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您的检索式：作者名="Marija Mojsin"
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| 1 | Interplay of SOX transcription factors and microRNAs in the brain under physiological and pathological conditions显示文摘Precise tuning of gene expression,accomplished by regulato ry networks of transcription factors,epigenetic modifiers,and microRNAs,is crucial for the proper neural development and function of the brain cells.The SOX transcription factors are involved in regulating diverse cellular processes during embryonic and adult neurogenesis,such as maintaining the cell stemness,cell prolife ration,cell fate decisions,and terminal diffe rentiation into neurons and glial cells.MicroRNAs represent a class of small non-coding RNAs that play important roles in the regulation of gene expression.Together with other gene regulatory factors,microRNAs regulate different processes during neurogenesis and orchestrate the spatial and temporal expression important for neurodevelopment.The emerging data point to a complex regulatory network between SOX transcription factors and microRNAs that govern distinct cellular activities in the developing and adult brain.Deregulated SOX/mic roRNA interplay in signaling pathways that influence the homeostasis and plasticity in the brain has been revealed in various brain pathologies,including neurodegenerative disorders,traumatic brain injury,and cancer.Therapeutic strategies that target SOX/microRNA interplay have emerged in recent years as a promising tool to target neural tissue regeneration and enhance neuro restoration.N umerous studies have confirmed complex intera ctions between microRNAs and SOX-specific mRNAs regulating key features of glioblastoma.Keeping in mind the crucial roles of SOX genes and microRNAs in neural development,we focus this review on SOX/microRNAs interplay in the brain during development and adulthood in physiological and pathological conditions.Special focus was made on their interplay in brain pathologies to summarize current knowledge and highlight potential future development of molecular therapies. | Milena Stevanovic Danijela Stanisavljevic Ninkovic Marija Mojsin Danijela Drakulic Marija Schwirtlich | 2022 | Neural Regeneration Research2022，17，11： | 2 |
| 2 | SOX transcription factors and glioma stem cells:Choosing between stemness and differentiation显示文摘Glioblastoma(GBM)is the most common,most aggressive and deadliest brain tumor.Recently,remarkable progress has been made towards understanding the cellular and molecular biology of gliomas.GBM tumor initiation,progression and relapse as well as resistance to treatments are associated with glioma stem cells(GSCs).GSCs exhibit a high proliferation rate and self-renewal capacity and the ability to differentiate into diverse cell types,generating a range of distinct cell types within the tumor,leading to cellular heterogeneity.GBM tumors may contain different subsets of GSCs,and some of them may adopt a quiescent state that protects them against chemotherapy and radiotherapy.GSCs enriched in recurrent gliomas acquire more aggressive and therapy-resistant properties,making them more malignant,able to rapidly spread.The impact of SOX transcription factors(TFs)on brain tumors has been extensively studied in the last decade.Almost all SOX genes are expressed in GBM,and their expression levels are associated with patient prognosis and survival.Numerous SOX TFs are involved in the maintenance of the stemness of GSCs or play a role in the initiation of GSC differentiation.The fine-tuning of SOX gene expression levels controls the balance between cell stemness and differentiation.Therefore,innovative therapies targeting SOX TFs are emerging as promising tools for combatting GBM.Combatting GBM has been a demanding and challenging goal for decades.The current therapeutic strategies have not yet provided a cure for GBM and have only resulted in a slight improvement in patient survival.Novel approaches will require the fine adjustment of multimodal therapeutic strategies that simultaneously target numerous hallmarks of cancer cells to win the battle against GBM. | Milena Stevanovic Natasa Kovacevic-Grujicic Marija Mojsin Milena Milivojevic Danijela Drakulic | 2021 | World Journal of Stem Cells2021，13，10： | 1 |
| 3 | TG-interacting Factor(TGIF) Downregulates SOX3 Gene Expression in the NT2/D1 Cell Line显示文摘SOX3 短袜基因家庭的一个成员在大脑形成和认知功能被含有。是在脊椎动物的最早神经的标记之一被认为,起在指定 neuronal 命运的一个作用。最近,我们证实了第一在故事(three-amino-acid 循环扩展) 之间连接蛋白质, PBX1 (pre-B-cell 白血病 homeobox 1 ) 并且 MEIS1 (myeloid ecotropic 病毒的集成地点 1 相当或相同事物) ,并且人的 SOX3 基因的表达式。这里我们在场 TGIF (交往 TG 因素) 是一个另外的故事总科成员的证据由和在首领 orthologue 倡导者被保存的一致绑定地点的直接相互作用在 NT2/D1 房间在人的 SOX3 基因表示的规定包含了。功能的分析证明 TGIF 有约束力的地点的那个变化导致了 SOX3 倡导者的激活。TGIF overexpression downregulates SOX3 倡导者活动和减少在 uninduced 和 retinoic 酸(RA ) 的内长的 SOX3 蛋白质表示导致了 NT2/D1 房间。直到现在,这是作为 SOX3 基因表示的一个否定管理者识别的第一个抄写因素。获得的结果进一步作为 SOX3 基因表示的重要 transcriptional 管理者强调故事蛋白质的意义。 | Marija Mojsin Jelena Popovic Natasa Kovacevic Grujicic Milena Stevanovic | 2012 | Journal of Genetics and Genomics2012，39，1： | 0 |
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