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| 1 | Regression of cardiovascular remodeling in hypertension:Novel relevant mechanisms显示文摘Asymptomatic organ damage due to progressive kidney damage, cardiac hypertrophy and remodeling put hypertensive patients at high risk for developing heart and renal failure, myocardial infarction and stroke. Current antihypertensive treatment normalizes high blood pressure, partially reverses organ damage, and reduces the incidence of heart and renal failure. Activation of the renin-angiotensin system(RAS) is a primary mechanism of progressive organ damage and, specifically, a major cause of both renal and cardiovascular fibrosis. Currently, inhibition of the RAS system [mainly with angiotensin I converting enzyme inhibitors or angiotensin II(Ang II) receptor antagonists] is the most effective antihypertensive strategy for normalizing blood pressure and preventing target organ damage. However, residual organ damage and consequently high risk for cardiovascular events and renal failure still persist. Accordingly, in hypertension, it is relevant to develop new therapeutic perspectives, beyond reducing blood pressure to further prevent/reduce target organ damage by acting on pathways that trigger and maintain cardiovascular and renal remodeling. We review here relevant novel mechanisms of target organ damage in hypertension, their role and evidence in prevention/regression of cardiovascular remodeling and their possible clinical impact as well. Specifically, we focus on the signaling pathway Rho A/Rho kinase, on the impact of the vasodilatory peptides from the RAS and some insights on the role of estrogens and myocardial chymase in cardiovascular hypertensive remodeling. | Jorge E Jalil María P Ocaranza | 2016 | World Journal of Hypertension2016，6，1： | 2 |
| 2 | Biología de Oxalis latifolia:revisión acerca de su origen,ciclo anual,características biológicas más notables y formas taxonómicas显示文摘 | Aritz R E María L L | 2008 | Agronomía Mesoamericana2008，，02： | 1 |
| 3 | Tight bounds from a path based formulation for the tree of hub location problem显示文摘 | Contreras I Fernández E Marín A | 2009 | Computers&Operations Research2009，36，12： | 1 |
| 4 | The tree of hubs location problem显示文摘 | Contreras I Fernández E Marín A | 2010 | European Journal of Operational Research2010，202，2： | 1 |
| 5 | Influence of amount of recycled coarse aggregates and production process on properties of recycled aggregate concrete显示文摘 | Etxeberria M Vázquez E MaríA Barra M | 2007 | Cement and Concrete Research2007，37，73： | 1 |
| 6 | Determination of bioavailable soluble arsenic and phosphates in mine tailings by spectrophotometric sequential injection analysis显示文摘 | Belén E Ramírez Cordero María P Canizares-Macías | 2009 | Talanta2009，78，3： | 1 |
| 7 | DPPH and oxygen free radicals as prooxidant of biomolecules显示文摘 | María E Alfredo M Juan C | 2008 | Toxicology in Vitro2008，22，： | 1 |
| 8 | Seed mass, germination and seedling traits for some central Argentinian cacti显示文摘 | María S P Guillermo F Ana E F | 2014 | Seed Science Research2014，24，1： | 1 |
| 9 | Comparison of chromatuc propertues,stability and antioxidant capacity of anthocyanin-based aqueous extracts from grape pomace obtained from different vinification methods显示文摘 | Gómec-plaza E Miano A María Ló pez-Roca L | 2005 | Food Chemistry2005，25，3： | 1 |
| 10 | Quality and microbial stability of partially baked bread during storage显示文摘 | Lainez Elizabeth Vergara Fidel Bárcenas María E | | 0，，04： | 1 |
| 11 | Regional geologic and tectonic setting of the Maracaibo supergiant basin,western Venezuela显示文摘 | Paul M Alejandro E María V C | 2006 | AAPG2006，90，4： | 1 |
| 12 | Efficacy of moxifloxacin in the treatment of bronchial colonisation in COPD显示文摘 | Miravitlles M Marín A Monsó E | 2009 | Eur Respir J2009，34，5： | 1 |
| 13 | Evaluation of different electrochemical methods on the oxidation and degradation of Reactive Blue 4 in aqueous solution显示文摘 | Patricia A Carneiro Marly E Osugi Cecílio S Fugivara | 2005 | Chemosphere2005，59，3： | 1 |
| 14 | Simplified method for the calculation of long-term deflections in FRP-strengthened reinforced concrete beams显示文摘 | MARí A R OLLER E BAIRáN J M | 2013 | Composites Part B: Engineering2013，45，1： | 1 |
| 15 | High rate of long-term survival for high-risk lymphoma patients t reated with hematopoietic stem cell transplantation as consolidation or salvage therapy显示文摘 | Espigado I Ríos E Marín-Niebla A | 2008 | Transplant Proc2008，40，9： | 1 |
| 16 | Maize Kernel composition and PostFlowering Source-Sink Ratio显示文摘 | Lucas B Jos é A C Mar í a E O | 2002 | Crop Science2002，42，： | 1 |
| 17 | Comb-like Complexes of Poly(Itaconic Acid)and Alkyltrimethylamonium Cationic Surfactants显示文摘 | María E Báez Eucarys Jiménez Estrella Laredo | 2007 | Polymer Bulletin2007，58，： | 1 |
| 18 | Electric,Dielectric and Dynamic Mechanical Behavior of Carbon Black/Styrene-butadiene-styrene Comoposites显示文摘 | María E L Guilherme M O Ana C F | 2003 | Journal of Polymer Science:Part B:Polymer Physics2003，41，23： | 1 |
| 19 | Rural tourism in Spain显示文摘 | Rosa María Yagüe Perales | 2002 | Annals of Tourism Research2002，，4： | 1 |
| 20 | Capillary electrophoresis of free fatty acids by indirect ultraviolet显示文摘 | María V B Aaron E D María J L G | 2011 | Journal of Agricultural and Food Chemistry2011，59，10： | 1 |
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