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| 1 | Early-onset colorectal cancer:A review of current knowledge显示文摘Colorectal cancer(CRC)is one of the most prevalent malignancies worldwide.Although most prevalent among older people,its incidence above 50 years old has been decreasing globally in the last decades,probably as a result of better screening.Paradoxically,its incidence in patients below 50 years old[early-onset CRC(EO-CRC)]has been increasing,for reasons not yet fully understood.EOCRC’s increasing incidence is genre independent but shows racial disparities and has been described to occur worldwide.It follows a birth-cohort effect which probably reflects a change in exposure to CRC risk factors.Its incidence is predicted to double until 2030,which makes EO-CRC a serious public health issue.Both modifiable and non-modifiable risk factors have been identified-some are potential targets for preventive measures.EO-CRC is often diagnosed at advanced stages and histological features associated with poor prognosis have been described.EO-CRC presents some distinctive features:Microsatellite instability is common,but another subtype of tumours,both microsatellite and chromosome stable also seems relevant.There are no age-specific treatment protocols and studies on EO-CRC survival rates have shown conflicting data.Due to the higher germline pathological mutations found in EO-CRC patients,an accurate genetic risk evaluation should be performed.In this review,we summarize the current evidence on epidemiological,clinical,histopathological and molecular features of EO-CRC and discuss the contribution of genetics and lifestyle risk factors.We further comment on screening strategies and specific dimensions to consider when dealing with a younger cancer patient. | Margarida R Saraiva Isadora Rosa Isabel Claro | 2023 | World Journal of Gastroenterology2023，29，8： | 3 |
| 2 | Openness and Technological Innova- tions in Developing Countries: Evidence from Finn- Level Surveys显示文摘 | Almeida R Margarida F | 2008 | The Journal of Development Studies2008，44，5： | 1 |
| 3 | The ionic strength effect on microcystin and natural organic matter surrogate adsorption onto PAC 显示文摘 | Margarida C Maria J R | 2006 | Colloid Interface Sci2006，299，2： | 1 |
| 4 | Mieroeystins removal by nanofiltration membranes 显示文摘 | Margarida R T Mafia J R | 2005 | Separation Purifi Technol2005，46，3： | 1 |
| 5 | Nutritional and lipid profiles in marine fish species from Brazil 显示文摘 | Carolina E F Margarida A S V Marisilda A R | 2014 | Food Chem2014，160，： | 1 |
| 6 | Modelling dominant height growth: Eucalyptus plantation in Portugal 显示文摘 | Amaro A David R Margarida T | 1998 | Forest Science1998，44，1： | 1 |
| 7 | Microcystins Removal by Nanofilt ration Membranes 显示文摘 | Margarida R T Maria J R | 2005 | Separation and Puri- fication Technology2005，46，3： | 1 |
| 8 | Modulation of mito- chondrial outer membrane permeabilization and apoptosis by ceram- ide metabolisra显示文摘 | Antonio R Margarida C Susana RC | 2012 | PLoS One2012，7，48： | 1 |
| 9 | A previous study of phenolic profiles of quince,pear and apple purees by HPLC diode array detection for the evaluation of quince puree genuineness显示文摘 | Paula B Andrade Alexandre R Carvalho Rosa M Seabra e Margarida A Ferreira | 1998 | J Agric Food Chem1998，46，： | 1 |
| 10 | Labelling of platelets with Indium-111 oxine and technetium-99m hexamethylprophlene amine oxine: suggested method 显示文摘 | Margarida R Helmut S Mathew T | 1999 | Eur J Nucl Med1999，26，12： | 1 |
| 11 | Surface water quality in Portugal during a drought period显示文摘 | Margarida C Barros Maria Jo(a)o M Mendo Francisco C R Negr(a)o | | 0，，： | 1 |
| 12 | Neurotoxic and hepatotoxic cyanotoxins removal by nanofiltration 显示文摘 | Margarida R T Maria J R | 2006 | Water Res2006，40，： | 1 |
| 13 | Effect of composted sewage sludge amendment on soil nitrogen and phosphorus availability 显示文摘 | Joao C Margarida A Olga R | 1997 | Communications in Soil Science and Plant Analysis1997，28，1920： | 1 |
| 14 | Spatial-Temporal Pat- terns in Mediterranean Carnivore Road Casualties: Conse- quences for Mitigation显示文摘 | Clara G John A B Margarida S R | 2009 | Biological Conservation2009，142，2： | 1 |
| 15 | Tm(DOTP)5-:A 23Na+ shift agent for perfused rat hearts显示文摘 | Buster D C Castro M Margarida C A Geraldes Carlos F G C Malloy C R Sherry A D Siemers T C | | 0，，01： | 1 |
| 16 | Network of GRAS transcription factors in plant development,fruit ripening and stress responses显示文摘The plant-specific family of GRAS transcription factors has been wide implicated in the regulation of transcriptional reprogramming associated with a diversity of biological functions ranging from plant development processes to stress responses.Functional analyses of GRAS transcription factors supported by in silico structural and comparative analyses are emerging and clarifying the regulatory networks associated with their biological roles.In this review,a detailed analysis of GRAS proteins’structure and biochemical features as revealed by recent discoveries indicated how these characteristics may impact subcellular location,molecular mechanisms,and function.Nomenclature issues associated with GRAS classification into different subfamilies in diverse plant species even in the presence of robust genomic resources are discussed,in particular how it affects assumptions of biological function.Insights into the mechanisms driving evolution of this gene family and how genetic and epigenetic regulation of GRAS contributes to subfunctionalization are provided.Finally,this review debates challenges and future perspectives on the application of this complex but promising gene family for crop improvement to cope with challenges of environmental transition. | Catarina Neves Beatriz Ribeiro Rute Amaro Jesús Expósito Jérôme Grimplet Ana Margarida Fortes | 2023 | Horticulture Research2023，10，12： | 0 |
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