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| 1 | Accuracy and responses of genomic selection on key traits in apple breeding显示文摘The application of genomic selection in fruit tree crops is expected to enhance breeding eficiency by increasing prediction accuracy,increasing selection intensity and decreasing generation interval.The objectives of this study were to assess the accuracy of prediction and selection response in commercial apple breeding programmes for key traits.The training population comprised 977 individuals derived from 20 pedigreed fllsib families.Historic phenotypic data were available on 10 traits related to productivity and fruit external appearance and genotypic data for 7829 SNPs obtained with an llumina 20K SNP array.From these data,a genome-wide prediction model was built and subsequently used to calculate genomic breeding values of five application fllsib families.The application families had genotypes at 364 SNPs from a dedicated 512 SNP array,and these genotypic data were extended to the high-density level by imputation.These five families were phenotyped for 1 year and their phenotypes were compared to the predicted breeding values.Accuracy of genomic prediction across the 10 traits reached a maximum value of 0.5 and had a median value of 0.19.The accuracies were strongly affected by the phenotypic distribution and heritability of traits.In the largest family,significant selection response was observed for traits with high heritability and symmetric phenotypic distribution.Traits that showed non-significant response often had reduced and skewed phenotypic variation or low heritability.Among the five application families the accuracies were uncorrelated to the degree of relatedness to the training population.The results underline the potential of genomic prediction to accelerate breeding progress in outbred fruit tree crops that still need to overcome long generation intervals and extensive phenotyping costs. | Hélène Muranty Michela Troggio Inès Ben Sadok Mehdi Al Rifaï Annemarie Auwerkerken Elisa Banchi Riccardo Velasco Piergiorgio Stevanato W.Eric van de Weg Mario Di Guardo Satish Kumar François Laurens Marco C.A.M.Bink | 2015 | Horticulture Research2015，2，1： | 14 |
| 2 | Cognitive disorder and dementia in type 2 diabetes mellitus显示文摘Insulin,a key pleiotropic hormone,regulates metabolism through several signaling pathways in target tissues including skeletal muscle,liver,and brain.In the brain,insulin modulates learning and memory,and impaired insulin signaling is associated with metabolic dysregulation and neurodegenerative diseases.At the receptor level,in aging and Alzheimer’s disease(AD)models,the amount of insulin receptors and their functions are decreased.Clinical and animal model studies suggest that memory improvements are due to changes in insulin levels.Furthermore,diabetes mellitus(DM)and insulin resistance are associated with age-related cognitive decline,increased levels ofβ-amyloid peptide,phosphorylation of tau protein;oxidative stress,pro-inflammatory cytokine production and dyslipidemia. Recent evidence shows that deleting brain insulin receptors leads to mildobesity and insulin resistance without influencing brain size and apoptosis development.Conversely, deleting insulin-like growth factor 1 receptor (IGF-1R) affects brain size anddevelopment, and contributes to behavior changes. Insulin is synthesized locally in the brain andis released from the neurons. Here, we reviewed proposed pathophysiological hypotheses toexplain increased risk of dementia in the presence of DM. Regardless of the exact sequence ofevents leading to neurodegeneration, there is strong evidence that mitochondrial dysfunctionplays a key role in AD and DM. A triple transgenic mouse model of AD showed mitochondrialdysfunction, oxidative stress, and loss of synaptic integrity. These alterations are comparable tothose induced in wild-type mice treated with sucrose, which is consistent with the proposal thatmitochondrial alterations are associated with DM and contribute to AD development. Alterationsin insulin/IGF-1 signaling in DM could lead to mitochondrial dysfunction and low antioxidantcapacity of the cell. Thus, insulin/IGF-1 signaling is important for increased neural processing andsystemic metabolism, and could be a specific target for therapeutic strategies to decreasealterations associated with age-related cognitive decline. | Genaro G Ortiz Miguel Huerta Héctor A González-Usigli Erandis D Torres-Sánchez Daniela LC Delgado-Lara Fermín P Pacheco-Moisés Mario A Mireles-Ramírez Blanca MG Torres-Mendoza Roxana I Moreno-Cih Irma E Velázquez-Brizuela | 2022 | World Journal of Diabetes2022，13，4： | 2 |
| 3 | Mas deficiency in FVB/N mice produces marked changes in lipid and glycemic metabolism显示文摘 | Santos S H Fernandes L R Mario E G | 2008 | Diabetes2008，57，： | 1 |
| 4 | Effects of pH, water stress and tem- perature on in vitro cultures of ectomycorrhizal fungi from Mediter- ranean forests显示文摘 | Fernando S Mario H Pilar T | 2001 | Cryp togamie Mycol2001，22，4： | 1 |
| 5 | Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption显示文摘 | Samira S Marios C Mariko H | 2005 | Nature2005，434，： | 1 |
| 6 | Physicochemical interaction study of non-steroidal anti-inflammatory drugs with dimyristoylphosphatidylethanolamine liposomes显示文摘 | Marcela M Jorg H Mario S | 2010 | Lett Drug Des Discov2010，7，1： | 1 |
| 7 | Integrated Photovoltaic Maximum Power Point tracking Converter显示文摘 | Johan H R Enslin Mario S Wolf Daniel B Snyman | 1997 | IEEE Transactions on Industrial Electronics1997，44，6： | 1 |
| 8 | An automatic iris occlusion estimation method based on high dimensional density estimation显示文摘 | Li Y H Marios S | 2013 | IEEE Transactions on Pattern Analysis and Machine Intelligence2013，35，4： | 1 |
| 9 | Integrated photovoltaie maximum power point tracking converter 显示文摘 | Johan H R Enslin Mario S Wolf Wernher Swiegers | 1997 | IEEE Transaction on Industrial Electronics1997，6，： | 1 |
| 10 | Ambulatory care of patients with left ventricular assist devices显示文摘 | Christof S Dieter H Mario CD | 1999 | Circulation1999，100，： | 1 |
| 11 | Magnesium implantation by plasma immersion in polymers for oxidation protection in low earth orbit environment显示文摘 | Ing H T Mario U Renato S D | 2007 | Plasma Processes and Polymers2007，4，0： | 1 |
| 12 | Physiological functions of beneficial elements显示文摘 | Elizabeth A H P S Colin F Q Wiebke T Mario M Michela S | 2009 | Current Opinion in Plant Biology2009，12，3： | 1 |
| 13 | Removal of Prymnesiumparvum (Haptophyceae) and its toxins using clay minerals 显示文摘 | MARIO R S JOHANNES A H EDNA G | 2005 | Harmful Algae2005，4，4： | 1 |
| 14 | Improved lipid andglucose metabolism in transgenic rats with increased circulatingangiotensin-(1-7) 显示文摘 | Santos S H Braga J F Mario E G | 2010 | Arterioscler Thromb Vase Biol2010，30，5： | 1 |
| 15 | Mas deficiency inFVB/N mice produces marked changes in lipid and glycemicmetabolism 显示文摘 | Santos S H Fernandes L R Mario E G ei al | 2008 | Diabetes2008，57，2： | 1 |
| 16 | Mas de-ficiency in FVB/N mice produces marked changes in lipid and gly-cemic metabolism显示文摘 | SANTOS S H S FERNANDES L R MARIO tG | 2008 | Diabetes2008，57，2： | 1 |
| 17 | Chilling responses of grapefruit as affected by cultivar and harvest date显示文摘 | MARIO S MARIO A GUY D H | 1998 | Advances in Horticulture Science1998，12，： | 1 |
| 18 | A variable elimination method to improve the parsimony of MLR models using the successive projections algorithm显示文摘 | Roberto K H G Mario C U A Wallace D F Edvan C S Gledson E J Sofacles F C S Henrique M P | 2008 | Chemometrics and Intelligent Laboratory Systems2008，92，： | 1 |
| 19 | Response of Tarocco oranges to picking date, postharvest hot water dips, and chilling storage temperature显示文摘 | MARIO S MARIO A GUY D H | 1997 | Journal of Agriculture and Food Chemistry1997，45，： | 1 |
| 20 | Detection and characterization of vascular lesions by intravascular ultrasound:an invitro study correlated with histology显示文摘 | D I MARIO C THE S H MADRESMA S | 1992 | J Am Soc Echocardiogy1992，5，： | 1 |
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