|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Comparative study of microRNA profiling in keloid fibroblast and annotation of differential expressed microRNAs显示文摘蟹状肿是由于皮损害的异常愈合成长的像肿瘤的皮疤,没有有效 treatment.The 分子的机制位于 \O 下面蟹状肿致病仍然大部分未知。在这研究,我们比较了表示在导出蟹状肿的成纤维细胞和正常成纤维细胞之间介绍的 microRNA (miRNA )( 包括胎儿、成年的真皮的成纤维细胞) 由 miRNA microarray 分析。我们发现在导出蟹状肿的成纤维细胞的 miRNA 侧面与在 normalfibroblasts 的那些是不同的。九 miRNAs 是表示其六在蟹状肿成纤维细胞(KF ) 是显著地起来调整的差别,包括 miR-152, miR-23b-3p, miR-31-5p, miR-320c, miR-30a-5p,和 hsv1-miR-H7,并且其三是调整 significantlydown 的包括 miR-4328, miR-145-5p,和 miR-143-3p。差别的功能的注解表示了他们在为疤创伤愈合重要的几条发信号的小径被充实的 miRNA targetsrevealed。在结论,我们 demonstratethat miRNA 表示侧面在 KF 被改变与相比可以为探索蟹状肿的致病在胎儿、成年的真皮的成纤维细胞,和 expressionprofile 提供有用线索。miRNAs 可能部分由影响相关的几条发信号的小径使创伤愈合留下疤痕贡献 etiologyof 蟹状肿。 | Chao Li Yuehong Bai Hua Liu Xuemei Zuo Haichang Yao Yiming Xu Manlin Cao | 2013 | Acta Biochimica et Biophysica Sinica2013，45，8： | 15 |
| 2 | Influence of Wind Deviation Angle on n-Hexane Evaporation Loss of Internal Floating-Roof Tanks显示文摘With the increasing attention to environmental protection,it is still necessary to strictly control the oil evaporation loss from the IFRT(internal floating-roof tank)to the atmosphere.Upon using n-hexane as a representative of light oil,the effects of the WDAs(wind deviation angles)on airflow distribution,the wind speed,the n-hexane vapor concentration,and the evaporation loss rate in the IFRT were investigated,and the mass transfer of the vapor-air was analyzed.The results are shown as follows:when the WDA is 0°,the vapor concentration in the gas space above the floating deck is the lowest;when the WDA is 22.5°,the oil evaporation loss rate is the largest;when the WDA is 45°,the vapor concentration is the highest,but the evaporation loss rate is the smallest.It is recommended to arrange the vent to the wind direction with an angle of 45°to reduce the evaporation loss and protect the atmospheric environment. | Huang Weiqiu Xu Manlin Li Fei Ji Hong Fang Jie | 2020 | China Petroleum Processing & Petrochemical Technology2020，22，2： | 1 |
| 3 | Isotoosendanin exerts inhibition on triple-negative breast cancer through abrogating TGF-β-induced epithelial—mesenchymal transition via directly targeting TGFβR1显示文摘As the most aggressive breast cancer,triple-negative breast cancer(TNBC) is still incurable and very prone to metastasis.The transform growth factor β(TGF-β)-induced epithelial—mesenchymal transition(EMT) is crucially involved in the growth and metastasis of TNBC.This study reported that a natural compound isotoosendanin(ITSN) reduced TNBC metastasis by inhibiting TGF-β-induced EMT and the formation of invadopodia.ITSN can directly interact with TGF-β receptor type-1(TGFβR1) and abrogated the kinase activity of TGFβR1,thereby blocking the TGF-β-initiated downstream signaling pathway.Moreover,the ITSN-provided inhibition on metastasis obviously disappeared in TGFβR1-overexpressed TNBC cells in vitro as well as in mice bearing TNBC cells overexpressed TGFβR1.Furthermore,Lys232 and Asp351 residues in the kinase domain of TGFβR1 were found to be crucial for the interaction of ITSN with TGFβR1.Additionally,ITSN also improved the inhibitory efficacy of programmed cell death 1 ligand 1(PD-L1) antibody for TNBC in vivo via inhibiting the TGF-β-mediated EMT in the tumor microenvironment.Our findings not only highlight the key role of TGFβR1 in TNBC metastasis,but also provide a leading compound targeting TGFβR1 for the treatment of TNBC metastasis.Moreover,this study also points out a potential strategy for TNBC treatment by using the combined application of anti-PD-L1 with a TGFβR1 inhibitor. | Jingnan Zhang Ze Zhang Zhenlin Huang Manlin Li Fan Yang Zeqi Wu Qian Guo Xiyu Mei Bin Lu Changhong Wang Zhengtao Wang Lili Ji | 2023 | Acta Pharmaceutica Sinica B2023，13，7： | 1 |
| 4 | A Reliable Routing Algorithm with Network Coding in Internet of Vehicles显示文摘The intelligent vehicle network uses advanced information technology to establish an efficient integrated vehicle transport system,which has received great attention in industry and academia. Internet of Vehicles(IoV)in an urban environment is operated in a wireless environment with high bit error rate and interference. In addition,the wireless link between vehicles is likely to be lost. All of this makes it an important challenge to provide reliable mobile routing in an urban traffic environment. In this paper,a reliable routing algorithm with network coding(RR_NC)is proposed to solve the above problems. A routing node sequence is discovered in IoV from source to destination by multi-metric ant colony optimization algorithm(MACO),and then clusters are formed around every node in the sequence. By adding linear encoding into the transmission of data between vehicle's clusters,the RR_NC provides much more reliable transmission and can recover the original message in the event of disorder and loss of message. Simulations are taken under different scenarios,and the results prove that this novel algorithm can deliver the information more reliably between vehicles in real-time with lower data loss and communication overhead. | Zhen Wang Jianqing Li Manlin Fang Yang Li Botao Feng | 2017 | China Communications2017，14，5： | 1 |
| 5 | Effect of Substrate Bias on Microstructure and Properties of Tetrahedral Amorphous Carbon Films显示文摘The microstructure and properties of tetrahedral amorphous carbon (ta-C) films deposited by the filtered cathodic vacuum arc technology has been investigated by visible Raman spectroscopy, AFM and Nano-indentor. The Raman spectra have been fitted with a single skewed Lorentzian lineshape described by BWF function defining coupling coefficient, which characterizes the degree of asymmetry and is correlated with the sp3 content. When the substrate bias is -80 V, the sp3 content is the most and simultaneously the coupling coefficient is the least, following with the minimum root mean square surface roughness (Rq=0.23 nm) and the highest hardness (51.49 GPa), Young′s modulus (512.39 GPa), and critical scratching load (11.72 mN). As the substrate bias is increased or decreased, the sp3 content and other properties lower correspondingly. | Jiaqi ZHU Jiecai HAN Songhe MENG Qiang LI Manlin TAN | 2003 | Journal of Materials Science & Technology2003，19，z1： | 0 |
| 6 | Effects of NaOH Treatment on Fiber, Crude Protein and Soluble Sugar Content of Corn Straw显示文摘[Objective] The paper was to study the effects of different levels of NaOH on fiber, crude protein and soluble sugar content of corn straw. [Method] Four treatments were designed in the test, namely control group, group 1, group 2 and group 3, which were added with 0, 2%, 3%and 4% NaOH according to the dry weight of corn straw, and the moisture of corn straw after treatment was 45%. After being treated at room tem-perature for 48 h, sensory evaluation and nutrient composition analysis were performed for each group, and the contents of neutral detergent fiber(NDF), acid detergent fiber(ADF), crude protein(CP) and soluble sugar(SS) were measured. [Result] With the increasing addition level of NaOH,the content of NDF and ADF decreased gradually, and significant differences were observed between group 3(adding 4% NaOH) and control group(P<0.05). There was no significant difference in CP content among treatment groups(P>0.05); the SS content gradually increased, and there were significant differences between treatment groups and control group(P<0.05). [Conclusion] 4% NaOH reduced the fiber content and increased the soluble sugar content of corn straw. | wei manlin li yang duan yongbo | 2018 | Animal Husbandry and Feed Science2018，10，4： | 0 |
| 7 | An Environment‑Tolerant Ion‑Conducting Double‑Network Composite Hydrogel for High‑Performance Flexible Electronic Devices显示文摘High-performance ion-conducting hydrogels(ICHs)are vital for developing flexible electronic devices.However,the robustness and ion-conducting behavior of ICHs deteriorate at extreme tempera-tures,hampering their use in soft electronics.To resolve these issues,a method involving freeze–thawing and ionizing radiation technology is reported herein for synthesizing a novel double-network(DN)ICH based on a poly(ionic liquid)/MXene/poly(vinyl alcohol)(PMP DN ICH)system.The well-designed ICH exhibits outstanding ionic conductivity(63.89 mS cm^(-1) at 25℃),excellent temperature resistance(-60–80℃),prolonged stability(30 d at ambient temperature),high oxidation resist-ance,remarkable antibacterial activity,decent mechanical performance,and adhesion.Additionally,the ICH performs effectively in a flexible wireless strain sensor,thermal sensor,all-solid-state supercapacitor,and single-electrode triboelectric nanogenerator,thereby highlighting its viability in constructing soft electronic devices.The highly integrated gel structure endows these flexible electronic devices with stable,reliable signal output performance.In particular,the all-solid-state supercapacitor containing the PMP DN ICH electrolyte exhibits a high areal specific capacitance of 253.38 mF cm^(-2)(current density,1 mA cm^(-2))and excellent environmental adaptability.This study paves the way for the design and fabrication of high-performance mul-tifunctional/flexible ICHs for wearable sensing,energy-storage,and energy-harvesting applications. | Wenchao Zhao Haifeng Zhou Wenkang Li Manlin Chen Min Zhou Long Zhao | 2024 | Nano-Micro Letters2024，16，5： | 0 |
| 8 | Liver Tumor Segmentation Based on Multi-Scale and Self-Attention Mechanism显示文摘Liver cancer has the second highest incidence rate among all types of malignant tumors,and currently,its diagnosis heavily depends on doctors’manual labeling of CT scan images,a process that is time-consuming and susceptible to subjective errors.To address the aforementioned issues,we propose an automatic segmentation model for liver and tumors called Res2Swin Unet,which is based on the Unet architecture.The model combines Attention-Res2 and Swin Transformer modules for liver and tumor segmentation,respectively.Attention-Res2 merges multiple feature map parts with an Attention gate via skip connections,while Swin Transformer captures long-range dependencies and models the input globally.And the model uses deep supervision and a hybrid loss function for faster convergence.On the LiTS2017 dataset,it achieves better segmentation performance than other models,with an average Dice coefficient of 97.0%for liver segmentation and 81.2%for tumor segmentation. | Fufang Li Manlin Luo Ming Hu Guobin Wang Yan Chen | 2023 | Computer Systems Science & Engineering2023，47，12： | 0 |
| 9 | Modified intratympanic steroid therapy for sudden sensorineural hearing loss via tympanic tube and gelfoam as a salvage treatment显示文摘Background: Sudden sensorineural hearing loss(SSNHL) is a prevalent emergency in ear, nose, and throat practice. Previous studies have demonstrated that intratympanic steroid therapy(IST) can serve as a salvage treatment for SSNHL after the failure of systemic steroid therapy(SST).Objective: This study aimed to analyze the efficacy of modified IST involving the insertion of a tympanic tube and gelfoam as a salvage treatment for patients with SSNHL, and to explore its associated factors.Methods: Totally, 74 patients who were aged 22–81 years with SSNHL were enrolled and allocated to either the control group(n = 25) or the treatment group(n = 49) based on their treatment modalities. All patients received SST lasting for at least 7 days. Subsequently, patients in the treatment group, after SST failure, underwent IST twice a week for 2–6 weeks, while the control group did not. Efficacy was assessed by the improvement in pure tone average at the affected frequency at the beginning and end of IST.Results: Hearing improvement in all patients after IST in the treatment group was 9.71 ± 14.84 dB, with significant improvement at affected frequencies(250-8000 Hz) compared with the control group(P < 0.05). The findings indicated the duration from the onset of SSNHL to the beginning of IST as an independent factor for pure tone average improvement after treatment(P = 0.002), whereas age, duration of SST, and time of IST were not(P > 0.05).Conclusion: The modified IST was demonstrated to be a safe and effective method as a salvage treatment for SSNHL. This study explored the efficacy of a modified IST approach, incorporating the utilization of tympanic tubes and gelfoam as key components. The findings underscore the advantages of gelfoam as a strategic drug carrier placed in the round window niche. By minimizing drug loss, extending action time, and increasing perilymph concentration, gelfoam enhances the therapeutic impact of IST, contributing to improved hearing outcomes in patients with SSNHL. | Sichao Liang Yunshuo Li Zhenping Guo Manlin Lu Xin Li Jia Xu Wenjing Chen Juanjuan Gao Haijin Yi | 2024 | Journal of Otology2024，19，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员