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您的检索式：作者名="Manson Fok"
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| 1 | Comparison of Hand-Sewn and Stapled Esophagogastric Anastomosis After Esophageal Resection for Cancer: A Prospective Randomized Controlled Trial显示文摘 | Simon Law Manson Fok Kent-Man Chu John Wong | 1997 | Annals of Surgery1997，，2： | 2 |
| 2 | Reexploration for complications after esophagectomy for canaer显示文摘 | Po-ChorTam Manson Fok Johnwong | 1989 | Thorac Cardiovasc Surg1989，98，： | 1 |
| 3 | COVID-19 Delta variants—Current status and implications as of August 2021显示文摘The SARS-CoV-2 Delta variant has evolved as the dominant strain of the current pandemic.Studies have shown that this variant has increased infectivity/viral load,and reduced neutralization by the host antibodies from convalescent patients/vaccinees.Clinically,Delta variant infection has been observed/documented in convalescent patients/vaccinees,although with less incidence of severe diseases,but can serve as reservoir to spread the infection to the unvaccinated.The current understanding(as of 18 August 2021)on the virologic aspect(including the amino acid substitutions),clinical implications,and public health implications will be discussed in this mini review,and recommendations to health authorities will be provided. | Flora Yu Lok-Ting Lau Manson Fok Johnson Yiu-Nam Lau Kang Zhang | 2021 | Precision Clinical Medicine2021，4，4： | 1 |
| 4 | HM30181A,a potent P-glycoprotein inhibitor,potentiates the absorption and in vivo antitumor efficacy of paclitaxel in an orthotopic brain tumor model显示文摘Objective:Delivery of chemotherapeutic drugs to the brain has remained a major obstacle in the treatment of glioma,owing to the presence of the blood-brain barrier and the activity of P-gp,which pumps its substrate back into the systemic circulation.The aim of the present study was to develop an intravenous formulation of HM30181 A(HM)to inhibit P-gp in the brain to effectively deliver paclitaxel(PTX)for the treatment of malignant glioma.Methods:Two formulations of solubilized HM were designed on the basis of different solid dispersion strategies:i)spray-drying[polyvinlypyrrolidone(PVP)-HM]and ii)solvent evaporation[HP-β-cyclodextrin(cyclodextrin)-HM].The P-gp inhibition of these 2 formulations was assessed on the basis of rhodamine 123 uptake in cancer cells.Blood and brain pharmacokinetic parameters were also determined,and the antitumor effect of cyclodextrin-HM with PTX was evaluated in an orthotopic glioma xenograft mouse model.Results:Although both PVP-HM and cyclodextrin-HM formulations showed promising P-gp inhibition activity in vitro,cyclodextrin-HM had a higher maximum tolerated dose in mice than did PVP-HM.Pharmacokinetic study of cyclodextrin-HM revealed a plasma concentration plateau at 20 mg/kg,and the mice began to lose weight at doses above this level.Cyclodextrin-HM(10 mg/kg)administered with PTX at 10 mg/kg showed optimal antitumor activity in a mouse model,according to both tumor volume measurement and survival time(P<0.05).Conclusions:In a mouse orthotopic brain tumor model,the intravenous co-administration of cyclodextrin-HM with PTX showed potent antitumor effects and therefore may have potential for glioma therapy in humans. | Wu Zeng Betty Yuen Kwan Law Vincent Kam Wai Wong Denise So Bik Chan Simon Wing Fai Mok Joyce Jia Ying Gao Rebecca Ka Yan Ho Xu Liang Jia Hao Li Ming Tsung Lee Weng Li Yoon Michael P Smolinski Johnson Yiu Nam Lau Christopher Wai Kei Lam Manson Fok | 2020 | Cancer Biology & Medicine2020，17，4： | 0 |
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