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| 1 | MicroRNA let-7b targets important cell cycle molecules in malignant melanoma cells and interferes with anchorage-independent growth显示文摘一幅 microRNA 表示屏幕被执行从良性的 melanocytic nevi 在 laser-microdissected 纸巾分析 157 不同 microRNAs (n = 10 ) 并且主要恶意的黑瘤(n = 10 ) ,用量的即时 PCR。微分表示被作出对有利的裁决 72 microRNAs。microRNAs 的 let-7 家庭的成员是显著地, down 作为与良性的 nevi 相比在主要黑瘤调整了,为是的这些分子的一个可能的角色暗示肿瘤在恶意的黑瘤压制 ors。有趣地,类似的调查结果为肺和结肠癌被描述了。在黑瘤房间试管内 down 的 let-7b 的 Overexpression 调整了 cyclins 的表示 D1, D3,和 A,和 cyclin 依赖的 kinase (Cdk ) 4,所有哪个被描述了在黑瘤开发起一个作用。蛋白质表示上的 let-7b 的效果由于单个 mRNAs 的 3'-untranslated 区域(3'UTRs ) 指向,为 cyclin D1 由记者基因分析例示。与它细胞周期管理者上的 down modulating 效果一致, let-7b 禁止了细胞周期前进和黑瘤细胞的抛锚无关的生长。总起来说,这些调查结果不仅指向早黑瘤开发的新规章的机制,而且可以打开大街因为未来指向了这个肿瘤的治疗。 | Julia Schultz Peter Lorenz Gerd Gross Saleh Ibrahim Manfred Kunz | 2008 | Cell Research2008，18，5： | 45 |
| 2 | High‐throughput sequencing of the melanoma genome显示文摘 | Manfred Kunz Michael Dannemann Janet Kelso | 2012 | Exp Dermatol2012，，1： | 1 |
| 3 | Antisense-mediated inhibition of survivin, hTERT and VEGF in bladdercancer cells in vitro and in vivo显示文摘 | Doreen Kunze Daniela Wuttig Ingo Kausch Caroline Blietz Lena Blumhoff Yvonne Burmeister Kai Kraemer Susanne Fuessel Marieta Toma Bernd Schwenzer Axel Meye Marc-Oliver Grimm Oliver Hakenberg Dieter Jocham Manfred Wirth | 2008 | International Journal of Oncology2008，，5： | 1 |
| 4 | A new treatment option for pulmonary valvar insufficiency: first experiences with implantation of a self-expanding stented valve without use of cardiopulmonary bypass <sup>☆</sup>显示文摘 | Christian Schreiber Jürgen H?rer Manfred Vogt Sohrab Fratz Markus Kunze Christoph Galm Andreas Eicken Rüdiger Lange | 2007 | European Journal of Cardio-Thoracic Surgery2007，，1： | 1 |
| 5 | Melanoma development: stage-dependent cancer competence of the melanocytic lineage显示文摘In a recent article in Science,Baggiolini et al.^(1) showed that the transforming ability of the BRAFM6QQE oncogene for melanoma development depends on the stage of the transformed melanocyte lineage cells.While neural crest cells and melanoblasts are vulnerable to malignant transformation in a zebrafish model,melanocytes only developed small patches of nevus-like cells after BRARJ6QQE expression. | Manfred Kunz | 2022 | Signal Transduction and Targeted Therapy2022，7，1： | 0 |
| 6 | Single-cell trajectories of melanoma cell resistance to targeted treatment显示文摘Objective:Cellular heterogeneity is regarded as a major factor affecting treatment response and resistance in malignant melanoma.Recent developments in single-cell sequencing technology have provided deeper insights into these mechanisms.Methods:Here,we analyzed a BRAFV600 E-mutant melanoma cell line by single-cell RNA-seq under various conditions:cells sensitive to BRAF inhibition with BRAF inhibitor vemurafenib and cells resistant to BRAF inhibition with vemurafenib alone or vemurafenib in combination with the MEK1/2 inhibitors cobimetinib or trametinib.Dimensionality reduction by t-distributed stochastic neighbor embedding and self-organizing maps identified distinct trajectories of resistance development clearly separating the 4 treatment conditions in cell and gene state space.Results:Trajectories associated with resistance to single-agent treatment involved cell cycle,extracellular matrix,and de-differentiation programs.In contrast,shifts detected in double-resistant cells primarily affected translation and mitogen-activated protein kinase pathway reactivation,with a small subpopulation showing markers of pluripotency.These findings were validated in pseudotime analyses and RNA velocity measurements.Conclusions:The single-cell transcriptomic analyses reported here employed a spectrum of bioinformatics methods to identify mechanisms of melanoma resistance to single-and double-agent treatments.This study deepens our understanding of treatmentinduced cellular reprogramming and plasticity in melanoma cells and identifies targets of potential relevance to the management of treatment resistance. | Maria Schmidt Lena Sünke Mortensen Henry Loeffler-Wirth Corinna Kosnopfel Knut Krohn Hans Binder Manfred Kunz | 2022 | Cancer Biology & Medicine2022，19，1： | 0 |
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