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| 1 | Phase angle obtained by bioelectrical impedance analysis independently predicts mortality in patients with cirrhosis显示文摘AIM To evaluate the prognostic value of the phase angle(PA)obtained from bioelectrical impedance analysis(BIA) for mortality prediction in patients with cirrhosis. METHODS In total, 134 male cirrhotic patients prospectively completed clinical evaluations and nutritional assessment by BIA to obtain PAs during a 36-mo follow-up period. Mortality risk was analyzed by applying the PA cutoff point recently proposed as a malnutrition marker(PA ≤ 4.9°) in Kaplan-Meier curves and multivariate Cox regression models. RESULTS The patients were divided into two groups according to the PA cutoff value(PA > 4.9°, n = 73; PA ≤ 4.9°, n = 61). Weight, height, and body mass index were similar in both groups, but patients with PAs > 4.9° were younger and had higher mid-arm muscle circumference, albumin, and handgrip-strength values and lower severe ascites and encephalopathy incidences, interleukin(IL)-6/IL-10 ratios and C-reactive protein levels than did patients with PAs ≤ 4.9°(P ≤ 0.05). Forty-eight(35.80%) patients died due to cirrhosis, with a median of 18 mo(interquartile range, 3.3-25.6 mo) follow-up until death. Thirty-one(64.60%) of these patients were from the PA ≤ 4.9° group. PA ≤ 4.9° significantly and independently affected the mortality model adjusted for Model for End-Stage Liver Disease score and age(hazard ratio = 2.05, 95%CI: 1.11-3.77, P = 0.021). In addition, Kaplan-Meier curves showed that patients with PAs ≤ 4.9° were significantly more likely to die. CONCLUSION In male patients with cirrhosis, the PA ≤ 4.9° cutoff was associated independently with mortality and identified patients with worse metabolic, nutritional, and disease progression profiles. The PA may be a useful and reliable bedside tool to evaluate prognosis in cirrhosis. | Giliane Belarmino Maria Cristina Gonzalez Raquel S Torrinhas Priscila Sala Wellington Andraus Luiz Augusto Carneiro D'Albuquerque Rosa Maria R Pereira Valéria F Caparbo Graziela R Ravacci Lucas Damiani Steven B Heymsfield Dan L Waitzberg | 2017 | World Journal of Hepatology2017，9，7： | 11 |
| 2 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 3 | Differential expression of apoptosis related proteins and nitric oxide synthases in Epstein Barr associated gastric carcinomas显示文摘瞄准:为了决定 Epstein Barr 的发生,病毒在巴西联系了胃的癌(GC ) 并且比较 apoptosis 的表情在 EBV 之间的相关蛋白质和氮的氧化物 synthases 积极、否定的胃的癌。方法:编码 EBV 的小 RNA-1 (EBER-1 ) 和 PCR 的原位杂交被执行在 GC 识别 EBV 的存在。Immunohistochemistry 被用来在 25 EBV 积极 GC 并且在 103 EBV 否定 GCS 识别 bcl-2, bcl-xl, bak, bax, p53, NOS-1, NOS-2,和 NOS-3 蛋白质的表情。结果:GC (25/208 ) 的 12% 盒子显示出 EBER-1 和 EBNA-1 表示。盒子是优先地 diffuse 打字与强烈淋巴在基质渗入。EBV 联系了 GC bcl-2 蛋白质的显示出的更高的表示和 bak 蛋白质的更低的表示与比在 EBV 否定 GC。确实, NOS-1 和 NOS-3 的表情经常在 EBV 被观察联系 GC。结论:我们的数据建议 EBV 感染可以保护肿瘤房间免受 apoptosis 的伤害,为永久房间骑车和增长给他们能力。另外, EBV 积极 GC 显示出能影响肿瘤前进和攻击性的组成的 NOS 的高表示。 | Maria D Begnami Andre L Montagnini Andre L Vettore Sueli Nonogaki Mariana Brait Alex Y Simoes-Sato Andrea Q A Seixas Fernando A Soares | 2006 | World Journal of Gastroenterology2006，12，31： | 5 |
| 4 | Pneumo-CT assessing response to neoadjuvant therapy in esophageal cancer: Imaging-pathological correlation显示文摘Pneumo-computed tomography (PnCT) is a technique primarily developed and used to study stenotic lesions of the esophagus, gastroesophageal junction and stom-ach for pre-surgical planning. It helps to define both upper and lower borders of neoplasms located in the aforementioned areas. It achieves maximum lumen distension with CO2 highlighting thickened areas of the esophageal wall, thus allowing an accurate quantifica-tion of their extents. Although there are other alterna-tives for distension (oral contrast agents, water and ef-fervescent granules), they may be suboptimal. Patients with locally advanced esophageal cancer have a dismal prognosis despite surgical resection. Therefore, neo-adjuvant treatment strategies using radiation therapy and chemotherapy were developed to improve sur-vival. Neoadjuvant therapy improves esophageal tumor prognosis in a substantial proportion of patients, and the use of imaging techniques is mandatory to detect their response. PnCT combined with virtual endoscopy and multiplanar reconstruction enhances morphologic details in esophageal cancer, and thus would allow animproved assessment of response to neoadjuvant treat-ment. Therefore, more information could be provided to assess the efficacy of pre-surgical treatment. We de-scribe the potential use of PnCT to assess the response to neoadjuvant therapy in esophageal cancer with an imaging pathologic correlation. | Marina Ulla Ernestina Gentile Ezequiel Levy Yeyati Maria L Diez Demetrio Cavadas Ricardo D Garcia-Monaco Pablo R Ros | 2013 | World Journal of Gastrointestinal Oncology2013，5，12： | 3 |
| 5 | Chemical factors for chemical-mechanical and electrochemical mechanical planarization of silver examined using potentiodynamic and impedance measurements 显示文摘 | SAMUEL B E JENNIFER L H MARIA A D | 2005 | Materials Chemistry and Physics2005，89，23： | 1 |
| 6 | Calibration of four species of Tillandsia as air pollution biomonitors 显示文摘 | Eduardo D Wannaz Maria L P | 2006 | Journal of Atmospheric Chemistry2006，53，： | 1 |
| 7 | Antioxidative responses of Calendula officinalis under salinity conditions显示文摘 | Nader C Maria L D | 2004 | Plant Physiology and Biochemistry2004，42，： | 1 |
| 8 | Relationship between human leucocyte antigen class I and class II and chronic idiopathic urticaria associated with aspirin and/or NSAIDs hypersensitivity 显示文摘 | MARIA L P GABRIELE D L PASQUALE M | 2006 | Mediators Inflamm2006，，62： | 1 |
| 9 | Car- diovagal response to acute mild exercise in young healthy subjects显示文摘 | Gizegore R Gian D P Maria T L R | 2005 | Circ J2005，69，： | 1 |
| 10 | An ongoing research for evaluation of treatment with BMPs or AGFs in long bone non-union:Protocol description and preliminary results显示文摘 | Maria Calori G D’Avino M Tagliabue L | | 0，，3： | 1 |
| 11 | Macroporous WO3 thin films active in NH3 sensing: role of the hosted Cr isolated centers and Pt nanoclusters显示文摘 | Arienzo M D Armelao L Maria C | 2011 | J Am Chem Soc2011，133，14： | 1 |
| 12 | Capillary electrophoresis of free fatty acids by indirect uhraviolet 显示文摘 | Maria V B Aaron E D Maria J L G | 2011 | Journal of Agriculture and Food Chemistry2011，59，10： | 1 |
| 13 | Present and future of recombinant gonadotropins in reproductive medicine 显示文摘 | Vincenzo D L Maria M C Alessandra D S | 2012 | Curr Pharmac Biotech2012，13，3： | 1 |
| 14 | Capillary e- lectrophoresis of free fatty acids by Indirect ultraviolet detection: application to the classification of vegetable oils according to their botanical origin显示文摘 | Maria V B Aar6n E D Jests L G M | 2011 | Food Chem- istry2011，59，10： | 1 |
| 15 | 难治性类风湿关节炎的临床特点:一项国际问卷调查研究显示文摘目的尽管按照目前欧洲抗风湿联盟(EULAR)的推荐对类风湿关节炎(rheumatoid arthritis,RA)患者进行治疗,难治性RA患者的临床症状却仍然没有得到完全控制,目前EULAR指南主要关注的是RA的早期治疗和药物治疗。本研究的目的在于分析难治性RA患者的临床特点,以及在患者管理中需要探索然而现有EULAR指南并未涉及的问题。方法对多个国家的风湿科医生进行问卷调查,分析难治性RA的临床特点。问卷包括多选题以及开放性问题,从开放性问题的回答中发现需要进一步阐明的问题以及现有EULAR指南需要增加的内容。结果410名受访者完成了调查问卷,关于难治性RA的特点:50%受访者认为基于28个关节评估的疾病活动评分(disease activity score assessing 28 joints,DAS28)>3.2或存在疾病活动的征象;42%受访者认为疲劳是其特点;48%认为至少两种传统合成改变病情抗风湿药(DMARDs)以及使用至少两种生物制剂或靶向合成DMARDs治疗失败;89%认为糖皮质激素不能减量到5 mg/天或泼尼松不能减量到10 mg/天或同等剂量的其他激素。另外,现有EULAR指南中应增加合并症和关节外表现的干预以及多种药物联合治疗等重要内容。结论目前风湿科医生对难治性RA的定义有很大争议。难治性RA患者的很多重要问题目前EULAR指南中均没有涉及。 | Nadia MT Roodenrijs Maria J H de Hair Marlies C van der Goes Johannes WG Jacobs Paco MJ Welsing Désirée van der Heijde Daniel Aletaha Maxime Dougados Kimme L Hyrich Iain B McInnes Ulf Mueller-Ladner Ladislav Senolt Zoltan Szekanecz Jacob Mvan Laar Nagy Gyorgy 黄艳荣(译) 张卓莉(审校) | 2019 | 英国医学杂志中文版2019，22，2： | 1 |
| 16 | Silica-immobilized piperazine:A sustainable organocatalyst for aldo/and knoevenage] reactions显示文摘 | SHANMUGANATHAN S GREINER L DE MARIA P D | 2010 | Tetrahedron Letters2010，51，50： | 1 |
| 17 | Endogenous salicylic acid potentiates cadmium-induced oxidative stress in Arabidopsis thalia显示文摘 | Myriam S Z Maria D G Maria L T | 2007 | Plant Science2007，173，2： | 1 |
| 18 | 限饲和再投喂对不同日龄鸡消化酶促反应的影响显示文摘试验旨在评价限饲和再投喂对两个不同日龄(7和35d)鸡酶活性和胃肠道器官重量的影响,在每种日龄下,鸡被限饲70%(30%自由采食)7d,然后自由采食3d。对照组自由采食10d。对胰腺中糜蛋白酶、胰蛋白酶、淀粉酶、脂肪酶活性和小肠中蔗糖酶、麦芽糖酶的活性进行分析,并且测量了腺胃、肌胃、小肠和大肠的重量。在14d,与对照组相比,限饲组的胰蛋白酶、淀粉酶活性均降低,但在42d,与对照组相比,限饲组蔗糖酶活性降低,表明限饲对酶活性的影响与日龄有关。限饲可以降低完成期(42d)各器官的重量。日龄35~42d的鸡,在再投喂后,器官重量增加,并且达到与对照组一致。在起始期(14d),腺胃和肌胃受限饲的影响很小,在完成期,肌胃也是受影响最小的器官,而小肠时受影响最严重。限饲的所有影响在恢复饲喂3d后被逆转,表明这种改变时快速且可逆的,并且限饲和再投喂与年龄有关。 | Cristiane R A Duarte Maria L M Vicentini P Pinheiro D F | 2014 | 饲料博览2014，0，10： | 1 |
| 19 | Refinement of the 12q14 microdeletion syndrome: primordial dwarfism and developmental delay with or without ostenpoikilosis 显示文摘 | Marl F Hermanns P Maria L Galluzzi F Scott D Lee B | 2009 | EuropJHumanGenet2009，17，10： | 1 |
| 20 | A practical, efficient, and atom economic alternative to the Witting and Horner- Wadsworth-Emmons reactions for the synthesis of (E)-α,β-unsaturated esters from aldehydes显示文摘 | Benjamin L Arno D Maria T | 2006 | Tetrahedron2006，，： | 1 |
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