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| 1 | Effect of probiotic Lactobacillus plantarum Dad-13 powder consumption on the gut microbiota and intestinal health of overweight adults显示文摘BACKGROUND Shifting on lifestyle,diet,and physical activity contributed on increasing number of obese people around the world.Multiple factors influence the development of obesity.Some research suggested that gut microbiota(GM)plays an important role in nutrient absorption and energy regulation of individuals,thus affecting their nutritional status.Report of Indonesia Basic Health Research showed that the prevalence of obesity in every province tended to increase.Although the root cause of obesity is excessive calorie intake compared with expenditure,the differences in gut microbial ecology between healthy and obese humans may affect energy homeostasis.GM affect body weight,especially obesity.Probiotics that are consumed while alive and able to colonize in the intestine are expected to increase the population of good bacteria,especially Bifidobacteria and Lactobacilli,and suppress pathogens such as Enterobacteriaceae and Staphylococcus.The strain of L.plantarum Dad-13 has been demonstrated to survive and colonize in the gastrointestinal tract of healthy Indonesian adults who consume fermented milk containing L.plantarum Dad-13.The consumption of probiotic L.plantarum Dad-13 powder decreased E.coli and non-E.coli coliform bacteria in school-aged children in Indonesia.L.plantarum is a dominant bacterium in the average Indonesian’s GM.For this reason,this bacterium is probably a more suitable probiotic for Indonesians.AIM To determine the effect of the consumption of indigenous probiotic Lactobacillus plantarum Dad-13 powder in overweight adults in Yogyakarta(Indonesia).METHODS Sixty overweight volunteers with a body mass index(BMI)equal to or greater than 25 consume indigenous probiotic powder L.plantarum Dad-13(2×109 CFU/gram/sachet)for 90 d.The study was a randomized,double-blind,placebocontrolled study.The volunteers filled in a diary on a daily basis,which consisted of questions on study product intake(only during ingestion period),other food intake,number of bowel movements,fecal quality(consistency and color),any medications received,and any symptom of discomfort,such as diarrhea,constipation,vomiting,gassing,sensation of illness,etc.Fecal samples and the subjects’diaries were collected on the morning of day 10+1,which was marked as the end of the baseline period and the start of the ingestion period.During the ingestion period(from day 11 to day 101),several parameters to measure and analyze the results included body weight and height(once a month),the lipid profile,GM analysis using MiSeq,short-chain fatty acid(SCFA)analysis using gas chromatography,and the measurement of fecal pH using a pH meter.RESULTS The consumption of indigenous probiotic powder L.plantarum Dad-13 caused the average body weight and BMI of the probiotic group to decrease from 84.54±17.64 kg to 83.14±14.71 kg and 33.10±6.15 kg/m2 to 32.57±5.01 kg/m2,respectively.No significant reduction of body weight and BMI in the placebo group was observed.An analysis of the microbiota showed that the number of Bacteroidetes,specifically Prevotella,increased significantly,while that of Firmicutes significantly decreased.No significant change in lipid profile in both groups was found.Also,no significant change in SCFAs(e.g.,butyrate,propionate,acetic acid)and pH level was found after the consumption of the probiotic.CONCLUSION No significant differences in pH before and after ingestion were observed in both the probiotic and placebo groups as well as in the lipid profile of both cholesterol and triglyceride,high-density lipoprotein(HDL),low-density lipoprotein(LDL),and the LDL/HDL ratio.In addition,no significant changes in the concentration of SCFAs(e.g.,acetic acid,propionate,and butyrate)were found after consumption.Interestingly,a significant decrease in body weight and BMI(P<0.05)was determined in the treatment group.An analysis of GM shows that L.plantarum Dad-13 caused the Firmicutes population to decrease and the Bacteroidetes population(especially Prevotella)to increase. | Endang Sutriswati Rahayu Mariyatun Mariyatun Nancy Eka Putri Manurung Pratama Nur Hasan Phatthanaphong Therdtatha Riko Mishima Husnita Komalasari Nurul Ain Mahfuzah Fathyah Hanum Pamungkaningtyas Wahyu Krisna Yoga Dina Aulia Nurfiana Stefanie Yolanda Liwan Mohammad Juffrie Agung Endro Nugroho Tyas Utami | 2021 | World Journal of Gastroenterology2021，27，1： | 6 |
| 2 | Upgrading of flash pyrolysis oil by reactive distillation using a high boiling alcohol and acid catalysts 显示文摘 | MAHFUD F H MELIAN C MANURUNG R | 2007 | Process Safety and Environmental Protection2007，85，： | 1 |
| 3 | Experimental and kinetic modelling studies on the acid-catalysed hydrolysis of the water hyaeinth plant to levulinic acid显示文摘 | Girisuta B Danon B Manurung R | 2008 | Bioresource Technology2008，99，： | 1 |
| 4 | Biomass to fuels:Upgrading of flash pyrolysis oil by reactive distillation using a high boiling alcohol and acid catalysts显示文摘 | MAHFUD F H MELIAN-CABRERA I MANURUNG R HEERES H J | 2007 | Process Saf Environ Prot2007，85，5： | 1 |
| 5 | Simulation and experimental study on distortion of butt and T-joints using WELD PLANNER显示文摘 | Mohd Shahar Sulaiman Yupiter HP Manurung Esa Haruman | 2011 | Journal of Mechaanical Science and Technology2011，25，10： | 1 |
| 6 | Simulation and experimental study ondistortion of butt and T-joints using WELD PLANNER显示文摘 | Sulaiman M S Manurung Y H P Haruman E | 2011 | Journal ofmechanical science and technol- ogy2011，25，10： | 1 |
| 7 | Predicting the GMAW 3F T-Fillet Geometry and Its Welding Parameter显示文摘 | Ghalib Tham Mohamad Yazman Yaakub Sunhaji Kiyai Abas Yupiter H.P. Manurung Bukhari Abu Jalil | 2012 | Procedia Engineering2012，，： | 1 |
| 8 | Experimental studies on the carboxymethylation of arrowroot starch in isopropanol- water media显示文摘 | KOOUMAN L M GANZEVELD K l MANURUNG R M | 2003 | Starch-Starke2003，55，11： | 1 |
| 9 | Effect of O-spodu- mene on the phase development in an alumina/aluminium-titan- ate system 显示文摘 | Manurung P Low I M O'Connor B H | 2005 | Materials Research Bulletin2005，40，12： | 1 |
| 10 | Exploratory studies on the carboxy methylation of cassava starch in water - miscible organic media 显示文摘 | Yao Jie Chen Wenren Manurung R M | 2004 | Starch/Starke2004，56，3： | 1 |
| 11 | Welding distortionanalysis of multipass joint combina- tion with different sequences using 3D FEM and ex- periment显示文摘 | Manurung Y H P Lidam R N Rahim M R | 2013 | International Journal of Pressure Vessels and Piping2013，11，： | 1 |
| 12 | Biomass to fuels: Upgrading of flash pyrolysis oil hy reactive distillation using a high boiling alcohol and acid catalysts显示文摘 | MAHFUD F H MELIAN-CABRERA I MANURUNG R HEERES H J | 2007 | Process Saf Environ Prot2007，85，5： | 1 |
| 13 | Exploratory studies on the carboxy methylation of cassava starch in water-miscible organic media 显示文摘 | Yao Jie Chen Wen-ren Manurung R M | 2004 | Starch/Starke2004，56，3： | 1 |
| 14 | Upgrading of flash pyrolysis oil by reactive distiliation using a high boiling alcohol and acid catalysts显示文摘 | F H Mahfud Melian Cabrera R Manurung H J Heeres | 2007 | Process Safety and Environmental Protection2007，85，： | 1 |
| 15 | Synthesis of higher fatty acid starch ester using vinyl laurate and stearate as reactants 显示文摘 | JUNISTIA L SUGIH AK MANURUNG R | 2008 | Starch2008，60，12： | 1 |
| 16 | Biomass to fuels: upgrading of flash pyrolysis oil by reactive distillation using a high boiling alcohol and acid catalysts 显示文摘 | MAHFUD F H MELIAN -CABRERA I MANURUNG R | 2007 | Process Saf Environ Prot2007，85，5： | 1 |
| 17 | Upgrading of flash pyrolysis oil by reactive distillation using a high boiling alcohol and acid catalysts显示文摘 | Mahfud F H Cabrera Melian Manurung R | 2007 | Process Safety and Enviromnental Protection2007，85，： | 1 |
| 18 | Experimental studies on the carboxymethylation of arrowroot starch in isopropanol-water media 显示文摘 | Laura M Kooijman Klaassien J Ganzeveld Robbed M Manurung | 2003 | Starch/Starke2003，55，： | 1 |
| 19 | Simulation and experimental study on distortion of butt and T-joints using weld planner 显示文摘 | Sulaiman M S Manurung Y H P Haruman E | 2011 | Journal of Mechanical Science and Technology2011，25，10： | 1 |
| 20 | Experimental studies on the carboxymethylation of arrowroot starch in isopropanol-water media 显示文摘 | Laura M Kooijman Klaassien J Ganzeveld Robbert M Manurung | 2003 | Starch/ Starke2003，55，： | 1 |
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