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| 1 | Modern approach to cholecysto-choledocholithiasis显示文摘Gallstones and common bile duct calculi are found to be associated in 8%-20% of patients, leading to possible life-threatening complications, such as acute biliary pancreatitis, jaundice and cholangitis. The gold standard of care for gallbladder calculi and isolated common bile duct stones is represented by laparoscopic cholecystectomy and endoscopic retrograde cholangiopancreatography, respectively, while a debate still exists regarding how to treat the two diseases at the same time. Many therapeutic options are also available when the two conditions are associated, including many different types of treatment, which local professionals often administer. The need to limit maximum discomfort and risks for the patients, combined with the economic pressure of reducing costs and utilizing resources, favors single-step procedures. However, a multitude of data fail to strongly demonstrate the superiority of any technique(including a two or multi-step approach), while rigorous clinical trials that include so many different types of treatment are still lacking, and it is most likely unrealistic to conduct them in the future. Therefore, the choice of the best management is often led by the local presence of professional expertise and resources, rather than by a real superiority of one strategy over another. | Lapo Bencini Cinzia Tommasi Roberto Manetti Marco Farsi | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，2： | 28 |
| 2 | New endoscopic imaging techniques in surveillance of inflammatory bowel disease显示文摘Endoscopy plays a crucial role in the management of inflammatory bowel disease(IBD). Advancesimaging techniques allow visualization of mucosal details, tissue characteristics and cellular alteration. In particular chromoendoscopy, magnification endoscopy, confocal laser endomicroscopy and endocytoscopy seem to have the possibility to radically modify the approach to surveillance and decision making. Dyebased chromoendoscopy(DBC) and magnification chromoendoscopy improve detection of dysplasia, and evaluation of inflammatory activity and extension of ulcerative colitis and are thus considered the standard of care. Dye-less chromoendoscopy could probably replace conventional DBC for surveillance. Narrow band imaging and i-scan have shown to improve activity and extent assessment in comparison to white-light endoscopy. Confocal laser endomicroscopy(CLE) can detect more dysplastic lesions in surveillance colonoscopy and predict neoplastic and inflammatory changes with high accuracy compared to histology. This technology is best used in conjunction with chromoendoscopy, narrow-band imaging, or autofluorescence because of its minute scanning area. This combination is useful for appropriate tissue classification of mucosal lesions already detected by standard or optically enhanced endoscopy. The best combination for IBD surveillance appear to be chromoendoscopy for identification of areas of suspicion, with further examination with CLE to detect intraepithelial neoplasia. However cost, availability, and experience are still an issue. | Tommaso Gabbani Natalia Manetti Andrea Giovanni Bonanomi Antonio Luca Annese Vito Annese | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，3： | 3 |
| 3 | Adipose-derived stem cells:Pathophysiologic implications vs therapeutic potential in systemic sclerosis显示文摘Adipose-derived stem cells(ADSCs)residing in the stromal vascular fraction(SVF)of white adipose tissue are recently emerging as an alternative tool for stem cell-based therapy in systemic sclerosis(SSc),a complex connective tissue disorder affecting the skin and internal organs with fibrotic and vascular lesions.Several preclinical and clinical studies have reported promising therapeutic effects of fat grafting and autologous SVF/ADSC-based local treatment for facial and hand cutaneous manifestations of SSc patients.However,currently available data indicate that ADSCs may represent a double-edged sword in SSc,as they may exhibit a pro-fibrotic and anti-adipogenic phenotype,possibly behaving as an additional pathogenic source of pro-fibrotic myofibroblasts through the adipocyte-to-myofibroblast transition process.Thus,in the perspective of a larger employ of SSc-ADSCs for further therapeutic applications,it is important to definitely unravel whether these cells present a comparable phenotype and similar immunosuppressive,anti-inflammatory,anti-fibrotic and pro-angiogenic properties in respect to healthy ADSCs.In light of the dual role that ADSCs seem to play in SSc,this review will provide a summary of the most recent insights into the preclinical and clinical studies employing SVF and ADSCs for the treatment of the disease and,at the same time,will focus on the main findings highlighting the possible involvement of these stem cells in SSc-related fibrosis pathogenesis. | Irene Rosa Eloisa Romano Bianca Saveria Fioretto Marco Matucci-Cerinic Mirko Manetti | 2021 | World Journal of Stem Cells2021，13，1： | 3 |
| 4 | Contrast-enhanced ultrasound Liver Imaging Reporting and Data System:Lights and shadows in hepatocellular carcinoma and cholangiocellular carcinoma diagnosis显示文摘BACKGROUND Contrast-enhanced ultrasound(CEUS)is considered a secondary examination compared to computed tomography(CT)and magnetic resonance imaging(MRI)in the diagnosis of hepatocellular carcinoma(HCC),due to the risk of misdiagnosing intrahepatic cholangiocarcinoma(ICC).The introduction of CEUS Liver Imaging Reporting and Data System(CEUS LI-RADS)might overcome this limitation.Even though data from the literature seems promising,its reliability in real-life context has not been well-established yet.AIM To test the accuracy of CEUS LI-RADS for correctly diagnosing HCC and ICC in cirrhosis.METHODS CEUS LI-RADS class was retrospectively assigned to 511 nodules identified in 269 patients suffering from liver cirrhosis.The diagnostic standard for all nodules was either biopsy(102 nodules)or CT/MRI(409 nodules).Common diagnostic accuracy indexes such as sensitivity,specificity,positive predictive value(PPV),and negative predictive value(NPV)were assessed for the following associations:CEUS LR-5 and HCC;CEUS LR-4 and 5 merged class and HCC;CEUS LR-M and ICC;and CEUS LR-3 and malignancy.The frequency of malignant lesions in CEUS LR-3 subgroups with different CEUS patterns was also determined.Inter-rater agreement for CEUS LI-RADS class assignment and for major CEUS pattern identification was evaluated.RESULTS CEUS LR-5 predicted HCC with a 67.6%sensitivity,97.7%specificity,and 99.3%PPV(P<0.001).The merging of LR-4 and 5 offered an improved 93.9%sensitivity in HCC diagnosis with a 94.3%specificity and 98.8%PPV(P<0.001).CEUS LR-M predicted ICC with a 91.3%sensitivity,96.7%specificity,and 99.6%NPV(P<0.001).CEUS LR-3 predominantly included benign lesions(only 28.8%of malignancies).In this class,the hypo-hypo pattern showed a much higher rate of malignant lesions(73.3%)than the iso-iso pattern(2.6%).Inter-rater agreement between internal raters for CEUS-LR class assignment was almost perfect(n=511,k=0.94,P<0.001),while the agreement among raters from separate centres was substantial(n=50,k=0.67,P<0.001).Agreement was stronger for arterial phase hyperenhancement(internal k=0.86,P<2.7×10-214;external k=0.8,P<0.001)than washout(internal k=0.79,P<1.6×10-202;external k=0.71,P<0.001).CONCLUSION CEUS LI-RADS is effective but can be improved by merging LR-4 and 5 to diagnose HCC and by splitting LR-3 into two subgroups to differentiate iso-iso nodules from other patterns. | Gianpaolo Vidili Marco Arru Giuliana Solinas Diego Francesco Calvisi Pierluigi Meloni Assunta Sauchella Davide Turilli Claudio Fabio Antonio Cossu Giordano Madeddu Sergio Babudieri Maria Assunta Zocco Giovanni Iannetti Enza Di Lembo Alessandro Palmerio Delitala Roberto Manetti | 2022 | World Journal of Gastroenterology2022，28，27： | 3 |
| 5 | Prevalence of thyroid disease in patients with acromegaly:results of an Italian multi-center study显示文摘 | Gasperi M Martino E Manetti L | 2002 | J Endocrinol Invest2002，25，3： | 1 |
| 6 | Synthesis and pharmacological evaluation of some (pyridyl)cyclopropylmethyl amines and their methiodides as nicotinic receptor ligands显示文摘 | Guandalini L Dei S Manetti D | 2002 | Farmaco2002，57，： | 1 |
| 7 | Asymmetric rifts due to asymmetric Mohos:an experimental approach显示文摘 | Corti G Manetti P | 2006 | Earth and Planetary Science Letters2006，245，： | 1 |
| 8 | Binding of the helicobacter pylori vacuolating cytotoxin to target cells 显示文摘 | Massari P Manetti R Burroni D | 1998 | Infection and Immunity1998，66，8： | 1 |
| 9 | Natural killer cell stimulatory factor (interleukin 12 ) induces T helper type I(Th1) - specific immune responses and inhibits the development of IL - 4 - producing Th cells显示文摘 | Manetti R Parronchi P Giudizi MG | 1993 | J Exp Med1993，177，4： | 1 |
| 10 | Protected Carotid Stentiug: Clinical advantages and complications of embolic protection devices in 442 consecutive patients显示文摘 | Cremonesi A Manetti R Setacci F | 2003 | Stroke2003，34，8： | 1 |
| 11 | RAS genes influence exercise-induced left ventricular hypertrophy:An elite athletes study显示文摘 | FATINI C GUAZZELLI R MANETTI P | 2000 | Med Sci Sports Exe2000，32，： | 1 |
| 12 | Log-domain filter design based on impedance scaling of LC ladder structures 显示文摘 | Manetti S Piccirilli M C | 2011 | Circuits Systems and Signal Processing2011，30，2： | 1 |
| 13 | Assurance Services for Sustainability Reports: Standards and Empirical Evidence显示文摘 | Giacomo Manetti Lucia Becatti | 2009 | Journal of Business Ethics2009，，1： | 1 |
| 14 | Modem approach to cho- lecysto-choledocholithiasis 显示文摘 | Bencini L Tommasi C Manetti R | 2014 | World J Gastrointest Endosc2014，6，2： | 1 |
| 15 | Thyroid function differ- ently affects serum cystatin C and creatinine concentrations 显示文摘 | Manetti L Pardini E Genovesi M | 2005 | J Endocrinol Invest2005，28，4： | 1 |
| 16 | A singular-value decomposition approach for ambiguity group determination in analog circuits显示文摘 | Manetti S Piccirilli M C | 2003 | Circuits and Systems I: Fundamental Theory and Applications2003，50，4： | 1 |
| 17 | Bone marrow-derived mes-enchymal stem cells from early diffuse systemic sclerosis exhibit aparacrine machinery and stimulate angiogenesis in vitro 显示文摘 | Guiducci S Manetti M Romano E | 2011 | AnnRheum Dis2011，70，11： | 1 |
| 18 | The role eolonoscopy in early diagnosis of intraluminal recurrences in patients already treated for eoloreetal cancer显示文摘 | Barillari P Manetti G | 1996 | Minerva Chit1996，51，11： | 1 |
| 19 | Finding ambiguity groups in low testability analog circuits 显示文摘 | Starzyk J A Pang J Manetti S | 2000 | Circuits and Systems I: Fundamental Theory and Applications2000，47，： | 1 |
| 20 | Acute liver failure in children 显示文摘 | Denis Devictor Pierre Tissieres Mickael Manetti | 2011 | Clinics and Research in Hepatology and Gastroenterology2011，35，6： | 1 |
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