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    题名 作者 年代 出处 被引量
1Stem cell therapy in the management of shoulder rotator cuff disorders显示文摘Rotator cuff tears are frequent shoulder problems that are usually dealt with surgical repair. Despite improved surgical techniques, the tendon-to-bone healing rate is unsatisfactory due to difficulties in restoring the delicate transitional tissue between bone and tendon. It is essential to understand the molecular mechanisms that determine this failure. The study of the molecular environment during embryogenesis and during normal healing after injury is key in devising strategies to get a successful repair. Mesenchymal stem cells(MSC) can differentiate into different mesodermal tissues and have a strong paracrine, anti-inflammatory, immunoregulatory and angiogenic potential. Stem cell therapy is thus a potentially effective therapy to enhance rotator cuff healing. Promising results have been reported with the use of autologous MSC of different origins in animal studies: they have shown to have better healing properties, increasing the amount of fibrocartilage formation and improving the orientation of fibrocartilage fibers with less immunologic response and reduced lymphocyte infiltration. All these changes lead to an increase in biomechanical strength. However, animal research is still inconclusive and more experimental studies are needed before human application. Future directions include expanded stem cell therapy in combination with growth factors or different scaffolds as well as new stem cell types and gene therapy.Maria Valencia Mora Miguel A Ruiz Ibán Jorge Díaz Heredia Raul Barco Laakso Ricardo Cuéllar Mariano García Arranz 2015World Journal of Stem Cells2015，7，4：6
2Effective use of FibroTest to generate decision trees in hepatitis C显示文摘AIM:To assess the usefulness of FibroTest to forecast scores by constructing decision trees in patients with chronic hepatitis C.METHODS:We used the C4.5 classification algorithm to construct decision trees with data from 261 patients with chronic hepatitis C without a liver biopsy.The FibroTest attributes of age,gender,bilirubin,apolipoprotein,haptoglobin,α2 macroglobulin,and γ-glutamyl transpeptidase were used as predictors,and the FibroTest score as the target.For testing,a 10-fold cross validation was used.RESULTS:The overall classification error was 14.9%(accuracy 85.1%).FibroTest's cases with true scores of F0 and F4 were classified with very high accuracy(18/20 for F0,9/9 for F0-1 and 92/96 for F4) and the largest confusion centered on F3.The algorithm produced a set of compound rules out of the ten classification trees and was used to classify the 261 patients.The rules for the classification of patients in F0 and F4 were effective in more than 75% of the cases in which they were tested.CONCLUSION:The recognition of clinical subgroups should help to enhance our ability to assess differences in fibrosis scores in clinical studies and improve our understanding of fibrosis progression.Dana Lau-Corona Luís Alberto Pineda Héctor Hugo Avilés Gabriela Gutiérrez-Reyes Blanca Eugenia Farfan-Labonne Rafael Núez-Nateras Alan Bonder Rosalinda Martínez-García Clara Corona-Lau Marco Antonio Olivera-Martínez Maria Concepción Gutiérrez-Ruiz Guillermo Robles-Díaz David Kershenobich 2009World Journal of Gastroenterology2009，15，21：2
3Clinical characteristics and type of antithrombotic treatment in a Spanish cohort of elderly patients with atrial fibrillation according to dependency, frailty and cognitive impairment显示文摘根据相关性,脆弱和认知缺陷与 atrial 纤维性颤动(AF ) 考虑老病人的临床的侧面和管理的 BackgroundAvailable 数据是少见的。学习的目的是根据相关性分析 biodemographic 数据,临床的侧面和 antithrombotic 治疗,吗在patients.MethodsCross部分的老 AF 和学习在 75 年与 3 个月在 Spain.ResultsA 在内部药部门出席了的口头的抗凝剂对待的连续 AF 病人执行了的多中心的脆弱和认知缺陷 837 总计病人( 83.0 ???????????????????吗???????????????????￡??Jose Maria Mostaza Manuel Jesús Romero Jiménez Fernando José Ruiz Laiglesia José Antonio Díaz Peromingo Manuel Beltrán Robles Ernesto Guevara Sierra Ana Santander Bilbao Carmen Suárez 2018Journal of Geriatric Cardiology2018，15，4：2
4Atherosclerosis, oxidative stress and physical activity显示文摘Calderon JC Fernandez AZ Maria de 2008Invest Clin2008，49，3：1
5Urbanization patterns and their impacts on social restructuring of urban space in Chilean mid-cities: The case of Los Angeles, Central Chile显示文摘Gerardo Azócar Hugo Romero Rodrigo Sanhueza Claudia Vega Mauricio Aguayo Maria Dolores Mu?oz 2005Land Use Policy2005，，1：1
6Evaluation of different sample extraction strategies for selenium determination in selenium-enriched plants ( Allium sativum and Brassica juncea ) and Se speciation by HPLC-ICP-MS显示文摘Maria Montes-Bayón Maria José Díaz Molet Elisa Blanco González Alfredo Sanz-Medel 2005Talanta2005，，4：1
7Effect of heat waves on morbidity and mortality due to Parkinson’s disease in Madrid: A time-series analysis显示文摘Cristina Linares Pablo Martinez-Martin Carmen Rodríguez-Blázquez Maria Jo?o Forjaz Rocío Carmona Julio Díaz 2016Environment International2016，，：1
8Postoperative Cognitive Dysfunction in Middle-aged Patients显示文摘Tim Johnson Terri Monk Lars S. Rasmussen Hanne Abildstrom Peter Houx Kari Korttila Harrie M. Kuipers Chris D. Hanning Volkert D. Siersma Diana Kristensen Jaume Canet Maria Teresa Iba?az Jakob T. Moller 2002Anesthesiology2002，，6：1
9Ultrastructural localization and epitope mapping of the methyltransferase-like and helicase-like proteins of Beet yellow virus显示文摘 Maria VV Roman AZ 2001J Gen Virol2001，82，：1
10Paraneoplastic hyperinsulinism and secondary hypoglycaemia in a patient with advanced colon cancer: A rare association显示文摘We review the case of a 74-year-old patient with ad-vanced colon cancer who suffered recurrent bouts of hypoglycemia. A state of inappropriate, non-suppressed hyperinsulinism in the presence of severe hypoglycemia was diagnosed. We finally discuss the known mecha-nisms behind fasting hypoglycemia in patients with ad-vanced cancer, the diagnosis, and possible treatments of this rare paraneoplastic endocrine complication.Roberto Díaz Jorge Aparicio Andrea Mendizábal Marisa Faus Tania Fleitas Francisco Aparisi Maria Martín 2008World Journal of Gastroenterology2008，14，12：1
11Synthesis and structural characterization of MWW type zeolite ITQ-1,the pure silica analog of MCM-22 and SSZ-25显示文摘 Díaz C Maria J 1998J Phys Chem B1998，102，1：1
12Control and prevention of gas outburst in coal mines, Riosa - Olloniego Coalfield, Spain 显示文摘MARIA B D GONZJtLEZ NICIE- ZA 2007Interna- tional Journal of Coal Geology2007，69，4：1
13Insulin-like growth factor-1 and neurogenesis in the adult mammalian brain 显示文摘Michelle F Anderson A Maria AZ 2002Development Brain Research2002，134，1：1
14Evaluation of different sample extraction strategies for selenium determination in selenium-enriched plants ( Allium sativum and Brassica juncea ) and Se speciation by HPLC-ICP-MS显示文摘Maria Montes-Bayón Maria José Díaz Molet Elisa Blanco González Alfredo Sanz-Medel 2005Talanta2005，，4：1
15Turbo-taxonomy to assemble a megadiverse lichen genus:seventy new species of Cora(Basidiomycota:Agaricales:Hygrophoraceae),honouring David Leslie Hawksworth’s seventieth birthday显示文摘Following a large-scale phylogenetic study of the lichenized genus Cora(Basidiomycota:Agaricales:Hygrophoraceae),we formally describe 70 new species,honouring the seventieth birthday of David Leslie Hawksworth,one of the preeminent figures in mycology and lichenology in the past 50 years.Based on an updated phylogeny using the ITS fungal barcoding locus,we now recognize 189 taxa in a genus that until recently was considered to represent a single species;including this contribution,92 of these are formally recognized,including five taxa based on historical names or collections that have not been sequenced.Species of Cora can be recognized by a combination of morphological(size,colour,lobe configuration,surface hairs,hymenophore size and shape),anatomical(thallus thickness,cortex structure,photobiont type,hyphal papillae),and ecogeographical features(substrate,habitat,distribution),and a keytable allowing the identification of all accepted taxa is provided.The new species are:Cora accipiter Moncada,Madrin˜a´n&Lücking spec.nov.,C.applanata Moncada,Soto-Medina&Lücking spec.nov.,C.arachnodavidea Moncada,Dal Forno&Lücking spec.nov.,C.arborescens Dal Forno,Chaves&Lücking spec.nov.,C.arcabucana Moncada,C.Rodrı´guez&Lücking spec.nov.,C.aturucoa Lücking,Moncada&C.Vargas spec.nov.,C.auriculeslia Moncada,Ya´nez-Ayabaca&Lücking spec.nov.,C.barbifera Moncada,Patin˜o&Lücking spec.nov.,C.boleslia Lücking,E.Morales&Dal Forno spec.nov.,C.caliginosa Holgado,Rivas Plata&Perlmutter spec.nov.,C.campestris Dal Forno,Eliasaro&Spielmann spec.nov.,C.canari Nugra,Dal Forno&Lücking spec.nov.,C.caraana Lücking,Martins&Lucheta spec.nov.,C.casasolana Moncada,R.-E.Pe´rez&Lücking spec.nov.,C.caucensis Moncada,M.Gut.&Lücking spec.nov.,C.celestinoa Moncada,CabreraAmaya&Lücking spec.nov.,C.comaltepeca Moncada,R.-E.Pe´rez&Herrera-Camp.spec.nov.,C.corani Lücking,E.Morales&Dal Forno spec.nov.,C.corelleslia Moncada,A.Sua´rez-Corredor&Lücking spec.nov.,C.crispoleslia Moncada,J.Molina&Lücking spec.nov.,C.cuzcoensis Holgado,Rivas Plata&Perlmutter spec.nov.,C.dalehana Moncada,Madrin˜a´n&Lücking spec.nov.,C.davibogotana Lücking,Moncada&Coca spec.nov.,C.davicrinita Moncada,Madrin˜a´n&Lücking spec.nov.,C.davidia Moncada,L.Vargas&Lücking spec.nov.,C.dewisanti Moncada,A.Sua´rez-Corredor&Lücking spec.nov.,C.dulcis Moncada,R.-E.Pe´rez&Lücking spec.nov.,C.elephas Lücking,Moncada&L.Vargas spec.nov.,C.fuscodavidiana Lücking,Moncada&L.Vargas spec.nov.,C.garagoa Simijaca,Moncada&Lücking spec.nov.,C.gigantea Lücking,Moncada&Coca spec.nov.,C.gomeziana Dal Forno,Chaves&Lücking spec.nov.,C.guajalitensis Lücking,Robayo&Dal Forno spec.nov.,C.hafecesweorthensis Moncada,Lücking&R.Pela´ez spec.nov.,C.haledana Dal Forno,Chaves&Lücking spec.nov.,C.hawksworthiana Dal Forno,P.Nelson&Lücking spec.nov.,C.hochesuordensis Lücking,E.Morales&Dal Forno spec.nov.,C.hymenocarpa Lücking,Chaves&Lawrey spec.nov.,C.imi Lücking,Chaves&Lawrey spec.nov.,C.itabaiana Dal Forno,Aptroot&M.Ca´ceres spec.nov.,C.leslactuca nov.,C.maxima Wilk,Dal Forno&Lücking spec.nov.,C.minutula Lücking,Moncada&Ya´nez-Ayabaca spec.nov.,C.palaeotropica Weerakoon,Aptroot&Lücking spec.nov.,C.palustris Dal Forno,Chaves&Lücking spec.nov.,C.parabovei Dal Forno,Kukwa&Lücking spec.nov.,C.paraciferrii Lücking,Moncada&J.E.Hern.spec.nov.,C.paraminor Dal Forno,Chaves&Lücking spec.nov.,C.pastorum Moncada,Patin˜o&Lücking spec.nov.,C.pichinchensis Paredes,Jonitz&Dal Forno spec.nov.,C.pikynasa J.-M.Torres,Moncada&Lücking spec.nov.,C.pseudobovei Wilk,Dal Forno&Lücking spec.nov.,C.pseudocorani Lücking,E.Morales&Dal Forno spec.nov.,C.putumayensis L.J.Arias,Moncada&Lücking spec.nov.,C.quillacinga Moncada,F.Ortega&Lücking spec.nov.,C.rothesiorum Moncada,Madrin˜a´n&Lücking spec.nov.,C.rubrosanguinea Nugra,Moncada&Lücking spec.nov.,C.santacruzensis Dal Forno,Bungartz&Ya´nezAyabaca,spec.nov.,C.schizophylloides Moncada,C.Rodrı´guez&Lücking spec.nov.,C.smaragdina Lücking,Rivas Plata&Chaves spec.nov.,C.soredavidia Dal Forno,Marcelli&Lücking spec.nov.,C.subdavicrinita Moncada,J.Molina&Lücking spec.nov.,C.suturifera Nugra,Besal&Lücking spec.nov.,C.terrestris Dal Forno,Chaves&Lücking spec.nov.,C.terricoleslia Wilk,Dal Forno&Lücking spec.nov.,C.udebeceana Moncada,R.Pela´ez&Lücking,Moncada&R.Pela´ez spec.Lücking spec.nov.,C.urceolata Moncada,Coca&Lücking spec.nov.,C.verjonensis Lücking,Moncada&Dal Forno spec.nov.,C.viliewoa Lücking,Chaves&Soto-Medina spec.nov.,and C.yukiboa Mercado-Dı´az,Moncada&Lücking spec.nov.Furthermore,the taxonomic status of the recently described or recognized species C.arachnoidea,C.aspera,C.ciferrii,and C.reticulifera,is revised.Robert Lücking Manuela Dal Forno Bibiana Moncada Luis Fernando Coca Leidy Yasmín Vargas-Mendoza André Aptroot Laura Juliana Arias Betty Besal Frank Bungartz Diego Mauricio Cabrera-Amaya Marcela E.S.Cáceres José Luis Chaves Sionara Eliasaro Martha Cecilia Gutiérrez Jesús E.Hernández Marin María de los Ángeles Herrera-Campos María E.Holgado-Rojas Harald Jonitz Martin Kukwa Fabiane Lucheta Santiago Madriñán Marcelo Pinto Marcelli Suzana Maria de Azevedo Martins Joel A.Mercado-Díaz Jorge Alberto Molina Eduardo A.Morales Peter R.Nelson Freddy Nugra Francisco Ortega Telma Paredes Ayda Lucía Patiño Rouchi Nadine Peláez-Pulido Rosa Emilia Pérez Pérez Gary B.Perlmutter Eimy Rivas-Plata Javier Robayo Camilo Rodríguez Diego Fernando Simijaca Edier Soto-Medina Adriano Afonso Spielmann Alejandra Suárez-Corredor Jean-Marc Torres Carlos Alberto Vargas Alba Yánez-Ayabaca Gothamie Weerakoon Karina Wilk Marcela Celis Pacheco Mauricio Diazgranados Grischa Brokamp Thomas Borsch Patrick M.Gillevet Masoumeh Sikaroodi James D.Lawrey 2017Fungal Diversity2017，，3：0
16A High-Performance Solid-State Na–CO_(2)Battery with Poly(Vinylidene Fluoride-co-Hexafluoropropylene)−Na_(3.2)Zr_(1.9)Mg_(0.1)Si_(2)PO_(12)Electrolyte显示文摘The recovery and utilization of carbon dioxide(CO_(2))is the key to achieve the targets of peak carbon dioxide emissions and carbon neutrality.The Na-CO_(2)battery made with cheap alkali metal sodium and greenhouse gas CO_(2)is an effective strategy to consume CO_(2)and store clean renewable energy.However,the liquid electrolyte volatilization in the open battery system and inevitable dendrite growth restrict the application of Na-CO_(2)batteries.In this work,magnesium-doped Na_(3)Zr_(2)Si_(2)PO_(12)(NZSP)was studied as a solid electrolyte for solid-state Na-CO_(2)batteries.The ionic conductivity of Na_(3.2)Zr_(1.9)Mg_(0.1)Si_(2)PO_(12)reaches 1.16 mS cm^(−1)at room temperature by replacing Zr ions in Na_(3.2)Zr_(1.9)Mg_(0.1)Si_(2)PO_(12)with Mg ions,and the structural changes are analyzed by neutron powder diffraction.The composite electrolyte consisting of highly conductive Na_(3.2)Zr_(1.9)Mg_(0.1)Si_(2)PO_(12)and high processability poly(vinylidene fluoride-co-hexafluoropropylene)(PVDF-HFP)is utilized for the first time to assemble a solid-state Na-CO_(2)battery.The cell shows a full discharge capacity of 7720 mAh g^(−1)at 200 mA g^(−1).The middle gap voltage is lower than 2 V after 120 cycles at 200 mA g^(−1)and at a cut-off capacity of 500 mAh g^(−1).This work demonstrates a promising strategy to design high-performance solid-state Na-CO_(2)batteries.Liang Lu Chunwen Sun Jian Hao Zelin Wang Sergio F.Mayer Maria Teresa Fernandez-Diıaz Jose Antonio Alonso Bingsuo Zou 2023Energy & Environmental Materials2023，6，3：0
17Ni-based catalysts obtained from perovskites oxides for ethanol steam reforming显示文摘Perovskites as host structures of cations were used in order to generate in situ active and stable catalysts for ethanol steam reforming. For this purpose,La_(1-x)Mg_xAl_(1-y)Ni_yO_3(x = 0.1; y = 0,0.1,0.2,0.3) perovskites were synthetized by the citrate method.Ni segregation is evident for a substitution level higher than 0. 2. The segregation of Ni as NiO generated species interacts with different metal-support after the reduction step. The y = 0.1 catalyst presents the highest H_2 yield value about 85% during reaction time,with low mean values of CH_4 and CO selectivities of 3.4% and 11%,respectively and a low carbon formation. The better performance of y = 0.1 catalyst could be attributed to the minor proportion of segregated phases,thus a controlled expulsion of Ni is successfully reached.Fabiola Nerina Agüero Jose Antonio Alonso Maria Teresa Fernández-Díaz Luis Eduardo Cadus 2018燃料化学学报2018，46，11：0
18Crop phenotyping in a context of global change:What to measure and how to do it显示文摘High-throughput crop phenotyping,particularly under field conditions,is nowadays perceived as a key factor limiting crop genetic advance.Phenotyping not only facilitates conventional breeding,but it is necessary to fully exploit the capabilities of molecular breeding,and it can be exploited to predict breeding targets for the years ahead at the regional level through more advanced simulation models and decision support systems.In terms of phenotyping,it is necessary to determined which selection traits are relevant in each situation,and which phenotyping tools/methods are available to assess such traits.Remote sensing methodologies are currently the most popular approaches,even when lab-based analyses are still relevant in many circumstances.On top of that,data processing and automation,together with machine learning/deep learning are contributing to the wide range of applications for phenotyping.This review addresses spectral and red-green-blue sensing as the most popular remote sensing approaches,alongside stable isotope composition as an example of a lab-based tool,and root phenotyping,which represents one of the frontiers for field phenotyping.Further,we consider the two most promising forms of aerial platforms(unmanned aerial vehicle and satellites)and some of the emerging data-processing techniques.The review includes three Boxes that examine specific case studies.Jose Luis Araus Shawn Carlisle Kefauver Omar Vergara-Díaz Adrian Gracia-Romero Fatima Zahra Rezzouk Joel Segarra Maria Luisa Buchaillot Melissa Chang-Espino Thomas Vatter Rut Sanchez-Bragado JoséArmando Fernandez-Gallego Maria Dolores Serret Jordi Bort 2022Journal of Integrative Plant Biology2022，64，2：0
19Polymorphism AGT2(rs4762)is involved in the development of dermatologic events:Proof-of-concept in hepatocellular carcinoma patients treated with sorafenib显示文摘BACKGROUND Dermatologic adverse events(DAEs)are associated with a better outcome in patients with hepatocellular carcinoma(HCC)irrespective of the therapeutic agent received.The exact mechanisms associated with the development of DAEs are unknown although several studies point to direct toxicity of tyrosine kinase inhibitors(TKIs)to the skin or an immune-mediated reaction triggered by the oncologic treatment.As is the case in other conditions,individual genetic variants may partially explain a higher risk of DAEs.AIM To evaluate the contribution of several gene variants to the risk of developing DAEs in HCC patients treated with TKIs.METHODS We first analyzed 27 single-nucleotide polymorphisms(SNPs)from 12 genes selected as potential predictors of adverse event(AE)development in HCC patients treated with sorafenib[Barcelona Clinic Liver Cancer 1(BCLC1)cohort].Three additional cohorts were analyzed for AGT1(rs699)and AGT2(rs4762)polymorphisms-initially identified as predictors of DAEs:BCLC2(n=79),Northern Italy(n=221)and Naples(n=69)cohorts,respectively.The relation between SNPs and DAEs and death were assessed by univariate and multivariate Cox regression models,and presented with hazard ratios and their 95%confidence intervals(95%CI).RESULTS The BCLC1 cohort showed that patients with arterial hypertension(AHT)(HR=1.61;P value=0.007)and/or AGT SNPs had an increased risk of DAEs.Thereafter,AGT2(rs4762)AA genotype was found to be linked to a statistically significant increased probability of DAEs(HR=5.97;P value=0.0201,AA vs GG)in the Northern Italy cohort by multivariate analysis adjusted for BCLC stage,ECOG-PS,diabetes and AHT.The value of this genetic marker was externally validated in the cohort combining the BCLC1,BCLC2 and Naples cohorts[HR=3.12(95%CI:1.2-8.14),P value=0.0199,AGT2(rs4762)AA vs AG genotype and HR=2.73(95%CI:1.18-6.32)P value=0.0188,AGT2(rs4762)AA vs GG genotype].None of the other gene variants tested were found to be associated with the risk of DAE development.CONCLUSION DAE development in HCC patients receiving TKIs could be explained by the AGT2(rs4762)gene variant.If validated in other anti-oncogenic treatments,it might be considered a good prognosis marker.Víctor Sapena Massimo Iavarone Loreto Boix Floriana Facchetti Maria Guarino Marco Sanduzzi Zamparelli Alessandro Granito Esther Samper Mario Scartozzi Josep Corominas Giorgia Marisi Alba Díaz Andrea Casadei-Gardini Laura Gramantieri Pietro Lampertico Filomena Morisco Ferran Torres Jordi Bruix María Reig 2022World Journal of Hepatology2022，14，7：0
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