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| 1 | 成人缺血性卒中早期处理指南显示文摘本指南旨在对成年急性缺血性卒中患者评价和治疗各要素的现有证据做一回顾。目标读者是那些为发病后48h内的卒中患者提供治疗的内科医生和其他急诊医疗保健人员。另外,也包括向医疗保健政策制定者提供的信息。方法:专家小组成员由美国心脏协会(AHA)卒中委员会科学声明监督委员会任命,他们代表了来自不同领域的专家。专家小组以2003年后发表的报道为重点,对相关文献进行回顾,采用AHA卒中委员会的证据水平分级标准对证据进行分级并做出推荐。本声明经专家小组认可后,再由AHA科学顾问和协调委员会进行同行评议和正式批准。本指南打算在3年内做全面更新。结果:对急性缺血性卒中患者的处理仍然是多方面的,包括尚未在临床试验中进行过验证的一些医疗诊治方面。本声明包括从急诊医疗服务人员开始接触患者到入院初期处理的推荐意见。静脉重组组织型纤溶酶原激活剂仍然是已得到证实的最有效的卒中急诊治疗干预方法。包括动脉应用溶栓药和机械介入在内的一些方法显示出希望。因为许多推荐是在有限的证据基础上做出的,因此需要对急性缺血性卒中的治疗进行更多的研究。 | Harold P. Adams Gregory del Zoppo Mark J. Alberts Deepak L. Bhatt Lawrence Brass Anthony Furlan Robert L. Grubb Randall T. Higashida Edward C. Jauch Chelsea Kidwell Patrick D. Lyden Lewis B. Morgenstern Adnan I. Qureshi Robert H. Rosenwasser Phillip A. Scott Eelco F.M. Wijdicks 李焰生(译) 熊昕丽(译) 林岩(译) 沈沸(译) 俞羚(译) 邹静(译) 张静芳(译) 孙亚蒙(译) 周洁茹(译) 蒋仙国(译) 陈莺(译) | 2007 | 国际脑血管病杂志2007，15，6： | 18 |
| 2 | Characterization of Gibberellin Receptor Mutants of Barley (Hordeum vulgare L.)显示文摘Gid1 的顺序(为赤霉素(GA ) 的基因从米饭的受体) 被用来从大麦识别通常认为的 orthologue。这在 E 被表示。coli,并且生产了能与结构的特性和 saturability 在 vitro 绑 GA 的蛋白质。它在 GA 回答的潜在的角色与减少的 GA 敏感(gse1 异种) 用大麦异种被调查。十六不同 gse1 异种各在这个序列带了唯一的核苷酸替换。在里面几乎一个案例,这些变化导致了单个氨基酸替换,并且,为留下的异种,在 mRNA 的 5 untranslated 区域的替换被建议防碍翻译开始。在分离有完美的连接在新变异的等位基因和 gse1 显型之间的人口,导致在大麦的通常认为的 GID1 GA 受体顺序对应于 Gse1 地点的结论。在异种之一的内长的 GA 内容的决心揭示了 C20 GA 先锋的 bioactive GA1,和赤字的提高的累积。所有在通常正在浸透的集中 gse1 异种把敏感归结为外长的 GA3,并且到 AC94377 (GA 类似物) ,,但是,在高得多的集中,经常有可观的回答。在大麦和米饭异种之间的比较揭示这之间的有趣的差别在 GA 的二谷物种神经质的生理学。 | Peter M. Chandler Carol A. Harding Anthony R. Ashton Mark D. Mulcair Nicholas E. Dixonb Lewis N. Manderb | 2008 | Molecular Plant2008，1，2： | 10 |
| 3 | Multifaceted signaling regulators of chondrogenesis:Implications in cartilage regeneration and tissue engineering显示文摘Defects of articular cartilage present a unique clinical challenge due to its poor self-healing capacity and avascular nature.Current surgical treatment options do not ensure consistent regeneration of hyaline cartilage in favor of fibrous tissue.Here,we review the current understanding of the most important biological regulators of chondrogenesis and their interactions,to provide insight into potential applications for cartilage tissue engineering.These include various signaling pathways,including fibroblast growth factors(FGFs),transforming growth factor b(TGF-b)/bone morphogenic proteins(BMPs),Wnt/b-catenin,Hedgehog,Notch,hypoxia,and angiogenic signaling pathways.Transcriptional and epigenetic regulation of chondrogenesis will also be discussed.Advances in our understanding of these signaling pathways have led to promising advances in cartilage regeneration and tissue engineering. | Jordan D.Green Viktor Tollemar Mark Dougherty Zhengjian Yan Liangjun Yin Jixing Ye Zachary Collier Maryam K.Mohammed Rex C.Haydon Hue H.Luu Richard Kang Michael J.Lee Sherwin H.Ho Tong-Chuan He Lewis L.Shi Aravind Athiviraham | 2015 | Genes & Diseases2015，2，4： | 9 |
| 4 | Intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT): a randomised pilot trial显示文摘 | Craig S Anderson Yining Huang Ji Guang Wang Hisatomi Arima Bruce Neal Bin Peng Emma Heeley Christian Skulina Mark W Parsons Jong Sung Kim Qing Ling Tao Yue Chun Li Jian Dong Jiang Li Wen Tai Jin Li Zhang En Xu Yan Cheng Stephane Heritier Lewis B Morgenste | 2008 | Lancet Neurology2008，，5： | 4 |
| 5 | Effects of Early Intensive Blood Pressure-Lowering Treatment on the Growth of Hematoma and Perihematomal Edema in Acute Intracerebral Hemorrhage: The Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT)显示文摘 | Craig S. Anderson Yining Huang Hisatomi Arima Emma Heeley Christian Skulina Mark W. Parsons Bin Peng Qiang Li Steve Su Qing Ling Tao Yue Chun Li Jian Dong Jiang Li Wen Tai Jin Li Zhang En Xu Yan Cheng Lewis B. Morgenstern John Chalmers Ji Guang Wang | 2010 | Stroke2010，，2： | 3 |
| 6 | Prognostic significance of endoluminal ultrasound-defined disease length and tumor volume (EDTV) for patients with the diagnosis of esophageal cancer显示文摘 | Christopher P. Twine S. Ashley Roberts Wyn G. Lewis B. Vicki Dave Claire E. Rawlinson David Chan Mark Robinson Tom D. Crosby | 2010 | Surgical Endoscopy2010，，4： | 2 |
| 7 | Evolution in the Management of Hepatic Trauma: A 25-Year Perspective显示文摘 | J. David Richardson Glen A. Franklin James K. Lukan Eddy H. Carrillo David A. Spain Frank B. Miller Mark A. Wilson Hiram C. Polk Lewis M. Flint | 2000 | Annals of Surgery2000，，3： | 2 |
| 8 | Use of a novel mutagenesis strategy,optimized residue substitution,to decrease the off-rate of an anti-gp120 antibody显示文摘 | Lewis CM Hollis GF Mark GE | 1995 | Mol Immunol1995，32，1415： | 1 |
| 9 | Use of a novel mutagenesis strategy, optimized residue substitution, to decrease the off-rate of an anti-gp120 antibody显示文摘 | Lewis CM Hollis GF Mark GE | 1995 | Mol Immunology1995，32，1415： | 1 |
| 10 | Discrete and ultra discrete models for epi- demics and other stories显示文摘 | Mark A Lewis Joanna Renclawowicz Pvan den Driessche | 2006 | Bulletin of Mathematical Biology2006，68，3： | 1 |
| 11 | Diabetes and Hypertension: Pathogenesis, Prevention and Treatment ?显示文摘 | Lewis Landsberg Mark Molitch | 2004 | Clinical and Experimental Hypertension (-)2004，，7： | 1 |
| 12 | Subsyndromal symptomatic depression: A New Mood Disorder ? 显示文摘 | Lewis LJ Mark HR | 1994 | J Clin Psychiatry1994，55，： | 1 |
| 13 | Critical design issues for airbreathing hypersonic waverider missiles 显示文摘 | RYAN P STARKEY MARK LEWIS J | 2001 | Journal of Spacecraf and Rockets2001，38，4： | 1 |
| 14 | Radiopharmaceuticals in preclinical and clinical development for monitoring of therapy with PET显示文摘 | Mark PS Dunphy Jason S Lewis | 2009 | J Nucl Med2009，50，1： | 1 |
| 15 | Application of Proportional-integral and Disturbance Accommodating Control to Variable Speed Variable Pitch Horizontal Axis Wind Turbines显示文摘 | Kendall Lewis Balas Mark J Lee Yung Jae | | 0，，01： | 1 |
| 16 | Purification and characterization of ciguatoxins from moray eel (Lycodontis javanicus, Mu- raenidae) 显示文摘 | LEWIS R J SELLIN M MARK A | 1991 | Toxicon1991，29，9： | 1 |
| 17 | Prevalence of Migraine in Patients With Celiac Disease and Inflammatory Bowel Disease显示文摘 | Alexandra K. Dimitrova Ryan C. Ungaro Benjamin Lebwohl Suzanne K. Lewis Christina A. Tennyson Mark W. Green Mark W. Babyatsky Peter H. Green | 2012 | Headache: The Journal of Head and Face Pain2012，，2： | 1 |
| 18 | Right Ventricular Function and Failure: Report of a National Heart, Lung, and Blood Institute Working Group on Cellular and Molecular Mechanisms of Right Heart Failure显示文摘 | Norbert F. Voelkel Robert A. Quaife Leslie A. Leinwand Robyn J. Barst Michael D. McGoon Daniel R. Meldrum Jocelyn Dupuis Carlin S. Long Lewis J. Rubin Frank W. Smart Yuichiro J. Suzuki Mark Gladwin Elizabeth M. Denholm Dorothy B. Gail | 2006 | Circulation2006，，17： | 1 |
| 19 | Greenhouse gas emissions trading in BP显示文摘 | Akhurst Mark Jeff Morgheim Rzchel Lewis | 2003 | Energy Policy2003，31，： | 1 |
| 20 | Urban Wages and Labor Market Agglomeration显示文摘 | William C. Wheaton Mark J. Lewis | 2002 | Journal of Urban Economics2002，，3： | 1 |
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