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| 1 | Intraoperative cell salvage with autologous transfusion in liver transplantation显示文摘Liver transplant(LT) is the primary treatment for patients with end-stage liver disease. About 25000 LTs are performed annually in the world. The potential for intraoperative bleeding is quite variable. However, massive bleeding is common and requires blood transfusion. Allogeneic blood transfusion has an immunosuppressive effect and an impact on recipient survival, in addition to the risk of transmission of viral infections and transfusion errors, among others.Techniques to prevent excessive bleeding or to use autologous blood have been proposed to minimize the negative effects of allogeneic blood transfusion.Intraoperative reinfusion of autologous blood is possible through previous selfdonation or blood collected during the operation. However, LT does not normally allow autologous transfusion by prior self-donation. Hence, using autologous blood collected intraoperatively is the most feasible option. The use of intraoperative blood salvage autotransfusion(IBSA) minimizes the perioperative use of allogeneic blood, preventing negative transfusion effects without negatively impacting other clinical outcomes. The use of IBSA in patients with cancer is still a matter of debate due to the theoretical risk of reinfusion of tumor cells. However, studies have demonstrated the safety of IBSA in several surgical procedures, including LT for hepatocellular carcinoma. Considering the literature available to date, we can state that IBSA should be routinely used in LT, both in patients with cancer and in patients with benign diseases. | Marcelo A Pinto Marcio F Chedid Leo Sekine Andre P Schmidt Rodrigo P Capra Carolina Prediger Jo?o E Prediger Tomaz JM Grezzana-Filho Cleber RP Kruel | 2019 | World Journal of Gastrointestinal Surgery2019，11，1： | 16 |
| 2 | Twenty-five years of research on the effects of exercise training in breast cancer survivors:A systematic review of the literature显示文摘AIM:To investigate the role of exercise training the past 25 years on major physiological-psychological outcomes studied thus far in this patient population.METHODS:Pub Med, Medline Plus, the Cochrane Library, Web of Science, SportD iscus, Embase, Scorpus, and Google Scholar were searched from September to November 2013 to identify exercise training studies that used objective measurements of fitness and/or patient reported outcomes assessed pre and post-exercise training with statistical analyses performed in at least one of the following outcome measurements:Cardiorespiratory function, body composition, muscular strength, fatigue, depression, and overall quality of life. Five reviewers independently identified the studies that met the criteria for the review and discrepancies were resolved by consensus among all authors.RESULTS:Fifty-one studies were included in this review with 5 from the period between 1989-1999, 11 from 2000-2006, and 35 from 2007-2013. The evolution of study designs changed from aerobic only exercise training interventions(1989-1999), to a combination of aerobic and resistance training(2000-2006), to studies including an arm of resistance training or examining the effects of resistance training as the main mode of exercise(2007-2013). Overall, the benefits of exercise showed improvements in cardiorespiratory function, body composition, strength, and patient reported outcomes including fatigue, depression, and quality of life.CONCLUSION:Exercise training appears to be safe for most breast cancer patients and improvements in physiological, psychological, and functional parameters can be attained with regular participation in moderate intensity exercise. | Claudio L Battaglini Robert C Mills Brett L Phillips Jordan T Lee Christina E Story Marcelo GB Nascimento Anthony Carl Hackney | 2014 | World Journal of Clinical Oncology2014，5，2： | 3 |
| 3 | Role of pentoxifylline in non-alcoholic fatty liver disease in high-fat diet-induced obesity in mice显示文摘AIM:To study pentoxifylline effects in liver and adipose tissue inflammation in obese mice induced by high-fat diet(HFD).METHODS: Male swiss mice(6-wk old) were fed a highfat diet(HFD; 60% kcal from fat) or AIN-93(control diet; 15% kcal from fat) for 12 wk and received pentoxifylline intraperitoneally(100 mg/kg per day) for the last 14 d. Glucose homeostasis was evaluated by measurements of basal glucose blood levels and insulin tolerance test two days before the end of the protocol. Final body weight was assessed. Epididymal adipose tissue was collected and weighted for adiposity evaluation. Liver and adipose tissue biopsies were homogenized in solubilization buffer and cytokines were measured in supernatant by enzyme immunoassay or multiplex kit, respectively. Hepatic histopathologic analyses were performed in sections of paraformaldehyde-fixed, paraffin-embedded liver specimens stained with hematoxylin-eosin by an independent pathologist. Steatosis(macrovesicular and microvesicular), ballooning degeneration and inflammation were histopathologically determined. Triglycerides measurements were performed after lipid extraction in liver tissue. RESULTS: Pentoxifylline treatment reduced microsteatosis and tumor necrosis factor(TNF)-α in liver(156.3 ± 17.2 and 62.6 ± 7.6 pg/mL of TNF-α for non-treated and treated obese mice, respectively; P < 0.05). Serum aspartate aminotransferase levels were also reduced(23.2 ± 6.9 and 12.1 ± 1.6 U/L for nontreated and treated obese mice, respectively; P < 0.05) but had no effect on glucose homeostasis. In obese adipose tissue, pentoxifylline reduced TNF-α(106.1 ± 17.6 and 51.1 ± 9.6 pg/mL for non-treated and treated obese mice, respectively; P < 0.05) and interleukin-6(340.8 ± 51.3 and 166.6 ± 22.5 pg/mL for non-treated and treated obese mice, respectively; P < 0.05) levels; however, leptin(8.1 ± 0.7 and 23.1 ± 2.9 ng/mL for non-treated and treated lean mice, respectively; P < 0.05) and plasminogen activator inhibitor-1(600.2 ± 32.3 and 1508.6 ± 210.4 pg/mL for non-treated and treated lean mice, respectively; P < 0.05) levels increased in lean adipose tissue. TNF-α level in the liver of lean mice also increased(29.6 ± 6.6 and 75.4 ± 12.6 pg/mL for non-treated and treated lean mice, respectively; P < 0.05) while triglycerides presented a tendency to reduction.CONCLUSION: Pentoxifylline was beneficial in obese mice improving liver and adipose tissue inflammation. Unexpectedly, pentoxifylline increased pro-inflammatory markers in the liver and adipose tissue of lean mice. | Simone Coghetto Acedo Cintia Rabelo e Paiva Caria érica Martins Ferreira Gotardo José Aires Pereira José Pedrazzoli Marcelo Lima Ribeiro Alessandra Gambero | 2015 | World Journal of Hepatology2015，7，24： | 2 |
| 4 | Incidence and survival of stomach cancer in a high-risk population of Chile显示文摘AIM:To study the incidence and survival rate of stomach cancer(SC)and its associated factors in a high risk population in Chile. METHODS:The population-based cancer registry of Valdivia,included in the International Agency for Research on Cancer system,covers 356 396 residents of Valdivia Province,Southern Chile.We studied all SC cases entered in this Registry during 1998-2002 (529 cases).Population data came from the Chilean census(2002).Standardized incidence rates per 100 000 inhabitants(SIR)using the world population, cumulative risk of developing cancer before age 75, and rate ratios by sex,age,ethnicity and social factors were estimated.Relative survival(EdererⅡmethod) and age-standardized estimates(Brenner method) were calculated.Specific survival rates(Kaplan-Meier) were measured at 3 and 5 years and survival curves were analyzed with the Logrank and Breslow tests. Survival was studied in relation to demographics, clinical presentation,laboratory results and medical management of the cases.Those variables significantly associated with survival were later included in a Cox multivariate model. RESULTS:Between 1998 and 2002,529 primary gastric cancers occurred in Valdivia(crude incidence rate 29.2 per 100000 inhabitants).Most cases were male(69.0%), residents of urban areas(57.5%)and Hispanic(83.2%), with a low education level(84.5%<8 school years). SC SIR was higher in men than women(40.8 and 14.8 respectively,P<0.001),risk factors were low education RR 4.4(95%CI:2.9-6.8)and 1.6,(95%CI:1.1-2.1) for women and men respectively and Mapuche ethnicity only significant for women(RR 2.2,95%CI:1.2-3.7).Of all cases,76.4%were histologically confirmed,11.5% had a death certificate only(DCO),56.1%were TNM stageⅣ;445 cases(84.1%)were eligible for survival analysis,all completed five years follow-up;42 remained alive,392 died of SC and 11 died from other causes. Specific 5-year survival,excluding cases with DCO,was 10.6%(95%CI:7.7-13.5);5-year relative survival rate was 12.3%(95%CI:9.1-16.1),men 10.9%(95%CI: 7.4-15.2)and women 16.1%(95%CI:9.5-24.5).Fiveyear specific survival was higher for patients aged<55 years(17.3%),with intestinal type of cancer(14.6%), without metastasis(22.2%),tumor size<4 cm(60.0%), without lymphatic invasion(77.1%),only involvement of the mucous membrane(100%).Statistically significant independent prognostic factors were:TNM staging, diffuse type,metastasis,supraclavicular adenopathy, palpable tumor,and hepatitis or ascites. CONCLUSION:Social determinants are the main risk factors for SC,but not for survival.An advanced clinical stage at consultation is the main cause of poor SC survival. | Katy Heise Enriqueta Bertran Marcelo E Andia Catterina Ferreccio | 2009 | World Journal of Gastroenterology2009，15，15： | 2 |
| 5 | Uric acid renal excretion and renal insufficiency in decompensated severe heart failure 显示文摘 | Marcelo E Ochiai Antonio CP | 2005 | The European Journal of Heart Failure2005，7，： | 1 |
| 6 | Catalytic oxidative desulfurization ( ODS ) of diesel fuel on a continuous fixed-bed reactor 显示文摘 | Antonio Chica Avelino Corma Marcelo E DOmine | 2006 | Journal of Catalysis2006，242，9： | 1 |
| 7 | The Phenomenology of Seitures and Epilepsy After Stroke显示文摘 | Lambrakis Marcelo E | 1998 | J Epilepsy1998，11，： | 1 |
| 8 | Differential responses of superoxide dismutase in freezing resistant Solanum curtilobum and freezing sensitive Solanum tuberosum subjected to oxidative and water stress显示文摘 | Carlos A Martinez Marcelo E | 2001 | Plant Science2001，160，： | 1 |
| 9 | Relationship between follicle size and ultrasound-guided transvaginal oocyte recovery显示文摘 | MARCELO M S CESAR R E JOAQUIM M G etal | 2001 | Anim Reprod Sci2001，67，： | 1 |
| 10 | A Method for Extracting the Fundamental Frequency Positive Sequence Voltage Vector Based on Simple Mathematical Transformations显示文摘 | Helber E P de Souza Fabrício Bradaschia Francisco A S Neves Marcelo C Cavalcanti Gustavo M S Azevedo Josué P de Arruda | | 0，，05： | 1 |
| 11 | Euglena gracilis as a model for the study of Cu^2+ and Zn^2+ toxicity and accumulation in eukaryotic cells 显示文摘 | Marcelo E L Gustavo A M Fernandesa T B | 2002 | Environmental Pollution2002，120，： | 1 |
| 12 | Thermal dynamic analysis of a coke dry quenching unit 显示文摘 | Marcelo R E Luiz F M | 2000 | Energy Conversion & Management2000，41，： | 1 |
| 13 | New aluminosilicate and titanosilicate delaminatedmaterials active for acid catalysis and oxidation reactionsusing H2O2显示文摘 | AVELINO C URBANO D MARCELO E D | 2000 | J Am Chem Soc2000，122，12： | 1 |
| 14 | Optimum zinc supplementation level in Nile tilapia Oreochromis niloticus juveniles diets显示文摘 | Marcelo Luiz E P | 2004 | Aquaculture2004，，238： | 1 |
| 15 | Optimum zinc supplementation level in Nile tilapia Oreo chromis niloticus juveniles diets 显示文摘 | Marcelo V C Luiz E P Margarida M B F | 2004 | Aquaculture2004，，238： | 1 |
| 16 | Constitutive modeling of viscoelastic materials with damage computational aspects 显示文摘 | MARCELO E C ERIC B B SEBNEM Ozupek | 2001 | Comput Methods Appl Mech Engrg2001，190，： | 1 |
| 17 | A generalized delayed signal cancellation method for detecting fundamental-frequency positive-sequence three- phase signals显示文摘 | FRANCISCO A S N MARCELO C HELBER E | 2010 | IEEE Transactions on power delivery2010，725，3： | 1 |
| 18 | Conformational properties of poly (diallyldimethyl ammonium chloride) (PDDA)determined by combination of molecular dynamics,rotational isomeric states and Monte Carlo procedures显示文摘 | Marcelo G Tarazona-M P Saiz E | 2004 | Polymer2004，45，： | 1 |
| 19 | Formation of an Fe-Sn Intermetallic Layer during the Refow Process after Tin Plating 显示文摘 | Marcelo J L G Gonzalo B J Walter E | 2003 | Plating & Surface Finishing2003，90，10： | 1 |
| 20 | Catalytic oxidative desulfurization (ODS) of diesel fuel on a continuous fixed-bed reactor显示文摘 | Antonio Chica Avelino Corma Marcelo E Dómine | 2006 | Journal of Catalysis2006，242，9： | 1 |
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