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| 1 | Helicobacter pylori in human health and disease:Mechanisms for local gastric and systemic effects显示文摘Helicobacter pylori(H. pylori) is present in roughly 50% of the human population worldwide and infection levels reach over 70% in developing countries. The infection has classically been associated with different gastro-intestinal diseases, but also with extra gastric diseases. Despite such associations, the bacterium frequently persists in the human host without inducing disease, and it has been suggested that H. pylori may also play a beneficial role in health. To understand how H. pylori can produce such diverse effects in the human host, several studies have focused on understanding the local and systemic effects triggered by this bacterium. One of the main mechanisms by which H. pylori is thought to damage the host is by inducing local and systemic inflammation. However, more recently, studies are beginning to focus on the effects of H. pylori and its metabolism on the gastric and intestinal microbiome. The objective of this review is to discuss how H. pylori has co-evolved with humans, how H. pylori presence is associated with positive and negative effects in human health and how inflammation and/or changes in the microbiome are associated with the observed outcomes. | Denisse Bravo Anilei Hoare Cristopher Soto Manuel A Valenzuela Andrew FG Quest | 2018 | World Journal of Gastroenterology2018，24，28： | 32 |
| 2 | Helicobacter pylori-induced inflammation and epigenetic changes during gastric carcinogenesis显示文摘The sequence of events associated with the development of gastric cancer has been described as 'the gastric precancerous cascade'. This cascade is a dynamic process that includes lesions, such as atrophic gastritis, intestinal metaplasia and dysplasia. According to this model, Helicobacter pylori(H. pylori) infection targets the normal gastric mucosa causing non-atrophic gastritis, an initiating lesion that can be cured by clearing H. pylori with antibiotics or that may then linger in the case of chronic infection and progress to atrophic gastritis. The presence of virulence factors in the infecting H. pylori drives the carcinogenesis process. Independent epidemiological and animal studies have confirmed the sequential progression of these precancerous lesions. Particularly long-term follow-up studies estimated a risk of 0.1% for atrophic gastritis/intestinal metaplasia and 6% in case of dysplasia for the long-term development of gastric cancer. With this in mind, a better understanding of the genetic and epigenetic changes associated with progression of the cascade is critical in determining the risk of gastric cancer associated with H. pylori infection. In this review, we will summarize some of the mostrelevant mechanisms and focus predominantly but not exclusively on the discussion of gene promoter methylation and mi RNAs in this context. | Manuel A Valenzuela Jimena Canales Alejandro H Corvalán Andrew FG Quest | 2015 | World Journal of Gastroenterology2015，21，45： | 33 |
| 3 | Critical evaluation of fiber coatings for organotin determination by using solid phase microextraction in headspace mode显示文摘 | Manuel Bravo M An í bal Valenzuela S Edwar Fuentes P | | 0，，03： | 1 |
| 4 | Survivin expression promotes VEGF-induced tumor angiogenesisvia PI3K/Akt enhanced 13 -catenin/Tcf-Lef dependent transcription显示文摘 | Jaime G Fern 6 ndez Diego A Rodr ~ guez Manuel Valenzuela | 2014 | Molecular Cancer2014，13，209： | 1 |
| 5 | Critical evaluation of fiber coatings for organotin determination by using solid phase microextraction in headspace mode显示文摘 | Manuel Bravo M An(i)bal Valenzuela S Edwar Fuentes P | | 0，，03： | 1 |
| 6 | Control concepts for direct steam generation in parabolic troughs 显示文摘 | Loreto Valenzuela Eduardo Zarza Manuel Berenguel | 2005 | Solar Energy2005，78，： | 1 |
| 7 | Involvement of ethylene receptors in the salt tolerance response of Cucurbita pepo显示文摘Abiotic stresses have a negative effect on crop production,affecting both vegetative and reproductive development.Ethylene plays a relevant role in plant response to environmental stresses,but the specific contribution of ethylene biosynthesis and signalling components in the salt stress response differs between Arabidopsis and rice,the two most studied model plants.In this paper,we study the effect of three gain-of-function mutations affecting the ethylene receptors CpETR1B,CpETR1A,and CpETR2B of Cucurbita pepo on salt stress response during germination,seedling establishment,and subsequent vegetative growth of plants.The mutations all reduced ethylene sensitivity,but enhanced salt tolerance,during both germination and vegetative growth,demonstrating that the three ethylene receptors play a positive role in salt tolerance.Under salt stress,etr1b,etr1a,and etr2b germinate earlier than WT,and the root and shoot growth rates of both seedlings and plants were less affected in mutant than in WT.The enhanced salt tolerance response of the etr2b plants was associated with a reduced accumulation of Na^(+)in shoots and leaves,as well as with a higher accumulation of compatible solutes,including proline and total carbohydrates,and antioxidant compounds,such as anthocyanin.Many membrane monovalent cation transporters,including Na^(+)/H^(+)and K^(+)/H^(+)exchangers(NHXs),K^(+)efflux antiporters(KEAs),high-affinity K^(+)transporters(HKTs),and K^(+)uptake transporters(KUPs)were also highly upregulated by salt in etr2b in comparison with WT.In aggregate,these data indicate that the enhanced salt tolerance of the mutant is led by the induction of genes that exclude Na+in photosynthetic organs,while maintaining K^(+)/Na^(+)homoeostasis and osmotic adjustment.If the salt response of etr mutants occurs via the ethylene signalling pathway,our data show that ethylene is a negative regulator of salt tolerance during germination and vegetative growth.Nevertheless,the higher upregulation of genes involved in Ca^(2+)signalling(CpCRCK2A and CpCRCK2B)and ABA biosynthesis(CpNCED3A and CpNCED3B)in etr2b leaves under salt stress likely indicates that the function of ethylene receptors in salt stress response in C.pepo can be mediated by Ca^(2+)and ABA signalling pathways. | Gustavo Cebrian Jessica Iglesias-Moya Alicia Garcia Javier MartInez Jonathan Romero Jose Javier Regalado Cecilia Martinez Juan Luis Valenzuela Manuel Jamilena | 2021 | Horticulture Research2021，8，1： | 0 |
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