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| 1 | Impairment of pre-mRNA splicing in liver disease: Mechanisms and consequences显示文摘Pre-mRNA splicing is an essential step in the process of gene expression in eukaryotes and consists of the removal ofintrons and the linking of exons to generate mature mRNAs. This is a highly regulated mechanism that allows the alternative usage of exons, the retention ofintronic sequences and the generation of exonic sequences of variable length. Most human genes undergo splicing events, and disruptions of this process have been associated with a variety of diseases, including cancer. Hepatocellular carcinoma (HCC) is a molecularly heterogeneous type of tumor that usually develops in a cirrhotic liver. Alterations in pre-mRNA splicing of some genes have been observed in liver cancer, and although still scarce, the available data suggest that splicing defects may have a role in hepatocarcinogenesis. Here we briefly review the general mechanisms that regulatepre-mRNA splicing, and discuss some examples that illustrate how this process is impaired in liver tumorigenesis, and may contribute to HCC development. We believe that a more thorough examination of pre-mRNA splicing is still needed to accurately draw the molecular portrait of liver cancer. This will surely contribute to a better understanding of the disease and to the development of new effective therapies. | Carmen Berasain Saioa Gońi Josefa Castillo Maria Ujue Latasa Jesús Prieto Matias A Avila | 2010 | World Journal of Gastroenterology2010，16，25： | 2 |
| 2 | CT in nontraumatie acute thorac- ic aortic disease: typical and atypical features and complications 显示文摘 | Eva C Maria A Xavier Go | 2003 | Radiographi2003，23，： | 1 |
| 3 | Outcome of expectant management of cervical intraepithelial neoplasia grade 2 in women followed for 12 months显示文摘 | Michelle GD Carlos ASS Maria GO | 2011 | Eur J Obs Gynecol Rep Biol2011，155，2： | 1 |
| 4 | Clinical transplantation of a tissue-engineered airway显示文摘 | Paolo Macchiarini Philipp Jungebluth Tetsuhiko Go M Adelaide Asnaghi Louisa E Rees Tristan A Cogan Amanda Dodson Jaume Martorell Silvia Bellini Pier Paolo Parnigotto Sally C Dickinson Anthony P Hollander Sara Mantero Maria Teresa Conconi Martin A Birchall | 2008 | The Lancet2008，，9655： | 1 |
| 5 | The Wnt signaling pathway and rheu- matoid arthritis 显示文摘 | Francieli de Sousa Rabelo Licia Maria Henrique da Mota Rodri- go Aires Corra Lima | 2010 | Autoimmun Rev2010，9，4： | 1 |
| 6 | Sources and distribution of organic matter in a river-dominated estuary (Winyah Bay, SC, USA)显示文摘 | Miguel A. Go?i Maria J. Teixeira David W. Perkey | 2003 | Estuarine Coastal and Shelf Science2003，，5： | 1 |
| 7 | Effects of grape antioxidant dietary fiber in cardiovascular disease risk factors显示文摘 | Jara Pérez Jiménez Jose Serrano Maria Tabernero Sara Arranz M. Elena Díaz-Rubio Luis García-Diz Isabel Go?i Fulgencio Saura-Calixto | 2008 | Nutrition2008，，7： | 1 |
| 8 | An influence of the local environment on local magnetic moments and hyperfine fields in Fe3-xCrxSi显示文摘 | Anna Go Maria Pugaczowa-Michalska Ludwik Dobrzy ski | 2004 | Journal of Magnetism and Mag- netic Materials2004，，： | 1 |
| 9 | Physiological responses to positive expiratory pressure breathing: a comparison of the PEP bottle and the PEP mask显示文摘 | Maria Sehlin RPT MSc FredrikO hberg GO ran Johansson MSc | 2007 | Respiratory Care2007，52，8： | 1 |
| 10 | 组织工程气管临床移植显示文摘背景失去正常气道会造成灾难性的后果,而大气道置换的各种尝试均遇到严重问题,组织工程气管置换的先决条件是该组织工程材料必须具备合适的基质、细胞、理想的机械性能而且无抗原性。本文中,作者旨在利用组织工程的原理和技术,通过生物工程气管基质的临床应用,评估该技术在一例患有终末期气道疾病患者中的应用情况。方法通过特定的技术去除供体一段气管的细胞和主要组织相容性复合体(MHC)抗原,将来源于受体(一名30岁患有终末期支气管软化的女性患者)的上皮细胞和间充质干细胞源性软骨细胞经细胞培养后种植于该段移植物基质中,然后用该移植物置换受体的左主支气管。结果术后该移植物立即建立了功能性气道,患者的生活质量得到了改善,在术后4个月时该段气管外观和机械性能保持正常,患者未产生抗供体的抗体,也未接受任何抗排异药物治疗。结论结果表明,该生物组织工程气管具有良好的机械性能,具备气管的正常功能,并且无免疫排异反应。这一结果提示自体细胞与适当生物材料结合的移植物可成功治疗某些严重的临床疾病。 | Paolo Macchiarini Philipp Jungebluth Tetsuhiko Go M Adelaide Asnaghi Louisa E Rees Tristan A Cogan Amanda Dodson Jaume Martorell Silvia Bellini Pier Paola Pamigotto Sally C Dickinson Anthony P Hollander Sara Mantero Maria Teresa Conconi Martin A Birchall 哈肖别克·卡斯木(译) | 2009 | 世界临床医学2009，3，2： | 0 |
| 11 | 病例报告:Proteus综合征的牙周特点和其他口腔表现显示文摘Proteus综合征是一种极其罕见的先天性疾病.其特征是多种组织出现进行性非对称性过度生长。目前为止,该综合征病因尚不清楚。本文描述了一例Proteus综合征患者牙周组织的临床特点和影像学特点.以及其他口腔表现。该Proteus综合征患者是一个13岁巴西白人女孩。我们对患者进行了临床检查和全口的口内影像学分析.发现患者表现有骨骼畸形、巨人症、特征性面型以及包括颅骨、左手和下肢在内的多种组织非对称性过度生长。患者左脚跖面有脑回状结缔组织痣,双手关节活动度也有所下降。口内检查结果显示患者还表现有其他的口腔问题.包括局限于口腔左侧的恒牙釉质发育不全、广泛性牙龈增生、大量牙菌斑沉积和牙齿错位。未检出牙周袋和牙槽骨的破坏。总之.这例Proteus综合征患者的口腔表现包括:牙龈增生、牙齿错位以及单侧牙齿釉质发育不全。 | Antonioa Canabarro Jr,DDS Tania Maria Ga he go,DDS Diogo Galheigo de Oliveria e Silva,MD Eduardo Muniz Barretto Tinoco.DDS 张趁英(译) 赵玉鸣(译) 郑树国(审) | 2010 | 中国口腔医学继续教育杂志2010，13，4： | 0 |
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