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| 1 | Age-dependentaccumulation of soluble amyloid p (Ap) oligomers reversesthe neuroprotective effect of soluble amyloid precursor protein-(sAPP) by modulating phosphatidylinositol 3-kinase (PI3K) /Akt-GSK-3 pathway in Alzheimer mouse model 显示文摘 | Sebastian J Manuel T Marisa V | 2011 | J BiolChem2011，286，18： | 1 |
| 2 | Transcripts of a chimeric cDNA of hepatitis C virus genotype lb are infectious in vivo显示文摘 | Masayuki Y Marisa S T Max S | 1998 | Virology1998，244，： | 1 |
| 3 | 5-Bromo-8-methoxy-l-methyl-ff carboline, an alkaloid from the New Zealand marine bryozo- an Pterocellavesiculosa显示文摘 | Marisa T Mich61e R P | 2009 | J Nat Prod2009，72，： | 1 |
| 4 | Binuclear copper(I) complexes containing bis(diphenylphosphino)methane bridging ligands:crystal structure of 2 显示文摘 | Josefina Díez Gamasa M Pilar José Gimeno Antonio T Marisa T C | 1987 | J Chem Soc Dalton Trans1987，，： | 1 |
| 5 | Deprotection of peracetylated methyl D - ribosides through enzymatic alcoholysis: different recognition of the anomers 显示文摘 | SABRINA I MARISA T P JAVIER M M | 2005 | Molecular Catalysis B: Enzymatic2005，35，： | 1 |
| 6 | Using greenways to reclaim nature in Brazilian cities显示文摘 | Marisa T Mamede F Paulo P | 2006 | Landscape and Urban Planning2006，76，14： | 1 |
| 7 | Tissue Microarray Analysis of Hepatocyte Growth Factor/Met Pathway Components Reveals a Role for Met,Matriptase,and Hepatocyte Growth Factor Activator Inhibitor 1 in the Progression of Node-negative Breast Cancer显示文摘 | Jung Y K Marisa D F Idris T O | 2003 | Cancer Research2003，63，： | 1 |
| 8 | Thermophysical Characterization of Ionic Liquids Able to Dissolve显示文摘 | Mara G F Ana R T Marisa A | 2011 | Journal of Chemical and Emgineering Data2011，56，12： | 1 |
| 9 | Study of composites based on polypropylene and calcium carbonate by experimental design显示文摘 | Marisa C G Rocha Antonio H M F T Silva Fernanda M B Coutinho | | 0，，08： | 1 |
| 10 | Study of composites based on polypropylene and calcium carbonate by experimental design显示文摘 | Marisa C G Rocha Antonio H M F T Silva Fernanda M B Coutinho | 2005 | Polymer Testing2005，24，8： | 1 |
| 11 | Optimization of the tradeoff between switching speed of the internal diode and on-resistance in gold-and platinum- implanted power metal-oxide-semiconductor devices 显示文摘 | Marisa F C Ferruccio F Nella T | 1992 | IEEE Trans on Electron Devices1992，39，12： | 1 |
| 12 | Absorption of lycopene from single or daily portions of raw and processed tomato显示文摘 | Marisa P Patrizia R Giulio T | 1998 | Br J Nuts1998，80，4： | 1 |
| 13 | Neuropsychological features of progranulin-associated frontotemporal dementia: a nested case-control study显示文摘The distinction between sporadic and genetic behavioural-variant frontotemporal dementia(bvFTD)regarding some neuropsychological(NP)features remains challenging.Specifically,progranulin(GRN)-associated bvFTD frequently presents with early episodic memory impairment and some degree of parietal dysfunction which are supporters of Alzheimer’s disease(AD)diagnosis.In this context,we aimed to characterize the NP profile of GRN-bvFTD as compared to sporadic-bvFTD and AD in patients with mild dementia(Mini-Mental State Examination score≥17 and Clinical Dementia Rating Scale score≤1.We identified 21 patients at Centro Hospitalar e Universitário de Coimbra,Portugal with GRN mutations belonging to fifteen different families.As our focus was bvFTD variants,FTD-related aphasic forms(3 patients)were excluded.The remaining 18 GRN-bvFTD were further matched with 18 sporadic-bvFTD and 18 AD patients according to disease staging,age and education.All patients completed the Mini-Mental State Examination,Montreal Cognitive Assessment(MoCA)and a comprehensive NP assessment battery.Results were converted into z-scores.Differences between groups in individual NP measures and NP domains were assessed through non-parametric tests(Kruskal-Wallis test analysis)and eta squared(ŋ2)was calculated as a measure of effect size.Group comparisons show that GRN patients have worse performances on verbal retrieval processes(P=0.039,ŋ2=0.110)and visuoconstructive abilities(P=0.039,ŋ2=0.190)than sporadic bvFTD forms.When compared to AD,GRN patients present a higher impairment in frontal(P=0.001,ŋ2=0.211)and parietal(P=0.041,ŋ2=0.129)measures and a better performance in memory tasks(P=0.020,ŋ2=0.120).Sporadic-bvFTD forms are worse than AD in frontal measures(P=0.032,ŋ2=0.200),being better in both memory(P=0.010,ŋ2=0.131)and visuospatial skills(P=0.023,ŋ2=0.231).Considering these results,we conclude that GRN-bvFTD patients present a NP profile that associates the typical patterns of FTD and AD deficits.This is particularly expressive in visuoconstructive abilities,which was the more discriminative feature between groups,followed by episodic verbal memory.This study was approved by the Institutional Ethics Committee of Centro Hospitalar e Universitário de Coimbra,Portugal(CE-029/2019)on June 24,2019. | Marisa Lima Miguel Tábuas-Pereira Diana Duro João Durães Daniela Vieira Inês Baldeiras Maria Rosário Almeida Isabel Santana | 2021 | Neural Regeneration Research2021，16，5： | 0 |
| 14 | Buddy Study: Partners for better health in adolescents with type 2 diabetes显示文摘AIM: To investigate whether assigning young, healthy and motivated lay volunteer partners('buddies') to adolescents with type 2 diabetes improves hemoglobin A1c(HbA 1c). METHODS: Adolescents with type 2 diabetes were randomized to partnering with a 'buddy' or to conventional treatment. During the initial screening visit, which coincided with a routine outpatient diabetes clinic visit, patients with type 2 diabetes underwent a physical examination, detailed medical history, laboratory measurement of HbA 1c, and completed two questionnaires(Pediatric Quality of Life Inventory and Children's Depression Inventory) to assess their overall quality of life and the presence of depressive symptoms. Patients were then randomized to the intervention(the buddy system) or conventional treatment(standard care). All patients were scheduled to return for followup at 3- and 6-mo after their initial visit. Hb A1 c was determined at all visits(i.e., at screening and at the 3- and 6-mo follow-up visits) and quality of life and depressive symptoms were evaluated at the screening visit and were reassessed at the 6-mo visit. RESULTS: Ten adolescents, recruited from a pool of approximately 200 adolescents, enrolled over a twoyear time period, leading to premature termination of the study. In contrast, we easily recruited motivated lay volunteers. We found no change in HbA 1c from the initial to the 6-mo visit in either group, yet our small sample size limited systematic assessment of this outcome. Participants repeatedly missed clinic appointments, failed to conduct self-glucose-monitoring and rarely brought their glucometers to clinic visits. Total quality of life scores(72.6 ± 6.06) at screening were similar to previously reported scores in adolescents with type 2 diabetes(75.7 ± 15.0) and lower than scores reported in normal-weight(81.2 ± 0.9), overweight(83.5 ± 1.8), and obese youths without diabetes(78.5 ± 1.8) or in adolescents with type 1 diabetes(80.5 ± 13.1). Among adolescents who returned for their 6-mo visit, there were no differences in total quality of life scores(70.2 ± 9.18) between screening and follow-up.CONCLUSION: Our approach, effective in adults with type 2 diabetes, was unsuccessful among adolescents and emphasizes the need for innovative strategies for diabetes treatment in adolescent patients. | Allison C Sylvetsky Radha Nandagopal Tammy T Nguyen Marisa R Abegg Mahathi Nagarur Paul Kaplowitz Kristina I Rother | 2015 | World Journal of Diabetes2015，6，18： | 0 |
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