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| 1 | 精子DNA完整性与形态超高倍检测在辅助生殖技术妊娠结局中的临床价值显示文摘近年来,涌现出许多重要的男性不育诊疗新技术。本研究旨在探讨精@DNA完整性与精子空泡率检测对以男性不育因素行IvF或IcsI治疗的不育症的治疗结局。本研究针对152对不育症夫妻行ART技术前进行的精子DNA碎片率与形态学超高倍分析进行队列研究。我们发现对妊娠结局最有预测价值的DNA碎片率切点值为25.5%,阴性预测值为72.7%(P=0.02)。在对空泡率的研究中发现,3、4级的空泡精子的最有预测价值切点值为73.5%,阴性预测值为39.4%(P=0.09),差异无统计学意义。总之,当精子DNA碎片率大于25%时,IVF失败的概率增大,而精子形态学超高倍检测结果对预测患者的妊娠结局无明显获益。 | Gemma López Rafael Lafuente Miguel A Checa Ramón Carreras Mario Brassesco | 2013 | Asian Journal of Andrology2013，15，6： | 12 |
| 2 | A high-density, multi-parental SNP genetic map on apple validates a new mapping approach for outcrossing species显示文摘Quantitative trait loci(QTL)mapping approaches rely on the correct ordering of molecular markers along the chromosomes,which can be obtained from genetic linkage maps or a reference genome sequence.For apple(Malus domestica Borkh),the genome sequence v1 and v2 could not meet this need;therefore,a novel approach was devised to develop a dense genetic linkage map,providing the most reliable marker-loci order for the highest possible number of markers.The approach was based on four strategies:(i)the use of multiple full-sib families,(ii)the reduction of missing information through the use of HaploBlocks and alternative calling procedures for single-nucleotide polymorphism(SNP)markers,(iii)the construction of a single backcross-type data set including all families,and(iv)a two-step map generation procedure based on the sequential inclusion of markers.The map comprises 15417 SNP markers,clustered in 3 K HaploBlock markers spanning 1267 cM,with an average distance between adjacent markers of 0.37 cM and a maximum distance of 3.29 cM.Moreover,chromosome 5 was oriented according to its homoeologous chromosome 10.This map was useful to improve the apple genome sequence,design the Axiom Apple 480 K SNP array and perform multifamily-based QTL studies.Its collinearity with the genome sequences v1 and v3 are reported.To our knowledge,this is the shortest published SNP map in apple,while including the largest number of markers,families and individuals.This result validates our methodology,proving its value for the construction of integrated linkage maps for any outbreeding species. | Erica A Di Pierro Luca Gianfranceschi Mario Di Guardo Herma JJ Koehorst-van Putten Johannes W Kruisselbrink Sara Longhi Michela Troggio Luca Bianco Hélène Muranty Giulia Pagliarani Stefano Tartarini Thomas Letschka Lidia Lozano Luis Larisa Garkava-Gustavsson Diego Micheletti Marco CAM Bink Roeland E Voorrips Ebrahimi Aziz Riccardo Velasco François Laurens W Eric van de Weg | 2016 | Horticulture Research2016，3，1： | 3 |
| 3 | Structural control of floating wind turbines显示文摘 | Matthew A L Mario A R | 2011 | Mechatronics2011，21，4： | 1 |
| 4 | Label-free electroehemical detection of protein based on a ferrocene-bearing cationic polythiophene and aptamer显示文摘 | Fabien L F Hoang A H Mario L | 2006 | Anal Chem2006，，78： | 1 |
| 5 | Clinical usefulness of serum pepsinogens I and II,gastrin-17 and anti-Helicobacterpylori antibodies in the management of dyspeptic patients in primary care显示文摘 | GERMAN(A) B DI MARIO F CAVALLARO L G | | 0，，： | 1 |
| 6 | Phase variation in Helicobacter pylori lipopolysaccharide due to change in the lengths of poly(c)tracts inα3-fucosyltransferase genes显示文摘 | Martin Steve L Monteiro Mario A | 1999 | Infect Immun1999，67，10： | 1 |
| 7 | Functional polythiophenes as optical chemoand biosensors显示文摘 | Maite B A Ho H A Mario L | 2004 | Tetrahedron2004，60，11： | 1 |
| 8 | Contextual factors and the creativity of frontline employee:the mediating effects of role stress and intrinsic motivition显示文摘 | FILIPE C MARIO A LUIS F L | 2011 | Journal of Retailing2011，87，1： | 1 |
| 9 | Resource manipulation reveals flexible allocation rules to growth and reproduction in a Mediterranean evergreen oak显示文摘Aims In plants,resource allocation to growth and reproduction may depart from trade-off expectations if(i)investment in growth and reproduction relies on different resource pools,(ii)allocation to reproduction is dependent upon reaching some growth threshold or(iii)reproduction is developmentally linked to growth,both functions relying on the same resource pool.We examined the effects of enhanced resource level on patterns of resource allocation to growth and reproduction in holm oak(Quercus ilex sbsp.ballota),a Mediterranean evergreen tree.Methods In the experimental year(2003),we manipulated the amount of soil nutrients in autumn(to increase nutrient uptake during shoot elongation in the following spring)and soil water in summer(to increase water uptake during acorn growth).Indicators of growth and male and female reproduction were estimated in the preexperimental(2002),experimental(2003)and post-experimental(2004)years.Important Findings Fertilized trees produced significantly longer shoots,but the number of female flowers per shoot was not affected by treatments.The production of male catkins was also enhanced by fertilization.Irrigation did not affect the production of female flowers or abortion rates.Growth and female reproduction showed no consistent relationship in untreated trees,but resource addition elicited a growth-female reproduction trade-off in the experimental year.The sign of this significant relationship changed in the post-experimental year,indicating the existence of lagged effects of resource manipulation on acorn production.Overall,patterns of allocation to growth and reproduction varied as a function of sex,resource availability and year,a result consistent with extreme allocational plasticity in holm oak. | Fernando Pulido Gerardo Moreno Eustolia García José J.Obrador Raúl Bonal Mario Díaz | 2014 | Journal of Plant Ecology2014，7，1： | 1 |
| 10 | Autonomous fault emulation:a new FPGA-based acceleration system for hardness evalua-tion显示文摘 | Celia López-Ongil Mario García-Valderas Marta Por-tela-García | | 0，，01： | 1 |
| 11 | Functional polythiophenes as optical chemoand biosensors 显示文摘 | Maite B A Ho H A Mario L | 2004 | Tetrahedron2004，60，11： | 1 |
| 12 | Landmark identification er- ror in posteroanterior cephalometric radiography 显示文摘 | Rosalia L Alberto A Mario C | 2008 | AngleOrthod2008，78，4： | 1 |
| 13 | Current treatment and outcomes of perinephric abscesses 显示文摘 | Meng M V Mario L A McAninch J W | 2002 | J Urol2002，168，4： | 1 |
| 14 | R&D and performance persistence-Evidence from the United Kingdom显示文摘 | SERAINA C A MARIO L | 2008 | The International Journal of Accounting2008，，43： | 1 |
| 15 | Expression of p15 (ink4b) gene during megakaryoeytic differentiation of normal and myelodysplastie hematopoietic progenitors 显示文摘 | Teofili L Martini M Di Mario A | 2001 | Blood2001，98，2： | 1 |
| 16 | A New Convenient Transformation of Erythromycin A Into Clarithromycin 显示文摘 | PIETRO A ALESSANDRA L MARIO A | 1999 | Bioorganic & Medicinal Chemistry1999，7，12： | 1 |
| 17 | Mielitis transversa en síndrome de Sj?gren y lupus eritematoso sistémico: presentación de 3 casos显示文摘 | Raúl Menor Almagro María del Mar Ruiz Tudela Juan Girón úbeda Mario H. Cardiel Rios José Javier Pérez Venegas Carmen García Guijo | 2014 | Reumatologia Clinica2014，，： | 1 |
| 18 | Molecular evolution of rbcL in three gymnosperm families:identifying adaptive and coevolutionary patterns 显示文摘 | Sen L Mario A Fares Liang B | 2011 | Biolog''r Direct2011，6，： | 1 |
| 19 | Benign Symmetric Lipomatosis (Madelung’s Disease): Case Reports and Current Management显示文摘 | Raúl González-García M.D. Francisco J. Rodríguez-Campo M.D. Jesús Sastre-Pérez M.D. Mario F. Mu?oz-Guerra M.D. Ph.D | 2004 | Aesthetic Plastic Surgery2004，，2： | 1 |
| 20 | Carbon-13 and proton magic-angle-spinning NMR studies of the conversion of methanol over offretite/erionite intergrowths 显示文摘 | Michael W A Mario L O Jacek K | 1992 | J Phys Chem1992，96，1： | 1 |
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