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| 1 | Resuscitation Training: A Time for Reassessment显示文摘 | Mancini M E Kaye W | 1996 | J Card Nurs1996，10，4： | 1 |
| 2 | Line broadening analysis of implosion core conditions at Z using argon K shell spectroscopy 显示文摘 | Burris-Mog T J Mancini R C Bailey J E | 2006 | Journal of Quantitative Spectroscopy and Radiation Transfer2006，99，13： | 1 |
| 3 | Seminal antioxidant capacity in pre- and postoperative varicocele 显示文摘 | Mancini A Meucci E Milardi D | 2004 | J Androl2004，25，1： | 1 |
| 4 | Working together, nurses can make a difference in resuscitation outcomes:an update on the A- merican Heart Association's 2010 guidelines for cardio- pulmonary resuscitation and emergency cardiovascular care显示文摘 | Mancini M E | 2011 | Jpn J Nurs Sci2011，8，1： | 1 |
| 5 | Cardiac effects of chronic inflamma- tion in dialysis patients 显示文摘 | Santoro A Mancini E | 2012 | Nephrol Dial Transplant2012，17，8： | 1 |
| 6 | Galileo high-resolution encoder system显示文摘 | MANCINI D CASCONE E SCHIPANI P | | SPIE0，3112，： | 1 |
| 7 | Impact of future climate and emission ehanges on stratospheric aerosols and ozone 显示文摘 | Pitari G Mancini E Rizi V | 2002 | J Atmos Sei2002，59，： | 1 |
| 8 | Mitochondrial proliferation and paradoxical membrane depolarization during terminal differentiation and apoptosis in a human colon carcinoma cell line显示文摘 | Mancini M Anderson BO Caldwell E | 1997 | J Cell Biol1997，138，2： | 1 |
| 9 | Mesozoic ( Upper Jura- ssic-Lower Cretaceous ) deep gas reservoir play, central and eastern Gulf coastal plain 显示文摘 | Mancini E A Li P Goddard D A | 2008 | AAPG Bulletin2008，92，3： | 1 |
| 10 | Liver support systems显示文摘 | Santoro A Mancini E Ferramosca E | | 0，，： | 1 |
| 11 | Blood volume regulation during hemodialysis显示文摘 | Santoro A Mancini E Paolini F | 1998 | Am J Kidney Dis1998，32，5： | 1 |
| 12 | Sequential screening for diabetes-evaluation of a campaign in Swiss community pharmacies显示文摘 | HERSBERGER K E BOTOMINO A MANCINI M | 2006 | Phurm World Sci2006，28，3： | 1 |
| 13 | Mechanisms of pulmonary gas exchange improvement during a protective ventilatory strategy in ARDS显示文摘 | Mancini M Zavala E Macebo J | 2001 | Am J Respir Crit Med2001，164，： | 1 |
| 14 | The effect of on-line high-flux hemofiltration versus low-flux hemodialysis on mortality in chronic kidney failure:a small randomized controlled trial显示文摘 | Santoro A Mancini E Bolzani R | 2008 | Am J Kidney Dis2008，52，3： | 1 |
| 15 | Induction of anti-human immunodeficiency virus (HIV) neutralizing antibodies in rabbits immunized with recombinant HIV-hepatitis B surface antigen particles显示文摘 | M L Michel M Mancini E Sobczak | 1988 | Proc Nat Acad Sci USA1988，，85： | 1 |
| 16 | Determination of organic acid anions in Italian beers by a new HPLC method显示文摘 | MANCINI F MINIATI E MONTANARI L | 2000 | Ital Journal of Food Science2000，12，4： | 1 |
| 17 | Comparing the immunogenicity of glycosidase-directed resiquimod prodrugs mediated by cancer cell metabolism显示文摘We have recently developed an enzyme-directed immunostimulant(EDI)prodrug motif,which is metabolized to active immunostimulant by cancer cells and,following drug efflux,activates nearby immune cells,resulting in immunogenicity.In this study,we synthesized several EDI prodrugs featuring an imidazoquinoline immunostimulant resiquimod(a Toll-like receptor 7/8 agonist)covalently modified with glycosidase enzyme-directing groups selected from substrates of β-glucuronidase,α-mannosidase,or β-galactosidase.We compared the glycosidase-dependent immunogenicity elicited by each EDI in RAW-Blue macrophages following conversion to active immunostimulant by complementary glycosidase.At a cellular level,we examined EDI metabolism across three cancer cell lines(B16 melanoma,TC2 prostate,and 4T1 breast cancer).Comparing the relative immunogenicity elicited by each EDI/cancer cell combination,we found that B16 cells produced the highest EDI prodrug immunogenicity,achieving>95% of that elicited by unmodified resiquimod,followed by TC2 and 4T1 cells(40% and 30%,respectively).Immunogenicity elicited was comparable for a given cell type and independent of the glycosidase substrate in the EDIs or differences in functional glycosidase activity between cell lines.Measuring drug efflux of the immunostimulant payload and efflux protein expression revealed that EDI/cancer cell-mediated immunogenicity was governed by efflux potential of the cancer cells.We determined that,following EDI conversion,immunostimulant efflux occurred through both P-glycoprotein-dependent and P-glycoprotein-independent transport mechanisms.Overall,this study highlights the broad ability of EDIs to couple immunogenicity to the metabolism of many cancers that exhibit drug efflux and suggests that designing future generations of EDIs with immunostimulant payloads that are optimized for drug efflux could be particularly beneficial. | Austin T Ryan Anunay J Pulukuri Maryam Davaritouchaee Armina Abbasi Aaron T Hendricksen Larissa K Opp Anthony J Burt Amy E Nielsen Rock J Mancini | 2020 | Acta Pharmacologica Sinica2020，41，7： | 1 |
| 18 | Prometheus system: a technological support in liver failure 显示文摘 | Santoro A Faenza S Mancini E | 2006 | Transplantation Proceedings2006，38，： | 1 |
| 19 | Upper Jurassic thrombolite reservoir play, north- eastern Gulf of Mexieo显示文摘 | MANCINI E A LLINA' S J C PARCELL W C | 2004 | AAPG Bulletin2004，88，11： | 1 |
| 20 | Genetic Modulation of Plasma Fibrinogen Concentrations:Possible Importance of Interleukin-6显示文摘 | Margaglione M Grandone E Mancini FP el al | 1996 | J Thromb Thrombolysis1996，3，1： | 1 |
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