal to 8.4(95%CI:1.1-64.2) and P < 0.01.The prevalence was higher among girls(0.48%) than boys(0.29%) with P > 0.05. C ON C LU S I ON :T he E gy pt ian c ompuls or y H B V vaccination program provides adequate protection. Occult HBV infection exists among apparently healthy vaccinated children. Adherence to infection control measures is mandatory. | Iman I Salama Samia M Sami Zeinab Nabil Ahmed Said Manal H El-Sayed Lobna A El Etreby Thanaa M Rabah Dalia M Elmosalami Amany T Abdel Hamid Somaia I Salama Aida M Abdel Mohsen Hanaa M Emam Safaa M Elserougy Amal I Hassanain Naglaa F Abd Alhalim Fatma A Shaaban Samia A Hemeda Nihad A Ibrahim Ammal M Metwally | 2015 | World Journal of Hepatology2015，7，22： | 2 |
| 4 | Melatonin and/or rowatinex attenuate streptozotocin-induced diabetic renal injury in rats显示文摘The study aimed to explore the prophylactic effect of melatonin, rowatinex; a naturally occurring renal drug, and its combination on diabetic nephropathy in type 2 diabetic rats. Diabetes was induced by intraperitoneal injection of a single dose of streptozotocin(50 mg/g body weight). Three days before diabetes induction, rats were daily treated with melatonin, rowatinex and their combination continuously for 8 weeks. Evaluation was done through measuring blood urea nitrogen(BUN), serum uric acid, serum creatinine, urine creatinine, creatinine clearance, nitric oxide(NO), malondialdehyde(MDA), superoxide dismutase(SOD), glutathione(GSH), total antioxidant capacity(TAC),kidney injury molecule-1(KIM-1), heat shock protein-70(HSP-70), caspase-3, transforming growth factor β1(TGFβ1), DNA degradation by the comet assay and total protein contents. Histopathologic study was also done for the kidney and the pancreas. Drastic changes in all measured parameters of the diabetic rats were observed. Treatment with melatonin and rowatinex showed amelioration to variable degrees. In conclusion, melatonin showed the most potent effect on protecting rats from deleterious action of diabetic nephropathy followed by its combination with rowatinex. | Tarek K Motawi Samia A Ahmed Manal A Hamed Shohda A El-Maraghy Wessam M Aziz | 2019 | The Journal of Biomedical Research2019，33，2： | 2 |
| 5 | Association of XRCC1 gene polymorphisms with breast cancer suscepti- bility in saudi patients 显示文摘 | Fatima M Mohammed A Manal S | 2013 | Asian Pacific J Cancer Prev2013，14，6： | 1 |
| 6 | Oral capecitabine for the treatment of hepatocellular carcinoma,cholangiocarcinoma,and gallbladder carcinoma显示文摘 | Yehuda Z Manal M Alvaro A | | 0，，03： | 1 |
| 7 | Recombinant human insuling-like crowth factor 1 stimulates all stages of 11-ketotestosterone-induced spermatogenesis in the Japanese eel,Anguilla japonica in vitro显示文摘 | Manal R N Takeshi M Nobutaka A | 1999 | Biology of Reproduction1999，61，： | 1 |
| 8 | Improvement of carotenoid pigments produced by Rhodotorula glutinis显示文摘 | Hany M Y Ebtesam M A O Manal FE | 2013 | Life Science Journal2013，10，4： | 1 |
| 9 | Prophylactic effect of green tea polyphenols against liver and kidney injury induced by fenitrothion insecticide显示文摘 | Manal E A Elhalwagy Darwish N S Zaher E M | 2008 | Pesticide Biochemistry and Physiology2008，91，2： | 1 |
| 10 | Effects of alfalfa saponins on themoth(Spodoptera littoralis)显示文摘 | Manal M A Frantisek S Marian J | 2000 | Journal of Chemical Ecology2000，26，4： | 1 |
| 11 | Humic acid foliar appli-cation to minimize soil applied fertilization of surface-irrigatedwheat显示文摘 | Shaaban S A Manal F M Afifi M M | 2009 | World Journal of Agricultural Sciences2009，5，2： | 1 |
| 12 | Cellular uptake and metabolism of flavonoids and their metabolites: implications for their bioactivity 显示文摘 | Spencer J P E Manal M Mohsen A E | 2004 | Arch Biochem Biophys2004，423，： | 1 |
| 13 | Biodiversity of arbuscular mycorrhizal fungi in roots and soils of two salt marshes 显示文摘 | Wilde P Manal A Stodden M | 2009 | Environmental Microbiology2009，11，6： | 1 |
| 14 | Effect of umbilical vein blood flow on perinatal outcome of fetuses with lean and or hypo - coiled umbilical cord显示文摘 | Manal M Behery El Amal A | 2011 | Arch Gynecol Obstet2011，283，1： | 1 |
| 15 | Biodiversity of arbuscular mycorrhizal fungi in roots and soils of two salt marshes 显示文摘 | Wilde P Manal A Stodden M | 2009 | Environmental Microbiology2009，11，6： | 1 |
| 16 | Rela- tion between anemia and blood levels of lead, copper, zinc and iron a- mong children 显示文摘 | Amal A Hegazy Manal M Zaher Manal A Abdelhafez | 2010 | BMC Research Notes2010，3，1： | 1 |
| 17 | Electrostatic fabrication of ultrafine conductive fibers: Polyaniline/poly(ethylene oxide)显示文摘 | Norris I D Manal M MacDiarmid A G | 2000 | Synthetic Metals2000，114，2： | 1 |
| 18 | Interaction of the Cyto- chrome P4501A2, SULT1A1 and NAT gane polymorphisms with smoking and dietary mutagen intake in modification of the risk of pan- creatic cancer显示文摘 | Hideo Suzuki Jeffrey S Morris Yanan Li Mark A Doll David W Hein Jun Liu Li ]ian Manal M Hassan Rena S Day Melissa L Bondy James L Abbruzzese and Donghui Li | 2008 | Carcinogenesis2008，29，6： | 1 |
| 19 | Uptake and metabolism of epicatechin and its access to the brain after oral ingestion显示文摘 | Manal M Abd El Mohsen Gunter Kuhnle Andreas R Rechner Hagen Schroeter Sarah Rose Peter Jenner Catherine A Rice-Evans | 2002 | Free Radical Biology and Medicine2002，，12： | 1 |
| 20 | Effect of Saccharomyces boulardii on intestinal and caecal colonization of Salmonella typhimurium and Clostridium perfringens in boirler chickens 显示文摘 | Award M Manal A A Sahar A Z and Basma S | 2003 | J Vet Sci2003，37，： | 1 |
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