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1篇 您的检索式：作者名="Mark ECooper"

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		题名	作者	年代	出处	被引量
	1	Inhibition of pancreatic EZH2 restores progenitor insulin in T1D donor显示文摘Type 1 diabetes(T1D)is an autoimmune disease that selectively destroys insulin-producingβ-cells in the pancreas.An unmet need in diabetes management,current therapy is focussed on transplantation.While the reprogramming of progenitor cells into functional insulin-producingβ-cells has also been proposed this remains controversial and poorly understood.The challenge is determining why default transcriptional suppression is refractory to exocrine reactivation.After the death of a 13-year-old girl with established insulin-dependent T1D,pancreatic cells were harvested in an effort to restore and understand exocrine competence.The pancreas showed classic silencing ofβ-cell progenitor genes with barely detectable insulin(Ins)transcript.GSK126,a highly selective inhibitor of EZH2 methyltransferase activity influenced H3K27me3 chromatin content and transcriptional control resulting in the expression of coreβ-cell markers and ductal progenitor genes.GSK126 also reinstated Ins gene expression despite absoluteβ-cell destruction.These studies show the refractory nature of chromatin characterises exocrine suppression influencingβ-cell plasticity.Additional regeneration studies are warranted to determine if the approach of this n-of-1 study generalises to a broader T1D population.	Keith Al-Hasani Ishant Khurana Lina Mariana Thomas Loudovaris Scott Maxwell K.N.Harikrishnan Jun Okabe Mark ECooper Assam El-Osta	2022	Signal Transduction and Targeted Therapy2022，7，8：	0

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