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| 1 | WONCA研究论文摘要汇编——急性颅内出血后血压变异性及转归:INTERACT2研究的析因分析,一项随机对照试验显示文摘背景高血压是急性脑卒中的预后因子,血压变异性或许可以独立预测脑卒中的转归。我们评估了血压变异性对INTERACT2参试者脑卒中预后的预测价值, INTERACT2是一项开放标签随机对照试验。方法 INTERACT2将患有自发性颅内出血(ICH)、高收缩压(150~220 mm Hg)、对早期降压强化疗法无明确适应证或禁忌证的2839例成人纳入研究。将患者随机分为强化治疗组(经静脉给药,1 h内目标收缩压降至<140 mm Hg )和指南推荐的治疗组( ICH 后6 h 内,目标收缩压降至<180 mm Hg)。主要转归为死亡或90 d内发生生活大部分无法自理(改良Rankin量表评分≥3分);次要转归为90 d内改良Rankin量表评分发生顺序移动,调查员在评分时并不知晓患者接受了哪种治疗。根据标准定义血压变异性:在发病头24 h (超急性期)进行5次测量,在发病后2~7 d (急性期)进行不少于12次的测量。采用比例优势逻辑回归模型评价血压变异性与转归之间的关联。血压变异性关键指标为收缩压的标准差,按五分位数加以分类。发现研究者对2645例(93.2%)处于超急性期的患者和2347例(82.7%)处于急性期的患者进行了调查。将两个治疗组的数据一起分析,在超急性期〔最高五分位数校正OR=1.41,95%CI (1.05,1.90); P=0.0167〕和急性期〔最高五分位数校正OR=1.57,95%CI (1.14,2.17); P=0.0124〕,收缩压的标准差与主要转归均呈线性相关。对转归最强的预测指标为超急性期最高收缩压和急性期收缩压的标准差为结果的最强预示因子。对次要转归进行分析,得到的结果与以上结果相似〔超急性期最高五分位数,校正OR=1.43,95%CI (1.14,1.80); P=0.0014;急性期OR=1.46,95%CI (1.13,1.88); P=0.0044〕。解释收缩压变异性似乎可预测急性颅内出血患者的不良转归。早期治疗将收缩压降至140 mm Hg以下获得的收益,可通过平稳并持续血压控制进行强化,避免出现收缩压峰值尤为重要。 | Manning L Hirakawa Y Arima H 周淑新 | 2014 | 中国全科医学2014，17，21： | 56 |
| 2 | One-step palliative treatment method for obstructive jaundice caused by unresectable malignancies by percutaneous transhepatic insertion of an expandable metallic stent显示文摘瞄准:为了描述包含可扩充的金属的经皮的 transhepatic 插入的一个简单一步舞方法,在妨碍的黄疸的治疗使用的斯滕特氏印模膏(他们) 由 unresectable 恶意引起了。方法:由于 unresectable 恶意与妨碍的黄疸诊断的十四个病人在学习被包括。在这些病人的恶意是很先进的癌或老年的结果。经皮的 transhepatic 胆管造影术在 ultrasonographic 指导下面被执行。在有一个内部金属性的指南的一根导管是先进的进十二指肠以后,一他们被放在胆总管,在一个点之间在到肝的核的 Vater 和入口的乳头状的小突起以外的 1 厘米。在用就一个单身者跨越距离是困难的情况中他们,另外的斯滕特氏印模膏被放。一根排水导管在地方被离开充当一把止血钳子。在胆汁郁积和斯滕特氏印模膏明显的分辨率被证实以后,导管被移开 2 或 3 d 过程以后。结果:EMS 的一步舞插入与 24.4 min 的一过程平均数时间在所有病人被完成。从要求了 2 他们的病人, 4 需要一过程时间超过 30 min。导管的移动的吝啬的时间过程以后是 2.3 d。所有病人与 7.8 瞬间的一吝啬的后续时间死于恶意。没有 stent 相关的复杂并发症或斯滕特氏印模膏阻塞被遇到。结论:他们的一步舞经皮的 transhepatic 插入是为决定胆汁的阻塞和罐头有效地改进病人生命的质量的一个简单过程。 | Hiroshi Yoshida Yasuhiro Mamada Nobuhiko Taniai Yoshiaki Mizuguchi Tetsuya Shimizu Shigeki Yokomuro Takayuki Aimoto Yoshiharu Nakamura Eiji Uchida Yasuo Arima Manabu Watanabe Eiichi Uchida Takashi Tajiri | 2006 | World Journal of Gastroenterology2006，12，15： | 28 |
| 3 | 丙型肝炎病毒的血清抗体检测及基因组cDNA扩增显示文摘采用抗HCV-N14和抗HCV-C100-3抗体试剂盒检测丙型肝炎(丙肝)高危人群血液标杯1544人份。丙肝抗体阳性率为:输血后肝炎64.5%、血液透析病人28.6%、肝硬变19.1%、肝细胞癌10.5%、临床非甲非乙型肝炎7.3%、献血员4.1%和医院工作人员2.6%,表明丙型肝炎病毒(HCV)感染在我国相当严重。抗HCV-N4抗体出现较早,且与多聚酶链反应PCR的基因诊断有较好的相关性,是判定HCV感染及其传染性的重要指标。 | 戚中田 潘卫 杜平 孟宗达 Terukatsu Arima | 1992 | 第二军医大学学报1992，13，1： | 17 |
| 4 | Postoperative bile leakage managed successfully by intrahepatic biliary ablation with ethanol显示文摘我们报导手术后的倔强的胆汁漏的一个案例与乙醇由肝内的胆汁的脱离成功地设法。与肝细胞癌诊断的一个 75 岁的人包括有尾的脑叶和前面的片断的部分经历了扩大以后的 segmentectomy。纳入胆汁管的前面的分支的肝的肿瘤小心地被分开并且 resected。手术后地从肝表面排干的液体包含了全部的胆红素的高集中,在每天的 150 mL 的经常的体积。在 d 上 32 在外科以后,引流管的 fistulogram 表明了前面的胆汁管的改进。内视镜后退胆管造影术表明了近似前面的胆汁管和外部前面的胆汁管的没有改进的完全的阻塞。在 d 上 46 在外科以后,一后退 transhepatic 胆汁的排水(RTBD ) 试管在开的外科下面被插入到前面的胆汁管。然而,拿的 RTBD 的对比研究 7 瞬间外科以后表明尽管有延长保守管理,管仍然是专利,我们因此决定执行孤立的胆汁管的乙醇脱离。四 mL 纯乙醇被注入孤立的前面的胆汁管十分钟,过程一个星期正在被重复五次。追随者 23 尝试,胆汁果汁的体积每天到达了不到 10 mL。RTBD 二天以后被夹钳并且搬迁。在 RTBD 移动以后,病人没有抱怨或症状。没有肝脓肿形成,后续磁性的回声成像表明了注射乙醇的前面的片断的萎缩。 | Tetsuya Shimizu Hiroshi Yoshida Yasuhiro Mamada Nobuhiko Taniai Satoshi Matsumoto Yoshiaki Mizuguchi Shigeki Yokomuro Yasuo Arima Koho Akimaru Takashi Tajiri | 2006 | World Journal of Gastroenterology2006，12，21： | 9 |
| 5 | A short history of nuclear magnetic moments and GT transitions显示文摘We summarize the history and our present understanding of nuclear magnetic moments and Gamow-Teller transitions.The roles of configuration mixing,meson exchange currents and relativistic effects are examined.Experimental evidence for the importance of tensor correlations is also discussed. | ARIMA Akito | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，2： | 7 |
| 6 | A new index for non-invasive assessment of liver fibrosis显示文摘AIM:To construct and evaluate a new non-invasive fibrosis index for assessment of the stage of liver f ibrosis. METHODS:A new f ibrosis index (Fibro-Stiffness index) was developed in 165 of 285 patients with chronic hepatitis C, and was validated in the other 120 patients where liver biopsy was performed. Its usefulness was compared with liver stiffness (LS) measured by FibroScan, the aminotransferase-to-platelet ratio index, the Forns index and the FibroIndex. RESULTS: The Fibro-Stiffness index consists of LS,platelet count and prothrombin time. The values of the Fibro-Stiffness index differed signif icantly between neighboring f ibrosis stages except F0-F1. The area under the receiver operating characteristics curves of the Fibro-Stiffness index for prediction of F≥2 (0.90), F≥ 3 (0.90) and F= 4(0.92) in the estimation group and those for F≥ 3 (0.93) and F =4 (0.97) in the validation group were the highest among the 5 methods examined. The accuracy of the Fibro-Stiffness index had highest values for F≥2, F≥3 and F=4 in both the estimation and validation groups. The diagnostic performance for F= 4 was improved by a combination of the Fibro-Stiffness index with serum hyaluronic acid level. CONCLUSION: The Fibro-Stiffness index was constructed and validated. It showed superior diagnostic performance to other indices for F ≥ 2,3 and 4. | Naohiro Ichino Keisuke Osakabe Toru Nishikawa Hiroko Sugiyama Miho Kato Shiho Kitahara Senju Hashimoto Naoto Kawabe Masao Harata Yoshifumi Nitta Michihito Murao Takuji Nakano Yuko Arima Hiroaki Shimazaki Koji Suzuki Kentaro Yoshioka | 2010 | World Journal of Gastroenterology2010，16，38： | 7 |
| 7 | Relativistic description of second-order correction to nuclear magnetic moments with point-coupling residual interaction显示文摘Using the single particle states and the residual interaction derived from the relativistic point-coupling model with the PC-F1 parameter set,the second-order core polarization corrections to nuclear magnetic moments of LS closed shell nuclei ±1 nucleon with A = 15,17,39 and 41 are studied and compared with previous non-relativistic results.It is found that the second-order corrections are significant.With these corrections,the isovector magnetic moments of the concerned nuclei are well reproduced,especially those for A = 17 and A = 41. | LI Jian MENG Jie RING Peter YAO JiangMing ARIMA Akito | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，2： | 7 |
| 8 | Int J Cardiol:非高密度脂蛋白胆固醇与冠心病的死亡率相关显示文摘非高密度脂蛋白(HDL)的胆固醇水平,一般不受空腹状态或血清甘油三酯水平的影响,可能有助于预测未来的心血管事件。2016年6月15日的《International Journal of Cardiology》刊载了一项研究,旨在探讨一般日本人群中,非高密度脂蛋白胆固醇在致命性冠状动脉事件和卒中的发展中的作用。 | Ito T Arima H Fujiyoshi A | 2016 | 疾病监测2016，31，7： | 6 |
| 9 | 持续气道正压通气在预防阻塞性睡眠呼吸暂停患者心血管事件中的作用显示文摘阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)导致阵发性低氧血症,夜间交感神经系统激活,血压、氧化应激和炎症指标的升高以及高凝血症。较大的胸内负压波动也会给心脏和大血管施加机械应力。基于人群和睡眠诊所的队列研究显示,OSA与心脑血管事件,特别是脑卒中相关。 | McEvoy RD Antic NA Heeley E Luo Y Ou Q Zhang X Mediano O Chen R Drager LF Liu Z Chen G Du B McArdle N Mukherjee S Tripathi M Billot L Li Q Lorenzi-Filho G Barbe F Redline S Wang J Arima H Neal B White DP Grunstein RR Zhong N Anderson CS 练桂丽 叶鹏 | 2016 | 中华高血压杂志2016，24，11： | 4 |
| 10 | Intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT): a randomised pilot trial显示文摘 | Craig S Anderson Yining Huang Ji Guang Wang Hisatomi Arima Bruce Neal Bin Peng Emma Heeley Christian Skulina Mark W Parsons Jong Sung Kim Qing Ling Tao Yue Chun Li Jian Dong Jiang Li Wen Tai Jin Li Zhang En Xu Yan Cheng Stephane Heritier Lewis B Morgenste | 2008 | Lancet Neurology2008，，5： | 4 |
| 11 | Sentinel Node Micrometastases Have High Proliferative Potential in Gastric Cancer显示文摘 | Shigehiro Yanagita Shoji Natsugoe Yoshikazu Uenosono Tsutomu Kozono Katsuhiko Ehi Takaaki Arigami Hideo Arima Sumiya Ishigami Takashi Aikou | 2008 | Journal of Surgical Research2008，，2： | 4 |
| 12 | Effect of heparin on high glucose induced proliferation and expression of matrix metalloproteinases in normal human mesangial cells显示文摘Background The pathogenesis of diabetic nephropathy (DN) is a complex pathophysiological process.Its precise mechanism is not fully known. In recent years it has been recognized that synthesis of various extracelluar matrix (ECM) components may increase, and that degradation of ECM may decrease in DN. It was reported heparin could inhibit mesangial cells proliferation in vitro. The main aim of this study is to explore whether heparin inhibits proliferation of mesangial cells grown in high glucose concentration and to measure the effect of heparin on matrix metalloproteinases (MMPs) expression in mesangial cells. Methods The medium contained either low glucose (5 mmol/L) or high glucose (25 mmol/L). The concentrations of heparin in the culture medium were 0, 25, 50,100, 200 or 400 μg/mL. A metabolic (WST-1) assay was used to measure mesangial cell proliferation and Western blot analysis was used to measure MMPs expression of mesangial cells. Results Normal human mesangial cell (NHMC) proliferation was higher in high glucose (HG) medium than in low glucose (LG) medium. They showed a 1.93 fold expansion after 72 h in high glucose in contrast to a 1.63 fold expansion in low glucose. In the presence of heparin, mesangial cells proliferation was inhibited, which was more obvious at high glucose concentrations than at low glucose concentrations. In high glucose, with heparin concentration of 50, 100, 200 and 400 μg/mL, the mesangial cells showed a 0. 61 fold, 0.52 fold, 0.52 fold and 0.41 fold reductions in cell number compared to cells grown without heparin. In low glucose, only concentrations of 200 μg/mL and 400 μg/mL showed reduction in cell number, namely 0.54 fold and 0.45 fold, when compared to cells grown without heparin. In Western blot analysis,MMP1, MMP2, MMP3 and MMP9 was expressed by mesangial cells expressed in both high and low glucose concentrations, which was more prominent in high glucose medium. Incubation of heparin further increased expression of MMP1, MMP2, MMP3 and MMP9. Conclusions This study suggests that glucose can accelerate mesangial cell proliferation while heparin can reduce proliferation, being more obvious at high glucose concentrations. Higher glucose concentrations led to increased MMP expression, which may take part in the regulation of mesangial matrix synthesis and degradation. Addition of heparin resulted in a corresponding increase in MMP expression, most notably at high glucose concentrations, indicating a potentially renoprotective role in DN. | ZHOU Qiao-ling Yasumoto Yuichiro Tsukamoto Masatoshi Nozaki Tsuyoshi Sogabe Atsushi Harada Kouji ZHANG Yi-xiang LIN Xiao-yan ZHANG Yang-de Arima Terukatsu | 2005 | Journal of Central South University of Technology2005，12，z1： | 3 |
| 13 | 采用冲击磨粉碎木屑的试验研究显示文摘为了研究生物质粉碎的机理和优化粉碎参数,利用冲击磨在不同给料量下粉碎不同含水率的木屑,通过对样品平均粒径、特征粒径、形貌、单位能耗以及磨机的最大处理能力的分析,探索生物质粉碎的机理,通过综合考虑粉碎比和单位能耗来优化粉碎的参数。结果表明:特征粒径和平均粒径分别约为625、470μm,并随给料量增加先增加后减小;冲击磨的最大处理能力在14-22kg/h范围内,且随着原料含水率的增加呈近似线性下降趋势;单位能耗约为100~400kWh/t,且随含水率的增加而增加;冲击磨的粉碎主要方式随给料量的增加逐渐由冲击粉碎变为摩擦粉碎;木屑断裂方式随着水分含量的增加逐渐由脆性断裂转变为韧性断裂。 | 尚志新 吴成宝 盖国胜 杨玉芬 Kenichi Arima | 2011 | 中国粉体技术2011，17，6： | 3 |
| 14 | Effects of Early Intensive Blood Pressure-Lowering Treatment on the Growth of Hematoma and Perihematomal Edema in Acute Intracerebral Hemorrhage: The Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT)显示文摘 | Craig S. Anderson Yining Huang Hisatomi Arima Emma Heeley Christian Skulina Mark W. Parsons Bin Peng Qiang Li Steve Su Qing Ling Tao Yue Chun Li Jian Dong Jiang Li Wen Tai Jin Li Zhang En Xu Yan Cheng Lewis B. Morgenstern John Chalmers Ji Guang Wang | 2010 | Stroke2010，，2： | 3 |
| 15 | A review of the~1600 Ma sedimentation,volcanism,and tectono-thermal events in the Singhbhum craton,Eastern India显示文摘The Palaeoproterozoic-Mesoproterozoic transition(~1600 Ma) is a significant event in the Earth history as a global thermal perturbation affected the pre-1600 Ma landmasses.Like other cratonic blocks of the world,lithospheric thinning,sedimentation,magmatism,metamorphism and crustal melting/anatexis are associated with this significant geological event in the Singhbhum cratonic province of India.This paper is a review of sedimentological,magmatic and tectono-thermal events in the Singhbhum craton at~1600 Ma.The Palaeo-Mesoproterozoic sedimentation and volcanism in the Singhbhum craton took place in a terrestrial intracontinental rift setting.The available geochronological data are indicative of late Palaeoproterozoic to Neoproterozoic tectono-thermal events in the Chhotanagpur Granite Gneissic Complex(CGGC),an east-west trending arcuate belt of granite gneisses,migmatites and metasedi-mentary rocks.A detailed multidisciplinary geo-scientific investigation of the Dalma volcanic belt and the area to its north(Chandil Formation) and further north in CGGC will enable us to constrain the extant surface processes and crust-mantle interactions,the collision events between the North and South Indian cratonic blocks,and the position of India in the Columbia supercontinent. | Priyanka Chatterjee Shuvabrata De Marinah Ranaivoson Rajat Mazumder Makoto Arima | 2013 | Geoscience Frontiers2013，4，3： | 2 |
| 16 | The orbital g-factor and related sum rules显示文摘The renormalization of the orbital g-factor in nuclei is discussed on the basis of gauge invariance.The relation of the orbital g-factor to the integrated E1 photoabsorption cross section is reviewed,and its relation to the M1 sum rule for the scissors mode of deformed nuclei is examined. | BENTZ Wolfgang ARIMA Akito | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，2： | 2 |
| 17 | Oncoplastic Surgery for Japanese Patients with Centrally Located Breast Cancer: Partial Resection and Reconstruction Using a Local Skin-Glandular Flap显示文摘 | Yuko Kijima Heiji Yoshinaka Munetsugu Hirata Tadao Mizoguchi Sumiya Ishigami Akihiro Nakajo Hideo Arima Youta Kawasaki Shinichi Ueno Shoji Natsugoe | 2011 | Journal of US-China Medical Science2011，8，3： | 2 |
| 18 | Characteristic of Local Boiling Heat Transfer of Ammonia and Ammonia/Water Binary Mixture on the Plate Type Evaporator显示文摘Power generation using small temperature difference such as ocean thermal energy conversion(OTEC)and discharged thermal energy conversion(DTEC)is expected to be the countermeasures against global warming problem.As ammonia and ammonia/water are used in evaporators for OTEC and DTEC as working fluids,the research of their local boiling heat transfer is important for improvement of the power generation efficiency.Measurements of local boiling heat transfer coefficients were performed for ammonia/water mixture(z=0.9-1)on a vertical flat plate heat exchanger in a range of mass flux(7.5-15 kg/m2s),heat flux(15-23 kW/m 2),and pressure(0.7-0.9 MPa).The result shows that in the case of ammonia/water mixture,the local heat transfer coefficients increase with an increase of mass flux and composition of ammonia,and decrease with an increase of heat flux. | Akio OKAMOTO Hirofumi ARIMA Yasuyuki IKEGAMI | 2011 | Journal of Thermal Science2011，20，4： | 2 |
| 19 | Effect of transforming growth factor-β1 on human intrahepatic cholangiocarcinoma cell growth显示文摘AIM: To elucidate the biological effects of transforming growth factor-β1 (TGF-β1) on intrahepatic cholan- giocarcinoma (ICC). METHODS: We investigated the effects of TGF-β1 on human ICC cell lines (HuCCT1, MEC, and HuH-28) by monitoring the influence of TGF-β1 on tumor growth and interleukin-6 (IL-6) expression in ICC cells. RESULTS: All three human ICC cell lines produced TGF-β1 and demonstrated accelerated growth in the presence of TGF-β1 with no apoptotic effect. Studies on HuCCT1 revealed a TGF-β1-induced stimulation of the expression of TGF-β1, as well as a decrease in TGF-β1 mRNA expression induced by neutralizing anti-TGF-β1 antibody. These results indicate that TGF-β1 stimulates the production and function of TGF-β1 in an autocrine fashion. Further, IL-6 secretion was observed in all three cell lines and exhibited an inhibitory response to neutralizing anti-TGF-β1 antibody. Experiments using HuCCT1 revealed a TGF-β1-induced acceleration of IL-6 protein expression and mRNA levels. These findings demonstrate a functional interaction between TGF-β1 and IL-6. All three cell lines proliferated in the presence of IL-6. In contrast, TGF-β1 induced no growth effect in HuCCT1 in the presence of small interfering RNA against a specific cell surface receptor of IL-6 and signal transducer and activator of transcription-3. CONCLUSION: ICC cells produce TGF-β1 and confer a TGF-β1-induced growth effect in an autocrine fashion.TGF-β1 activates IL-6 production, and the functional interaction between TGF-β1 and IL-6 contributes to ICC cell growth by TGF-β1. | Tetsuya Shimizu Shigeki Yokomuro Yoshiaki Mizuguchi Yutaka Kawahigashi Yasuo Arima Nobuhiko Taniai Yasuhiro Mamada Hiroshi Yoshida Koho Akimaru Takashi Tajiri | 2006 | World Journal of Gastroenterology2006，12，39： | 2 |
| 20 | Ameliorating effects of dan-shen and its major ingredient calcium/magnesium lithospermate B on cognitive deficiencies in senescence-accelerated mouse 显示文摘 | Arima T Namba T | 1997 | Nippon Yakurigaku Zasshi1997，110，1： | 1 |
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