|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cognitive disorder and dementia in type 2 diabetes mellitus显示文摘Insulin,a key pleiotropic hormone,regulates metabolism through several signaling pathways in target tissues including skeletal muscle,liver,and brain.In the brain,insulin modulates learning and memory,and impaired insulin signaling is associated with metabolic dysregulation and neurodegenerative diseases.At the receptor level,in aging and Alzheimer’s disease(AD)models,the amount of insulin receptors and their functions are decreased.Clinical and animal model studies suggest that memory improvements are due to changes in insulin levels.Furthermore,diabetes mellitus(DM)and insulin resistance are associated with age-related cognitive decline,increased levels ofβ-amyloid peptide,phosphorylation of tau protein;oxidative stress,pro-inflammatory cytokine production and dyslipidemia. Recent evidence shows that deleting brain insulin receptors leads to mildobesity and insulin resistance without influencing brain size and apoptosis development.Conversely, deleting insulin-like growth factor 1 receptor (IGF-1R) affects brain size anddevelopment, and contributes to behavior changes. Insulin is synthesized locally in the brain andis released from the neurons. Here, we reviewed proposed pathophysiological hypotheses toexplain increased risk of dementia in the presence of DM. Regardless of the exact sequence ofevents leading to neurodegeneration, there is strong evidence that mitochondrial dysfunctionplays a key role in AD and DM. A triple transgenic mouse model of AD showed mitochondrialdysfunction, oxidative stress, and loss of synaptic integrity. These alterations are comparable tothose induced in wild-type mice treated with sucrose, which is consistent with the proposal thatmitochondrial alterations are associated with DM and contribute to AD development. Alterationsin insulin/IGF-1 signaling in DM could lead to mitochondrial dysfunction and low antioxidantcapacity of the cell. Thus, insulin/IGF-1 signaling is important for increased neural processing andsystemic metabolism, and could be a specific target for therapeutic strategies to decreasealterations associated with age-related cognitive decline. | Genaro G Ortiz Miguel Huerta Héctor A González-Usigli Erandis D Torres-Sánchez Daniela LC Delgado-Lara Fermín P Pacheco-Moisés Mario A Mireles-Ramírez Blanca MG Torres-Mendoza Roxana I Moreno-Cih Irma E Velázquez-Brizuela | 2022 | World Journal of Diabetes2022，13，4： | 2 |
| 2 | Fuzzy approach to the environmental impact evaluation 显示文摘 | MARIO E GIUSEPPE S | 2001 | Ecological Modeling2001，35，3： | 1 |
| 3 | Use of angiotensin Ⅱ inhibitors in patients that develop encapsuiating peritoneal sclerosis显示文摘 | Denise E S Inna K Mario R K | 2010 | Peritoneal Dialysis International2010，6，30： | 1 |
| 4 | EIectrophysiological alterations of the central nervous system in diabetes mellitus显示文摘 | Di Mario U Morano S Valle E | 1995 | Diabetes Metab Rev1995，11，3： | 1 |
| 5 | Mas deficiency in FVB/N mice produces marked changes in lipid and glycemic metabolism显示文摘 | Santos S H Fernandes L R Mario E G | 2008 | Diabetes2008，57，： | 1 |
| 6 | Pressure mechanisms in the spinalcanal of post-mortem human subjects during rearend impact and correlation of resuhs to the neck injury criterion显示文摘 | Aron E Mario D Hermann S | 2000 | Accid Anal Prev2000，32，2： | 1 |
| 7 | L-histidinol dehydrogenase,a Zn2^+ -metalloenzyme显示文摘 | Charles G Marios S Alane E S | 1989 | Arch biochem biophys1989，272，2： | 1 |
| 8 | Robust H position control synthesis of an electro-hydraulic servo system 显示文摘 | VLADIMIR M ZELJKO S MARIO E | 2010 | ISA Transactions2010，49，4： | 1 |
| 9 | Osseous Landmarks of the femoral attachment of the anterior cruciate ligament : an anatumic study 显示文摘 | Mario F Max E Wei S | 2007 | Arthroseopy2007，23，： | 1 |
| 10 | Effects of stress hyperglycemia on acute myocardial infarction diabetes care显示文摘 | Raffaele M Mario S Katherine E | | 0，，11： | 1 |
| 11 | Biosorption of humie and fulvie acids to live activated sludge biomass 显示文摘 | Mario E S Westerhoff P | 2003 | Water Research2003，37，： | 1 |
| 12 | Inhibition of protein and lipid oxidation by rapeseed, camelina and soy meal in cooked pork meat patties 显示文摘 | Hanna S Mario E Riitta K | 2006 | European Food Research and Technology2006，223，： | 1 |
| 13 | Design and analysis of a composite beam for infrastructure applications, part I: preliminary investigation in bending显示文摘 | Mario S Gerard V E Amar K | 2006 | International Journal of Materials and Product Technology2006，25，4： | 1 |
| 14 | Design and analysis of a composite beam for infrastructure applications, part Ⅱ : preliminary investigation in shear and torsion 显示文摘 | Mario S Gerard V E Amar K | 2006 | International Journal of Materials and Product Technology2006，25，4： | 1 |
| 15 | Fuzzy approach to the environmental impact evaluation 显示文摘 | Mario E Giuseppe S | 2001 | Ecological Modelling2001，135，1： | 1 |
| 16 | L-histidinol dehydrogenase, a Zn2+-metalloenzyme 显示文摘 | Charles G Marios S Alane E S | 1989 | Arch Biochem Biophys1989，272，2： | 1 |
| 17 | Design and analysis of a composite beam for infrastructure applications, part Ⅲ : experimental results and non-linear FE analysis显示文摘 | Mario S Amar K Gerard V E | 2006 | International Journal of Materials and Product Technology2006，25，4： | 1 |
| 18 | Improved lipid andglucose metabolism in transgenic rats with increased circulatingangiotensin-(1-7) 显示文摘 | Santos S H Braga J F Mario E G | 2010 | Arterioscler Thromb Vase Biol2010，30，5： | 1 |
| 19 | Efficacy of amiodarone for the termination of persistent atrial fibrillation显示文摘 | GEORGE E K NIKOS E L MARIOS C S | 1999 | Am J Cardial1999，83，： | 1 |
| 20 | Mas deficiency inFVB/N mice produces marked changes in lipid and glycemicmetabolism 显示文摘 | Santos S H Fernandes L R Mario E G ei al | 2008 | Diabetes2008，57，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员