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| 1 | Significance of serum carcinoembryonic antigen in metastatic breast cancer patients:A prospective study显示文摘BACKGROUND Carcinoembryonic antigen(CEA)is an important serum tumour marker with a substantial role in diagnosis and monitoring of various solid tumours.About 36%-70%of breast cancers have elevated serum CEA.And the available studies show discrepancy in addressing the prognostic significance of CEA in advanced breast cancer.AIM To estimate the serum CEA level in our metastatic breast cancer patients and correlate it with response to treatment and clinical outcome.METHODS This was a prospective clinical study conducted on 50 metastatic breast cancer patients treated at breast clinic,with newly diagnosed metastatic breast cancer planned for palliative chemotherapy,targeted therapy,and hormonal treatment.We estimated the proportion of patients with elevated serum CEA level at baseline and after palliative treatment and also studied the association of serum CEA levels with known prognostic factors.The response to treatment was correlated with the serum CEA levels in the context of responders and nonresponders.RESULTS The median pre-treatment and post-treatment CEA levels were 7.9(1.8-40.7)ng/mL and 4.39(1.4-12.15)ng/mL,respectively,in the whole study population(P=0.032).No statistically significant difference was seen in baseline serum CEA between responders and non-responders.Even in the luminal group,pretreatment serum CEA was not a predictor of response,but post-treatment CEA was a significant predictor of tumour progression.In patients with liver and lung metastases,post-treatment CEA level difference was not statistically significant in both responders and non-responders though the values were higher in nonresponders.Among those with bone metastases,69.5%had elevated post-treatment serum CEA,and only 37.5%had elevated serum CEA in those with no bone metastases.CONCLUSION Elevated post-treatment serum CEA levels are associated with disease progression and poor response to therapy.Persistently elevated post-treatment serum CEA levels are significantly associated with bone metastases.Elevated serum CEA and hormonal status are significant predictors of treatment response. | Thattungal Manoharan Anoop Rona Joseph P Saikumar Soman Steffi Chacko Mintu Mathew | 2022 | World Journal of Clinical Oncology2022，13，6： | 2 |
| 2 | - 5-year follow-up of the DEFER Study 显示文摘 | Pijls NH Van Schaardenburgh P Manoharan Percutaneous coronary intervention of {unctionally nonsignificant stenosis | 2007 | JArn Coil Cardiol2007，49，21： | 1 |
| 3 | Concrete with ceramic waste aggregate显示文摘 | Senthamarai R M Devadas Manoharan P | 2005 | Cement & Concrete Compos- ites2005，，27： | 1 |
| 4 | Simultaneous on spontaneous occurrence of lympho-and myelo-proliferative disorders:a report of four case显示文摘 | Catovsky D Clein P | 1981 | Br J Haematol1981，48，1： | 1 |
| 5 | Concrete with ceramic waste aggregate显示文摘 | Senthamarai R M Manoharan P D | 2005 | Cement & Concrete Composites2005，27，： | 1 |
| 6 | Percutaneous coronary intervention of functionally nonsignificant stenosis:5-year follow-up of the DEFER Study显示文摘 | Pijls NH van Schaardenburgh P Manoharan G | | 0，，21： | 1 |
| 7 | Percutaneous coronary intervention of functionally nonsignificant stenosis: 5-year follow-up of the DEFER Study显示文摘 | PIJLS N H VAN SCHAARDENBURGH P MANOHARAN G | 2007 | J Am Coll Cardiol2007，49，： | 1 |
| 8 | Percutaneous coronary intervention of functionally nonsignificant stenosis: 5-year follow-up of DEFER study显示文摘 | Pijls NH van Schaardenburgh P Manoharan G | 2007 | J Am CoB Cardiol2007，49，21： | 1 |
| 9 | Percutaneous coronary intervention of functionally nonsignificantstenosis : 5-year follow-up of the DEFER Study 显示文摘 | Pijls NH van Schaardenburgh P Manoharan G | 2007 | J Am CollCardiol2007，49，： | 1 |
| 10 | Prostaglandins, not the leukotrienes, regulate C1-/HCO3- exchange ( DRA, SLC26A3 ) in villus cells in the chronically inflamed rabbit ileum 显示文摘 | Manoharan P Coon S Baseler W | 2013 | Biochim Biophys Acta2013，1828，2： | 1 |
| 11 | Reduced levels of microRNAs miR-124a and miR-150 are associated with increased proinflammatory mediator expression in Kriippel-like factor 2 (KLF2)- deficient macrophages显示文摘 | Manoharan P Basford JE Pilcher-Roberts R | 2014 | J Biol Chem2014，289，31： | 1 |
| 12 | Experimental bahaviour of eccentrically loaded slender circular hollow steel columns in-filled weith fibre reinforced cocrete 显示文摘 | Devadas Manoharan P Ramana Gopal S | 2006 | Journal of Constructional Steel Research2006，62，5： | 1 |
| 13 | Is calcium oxalate nucleation in postprandial urine of males with idiopathic recurrent calcium urolithiasis related to calcium phosphate nucleation and the intensity of stone formation? Studies allowing insight into a possible role of urinary free citrate and protein显示文摘 | Schwille P O Schmiedl A Manoharan M | 2004 | Clin Chem Lab Med2004，42，3： | 1 |
| 14 | Therapeutic Silencing of an Endog e nous Gene by Systemic Administration of Modifi-ed SiRNAs显示文摘 | Soutschek J Akinc A Bramlage B Charisse K Constien R Donoghu e M Elba shir S Geick A Hadwiger P Harborth J John M Kesavan V Lavine G Pandey RK Racie T Rajeev KG Rohl I Toudjarska I Wang G Wuschko S Bumcrot D Kotelia nsky V Limmer S Manoharan M Vornlocher | | 0，，： | 1 |
| 15 | Percu- taneous coronary intervention of functionally no significant stanosis : 5-year follow-up of the DEFER Study 显示文摘 | Pijls NHJ Van Schaardenburghet P Manoharan G | 2007 | J Am Coil Cardiol2007，49，： | 1 |
| 16 | Percutaneous coronary intervention of functionally nonsignificant stenosis:5-year follow-up of the DEFER Study 显示文摘 | Pijls NH van Schaardenburgh P Manoharan G | 2007 | J Am Coll Cardiol2007，49，21： | 1 |
| 17 | Topological resonance energy predictions of the stability of fullerene clusters显示文摘 | Manoharan M Balakrishnarajan M Venuvanalingam P | 1994 | Chem Phys Lett1994，222，： | 1 |
| 18 | Small cell carcinoma of the bladder显示文摘 | SVED P GOMEZ P MANOHARAN M | 2004 | BJU Int2004，94，： | 1 |
| 19 | Percutaneous coronary intervention of functionally nonsignificant stenosis:5-year follow-up of the DEFER Study显示文摘 | PIJLS N H VAN SCHAARDENBURGH P MANOHARAN G | 2007 | J Am Coll Cardiol2007，49，： | 1 |
| 20 | Dissected nucleus-independent chemical shift analysis of :r-aromaticity and antiaromaticity显示文摘 | Von Ragu6 Schleyer P Manoharan M Wang Zx | 2001 | Org Lett2001，，3： | 1 |
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