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| 1 | Arthroereisis in juvenile flexible flatfoot:Which device should we implant?A systematic review of literature published in the last 5 years显示文摘BACKGROUND Flexible flatfoot(FFF)is a very common condition in children,characterized by the loss of the medial arch and by an increase in the support base with valgus of the hindfoot.Arthroereisis(AR)procedures are widely performed corrective surgeries and are classified as subtalar AR and calcaneo-stop(CS).AIM We investigated the literature published in the last 5 years with the aim of providing an update on the evidence related to AR treatment in FFF patients.We report the principal findings of subtalar AR and CS procedures concerning clinical and radiological outcomes and complication rates in the general population,young athletes,and obese people according to material device.METHODS Following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses,a systematic review of studies published in the past 5 years and included the PubMed and Science Direct databases was performed on May 6,2020.The research string used was(pediatric OR children OR Juvenile NOT adult)AND(flexible NOT rigid)AND(flat foot OR pes planus)AND(calcaneo-Stop OR arthroereisis OR subtalar extra-articular screw OR SESA OR subtalar arthroereisis OR endosinotarsal).The risk of bias assessment was performed using the Dutch checklist form for prognosis.RESULTS A total of 47 articles were found.Ultimately,after reading the full text and checking reference lists,we selected 17 articles that met the inclusion and exclusion criteria.A total of 1864 FFFs were identified.Eight studies concerned the subtalar AR(47.1%)and nine concerning CS(52.9%).The average age of patients at start of treatment was 11.8 years,the average follow-up of the studies was 71.9 mo(range 29.1-130).Globally,complications occurred in 153 of the 1864 FFF treated,with a rate of 8.2%.CONCLUSION Both AR procedures are valid surgical techniques for treating FFF.Surgeon experience,implant cost,and cosmetic correction are the most common considerations included in the orthopedic device decision-making process.In obese patients,the subtalar AR is not recommended.In adolescents who need to improve sports performance,the CS screw had better results compared with other implants. | Andrea Vescio Gianluca Testa Mirko Amico Claudio Lizzio Marco Sapienza Piero Pavone Vito Pavone | 2021 | World Journal of Orthopedics2021，12，6： | 3 |
| 2 | What factors influence the uptake of GPP (green public procurement) practices? New evidence from an Italian survey显示文摘 | Francesco Testa Fabio Iraldo Marco Frey Tiberio Daddi | 2012 | Ecological Economics2012，，： | 1 |
| 3 | Growing pains: What do we know about etiology? A systematic review显示文摘BACKGROUND Growing pains is the most common cause of musculoskeletal pain in early childhood and was first described in 1823 by French physician Marcel Duchamp.Although it has been researched extensively, the etiology is still unknown.Several theories have been proposed throughout the years.AIM Analyze the available scientific literature to provide an update on the latest evidence on the etiology.METHODS According to the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses, the scientific literature on the etiology of growing pains was systematically reviewed using the following inclusion criteria: studies of any level of evidence reporting clinical or preclinical results and dealing with the etiology of growing pains. The medical electronic databases PubMed and Web of Science were searched by two independent authors on October 20, 2018.The search string used was '(growing pains OR benign nocturnal limb pains OR musculoskeletal pains) AND(etiology OR pathogenesis) AND(pediatrics)'.RESULTS A total of 32 articles were included. The etiology of growing pains still remains poorly understood. Many theories have been proposed, but none of them are decisive. A lower pain threshold has been found among patients suffering from growing pains in comparison to healthy controls. Furthermore, evidence suggests an association between growing pains and reduced bone strength in young patients, although this finding still remains controversial. Changes in the vascular perfusion pattern have also been studied. However, the etiology of growing pains does not seem related to a vascular component. The anatomical/mechanical theory has not been supported, but the role of vitamin D deficiency has been investigated many times. Strong recent evidence indicates a genetic susceptibility in the pathogenesis of growing pains. Furthermore,psychological factors also seem to play a strong role in the onset.CONCLUSION The scientific literature about the etiology of growing pains presents heterogeneity and lack of consensus; more studies are needed to understand the genesis of benign musculoskeletal pain syndrome of childhood. | Vito Pavone Andrea Vescio Fabiana Valenti Marco Sapienza Giuseppe Sessa Gianluca Testa | 2019 | World Journal of Orthopedics2019，10，4： | 1 |
| 4 | The effect of environmental regulation on firms’ competitive performance: The case of the building & construction sector in some EU regions显示文摘 | Francesco Testa Fabio Iraldo Marco Frey | 2011 | Journal of Environmental Management2011，，9： | 1 |
| 5 | Is an environmental management system able to influence environmental and competitive performance? The case of the eco-management and audit scheme (EMAS) in the European union显示文摘 | Fabio Iraldo Francesco Testa Marco Frey | 2009 | Journal of Cleaner Production2009，，16： | 1 |
| 6 | The effect of environmental regulation on firms' competitive performance: The case of the building & construction sector in some EU regions 显示文摘 | Francesco Testa Fabio Iraldo Marco Frey | 2011 | Journal of Environmental Management2011，，92： | 1 |
| 7 | The Effect of Environ- mental Regulation on Firms' Competitive Performance: The Case of the Building & Construction Sector in Some EU Regions显示文摘 | Francesco Testa Fabio Iraldo Marco Frey | 2011 | Journal of Environmental Management2011，，92： | 1 |
| 8 | Ethical considerations and rati onale of adult-to-adult living donor liver transplantation显示文摘 | Malago M Testa G Marcos A | 2001 | Liver Transpl2001，7，10： | 1 |
| 9 | The effect of environmental regulation on firms’ competitive performance: The case of the building & construction sector in some EU regions显示文摘 | Francesco Testa Fabio Iraldo Marco Frey | 2011 | Journal of Environmental Management2011，，9： | 1 |
| 10 | The Effect of Environmental Regulation on Firms, Competitive Performance: The Case of the Building & Construction Sector in Some EU Regions 显示文摘 | Francesco Testa Fabio Irado Marco Frey | 2011 | Journal of Environmental Management2011，，9： | 1 |
| 11 | Pathogenesis of chronic cardiorenal syndrome is there a role for oxidative stress显示文摘 | Speranza Rubattu Silvia Mennuni Marco Testa | 2013 | Int J Mol Sci2013，14，23： | 1 |
| 12 | Ethical considerations and rationale of adult-to-adult living donor liver transplantation显示文摘 | Malago M Testa G Marcos A | 2001 | Liver Transpl2001，7，10： | 1 |
| 13 | Catania flatfoot score:A diagnostic-therapeutic evaluation tool in children显示文摘BACKGROUND Flexible flatfoot(FFF)is a very common condition in children,but no evidencebased guidelines or assessment tools exist.Yet,surgical indication is left to the surgeon’s experience and preferences.AIM To develop a functional clinical score for FFF[Catania flatfoot(CTF)score]and a measure of internal consistency;to evaluate inter-observer and intra-observer reliability of the CTF Score;to provide a strong tool for proper FFF surgical indication.METHODS CTF is a medically compiled score of four main domains for a total of twelve items:Patient features,Pain,Clinical Parameters,and Functionality.Each item refers to a specific rate.Five experienced observers answered 10 case reports according to the CTF.To assess inter-and intra-observer reliability of the CTF score,the intra-class correlation coefficients’(ICCs)statistics test was performed,as well as to gauge the correlation between the CTF score and the surgical or conservative treatment indication.Values of 75%were chosen as the score cut-off for surgical indication.Sensitivity,specificity,positive likelihood ratio(PLHR),negative likelihood ratio(NLHR),positive predictive value(PPV),and negative predictive value(NPV).RESULTS Overall interobserver reliability ICC was 0.87[95%confidence interval(CI):0.846-0.892;P<0.001].Overall intra-observer reliability ICC was 0.883(95%CI:0.854-0.909;P<0.001).A direct correlation between the CTF score and surgical treatment indication[Pearson correlation coefficient=0.94(P<0.001)]was found.According to the 75%cut-off,the sensitivity was 100%(95%CI:83.43%-100%),specificity was 85.71%(95%CI:75.29%-92.93%),PLHR was 7(95%CI:3.94-12.43),NLHR was 0(95%CI:0-0),PPV was 75%(95%CI:62.83%-84.19%)and NPV was 100%(95%CI:100%-100%).CONCLUSION CTF represents a useful tool for orthopedic surgeons in the FFF evaluation.The CTF score is a quality questionnaire to reproduce suitable clinical research,survey studies,and clinical practice.Moreover,the 75%cutoff is an important threshold for surgical indication and helps in the decision-making process. | Andrea Vescio Gianluca Testa Alessia Caldaci Marco Sapienza Vito Pavone | 2023 | World Journal of Orthopedics2023，14，10： | 0 |
| 14 | Impact of severe left ventricular dysfunction on mid-term mortality in elderly patients undergoing transcatheter aortic valve implantation显示文摘有减少的左室的功能的 BackgroundWhether 病人在大动脉的阀门培植(TAVI ) 是的 transcatheter 以后介绍更坏的结果争论。这研究的目的是估计基线的影响严重的在有大动脉的狭窄的 TAVI.MethodsSix-hundred-forty-nine 病人后面的死亡上的左室的喷射部分(LVEF ) 的缺陷与 CoreValve 系统(92.8%) 或爱德华兹智慧阀门系统(7.2%) 经历了 TAVI。基线 LVEF 被 echocardiographic Simpson 方法测量。LVEF ≤ 的影响;30% 被考克斯 regression.ResultsPatients 与 LVEF ≤ 在死亡上估计;30%(n = 63 ) ,作为与那些相比与 LVEF >30%(n = 586 ) ,有 NHYA 班 > 的更高的流行;2 (P <0.001 ) 并且与更高的 Euroscore 介绍了(P <0.001 ) 。程序的成功在两个组是类似的(98.4% 对 97.2% , P = 1 ) 。在 436 天的中部的后续以后(25 th -75 th 百分位数, 357-737 天) ,所有原因死亡[23.8% 对 23.7% , P = 0.87,危险比率(HR ) :0.96, 95% 信心间隔(CI ) :0.56-1.63 ] 并且心脏的死亡(19.1% 对 17.6% , P = 0.89, HR:1.04, 95% CI:0.57-1.90 ) 在有 LVEF ≤ 的病人是类似的;30% 作为与那些相比与 LVEF >30% 。三十天的所有原因死亡不在二个组之间是显著地不同的(11.1% 对 6.3% , P = 0.14, HR:1.81, 95% CI:0.81-4.06 ) 。有 LVEF ≤ 的病人;30% 向 30 天的心脏的死亡的更高的风险有一个趋势(11.1% 对 5.3% ;P = 0.06, HR:2.16, 95% CI:0.95-4.90 ) ,它消失在 multivariable 调整以后(P = 0.22 ).ConclusionsBaseline LVEF 的严重缺陷不是一个预言者在 TAVI 以后增加了短期、中间的死亡。有左室的功能的严重缺陷的选择病人不应该被拒绝 TAVI。 | Giuseppe Ferrante Patrizia Presbitero Paolo Pagnotta Anna Sonia Petronio Nedy Brambilla Federico De Marco Claudia Fiorina Cristina Giannini Fabrizio D'Ascenzo Silvio Klugmann Marco L Rossi Federica Ettori Francesco Bedogni Luca Testa | 2016 | Journal of Geriatric Cardiology2016，13，4： | 0 |
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