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| 1 | 难治性类风湿关节炎的临床特点:一项国际问卷调查研究显示文摘目的尽管按照目前欧洲抗风湿联盟(EULAR)的推荐对类风湿关节炎(rheumatoid arthritis,RA)患者进行治疗,难治性RA患者的临床症状却仍然没有得到完全控制,目前EULAR指南主要关注的是RA的早期治疗和药物治疗。本研究的目的在于分析难治性RA患者的临床特点,以及在患者管理中需要探索然而现有EULAR指南并未涉及的问题。方法对多个国家的风湿科医生进行问卷调查,分析难治性RA的临床特点。问卷包括多选题以及开放性问题,从开放性问题的回答中发现需要进一步阐明的问题以及现有EULAR指南需要增加的内容。结果410名受访者完成了调查问卷,关于难治性RA的特点:50%受访者认为基于28个关节评估的疾病活动评分(disease activity score assessing 28 joints,DAS28)>3.2或存在疾病活动的征象;42%受访者认为疲劳是其特点;48%认为至少两种传统合成改变病情抗风湿药(DMARDs)以及使用至少两种生物制剂或靶向合成DMARDs治疗失败;89%认为糖皮质激素不能减量到5 mg/天或泼尼松不能减量到10 mg/天或同等剂量的其他激素。另外,现有EULAR指南中应增加合并症和关节外表现的干预以及多种药物联合治疗等重要内容。结论目前风湿科医生对难治性RA的定义有很大争议。难治性RA患者的很多重要问题目前EULAR指南中均没有涉及。 | Nadia MT Roodenrijs Maria J H de Hair Marlies C van der Goes Johannes WG Jacobs Paco MJ Welsing Désirée van der Heijde Daniel Aletaha Maxime Dougados Kimme L Hyrich Iain B McInnes Ulf Mueller-Ladner Ladislav Senolt Zoltan Szekanecz Jacob Mvan Laar Nagy Gyorgy 黄艳荣(译) 张卓莉(审校) | 2019 | 英国医学杂志中文版2019，22，2： | 1 |
| 2 | The Olsen-P method as an agronomic and environmental test for predicting phosphorus release from acid soils显示文摘 | Maria D C H Jose J | 2007 | Nutrient Cycling of Agroecosystem2007，77，： | 1 |
| 3 | Growth, feed efficiency and condition of common Octopus fed two formulated moist diets显示文摘 | Jesus C V Maria D H Felipe A G | 2008 | Aquaculture2008，275，： | 1 |
| 4 | Heavy met als in stream sediments from copper and gold mining areas in southern Brazil显示文摘 | MARIA H D P MILTON L L F ELBA C T | 1997 | Journal of Geochemical Exploration1997，58，： | 1 |
| 5 | Determina- tion of dithiocarbamate fungicide residues in food by a spectrophotometric method using a vertical disulfide re- action system显示文摘 | Eloisa D C Maria H C Maria C C | 2001 | Journal of Agriculuture and Chemistry2001，49，10： | 1 |
| 6 | Zooplanktonabundance in the Aliakmon river, Greece显示文摘 | Maria H Z Michaloudi E Bobori D C | 2000 | Belg J Zool2000，130，1： | 1 |
| 7 | Comparison of high- performance liquid chromatography and spectrofluorimetry for vitamin C analysis of green beans 显示文摘 | Maria Cortes S M Montana C H Carmen D M | 2000 | Eur Food Res Technol2000，210，： | 1 |
| 8 | Modulation of CD112by the alphaherpesvirus gD protein suppresses DNAM-1-dependent NK cell-mediated lysis of infected cells显示文摘 | Grauwet K Cantoni C Parodi M De Maria A Devriendt B Pende D Morettal Vitale M Favoreel H W | 2014 | Proc Natl Acad Sci U S A2014，111，16： | 1 |
| 9 | Myosin light chain is a novel shrimp allergen, Lit v 3 显示文摘 | Rosalia A Galina G Ludmilla B Teresa C Carlos B Maria D I Sampson H A Kirsten B | 2008 | Journal of Allergy and Clinical Immunology2008，122，4： | 1 |
| 10 | Antihypertensive peptides:production,bioavailability and incorporation into foods显示文摘 | BLANCA H L MARIA D M C ISIDRA R | 2011 | Advances inColloid and Interface Science2011，165，1： | 1 |
| 11 | Detection of alkylation damage in human lymphocyte DNA with the comet assay 显示文摘 | Andrew R C Maria D Alexandra H | 2001 | Acta Biochimica Polonica2001，48，3： | 1 |
| 12 | Predicting soil organic matter stability in agricultural fields through carbon and nitrogen stable isotopes显示文摘 | Tim D C Maria H Gerd D | 2015 | Soil Biology and Biochemistry2015，，： | 1 |
| 13 | The olsen P method as an agronomic and environmental test for predicting phosphate release from acid soils显示文摘 | Maria D C H Jose T | 2007 | Nutrient Cycling of Agroecosystem2007，77，： | 1 |
| 14 | Design of membrane modules used in hy- brid distillation/pervaporation systems 显示文摘 | Maria C D Patricia M H | 2004 | Industrial and Engineer- ing Chemistry Research2004，43，13： | 1 |
| 15 | Increased oxygen consumption and OXPHOS potential in superhealer mesenchymal stem cells显示文摘Background:Cell-based therapies show promise in repairing cardiac tissue and improving contractile performance following a myocardial infarction.Despite this,ischemia-induced death of transplanted cells remains a major hurdle to the efficacy of treatment.‘Superhealer’MRL/MpJ mesenchymal stem cells(MRL-MSCs)have been reported to exhibit increased engraftment resulting in reduced infarct size and enhanced contractile function.This study determines whether intrinsic differences in mitochondrial oxidative phosphorylation(OXPHOS)assist in explaining the enhanced cellular survival and engraftment of MRL-MSCs.Findings:Compared to wild type MSCs(WT-MSCs),mitochondria from intact MRL-MSCs exhibited an increase in routine respiration and maximal electron transport capacity by 2.0-and 3.5-fold,respectively.When routine oxygen utilization is expressed as a portion of maximal cellular oxygen flux,the MRL-MSCs have a greater spare respiratory capcity.Additionally,glutamate/malate-and succinate-supported oxygen consumption in permeabilized cells was elevated approximately 1.25-and 1.4-fold in the MRL-MSCs,respectively.Conclusion:The results from intact and permeabilized MSCs indicate MRL-MSCs exhibit a greater reliance on and capacity for aerobic metabolism.The greater capacity for oxidative metabolism may provide a protective effect by increasing ATP synthesis per unit substrate and prevent glycolysis-mediated acidosis and subsequent cell death upon transplantation into the glucose-and oxygen-deprived environment of the infarcted heart. | Curtis C Hughey Maria P Alfaro Darrell D Belke Jeffery N Rottman Pampee P Young David H Wasserman Jane Shearer | 2012 | Cell Regeneration2012，1，1： | 0 |
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