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| 1 | Excretion of biliary compounds during intrauterine life显示文摘In adults,the hepatobiliary system,together with the kidney,constitute the main routes for the elimination of several endogenous and xenobiotic compounds into bile and urine,respectively.However,during intrauterine life the biliary route of excretion for cholephilic compounds,such as bile acids and biliary pigments,is very poor.Although very early in pregnancy the fetal liver produces bile acids,bilirubin and biliverdin,these compounds cannot be efficiently eliminated by the fetal hepatobiliary system,owing to the immaturity of the excretory machinery in the fetal liver.Therefore,the potentially harmful accumulation of cholephilic compounds in the fetus is prevented by their elimination across the placenta.Owing to the presence of detoxifying enzymes and specifi c transport systems at different locations of the placental barrier,such as the endothe-lial cells of chorionic vessels and trophoblast cells,this organ plays an important role in the hepatobiliary-like function during intrauterine life.The relevance of this excretory function in normal fetal physiology is evident in situations where high concentrations of biliary compounds are accumulated in the mother.This may result in oxidative stress and apoptosis,mainly in the placenta and fetal liver,which might affect normal fetal development and challenge the fate of the pregnancy.The present article reviews current knowledge of the mechanisms underlying the hepatobiliary function of the fetal-placental unit and the repercussions of several pathological conditions on this tandem. | Rocio IR Macias Jose JG Marin Maria A Serrano | 2009 | World Journal of Gastroenterology2009，15，7： | 6 |
| 2 | The role of reduced intracellular concentrations of active drugs in the lack of response to anticancer chemotherapy显示文摘 | Jose JG MARIN Maria J MONTE Alba G BLAZQUEZ Rocio IR MACIAS Maria A SERRANO Oscar BRIZ | 2014 | Acta Pharmacologica Sinica2014，35，1： | 4 |
| 3 | Epistaxis in end stage liver disease masquerading as severe upper gastrointestinal hemorrhage显示文摘AIM:To describe the prevalence,diagnosis,treatment,and outcomes of end stage liver disease(ESLD) patients with severe epistaxis thought to be severe upper gastrointestinal hemorrhage(UGIH).METHODS:This observational single center study included all consecutive patients with ESLD and epistaxis identified from consecutive subjects hospitalized with suspected UGIH and prospectively enrolled in our databases of severe UGIH between 1998 and 2011.RESULTS:A total of 1249 patients were registered for severe UGIH in the data basis,461(36.9%) were cirrhotics. Epistaxis rather than UGIH was the bleeding source in 20 patients. All patients had severe coagulopathy. Epistaxis was initially controlled in all cases. Fifteen(75%) subjects required posterior nasal packing and 2(10%) embolization in addition to correction of coagulopathy. Five(25%) patients died in the hospital,12(60%) received orthotopic liver transplantation(OLT),and 3(15%) were discharged without OLT. The mortality rate was 63% in patients without OLT.CONCLUSION:Severe epistaxis in patients with ESLD is(1) a diagnosis of exclusion that requires upper endoscopy to exclude severe UGIH;and(2) associated with a high mortality rate in patients not receiving OLT. | Marine Camus Dennis M Jensen Jason D Matthews Gordon V Ohning Thomas O Kovacs Rome Jutabha Kevin A Ghassemi Gustavo A Machicado Gareth S Dulai | 2014 | World Journal of Gastroenterology2014，20，38： | 3 |
| 4 | Driving Factors for Forest Fire Occurrence in Durango State of Mexico:A Geospatial Perspective显示文摘Forest fire is one of the major causes of forest loss and therefore one of the main constraints for sustainable forest management worldwide.Identifying the driving factors and understanding the contribution of each factor are essential for the management of forest fire occurrence.The objective of this study is to identify variables that are spatially related to the occurrence and incidence of the forest fire in the State of Durango,Mexico.For this purpose,data from forest fire records for a five-year period were analyzed.The spatial correlations between forest fire occurrence and intensity of land use,susceptibility of vegetation,temperature,precipitation and slope were tested by Geographically Weighted Regression(GWR) method,under an Ordinary Least Square estimator.Results show that the spatial pattern of the forest fire in the study area is closely correlated with the intensity of land use,and land use change is one of the main explanatory variables.In addition,vegetation type and precipitation are also the main driving factors.The fitting model indicates obvious link between the variables.Forest fire was found to be the consequence of a particular combination of the environmental factors,and when these factors coexist with human activities,there is high probability of forest fire occurrence.Mandatory regulation of human activities is a key strategy for forest fire prevention. | Diana Avila-Flores Marin Pompa-Garcia Xanat Antonio-Nemiga Dante A Rodriguez-Trejo Eduardo Vargas-Perez Javier Santillan-Perez | 2010 | Chinese Geographical Science2010，20，6： | 3 |
| 5 | Liver fat deposition and mitochondrial dysfunction in morbid obesity:An approach combining metabolomics with liver imaging and histology显示文摘AIM: To explore the usefulness of magnetic resonance imaging(MRI) and spectroscopy(MRS) for assessment of non-alcoholic fat liver disease(NAFLD) as compared with liver histological and metabolomics findings. METHODS: Patients undergoing bariatric surgery following procedures involved in laparoscopic sleeve gastrectomy were recruited as a model of obesityinduced NAFLD in an observational, prospective, singlesite, cross-sectional study with a pre-set duration of 1 year. Relevant data were obtained prospectively and surrogates for inflammation, oxidative stress and lipid and glucose metabolism were obtained through standard laboratory measurements. To provide reliable data from MRI and MRS, novel procedures were designed to limit sampling variability and other sources of error using a 1.5T Signa HDx scanner and protocols acquired from the 3D or 2D Fat SAT FIESTA prescription manager. We used our previously described 1H NMRbased metabolomics assays. Data were obtained immediately before surgery and after a 12-mo period including histology of the liver and measurement of metabolites. Values from 1H NMR spectra obtained after surgery were omitted due to technical limitations.RESULTS: MRI data showed excellent correlation with the concentration of liver triglycerides, other hepatic lipid components and the histological assessment, w h i c h e xc l u d e d t h e p r e s e n c e o f n o n-a l c o h o l i c steatohepatitis(NASH). MRI was sufficient to follow up NAFLD in obese patients undergoing bariatric surgery and data suggest usefulness in other clinical situations. The information provided by MRS replicated that obtained by MRI using the-CH3 peak(0.9 ppm), the-CH2- peak(1.3 ppm, mostly triglyceride) and the-CH=CH- peak(2.2 ppm). No patient depicted NASH. After surgery all patients significantly decreased their body weight and steatosis was virtually absent even in patients with previous severe disease. Improvement was also observed in the serum concentrations of selected variables. The most relevant findings using metabolomics indicate increased levels of triglyceride and monounsaturated fatty acids in severe steatosis but those results were accompanied by a significant depletion of diglycerides, polyunsaturated fatty acids, glucose-6-phosphate and the ATP/AMP ratio. Combined data indicated the coordinated action on mitochondrial fat oxidation and glucose transport activity and may support the consideration of NAFLD as a likely mitochondrial disease. This concept may helpto explain the dissociation between excess lipid storage in adipose tissue and NAFLD and may direct the search for plasma biomarkers and novel therapeutic strategies. A limitation of our study is that data were obtained in a relatively low number of patients.CONCLUSION: MRI is sufficient to stage NAFLD in obese patients and to assess the improvement after bariatric surgery. Other data were superfluous for this purpose. | Nahum Calvo Raúl Beltrán-Debón Esther Rodríguez-Gallego Anna Hernández-Aguilera Maria Guirro Roger Mariné-Casadó Lidón Millá Josep M Alegret Fàtima Sabench Daniel del Castillo María Vinaixa Miguelàngel Rodríguez Xavier Correig Roberto García-álvarez Javier A Menendez Jordi Camps Jorge Joven | 2015 | World Journal of Gastroenterology2015，21，24： | 2 |
| 6 | Tei-index in patients with mild-to-moderate congestive heart failure显示文摘 | Bruch C Schmermund A Marin D | | 0，，： | 2 |
| 7 | The return plant location problem: Modeling and resolution 显示文摘 | Marin A Pelegrin B | 1998 | European Journal of Operational Research1998，104，2： | 1 |
| 8 | Tei-index in patients with mild-to-moderate congestive heart failure显示文摘 | Bruch C Schmermund A Marin D | 2000 | Eur Heart J2000，21，22： | 1 |
| 9 | Reforming of C7 hydrocarbons on sulfided commercial Pt/Al2O3 catalyst显示文摘 | Van Trimpont P A Marin G B Froment G F | 1988 | Ind Eng Chem Res1988，27，1： | 1 |
| 10 | Determination of adipate plasticizers in poly(vinyl chloride) by microwave- assisted extraction 显示文摘 | J M Cano M L Marin A Sanchez | 2002 | Journal of Chromatography A2002，963，： | 1 |
| 11 | Phosphorus clusters:synthesis in the gas-phase and possible cagelike and chain structures显示文摘 | Bulgakov A V Bobrenok O F Kosyakov V I Pzerov I Marine W Hed~n M Rohmund F Campbell E E B | | 0，，： | 1 |
| 12 | Dilution of mainstreamtobacco smoke and its effects upon the evaporation anddiffusion of nicotine显示文摘 | Lewis D A Colbeck I Mariner D C | 1995 | Journal of Aerosol Science1995，26，5： | 1 |
| 13 | Activated Carbons from KOH-activa- tion of Argan (Argania Spinosa) Seed Shells as Supercapaci- tor Electrodes显示文摘 | ELMOUWAHIDI A ZAPATA-BENABITHE Z CARRAS- CO- MARIN F | 2012 | Bioresource Technology2012，111，0： | 1 |
| 14 | Influence of Thermal Conditions on the Combustion Synthesis of Si2N2O Phase显示文摘 | Pradeilles N Record M C Marin A R M | 2008 | Materials Research Bulletion2008，43，： | 1 |
| 15 | Studies on the origin of microorganisms multiplying during manufacture of dry cured raw ham显示文摘 | CORNEJO I CARRASCOSA A V MARIN M E | 1992 | Fleischwirtschaft1992，72，10： | 1 |
| 16 | Synthesis,Properties, and Biological Activity of Poly 显示文摘 | ANDRIANOV A K MARIN A CHEN J P | 2006 | Biomacromol2006，，： | 1 |
| 17 | Formulating and solving splittable capacitated multiple allocation hub location problems 显示文摘 | Marin A | 2005 | Computers & Operations Research2005，32，12： | 1 |
| 18 | Protein sec ondary structure assignment revisited: a detailed analysis of different assignment methods 显示文摘 | MARTIN J LETELLIER G MARIN A | 2005 | BMC Struct Biol2005，5，1： | 1 |
| 19 | Evolution of nacre: Biochemistry and proteomics of the shell organic matrix of the cephalopod Nautilus macromphalus显示文摘 | MARIE B MARIN F MARIE A | 2009 | Chembiochem2009，10，： | 1 |
| 20 | Characterization of melting and solidification in a real scale PCM-air heat exchanger: Numerical model and experimental validation显示文摘 | DOLADO P LAZARO A MARIN J M | 2011 | Energy Conversion and Management2011，52，4： | 1 |
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