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| 1 | 抑郁症的非药物治疗:系统性综述与证据图显示文摘背景抑郁症非药物治疗的疗效比较目前仍然不清楚。方法我们对一些系统性综述作了概述,回顾了随机对照试验(RCT),比较抑郁症非药物治疗的有效性和认知行为治疗(CBT)。对多个电子数据库在2016年2月之前发表的所有文献进行了检索,不限制语言。成对的评阅人进行资料纳入、数据提炼并评估偏倚的风险。在适用的时候进行了荟萃分析。结果我们收录了367项RCT,纳入了约2000名患者,进行了11种治疗,导出17项独立的头对头比较。通过标准化的量表评估,发现CBT、自然疗法、行为干预与躯体活动干预可以降低抑郁的严重程度。然而,这些非药物干预的相对疗效仍然缺乏。这些干预对临床缓解和复发的效果不清楚。CBT的发生率比抗抑郁药物更低。局限性由于证据缺乏一致性、证据不清或偏倚风险高,导致证据的质量只是低到中等,限制了我们研究结果的可信度。结论抑郁症的非药物治疗能减少抑郁症状,在轻度到重度抑郁症患者中,应当合并抗抑郁药物治疗,一同进行。对于非药物治疗的选择,应当根据患者的价值观、偏好、临床和社会因素来与患者共同作出决定。 | Wigdan H Farah Mouaz Alsawas Maria Mainou Fares Alahdab Magdoleen H Farah Ahmed T Ahmed Essa A Mohamed Jehad Almasri Michael R Gionfriddo Ana Castaneda-Guarderas Khaled Mohammed Zhen Wang Noor Asi Craig N Sawchuk Mark D Williams Larry J Prokop M Hassan Murad Annie LeBlanc | 2017 | 英国医学杂志中文版2017，20，11： | 2 |
| 2 | Therapeutic drug monitoring in patients with inflammatory bowel disease显示文摘Thiopurine analogs and anti-tumor necrosis factor(TNF)agents have dramatically changed the therapeutics of inflammatory bowel diseases(IBD),improving short and long-term outcomes.Unfortunately some patients do not respond to therapy and others lose response over time.The pharmacokinetic properties of these drugs are complex,with high inter-patient variability.Thiopurine analogs are metabolized through a series of pathways,which vary according to the patients’pharmacogenetic profile.This profile largely determines the ratios of metabolites,which are in turn associated with likelihoods of clinical efficacy and/or toxicity.Understanding these mechanisms allows for manipulation of drug dose,aiming to reduce the development of toxicity while improving the efficacy of treatment.The efficacy of anti-TNF drugs is influenced by many pharmacodynamic variables.Several factors may alter drug clearance,including the concomitant use of immunomodulators(thiopurine analogs and methotrexate),systemic inflammation,the presence of anti-drug antibodies,and body mass.The treatment of IBD has evolved with the understanding of the pharmacologic profiles of immunomodulating and TNF-inhibiting medications,with good evidence for improvement in patient outcomesobserved when measuring metabolic pathway indices.The role of routine measurement of metabolite/drug levels and antibodies warrants further prospective studies as we enter the era of personalized IBD care. | Andres J Yarur Maria T Abreu Amar R Deshpande David H Kerman Daniel A Sussman | 2014 | World Journal of Gastroenterology2014，20，13： | 2 |
| 3 | Langerhans cells utilize CDla and langerin to efficiently present nonpeptide antigens to T cells显示文摘 | Robert E H Peter A S Maria T | 2004 | J Clin Invest2004，113，5： | 1 |
| 4 | Analyzing a fLrm' s In- ternational Portfolio of Technological Knowledge: A Declarative Ontology-based OWL Approach for Patent Documents显示文摘 | Maria B E Manuel N Nuria H T | 2013 | Ad- vanced Engineering Informatics2013，27，3： | 1 |
| 5 | Microwave reduction of a nickeliferous laterite ore 显示文摘 | MICHAIL S MARIA T RON H | 2012 | Minerals Engineering2012，34，： | 1 |
| 6 | Malignancies after renal transplantation during 33 years at a single center显示文摘 | Gyula Végs? Maria Tóth Márta Hídvégi éva Toronyi Robert Mlanger Elek Dinya András Tóth Ferenc Perner Jen? Járay | 2007 | Pathology & Oncology Research2007，，1： | 1 |
| 7 | Extraction of lignin from sugar cane bagasse and Pinus taeda wood chips using ethanol-water mixture and carbon dioxide at high pressures显示文摘 | DANIEL P MARIA T B LUIZ h F | 2005 | The Journal of Supercritical Fluids2005，36，1： | 1 |
| 8 | Expression of Adhesion Molecules by Human Endothelial Cells Exposed to Oxidized Low Density Lipoprotein Influences of Degree of Oxidation and Location of Oxidized LDL显示文摘 | AKIRA T YAN H MARIA F | 2001 | Atherosclerosis2001，，154： | 1 |
| 9 | 显示文摘 | Maria H Wu B H Kollmann T | 2014 | Advanced Functional Materials2014，24，21： | 1 |
| 10 | Heavy met als in stream sediments from copper and gold mining areas in southern Brazil显示文摘 | MARIA H D P MILTON L L F ELBA C T | 1997 | Journal of Geochemical Exploration1997，58，： | 1 |
| 11 | Ultra-deep oxidative desulfurization of diesel fuel by the Mo/Al2O3-H2O2 system: The effect of system parameters on catalytic activity显示文摘 | JOSE LUIS G G FUENTES G A MARIA EUGENIA H T | 2008 | Applied Catalysis A: General2008，334，： | 1 |
| 12 | Cadinane sesquiterpenoids of Phomopsis cassiae, an endophytic fungus associated with Cassia spectabilis ( Leguminosae ) 显示文摘 | Geraldo H S Helder L T Maria C M Y | 2006 | Phytachemistry2006，67，： | 1 |
| 13 | Extraction of lignin from sugar cane bagasse and Pinus taeda wood chips using ethanol-water mixtures and carbon dioxide at high pressures显示文摘 | DANIEL P MARIA T B P LUIZ H F | 2005 | The Journal of Supercritical Fluids2005，36，1： | 1 |
| 14 | Ultra-deep oxidative desulfurization of diesel fuel with H2O2 catalyzed under mild conditions by polymolybdates supported on Al2O3 显示文摘 | JOSE LUIS G G FUENTESG A MARIA EUGENIA H T | 2006 | Applied Catalysis A: General2006，305，： | 1 |
| 15 | Sugar cane bagasse pulping using supercritical CO2 associated with co-solvent 1-butanol/water显示文摘 | DANIEL P MARIA T B P LUIZ H F | 2005 | The Journal of Supercritical Fluids2005，34，2： | 1 |
| 16 | Sediment sorting and beach ero- sion along a coastal foreland: Magnetic measurements in Point Pelee National Park, Ontario, Canada 显示文摘 | Robert G H Maria T C Alan S T | 2010 | Sedimentary Geology2010，231，： | 1 |
| 17 | Occurrence and removal of p harmaceuticals and hormones through drinking water treatment显示文摘 | MAFIA H F MARIA T GALCERAN | 2011 | Water research2011，45，3： | 1 |
| 18 | From biomass to feedstock: one- step fractionation of lignocellulose components by the se- lective organic acid-catalyzed depolymerization of hemi- cellulose in a biphasic system 显示文摘 | T vom Stein P M Grande H Kayser F SibiUa W Leitner P Dor~nguez de Maria | 2011 | Green Chemistry2011，13，7： | 1 |
| 19 | Characterizations of Bacillus thuringiensis isolated from infections in burn wounds显示文摘 | PER H D JOSB MARIA V T | 1997 | FEMS Immunology and Medical Microbiology1997，18，： | 1 |
| 20 | Cytotoxic palladium comple- xes of bioreductive quinoxaline N1 , N4-dioxideprodrugs 显示文摘 | Carolina U Marisol V Maria H T | 2009 | Bioorganic & Medicinal Chemistry2009，17，： | 1 |
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