3篇
您的检索式：作者名="Mark M.Jones"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 几种络合剂的驱铅效果实验显示文摘小鼠一次或多次腹腔注射醋酸铅后,分别投给DMSA、Na_2CaEDTA、DPA、Na_3CaDTPA 和DMPS 测定这几种络合剂降低肝、肾、脾、骨和脑组织铅含量的效应。结果发现,在一些实验条件下,用络合剂处理后小鼠肝、肾、骨和脑铅含量明显低于对照组。检测的几种络合剂中,不论腹腔注射还是胃管注入DMSA,其从组织中驱铅的能力均比其它种络合剂更有效。结果提示这种络合剂是有发展前途的,值得临床上深入研究。 | 徐兆发 Mark M.Jones | 1990 | 中华劳动卫生职业病杂志1990，8，5： | 5 |
| 2 | Mobilization of Lead by Several Chelating Agents in Mice Injected with Lead显示文摘The relative abilities of several chelating agents to act as antagonists for acute and chronic lead poisoning have been examined in the mouse.The acute LD50 for lead acetate trihydrate was determined and found to be 135.3 mg Pb/kg for i. p. injection with a 95% confidence interval of 87.1 to 210.3 mg Pb/kg. The relative efficacy of chelating agents to reduce liver,kidney, spleen, bone and brain levels of lead was determined. The spleen levels were found to undergo little differences between the control and treated groups, but the liver, kidney, bone and brain levels showed significant differences in some cases. Of the compounds examind, meso-2, 3-dimercaptosuccinic acid (DMSA)and sodium 2,3-dimercaptopropane-1-sulfonate(DMPS) were as effective as disodium calcium ethylenediaminetetraacetate (Na2CaEDT A). The resuits indicated that DMSA was a promising chelating agent and may be worthy of further investigation in the clinic. | 徐兆发 Mark M.Jones | 1989 | 中国医科大学学报1989，18，S2： | 0 |
| 3 | Dim artificial light at night reduces the cellular immune response of the black field cricket, Teleogryllus commodus显示文摘A functioning immune system is crucial for protection against disease and illness,yet increasing evidence suggests that species living in urban areas could be suffering from immune suppression,due to the presence of artificial light at night(ALAN).This study examined the effects of ecologically relevant levels of ALAN on three key measures of immune function(haemocyte concentration,lytic activity,and phenoloxidase activity)using a model invertebrate species,the Australian black field cricket,Teleogryllus commodus.We reared crickets under an ecologically relevant daily light‐cycle consisting of 12 hr bright daylight(2600 lx)followed by either 12 h darkness(0 lx)or dim environmentally relevant ALAN(1,10,100 lx),and then assessed immune function at multiple time points throughout adult life using haemolymph samples.We found that the presence of ALAN had a clear negative effect on haemocytes,while the effects on lytic activity and phenoloxidase activity were more complex or largely unaffected by ALAN.Furthermore,the effects of lifelong exposure to ALAN of 1 lx were comparable to those of 10 and 100 lx.Our data suggest that the effects of ALAN could be large and widespread,and such reductions in the core immune response of individuals will likely have greater consequences for fitness and survival under more malign conditions,such as those of the natural environment. | Joanna Durrant Mark P.Green Theresa M.Jones | 2020 | Insect Science2020，27，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员