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| 1 | Oxidative stress and male reproductive health显示文摘有缺点的精子功能的主要原因之一是氧化应力,它不仅破坏精子 DNA 的正直而且在精子血浆膜由于蛋白质和类脂化合物的并行的损坏限制这些房间的使肥沃的潜力。如此的氧化压力的起源看起来包含精子线粒体,它有一个趋势作为一篇序言产生 superoxide 阴离子的高水平到进入内在的 apoptotic 串联。不幸地,这些房间有很小的能力因为他们仅仅在基础切除修理(BER ) 拥有第一酶,对如此的攻击作出回应小径, 8-oxoguanine glycosylase 1 (OGG1 ) 。后者成功地创造一个 abasic 地点,而是精子因为他们缺乏下游的蛋白质,不能进一步处理氧化损害(APE1, XRCC1 ) 需要完成修理过程。在第一个有丝分裂的部门的 S 阶段的开始以前继续 BER 小径是卵母细胞的责任。如果一个错误被卵母细胞在开发的这个阶段犯,一个变化将被创造那将在身体在每个房间被代表。如此的机制可以在在作为年龄的后果在他们的细菌线承受了氧化应力的男性的后代观察的童年癌症和另外的疾病解释增加,环境或生活方式因素。在男不孕病人的精子的氧化 DNA 损坏的高流行可以为在 vitro 构思的孩子的健康有含意并且在细菌线为对免费激进的产生的起源的当前的研究担任一位司机。 | Robert J Aitken Tegan B Smith Matthew S Jobling Mark A Baker Geoffry N De Iuliis | 2014 | Asian Journal of Andrology2014，16，1： | 48 |
| 2 | 卒中相关性肺炎的诊断卒中肺炎共识小组的推荐意见显示文摘背景和目的下呼吸道感染常并发于卒中并对转归造成不利影响。对于并发于卒中的下呼吸道感染性疾病,目前尚无公认的专业术语或诊断金标准,这导致临床诊疗和研究受到影响。本共识旨在提出急性卒中并发下呼吸道感染的标准化术语和可操作性诊断标准。方法对多个文献数据库进行系统检索,经过证据回顾和2轮讨论,最后于2014年9月在英国曼彻斯特召开共识会议,经75%以上共识小组成员达成一致意见后形成共识。结果达成的共识如下:(1)推荐使用卒中相关性肺炎(stroke-associated pneumonia, SAP )作为卒中发病后7 d内发生的下呼吸道感染性疾病的专业术语。(2)提议对 SAP 使用经过改良的美国疾病控制预防中心(Centers for Disease Control and Prevention, CDC)诊断标准:①很可能的 SAP:符合 CDC 诊断标准,但复查或动态监测胸部 X 片仍缺乏典型改变;②确诊的 SAP:符合 CDC 诊断标准,且胸部 X 片有典型改变。(3)关于白细胞计数或 C反应蛋白在 SAP 诊断中的作用证据有限。(4)其他生物学标记物(如降钙素原)的证据不足。结论提议根据 CDC 诊断标准对 SAP 的术语和诊断制定可操作性的共识标准,需要在卒中患者中进行前瞻性研究来确定其信度、效度以及对医生行为(包括抗生素选择)和临床转归的影响。 | Craig J. Smith Amit K Kishore Andy Vail Angel Chamorro Javier Garau Stephen J. Hopkins Mario Di Napoli Lalit Kalra Peter Langhorne Joan Montaner Christine Roffe Anthony G. Rudd Pippa J. TyrreU Diederik van de Peek Mark Woodhead Andreas Meisel 范琳琳 宿英英 | 2016 | 国际脑血管病杂志2016，24，2： | 17 |
| 3 | Science:'记忆碎片'是真的吗?显示文摘半个多世纪以来,神经学家们一直以为长期记忆是由于多个短期记忆储存起来形成的。而最近一项对记忆形成的神经回路的研究则表明这一说法有可能是错的,因为两种类型的记忆(长期与短期)能够同时产生。这项研究是由来自MIT的研究者们做出。他们参考了此前标记特殊”记忆”细胞的手段,并更进一步地强制性使小鼠对特定的记忆作出反应。并且断开了长期与短期记忆的连接。 | Takashi Kitamura Mark D. Morrissey Lillian M. Smith Roger L. Redondo | 2017 | 现代生物医学进展2017，17，17： | 11 |
| 4 | Neuronal failure in Alzheimer's disease: a view through the oxidative stress looking-glass显示文摘Considerable debate and controversy surround the cause(s) of Alzheimer's disease(AD). To date, several theories have gained notoriety, however none is universally accepted. In this review, we provide evidence for the oxidative stress-induced AD cascade that posits aged mitochondria as the critical origin of neurodegeneration in AD. | David J. Bonda Xinglong Wang Hyoung-Gon Lee Mark A. Smith George Perry Xiongwei Zhu | 2014 | Neuroscience Bulletin2014，30，2： | 7 |
| 5 | Cancer treatment and survivorship statistics, 2012显示文摘 | Rebecca Siegel Carol DeSantis Katherine Virgo Kevin Stein Angela Mariotto Tenbroeck Smith Dexter Cooper Ted Gansler Catherine Lerro Stacey Fedewa Chunchieh Lin Corinne Leach Rachel Spillers Cannady Hyunsoon Cho Steve Scoppa Mark Hachey Rebecca Kirch Ahmed | 2012 | CA: A Cancer Journal for Clinicians2012，，4： | 6 |
| 6 | Endoscopic retrograde cholangiography for pediatric choledocholithiasis: Assessing the need for endoscopic intervention显示文摘AIM:To assess pediatric patients for choledocholithiasis.We applied current adult guidelines to identify predictivefactors in children.METHODS:A single-center retrospective analysis was performed at a tertiary children's hospital.We evaluated 44 consecutive pediatric patients who underwent endoscopic retrograde cholangiography(ERCP) for suspected choledocholithiasis.Patients were stratified into those with common bile duct stones(CBDS) at ERCP vs those that did not using the American Society of Gastrointestinal Endoscopy(ASGE) guidelines(Very Strong and Strong criteria) for suspected CBDS.RESULTS:CBDS were identified in 84% at the time of ERCP.Abdominal ultrasound identified CBDS in 36% of patients.Conjugated bilirubin ≥ 0.5 mg/d L was an independent risk factor for CBDS(P = 0.003).The Very Strong(59.5%) and Strong(48.6%) ASGE criteria identified the majority of patients(P = 0.0001).A modified score using conjugated bilirubin had a higher sensitivity(81.2% vs 59.5%) and more likely to identify a stone than the standard criteria,odds ratio of 25.7 compared to 8.8.Alanine aminotransferase and gamma-glutamyl transferase values identified significant differences in a subset of patients with odds ratio of 4.1 and 3.25,respectively.CONCLUSION:Current adult guidelines identified the majority of pediatric patients with CBDS,but specific pediatric guidelines may improve detection,thus decreasing risks and unnecessary procedures. | Douglas S Fishman Bruno P Chumpitazi Isaac Raijman Cynthia Man-Wai Tsai E O’Brian Smith Mark V Mazziotti Mark A Gilger | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，11： | 6 |
| 7 | Mass Spectrometric Analyses Reveal a Central Role for Ubiquitylation in Remodeling the Arabidopsis Proteome during Photomorphogenesis显示文摘 | Victor Aguilar-Hernandez Do-Young Kim Robert J. Stankey Mark Scalf Lloyd M. Smith Richard D. Vierstra | 2017 | Molecular Plant2017，10，6： | 6 |
| 8 | Divalent metal transporter, iron, and Parkinson's disease: A pathological relationship显示文摘 | Hyun-pil Lee Xiongwei Zhu Gang Liu Shu G Chen George Perry Mark A Smith Hyoung-gon Lee | 2010 | Cell Research2010，20，4： | 5 |
| 9 | Handgrip strength and health outcomes: Umbrella review of systematic reviews with meta-analyses of observational studies显示文摘Purpose:The aim of the present study was to assess both the credibility and strength of evidence arising from systematic reviews with meta-analyses of observational studies on handgrip strength and health outcomes.Methods:An umbrella review of systematic reviews with meta-analyses of observational studies was conducted.We assessed meta-analyses of observational studies based on random-effect summary effect sizes and their p values,95%prediction intervals,heterogeneity,small-study effects,and excess significance.We graded the evidence from convincing(Class I)to weak(Class IV).Results:From 504 articles returned in a search of the literature,8 systematic reviews were included in our review,with a total of 11 outcomes.Overall,nine of the 11 of the outcomes reported nominally significant summary results(p<0.05),with 4 associations surviving the application of the more stringent p value(p<106).No outcome presented convincing evidence.Three associations showed Class II evidence(i.e.,highly suggestive):(1)higher handgrip values at baseline were associated with a minor reduction in mortality risk in the general population(n=34 studies;sample size=1,855,817;relative risk=0.72,95%confidence interval(95%CI):0.670.78),(2)cardiovascular death risk in mixed populations(n=15 studies;relative risk=0.84,95%CI:0.780.91),and(3)incidence of disability(n=7 studies;relative risk=0.76,95%CI:0.660.87).Conclusion:The present results show that handgrip strength is a useful indicator for general health status and specifically for early all-cause and cardiovascular mortality,as well as disability.To further inform intervention strategies,future research is now required to fully understand mechanisms linking handgrip strength scores to these health outcomes. | Pinar Soysal Christopher Hurst Jacopo Demurtas Joseph Firth Reuben Howden Lin Yang Mark A.Tully Ai Koyanagi Petre Cristian Ilie Guillermo F.Lopez-Sanchez Lukas Schwingshackl Nicola Veronese Lee Smith | 2021 | Journal of Sport and Health Science2021，10，3： | 5 |
| 10 | Karrikin and Cyanohydrin Smoke Signals Provide Clues to New Endogenous Plant Signaling Compounds显示文摘表明混合物的二种新类型由于他们刺激种子萌芽的能力在野火烟被发现了。第一发现了是 karrikins,它与植物荷尔蒙的 strigolactone 类分享某结构的类似,并且两个都通过普通 F 盒子蛋白质发信号。然而, karrikins 和 strigolactones 通过不那样不同的发信号的小径操作,各由特定的 / hydrolase 蛋白质区分了。基因分析建议植物包含通过 karrikin 小径明确地发信号的内长的混合物。在烟发现的另外的活跃混合物是在水解作用之上释放刺激萌芽的氰化物的氰醇。氰醇在植物广泛地发生并且在内长的氰化物发信号对另外的有机体,而是一个另外的角色在防卫有一个角色现在应该也被考虑。 | Gavin R. Flematti Mark T. Waters Adrian Scaffidi David J. Merritt Emilio L. Ghisalberti' Kingsley W.Dixon Steven M. Smith | 2013 | Molecular Plant2013，6，1： | 3 |
| 11 | 中国人群孕前队列研究先兆子痫:原理、研究方法和基线结果(英文)显示文摘目的:目前尚不清楚先兆子痫是由孕前因素还是妊娠因素所引起。本研究通过在中国湖南地区建立孕前队列以阐明先兆子痫的病因。方法:本研究拟在湖南浏阳地区招募5000对半年内有怀孕打算的未孕夫妇,并追踪研究对象的怀孕、分娩及产后情况。结果:目前本孕前队列共招募了1915对未孕夫妇。与孕前相比较,产妇的收缩压和舒张压在孕中早期有所下降,然而在孕后期有所上升。结论:孕前队列的建立将对孕期先兆子痫及产后心血管疾病的预防发挥重要的理论和实际意义。 | 文师吾 谭红专 谢日华 Graeme N. Smith Mark Walker | 2012 | 中南大学学报(医学版)2012，37，11： | 3 |
| 12 | Exploring relationships among IT-enabled sharing capability, supply chain flexibility, and competitive performance显示文摘 | Yan Jin Mark Vonderembse T.S. Ragu-Nathan Joy Turnheim Smith | 2014 | International Journal of Production Economics2014，，： | 2 |
| 13 | Differential Targeting of Prosurvival Bcl-2 Proteins by Their BH3-Only Ligands Allows Complementary Apoptotic Function显示文摘 | Lin Chen Simon N. Willis Andrew Wei Brian J. Smith Jamie I. Fletcher Mark G. Hinds Peter M. Colman Catherine L. Day Jerry M. Adams David C.S. Huang | 2005 | Molecular Cell2005，，3： | 2 |
| 14 | The safety of tenofovir disoproxil fumarate for the treatment of HIV infection in adults: the first 4 years显示文摘 | Mark R Nelson Christine Katlama Julio S Montaner David A Cooper Brian Gazzard Bonaventura Clotet Adriano Lazzarin Knud Schewe Joep Lange Christina Wyatt Sue Curtis Shan-Shan Chen Stephen Smith Norbert Bischofberger James F Rooney | 2007 | AIDS2007，，10： | 2 |
| 15 | Earnings management and cross listing: Are reconciled earnings comparable to US earnings?显示文摘 | Mark Lang Jana Smith Raedy Wendy Wilson | 2006 | Journal of Accounting and Economics2006，，1： | 2 |
| 16 | Cancer treatment and survivorship statistics, 2012显示文摘 | Rebecca Siegel Carol DeSantis Katherine Virgo Kevin Stein Angela Mariotto Tenbroeck Smith Dexter Cooper Ted Gansler Catherine Lerro Stacey Fedewa Chunchieh Lin Corinne Leach Rachel Spillers Cannady Hyunsoon Cho Steve Scoppa Mark Hachey Rebecca Kirch Ahmed | 2012 | CA: A Cancer Journal for Clinicians2012，，4： | 2 |
| 17 | The Systemic Inflammatory Response to Cardiopulmonary Bypass: Pathophysiological, Therapeutic, and Pharmacological Considerations显示文摘 | Richard I. Hall Mark Stafford Smith Graeme Rocker | 1997 | Anesthesia & Analgesia1997，，4： | 2 |
| 18 | Geographic categories:an ontological investigation显示文摘 | SMITH B MARK D | 2001 | International Journal of Geographic Information Science2001，15，7： | 2 |
| 19 | Cash flows and leverage adjustments显示文摘 | Michael Faulkender Mark J. Flannery Kristine Watson Hankins Jason M. Smith | 2011 | Journal of Financial Economics2011，，： | 2 |
| 20 | Fracture pattern and fixation type related to loss of reduction in bicondylar tibial plateau fractures显示文摘 | Michael J. Weaver Mitchel B. Harris Adam C. Strom R. Malcolm Smith David Lhowe David Zurakowski Mark S. Vrahas | 2011 | Injury2011，，6： | 1 |
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