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| 1 | Hepatitis C eradication with sofosbuvir leads to significant metabolic changes显示文摘AIM To assess the effect of sofosbuvir(SOF) based regimens on glycemic and lipid control.METHODS This is a retrospective analysis of hepatitis C virus(HCV)-infected patients treated and cured with a SOF regimen [SOF/ribavirin/interferon, SOF/simeprevir, or SOF/ledipasvir(LDV) ± ribavirin] from January 2014 to March 2015. Patients with hemoglobin A1C(HbA1C) and lipid panels within six months before and six months after therapy were identified and included in our study. Due to the known hemolytic effect of ribavirin, HbA1C was obtained a minimum of three months post-treatment for the patients treated with a ribavirin regimen. Medical history, demographics, HCV genotype, pre-therapy RNA, and liver biopsies were included in our analysis. The patients who started a new medication or had an adjustment of baseline medical management for hyper-lipidemia or diabetes mellitus(DM) were excluded from our analysis.RESULTS Two hundred and thirty-four patients were reviewed, of which 60 patients met inclusion criteria. Sixty-three point three percent were male, 26.7% were Caucasian, 41.7% were African American and 91.7% were infected with hepatitis C genotype 1. Mean age was 60.6 ± 6.7 years. Thirty-nine patients had HbA1C checked before and after treatment, of which 22 had the diagnosis of DM type 2. HbA1C significantly decreased with treatment of HCV(pretreatment 6.66% ± 0.95% vs posttreatment 6.14% ± 0.65%, P < 0.005). Those treated with SOF/LDV had a lower HbA1C response than those treated with other regimens(0.26% ± 0.53% vs 0.71% ± 0.83%, P = 0.070). Fifty-two patients had pre- and post-treatment lipid panels; there was a significant increase in low-density lipoprotein(LDL) and total cholesterol(TC) after treatment(LDL: 99.5 ± 28.9 mg/dL vs 128.3 ± 34.9 mg/dL, P < 0.001; TC: 171.6 ± 32.5 mg/dL vs 199.7 ± 40.0 mg/dL, P < 0.001). Pretreatment body-mass index(BMI) did not differ from post-treatment BMI(P = 0.684). CONCLUSION Eradication of HCV with a SOF regimen resulted in a significant drop in HbA1C and an increase in LDL and TC post therapy. | Amilcar L Morales Zachary Junga Manish B Singla Maria Sjogren Dawn Torres | 2016 | World Journal of Hepatology2016，8，35： | 2 |
| 2 | Image Texture Analysis:Methods and Comparisons显示文摘 | Manish H B Liu J J John F M | 2004 | Chemometrics and Intelligent Laboratory Systems2004，72，： | 1 |
| 3 | Image texture analysis: Methods and comparisons 显示文摘 | MANISH B H LIU J J JOHN G F M | 2004 | Chemomtrics and Intelligent Laboratory2004，72，1： | 1 |
| 4 | Plasma glucose and tumour necro- sis factor-ctin adult patientswith severe falciparum malaria 显示文摘 | Manish R Tfipathy R Das B | 2003 | Trop Med Int Health2003，8，： | 1 |
| 5 | Analysis of flow through an orifice meter:CFD simulation显示文摘 | MANISH S JYESHTHARAJ S JOSHI B | 2013 | Chemical Engineering Science2013，，71： | 1 |
| 6 | Carotid intima-media thickness and coronary artery disease an Indian perspective显示文摘 | Gupta H Kartikeya B Manish B | 2003 | Asican Cardiovasc Thorac Ann2003，11，3： | 1 |
| 7 | An alternative technique for implantation of a dual chamber pacemaker via a persistent left superior vena cava using a coronary sinus guiding catheter显示文摘 | Manish M Chris C Peter B | 2010 | J Cardiol Cases2010，2，： | 1 |
| 8 | Immunoadjuvant potential of Asparagus racemosus aqueous extract in experimental system显示文摘 | Manish Gautama Sham Diwanay b Sunil Gairola c Yojana Shinde Pralhad Patki c Bhushan Patwardhan | 2004 | Journal of Ethnopharmacology2004，91，： | 1 |
| 9 | A clustering algorithm using an evolutionary programming-based approach显示文摘 | Sarkar Manish Yegnanarayana B Khemani Deepak | 1997 | Pattern Recognition Letters1997，18，10： | 1 |
| 10 | Image texture analysis: Meth- ods and comparisons 显示文摘 | MANISH B H LIU J J JOHN G F M | 2004 | Chemomtrics and Intelligent Laboratory2004，72，1： | 1 |
| 11 | Correlation of spectral domain optical coherence tomography findings in sub-silicone oil foveal depression space and visual outcome in eyes undergoing silicone oil removal显示文摘 | Manish N Kalyani J B Pravin J | 2016 | Taiwan Journal of Ophthalmology2016，6，1： | 1 |
| 12 | A pulsedUWB receiver SoC for insect motion control 显示文摘 | DENIS C D PATRICK P M MANISH B | 2010 | IEEE Jof Solid-State Circuits2010，45，1： | 1 |
| 13 | Automatic target detection and tracking in forward-looking infrared image sequences using morphological connected operators 显示文摘 | Ulisses B N Manish C John G | 2004 | Journal of Electronic Imaging2004，13，4： | 1 |
| 14 | Cavitation on surfaces显示文摘 | NICOLAS B MANISH A CLAUS-DIETER O DETTEF L | 2005 | Journal of Physics:Condensed Matter2005，17，： | 1 |
| 15 | Interaction of cavitation bubble on a wall显示文摘 | NICOLAS B MANISH A STEPHAN M D DETTEF L | 2006 | Physics of Fluid2006，18，： | 1 |
| 16 | Selective N-monoalkylation of anilines catalyzed by a cationic ruthenium( II ) compound显示文摘 | Sipra N Manish B | 2007 | Tetrahedron Lett2007，48，19： | 1 |
| 17 | Synthesis and mechanical properties of nanocrystalline MoSi2-SiC composite显示文摘 | MANISH P SUBRAMANYUAM J PRASAD V V B | 2008 | Scripta Materialia2008，58，3： | 1 |
| 18 | A novel approach of medical image enhancement based on Wavelet transform显示文摘 | Anamika B Manish K S | 2012 | International Journal of Engineering Research and Applications2012，2，3： | 1 |
| 19 | A revised structure of fucoidan may explain some of its biological activities显示文摘 | Manish S P Sorgio O Toensend B | 1993 | Journal of biological Chemistry1993，268，21： | 1 |
| 20 | Cyclooxygenase inhibitors: a novel direction for Alzheimer' s management显示文摘 | Manish N Aryamitra B Harish P | 2008 | Pharmacol Rep2008，60，5： | 1 |
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