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| 1 | Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice显示文摘AIM To investigate the effect of probiotic supplementation during the development of an experimental model of colitis associated colon cancer(CAC). METHODS C57 BL/6 mice received an intraperitoneal injection of azoxymethane(10 mg/kg), followed by three cycles of sodium dextran sulphate diluted in water(5% w/v). Probiotic group received daily a mixture of Lactobacillus acidophilus, Lactobacil us rhamnosus and Bifidobacterium bifidum. Microbiota composition was assessed by 16 Sr RNA Illumina Hi Seq sequencing. Colon samples were collected for histological analysis. Tumor cytokines was assessed by Real Time-PCR(Polymerase Chain Reaction); and serum cytokines by Multiplex assay. All tests were two-sided. The level of significance was set at P < 0.05. Graphs were generated and statistical analysis performed using the software Graph Pad Prism 5.0. The project was approved by the institutional review board committee. RESULTS At day 60 after azoxymethane injection, the mean number of tumours in the probiotic group was 40% lower than that in the control group, and the probiotic group exhibited tumours of smaller size(< 2 mm)(P < 0.05). There was no difference in richness and diversity between groups. However, there was a significant difference in beta diversity in the multidimensional scaling analysis. The abundance of the genera Lactobacillus, Bifidobacterium, Allobaculum, Clostridium XI and Clostridium XVⅢ increased in the probiotic group(P < 0.05). The microbial change was accompanied by reduced colitis, demonstrated by a 46% reduction in the colon inflammatory index; reduced expression of the serum chemokines RANTES and Eotaxin; decreased p-IKK and TNF-α and increased IL-10 expression in the colon. CONCLUSION Our results suggest a potential chemopreventive effect of probiotic on CAC. Probiotic supplementation changes microbiota structure and regulates the inflammatory response, reducing colitis and preventing CAC. | Maria Carolina S Mendes Daiane SM Paulino Sandra R Brambilla Juliana A Camargo Gabriela F Persinoti José Barreto C Carvalheira | 2018 | World Journal of Gastroenterology2018，24，18： | 17 |
| 2 | Survival of elderly patients with stage 5 CKD : comparison of conservative management and renal replacement therapy 显示文摘 | Chandna SM Maria SG Catheriue M | 2011 | Nephrol Dial Transplant2011，26，5： | 1 |
| 3 | CXCR3 chemkine receptors distribution in normal and inflamed tissues: Expression on activated lymphocytes, endothelial cells, and dendritic cells显示文摘 | Francisco SM Jose M RF | 2001 | Lab Inve2001，81，3： | 1 |
| 4 | Alterations of the tumor suppressor gene parkin in non-small cell lung cancer显示文摘 | Maria CP Eric SM Rossano C | 2004 | Clinical Cancer Research2004，10，8： | 1 |
| 5 | Pure cystic nephroblastoma of the ovary with a review of extrarenal Wilms'tumors显示文摘 | Maria AI Suseelan V Chiramugathu SM | 2000 | Hum Pathol2000，31，6： | 1 |
| 6 | Bone metabolism in advanced cholestatic liver disease: analysis by bone histomorphometry显示文摘 | MsOhnica PD Maria LF Henrique SM | 2001 | J gastroenterol Hepatol2001，16，： | 1 |
| 7 | Bone metabolism in advanced cholestatic liver disease: analysis by bone histomorphometry显示文摘 | Mnica PD Maria LF Henrique SM | 2001 | J gastroenterol Hepatol2001，16，10： | 1 |
| 8 | Expression of constitutive and inducible nitric oxide synthase in the vascular wall of yong and aging rats显示文摘 | Maria RC Lourdes SM Margarita GD | 1998 | Circ Res1998，，3： | 1 |
| 9 | Targeted transgene integration into transgenic mouse fibroblasts carrying the full-length human AAVS1 locus mediated by HSV/AAV rep ( + ) hybrid amplicon vector 显示文摘 | Bakowska JC Di Maria MV Camp SM | 2003 | Gene Ther2003，10，19： | 1 |
| 10 | Effects of double ligation of Stensen's duct on the rabbit parotid gland 显示文摘 | Maria OM Maria SM Redman RS | 2014 | Biotech Histochem2014，89，3： | 1 |
| 11 | Effects of doubleligation of Stenseng duct of the rabbit parotid gland显示文摘 | Maria O Maria SM Redman R | 2013 | Bio-tech Histochem2013，，： | 1 |
| 12 | Alterations of the tumor suppressor gene parkin in non-small cell lung cancer显示文摘 | Maria CP Eric SM Rossano C | 2004 | Clin Cancer Res2004，10，8： | 1 |
| 13 | Metformin prevents anti-osteogenic in vivo and ex vivo effects of rosiglitazone in rats显示文摘 | Claudia S Maria SM Ana MC | 2011 | Eur J Pharmaeol2011，668，3： | 1 |
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