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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | A practical approachfor fish freshness determinations using a portable electronic nose显示文摘 | Manuela 0 Gabriela V Gustavo P ef al | 2001 | Sensors and Actuators B: Chemical2001，80，： | 1 |
| 3 | A practical approach for fish freshness determinations using a portable electronic nose显示文摘 | Manuela O Gabriela V Gustavo P R | 2001 | Sensors and Actuators B2001，80，2： | 1 |
| 4 | Apractical approach for fish freshness determinations using a portable electronic nose显示文摘 | MANUELA O GABRIELA V GUSTAVO P | 2001 | Sensors and Actuators B2001，80，： | 1 |
| 5 | D-Xylose Metabolism in Hypocrea jeoorina: Loss of the Xylitol Dehydrogenase Step Can Be Partially Compensated for by lad1- Encoded L- Arabinitol - 4 - Dehydrogenase 显示文摘 | Bernhard Seiboth Lukas Hard Manuela Pail Christian P Kubieek | 2003 | EUKARYOTIC CELL2003，2，5： | 1 |
| 6 | OTU deu- biquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis 显示文摘 | TYCHO E T M MANUELA K H PAUL P G | 2013 | Cell2013，154，： | 1 |
| 7 | Gene func tion and expression level influence the insertion/fixation dy namics of distinct transposon families in mammalian introns 显示文摘 | MANUELA S GIORGIA M GIACOMO P C | 2006 | Genome Biol2006，7，12： | 1 |
| 8 | Sensory memory during physiological aging indexed by mismatch negativity (MMN)显示文摘 | Manuela R Cornelia P Debora B | 2012 | Neurobiology of Aging2012，625，： | 1 |
| 9 | Enhanced motor cor- tex facilitation in patients with vascular cognitive impair- ment no dementia显示文摘 | Rita B Raffaele F Manuela P | 2011 | Neurosci Lett2011，503，3： | 1 |
| 10 | A pratical electronic nose显示文摘 | Manuela O Gabriela V Gustavo P | 2001 | Sensors and Actuators B2001，80，： | 1 |
| 11 | J Electroanal Chem显示文摘 | Francisco P Manuela R | 1999 | 474:601999，474，： | 1 |
| 12 | Growth, photosynthesis and water-use efficiency of two C4 Sahelian grasses subjected to water deficits显示文摘 | Maroco P Pereira S Manuela C M | 2000 | Journal of Arid Environments2000，45，： | 1 |
| 13 | A case - control study on bovine tuberculosis in the Veneto Region Italy 显示文摘 | Stefano M Marco M Manuela D P | 2008 | Preventive Veterinary Medicine2008，34，： | 1 |
| 14 | Iron overload and heart fibrosis in mice deficient for both β2- microglobulin and Ragl 显示文摘 | MANUELA M S MARIA D S LUKE H P | 2000 | Am J Pathol2000，157，6： | 1 |
| 15 | SBAS-based satellite orbit correction for the generation of DInSAR timeseries:application to RADARSAT-1 data显示文摘 | PEPE A BERARDINO P MANUELA B LEONARDO D E LANARI R SANSOSTI E | 2011 | IEEE2011，49，12： | 1 |
| 16 | Determination of organophosphorus pesticides using membrane-assisted solvent extraction combined with large volume injection-gas chromatography-mass spectrometric detection显示文摘 | Manuela S Barbara H Peter P | 2004 | Journal of Chromatography A2004，1040，： | 1 |
| 17 | HLB value, an important parameter for the development of essential oil phytopharmaeeutieals显示文摘 | Fernandes Caio P Mascarenhas Manuela P Zibetti Fiorella M et a! | 2013 | Revista Brasileira de Farmaeognosia - Brazilian Journal of Pharmacognosy2013，23，： | 1 |
| 18 | A practical approach for fish freshness determinations using a portable electronic nose显示文摘 | Manuela O C Gabriela V Gustavo P | 2001 | Sensors and Actuators B2001，80，： | 1 |
| 19 | Mechanism of nucleocapsid protein catalyzed structural isomerization of the dimerization initiation site of HIV-1显示文摘 | Manuela J R John P M | 2002 | Biochemistry2002，41，14： | 1 |
| 20 | Simultaneous HPLC analysis of triameinolone acetonide and budesonide in microdialysate and rat plasma: Application to a pharmacokinetic study 显示文摘 | Manuela de L T Vieira Rajandra P Singh Hartmut Derendorf | 2010 | J Chromatography B2010，878，29： | 1 |
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