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| 1 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 2 | Progesterone receptor gene variants and risk of endometrial cancer 显示文摘 | O'Mara TA Fahey P Ferguson K etal | 2011 | Carcinogenesis2011，32，3： | 1 |
| 3 | Reproduction after myomectomy:Comparison of patients with and without second-look laparoscopy 显示文摘 | Kubinova K Mara M Horak P | 2012 | Minim Inva Ther Allied Technol2012，21，2： | 1 |
| 4 | A gateway-based framework for transparent interconnection between WSN and IP network 显示文摘 | MARA K ABDEEN M HASHEM M | 2009 | EUROCON 2009 EUROCON''09 IEEE2009，2009，： | 1 |
| 5 | Near-fatal heat stroke during the1995heat wave in Chicago显示文摘 | Dematte JE O’Mara K Buescher J | 1998 | Annals of internal medicine1998，129，3： | 1 |
| 6 | Near-fatal heat stroke during the 1995 heat wave in Chicago显示文摘 | Dematte JE O'Mara K Buescher J | 1998 | Ann Intern Med1998，129，3： | 1 |
| 7 | Application of PLS and back-propagation neural networks for the estimation of soil properties显示文摘 | ZIAD R PHILIP K H MARA J J | 2005 | Chemometrics and Intelligent Laboratory Systems2005，75，1： | 1 |
| 8 | Performance evaluation of space time block codes over Keyhole weihull fading channels 显示文摘 | PEPPAS K MARAS A | 2008 | Wireless Personal Communications2008，46，4： | 1 |
| 9 | Uterine arteryembolization versus laparoscopic uterine artery occlusion; Theoutcomes of a prospective,nonrandomized clinical trial 显示文摘 | Mara M Kubinova K Maskova J | 2012 | Cardiovasc Intervent Radiol2012，35，5： | 1 |
| 10 | Hysteroseopy after uterine fibroid embolization: evaluation of intrauterine findings in 127 patients显示文摘 | Mara M Horak P Kubinova K | 2012 | J Obstet Gynaeeol Res2012，38，5： | 1 |
| 11 | Embolization of uterine fibroids from the point of view of the gynecologist:pros and cons显示文摘 | Mara M Kubinova K | 2014 | Int J Womens Health2014，2，6： | 1 |
| 12 | Genetic relation- ships of Aeromonas strains inferred from 16S rRNA,gyrB and rpoB gene sequences显示文摘 | MARA K PETER K BOZENA M K et at | 2006 | International Journal of Systematic and Evolutionary Microbiology2006，56，12： | 1 |
| 13 | Small municipal wastewater treatment plants in greece显示文摘 | Tsagarakis K P Mara D D Horan N J | 2000 | Water Science and technology2000，44，23： | 1 |
| 14 | A triple mutant of Escherichia coli lacking secondary acyl chains on Lipid A显示文摘 | Mara K Ramirea S Robert J | 2002 | J Biol Chem2002，277，14： | 1 |
| 15 | The diagnostic utility of dual phase Tc-99m sesetamibi parathyroid imaging显示文摘 | Peter K Robert O Mara | 1998 | J Clin Nucl Med1998，23，4： | 1 |
| 16 | Retinol sup- plementation induces oxidative stress and modulates antioxidant enzyme activities in rat sertoli cells 显示文摘 | FELIPE D FABIO K MARA S B | 2001 | Free Radical Research2001，34，4： | 1 |
| 17 | Near-fatal heat stroke during the 1995 heat wave in Chicago显示文摘 | Dematte JE O Mara K Buescher J | 1998 | Ann Intern Med1998，129，3： | 1 |
| 18 | Near-fatal heat stroke during the 1995 heat wave in Chicago 显示文摘 | Dematte JE O'Mara K Buescher J | 1998 | Ann Intern Med1998，129，3： | 1 |
| 19 | The bacterial quality of salad crops drip and furrow irrigated with waste stabilization pond effluent:an evaluation of the WHO guidelines显示文摘 | R K X Bastos D D Mara | 1995 | Water Science and Technology1995，31，12： | 1 |
| 20 | Near-fatal heat stroke during the 1995 heat wave in Chicago显示文摘 | Dematte JE O Mara K Buescher J | | 0，，： | 1 |
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