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| 1 | Role of endoscopic vacuum therapy in the management of gastrointestinal transmural defects显示文摘A gastrointestinal(GI) transmural defect is defined as total rupture of the GI wall,and these defects can be divided into three categories: perforations,leaks,and fistulas. Surgical management of these defects is usually challenging and may be associated with high morbidity and mortality rates. Recently,several novel endoscopic techniques have been developed,and endoscopy has become a firstline approach for therapy of these conditions. The use of endoscopic vacuum therapy(EVT) is increasing with favorable results. This technique involves endoscopic placement of a sponge connected to a nasogastric tube into the defect cavity or lumen. This promotes healing via five mechanisms,including macrodeformation,microdeformation,changes in perfusion,exudate control,and bacterial clearance,which is similar to the mechanisms in which skin wounds are treated with commonly employed wound vacuums. EVT can be used in the upper GI tract,small bowel,biliopancreatic regions,and lower GI tract,with variable success rates and a satisfactory safety profile. In this article,we review and discuss the mechanism of action,materials,techniques,efficacy,and safety of EVT in the management of patients with GI transmural defects. | Diogo Turiani Hourneaux de Moura Bruna Furia Buzetti Hourneaux de Moura Michael A Manfredi Kelly E Hathorn Ahmad N Bazarbashi Igor Braga Ribeiro Eduardo Guimaraes Hourneaux de Moura Christopher C Thompson | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，5： | 6 |
| 2 | Epidemiology and Management of Liver Metastases From Colorectal Cancer显示文摘 | Sylvain Manfredi C?me Lepage Cyril Hatem Olivier Coatmeur Jean Faivre Anne-Marie Bouvier | 2006 | Annals of Surgery2006，，2： | 2 |
| 3 | Measurements of ATP in mammalian cells显示文摘 | Manfredi G Yang L Gajewski C D | 2002 | Methods2002，26，： | 1 |
| 4 | Glossopharyngeal nerve contrast enhancement in recent-onset glossopharyngeal neuralgia显示文摘 | Truini A Colonnese C Manfredi | 2015 | Neurology2015，84，12： | 1 |
| 5 | Systemic Leukocyte filtration during cardiopulmonary bypass显示文摘 | Manfredi J Piccin C | 2001 | Perfusion2001，，： | 1 |
| 6 | Identification of the anti-angiogenic site within vascular basement membranederived tumstatin 显示文摘 | Maeshima Y Manfredi M Reimer C | 2001 | J Biol Chem2001，276，15： | 1 |
| 7 | Autoimmune pancreatitis:CT patterns and their changes after steroid treatment显示文摘 | Manfredi R Graziani R Cicero C | | 0，，： | 1 |
| 8 | Development length of FRP straight rebars显示文摘 | Manfredi C E Realfonzo G R | 2002 | Composites2002，，33： | 1 |
| 9 | Optimization of breeding schemes for sport horses 显示文摘 | DUBOIS C MANFREDI E RICARD A | 2008 | Livestock Science2008，18，： | 1 |
| 10 | Incidence andpatterns of recurrence after resection for cure of colonic cancer in awell defined population显示文摘 | MANFREDI S BOUVIER AM LEPAGE C | 2006 | Br J Surg2006，93，9： | 1 |
| 11 | Autoimmune pancreatitis: CT patterns and their changes after steroid treatment显示文摘 | Manfredi R Graziani R Cicero C | 2008 | Radiology2008，247，2： | 1 |
| 12 | Identification of the anti-angiogenic site within vascular basement membrane-derived tumstatin 显示文摘 | Maeshima Y Manfredi M Reimer C | 2001 | JBiol Chem2001，276，15： | 1 |
| 13 | Epidemiology and manage-ment of liver metastases from colorectal cancer 显示文摘 | Manfredi S Lepage C Hatem C | 2006 | Ann Surg2006，244，2： | 1 |
| 14 | Sequence analysis of the entire mitochondrial genome in parkinson's disease 显示文摘 | Vives-Bauza C Andreu A Manfredi G | 2002 | Biochem Biophys Res Commtm2002，290，： | 1 |
| 15 | Inhibition of apoptisis induced by ischemia-referfusion prevents inflammation显示文摘 | Rabuffetti M Sciorati C Tarrozzo G Clementi E Manfredi AA Beltramo M | 1999 | J Clin Invest1999，104，： | 1 |
| 16 | Epidemiology and management of liver metastases from colorectal cancer显示文摘 | Manfredi S Lepage C Hatem C | 2006 | Ann Surg2006，244，2： | 1 |
| 17 | Epidemiology and management of liver metastases from colorectal cancer 显示文摘 | Manfredi S Lepage C Hatem C | 2006 | Ann Surg2006，244，： | 1 |
| 18 | Incidence and patterns of recurrence after resection for cure of colonic cancer in a well defined population显示文摘 | Manfredi S Bouvier AM Lepage C | | 0，，09： | 1 |
| 19 | Epidemiology and man- agement of liver metastases from colorectal cancer 显示文摘 | Manfredi S Lepage C Hatem C el al | 2006 | Ann Surg2006，244，2： | 1 |
| 20 | Failures by SCC in buried pipelines 显示文摘 | MANFREDI C OTEGUI J L | 2002 | Engineering Failure Analysis2002，9，5： | 1 |
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