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| 1 | Predictors of mortality after transjugular portosystemic shunt显示文摘AIM:To investigate if echocardiographic and hemodynamic determinations obtained at the time of transjugular intrahepatic portosystemic shunt(TIPS)can provide prognostic information that will enhance risk stratification of patients.METHODS:We reviewed medical records of 467 patients who underwent TIPS between July 2003 and December 2011 at our institution.We recorded information regarding patient demographics,underlying liver disease,indication for TIPS,baseline laboratory values,hemodynamic determinations at the time of TIPS,and echocardiographic measurements both before and after TIPS.We recorded patient comorbidities that may affect hemodynamic and echocardiographic determinations.We also calculated Model for Endstage Liver Disease(MELD)score and Child Turcotte Pugh(CTP)class.The following pre-and post-TIPS echocardiographic determinations were recorded:Left ventricular ejection fraction,right ventricular(RV)systolic pressure,subjective RV dilation,and subjective RV function.We recorded the following hemodynamic measurements:Right atrial(RA)pressure before and after TIPS,inferior vena cava pressure before and after TIPS,free hepatic vein pressure,portal vein pressure before and after TIPS,and hepatic venous pressure gradient(HVPG).RESULTS:We reviewed 418 patients with portal hypertension undergoing TIPS.RA pressure increased by a mean ± SD of 4.8 ± 3.9 mmH g(P < 0.001),HVPG decreased by 6.8 ± 3.5 mmH g(P < 0.001).In multivariate linear regression analysis,a higher MELD score,lower platelet count,splenectomy and a higher portal vein pressure were independent predictors of higher RA pressure(R = 0.55).Three variables predicted 3-mo mortality after TIPS in a multivariate analysis:Age,MELD score,and CTP grade C.Change in the RA pressure after TIPS predicted long-term mortality(per 1 mm Hg change,HR = 1.03,95%CI:1.01-1.06,P < 0.012).CONCLUSION:RA pressure increased immediately after TIPS particularly in patients with worse liver function,portal hypertension,emergent TIPS placement and history of splenectomy.The increase in RA pressure after TIPS was associated with increased mortality.Age,splenectomy,MELD score and CTP grade were independent predictors of long-term mortality after TIPS. | Mona Ascha Sami Abuqayyas Ibrahim Hanouneh Laith Alkukhun Mark Sands Raed A Dweik Adriano R Tonelli | 2016 | World Journal of Hepatology2016，8，11： | 13 |
| 2 | Arylamine N-acetyltransferase 2 genotype-dependent N-acetylation of isoniazid in cryopreserved human hepatocytes显示文摘Cryopreserved human hepatocytes were used to investigate the role of arylamine Nacetyltransferase 2(NAT2; EC 2.3.1.5) polymorphism on the N-acetylation of isoniazid(INH). NAT2 genotype was determined by Taqman allelic discrimination assay and INH N-acetylation was measured by high performance liquid chromatography. INH N-acetylation rates in vitro exhibited a robust and highly significant(P o0.005) NAT2 phenotype-dependent metabolism. N-acetylation rates in situ were INH concentration-and time-dependent. Following incubation for 24 h with 12.5 or 100 mmol/L INH, acetylINH concentrations varied significantly(P = 0.0023 and P = 0.0002) across cryopreserved human hepatocytes samples from rapid, intermediate, and slow acetylators, respectively. The clear association between NAT2 genotype and phenotype supports use of NAT2 genotype to guide INH dosing strategies in the treatment and prevention of tuberculosis. | Mark A.Doll Raúl A.Salazar-González Srineil Bodduluri David W.Hein | 2017 | Acta Pharmaceutica Sinica B2017，7，4： | 3 |
| 3 | The CNS phenotype of X-linked Charcot-Marie-Tooth disease-More than a peripheral problem显示文摘 | Simon EM Marks HE | 2003 | Neurology2003，61，： | 1 |
| 4 | Ultrasound effect on osteoblast precursor cells in trabecular calcium phosphate scaffolds显示文摘 | Mark RA Sunho Oh Judith AC | 2007 | Biomaterials2007，28，32： | 1 |
| 5 | Histone deacetylases and cancer: causes and therapies 显示文摘 | Marks P Rifkind RA Richon VM | 2001 | Nat Rev Cancer2001，1，： | 1 |
| 6 | Histone deacetylases and cancer:causes and therapies显示文摘 | Marks P Rifkind RA Richon VM | 2001 | Nat Rre Cancer2001，1，3： | 1 |
| 7 | Histone deacetylases and cancer: causes and therapies显示文摘 | Marks P Rifkind RA Richon VM | 2001 | Nat Rev Cancer2001，1，3： | 1 |
| 8 | Broken pump or leak filter? Renal dysfunction in heart failure a contemporary review显示文摘 | Petrie CJ Mark PB Weir RA | 2008 | Int J Cardiol2008，128，2： | 1 |
| 9 | Histone deacetylases and cancer: causes and therapies显示文摘 | Marks P Ritkind RA Richon VM | 2001 | Nat Rev Cancer2001，1，： | 1 |
| 10 | p53 mutations in colorectal cancer显示文摘 | Nanda R Rowan RA Mark EF | 1990 | Proc Natl Acad Sci USA1990，87，： | 1 |
| 11 | Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells显示文摘 | Richon VM Rifkind RA | 2000 | J Natl Cancer Inst2000，92，15： | 1 |
| 12 | Histone deacetylases and cancer:causes and therapies显示文摘 | Marks PA Rifkind RA Richon VM | 2001 | Nature2001，1，3： | 1 |
| 13 | Conventional cytogenetics and FISH in the detection of BCR/ABL fusion in chronic myeloid leu- kemia (CML) 显示文摘 | Mark HF Sokolic RA Mark Y | 2006 | Exp Mol Pathol2006，81，1： | 1 |
| 14 | Hippocampal sclerosis: MR prediction of seizure intractability显示文摘 | Briellmann RS Mark Wellard R Masterton RA | 2007 | Epilepsia2007，48，： | 1 |
| 15 | Histone deacety-lases and cancer: causes and therapies显示文摘 | Marks P Rifkind RA Richon VM | 2001 | Nat Rev Cancer2001，1，： | 1 |
| 16 | Histone deacetylase inhibitors: inducers of differentiation or transformed cells 显示文摘 | Marks PA Richon VM Rifkind RA | 2000 | J Natl Cancer Inst2000，92，15： | 1 |
| 17 | Control of GL2 expression in Arabidopsis leaves and trichomes显示文摘 | Szymanski DB Jilk RA Pollock SM Marks MD | 1998 | Development1998，125，7： | 1 |
| 18 | Histone deacetylases and cancer:causes and therapies显示文摘 | Marks PA Rifkind RA Richon VM | 2001 | Nature Review Cancer2001，1，： | 1 |
| 19 | Molecular and immunological characterization of Mycobacterium tuberculosis CFP-10,an immunodiagnostic antigen missing in Mycobacterium bivis BCG显示文摘 | Davin CD Mark RA Craig HD | 2000 | J Clin Microbiolo2000，38，9： | 1 |
| 20 | Molecular and immunological characterization of M ycobacterium tuberculosis CFP10,an immunodiagnostic antigen missing in Mycobacterium bivis BCG显示文摘 | Davin CD Mark RA Craig HD | | 0，，09： | 1 |
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