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| 1 | Management of cholelithiasis in Italian children:A national multicenter study显示文摘AIM:To evaluate the management of Italian children with cholelithiasis observed at Pediatric and Surgical Departments linked to Italian Society of Pediatric Gastroenterology Hepatology and Nutrition. METHODS: One-hundred-eighty children (90 males, median age at diagnosis 7.3 years; range, 0-18 years) with echographic evidence of cholelithiasis were enrolled in the study; the data were collected by an anonymous questionnaire sent to participating centers. RESULTS: One hundred seventeen patients were treated with ursodeoxycholic acid; in 8 children dissolution of gallstones was observed, but the cholelithiasis recurred in 3 of them. Sixty-five percent of symptomatic children treated became asymptomatic. Sixty-four patients were treated with cholecystectomy and in only 2 cases a postoperative complication was reported. Thirty- four children received no treatment and were followed with clinical and echographic controls; in no case thedevelopment of complications was reported. CONCLUSION: The therapeutic strategies were extremely heterogeneous. Ursodeoxycholic acid was ineffective in dissolution of gallstones but it had a positive effect on the symptoms. Laparoscopic cholecystectomy was confirmed to be an efficacy and safe treatment for pediatric gallstones. | Claudia Della Corte Diego Falchetti Gabriella Nebbia Marisa Calacoci Maria Pastore Ruggiero Francavilla Matilde Marcellini Pietro Vajro Raffaele Iorio | 2008 | World Journal of Gastroenterology2008，14，9： | 6 |
| 2 | Non invasive evaluation of liver fibrosis in paediatric patients with nonalcoholic steatohepatitis显示文摘AIM: To identify the independent predictors of hepatic fibrosis in 69 children with nonalcoholic steatohepatitis (NASH) due to nonalcoholic fatty liver disease (NAFLD). METHODS: All patients with clinically suspected NASH underwent liver biopsy as a confirmatory test. The following clinical and biochemical variables at baseline were examined as likely predictors of fibrosis at histology: age, body mass index (BMI), systolic blood pressure (SBP), dyastolic blood pressure (DBP), fasting glucose, fasting insulin, homeostatic model assessment for insulin resistence (HOMA-IR), cholesterol, tryglicerides, alanine aminotransferase (ALT), aspartate aminotransferase (AST), AST/ALT ratio, gamma glutamil transferase (GT), platelet count, prothrombin time (PT). RESULTS: At histology 28 (40.6%) patients had no fibrosis and 41 (59.4%) had mild to bridging fibrosis. At multivariate analysis, BMI > 26.3 was the only independent predictor of fibrosis (OR = 5.85, 95% CI = 1.6-21). CONCLUSION: BMI helps identify children with NASH who might have fibrotic deposition in the liver. | Angelo Iacobellis Matilde Marcellini Angelo Andriulli Francesco Perri Gioacchino Leandro Rita Devito Valerio Nobili | 2006 | World Journal of Gastroenterology2006，12，48： | 5 |
| 3 | Gastric metastasis from ovarian adenocarcinoma presenting as a subepithelial tumor and diagnosed by endoscopic ultrasound-guided tissue acquisition显示文摘We describe an uncommon case of a patient with a metastatic adenocarcinoma of ovarian origin presented as a gastric subepithelial tumor(SET) and that was diagnosed by endoscopic ultrasound fine-needle biopsy(EUS-FNB). Malignant gastric lesions are rarely metastatic and the primary tumor is mainly breast, lung, esophageal cancer or cutaneous melanoma. Gastric metastasis from ovarian cancer is unusual, presenting synchronously with the primary tumor but also several years later than the initial diagnosis. From an endoscopic point of view, gastric metastasis does not present specific features. They may mimic both a primary gastric tumor or, less frequently, an SET.This case demonstrates the importance of EUS-FNB in distinguishing SETs and how this may alter treatment and prognosis. | Filippo Antonini Liboria Laterza Lorenzo Fuccio Massimo Marcellini Lucia Angelelli Sonia Calcina Corrado Rubini Giampiero Macarri | 2017 | World Journal of Gastrointestinal Oncology2017，9，11： | 3 |
| 4 | Correlation of serum TNF-alpha levels and histologic liver injury scores in pediatric nonalcoholic fatty liver disease显示文摘 | Manco M Marcellini M Giannone G | | 0，，06： | 1 |
| 5 | L-carnitine reduces lymphocyte apoptosis and oxidant stress in HIV-1- infected subjects treated with zidovudine and didanosine 显示文摘 | Moretti S Famularo G Marcellini S | 2002 | Antioxid Redox Signal2002，4，3： | 1 |
| 6 | L-carnitine reduces lymphocyte apoptosis and oxidant stress in HIV-1-infected subjects treated with zidovudine and didanosine显示文摘 | Moretti S Famularo G Marcellini S | | 0，，03： | 1 |
| 7 | DAQNE broad-band button electrodes显示文摘 | MARCELLINI F SERIO M STELLA A | 1998 | Nuclear Instruments and Methods in Physics Research A1998，402，： | 1 |
| 8 | Aging influences development and progression of early aortic atherosclerotic lesions in cholesterol-fed rabbits 显示文摘 | Orlandi A Marcellini M Spagnoli LG | 2000 | Arterioscler Thromb Vase Biol2000，20，： | 1 |
| 9 | Brain,aging and neurodegeneration:Role of zinc ion availability显示文摘 | Mocehegiani E Bertoni-Fruddari C Marcellini F | 2005 | Prog Neurobiol2005，75，： | 1 |
| 10 | Propionyl-L-camitine reduces proliferation and potentiates Bax-related apoptosis of aortic intimal smooth muscle cells by modulating nuclear factorkappaB activity显示文摘 | Orlandi A Francesconi A Marcellini M | 2007 | J Biol Chem2007，282，7： | 1 |
| 11 | Aging in Italy: Urban-rural differences显示文摘 | Marcellini F Giuli C Gagliardi C | 2007 | Archives of Gerontology and Geriatrics2007，44，3： | 1 |
| 12 | L-carnitine reduces lymphocyte apoptosis and oxidant stress in HIV- 1 - infected subjects treated with zidovudine and didanosine 显示文摘 | Moretti S FamularoG Marcellini S | 2002 | Antioxid Redox Signal2002，4，3： | 1 |
| 13 | L-carnitine reduces lymphocyte apoptosis and oxidant stress in HIV- 1 - infected subjects treated with zidovudine and didanosine 显示文摘 | Moretti S FamularoG Marcellini S etal | 2002 | Antioxid Redox Signal2002，4，3： | 1 |
| 14 | Aging in Italy:Urban-rural differences显示文摘 | Fiorella Marcellini Cinzia Giuli Cristina Gagliardi and Roberta Papa | 2006 | Archives of Gerontoloy and Geriatrics In Press Corrected Proof2006，14，5： | 1 |
| 15 | Aging influences development andprogression of early aortic atherosclerotic lesions in cholesterol-fed rabbits显示文摘 | Orlandi A Marcellini M Spagnoli LG | 2000 | Arterioscler Thromb Vasc Biol2000，20，： | 1 |
| 16 | The biflavonoid amentoflavone inhibits neovascularization preventing the activity of proangiogenic vascular endothelial growth factors显示文摘 | TARALLO V LEPORE L MARCELLINI M | 2011 | J Biol Chem2011，286，19： | 1 |
| 17 | Social and behavioural science perspectives on out-of-home mobility in later life: findings from the European project MOBILATE显示文摘 | Heidrun Mollenkopf Fiorella Marcellini Isto Ruoppila Zsuzsa Széman Mart Tacken Hans-Werner Wahl | 2004 | European Journal of Ageing2004，，1： | 1 |
| 18 | L-carnitine reduces lymphocyte apoptosis and oxidant stress in HIV-1- infected subjects treated with zidovudine and didanosine 显示文摘 | Morettis S Famularo G Marcellini S | 2002 | Antioxid Redox Signal2002，4，3： | 1 |
| 19 | Control of osteogenesis by the canonical Wnt and BMP pathways in vivo: cooperation and antagonism between the canonical Wnt and BMP pathways as cells differentiate from osteochondropr- ogenitors to osteoblasts and osteocytes 显示文摘 | Marcellini S Henriquez J P Bertin A | 2012 | Bioessays2012，34，11： | 1 |
| 20 | L-carnitine reduces lymphocyte apoptosis and oxidant stress in HIV-l-infected sub- jects treated with zidovudine and didanosine显示文摘 | Morettis S Famularo G Marcellini S | 2002 | Amtopxid Redox Signal2002，4，4： | 1 |
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