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| 1 | 限制热量摄入6个月对超重者寿命指标、代谢调节及氧化应激的影响——随机对照试验AuthorAffiliations:PenningtonBiomedicalResearchCenter.LouisianaStateUniversity.BatonRouge;andGarvan.InstituteforMedicalResearch.Dadinghurst,AustraIia(DrHeilbronn).显示文摘背景:长期限制热量摄入可延长啮齿类动物的寿命。但是,尚未有研究观测长期限制人体热量是否会影响其寿命及氧化应激指标,降低代谢率。
目的:在超重但不肥胖(体重指数为25—30)的人群中研究限制热量6个月伴/不伴运动对其产生的影响。
设计、地点及参试者:于2002年3月至2004年8月在位于路易斯安娜州首府巴顿鲁治的研究中心对48名不好动的健康人进行随机对照研究。
干预:参试者在6个月内随机分为4个组:对照组(饮食可维持体重);限制热量组(限制基线所需能量的25%);限制热量+运动组(限制12.5%的热量+运动增加12.5%的能耗);极低热量饮食组(每日摄入890keal,直至体重减少15%,随后采用维持体重的饮食)。
主要观测指标:机体组成;硫酸脱氢表雄酮(dehydroepiandrostemne sulfate,DHEAS)、葡萄糖及胰岛素水平;蛋白羰基化合物;DNA损伤;24小时能耗;核心体温。
结果:6个月时各组体重变化的均值(标准误)为:对照组-1.0%(1.1%);限制热量组-10.4%(0.9%);限制热量+运动组-10.0%(0.8%);极低热量饮食组-13.9%(0.7%)。6个月时,各干预组空腹血糖水平较基线明显降低(P均〈0.01),而DHEAS和葡萄糖水平没有改变。限制热量组及限制热量+运动组核心体温有所下降(P均〈0.05)。对机体组成进行校正后发现,对照组24小时静息能耗无变化,但限制热量组(-135kcal/d[42kcal/d])、限制热量+运动组(-117kcal/d[52kcal/d])和极低热量饮食组(-125kcal/d[35kcal/d])24小时静息能耗有所下降(P均〈0.008)。上述“代谢调节”(超出预计值的-6%)与对照组相比存在显著差异(P〈0.05)。6个月时,各组蛋白羰基化合物的浓度较基线时无变化,而各干预组DNA损伤有所减少(P〈0.005)。
结论:我们的研究结果显示,长期限制热量可降低人类寿命的2种指标(即空腹胰岛素水平和体温)。此外,我们的研究结果还支持下述理论,即限制热量能降低代谢率,且超过缩小代谢面积产生的相应效应。我们尚需开展远期研究来评价限制热量能否延缓人类衰老过程。 | Leonie K. Heibronn Lilian de Jonge Madlyn I. Frisard James P. DeLany D. Enette Larson-Meyer Jennifer Rood Tuong Nguyen Corby K. Martin Julia Volaufova Marlene M. Most Frank L. Greenway Steven R. Smith Walter A. Deutsch Donald A. Williamson Eric Ravussin 顾佳(译) | 2006 | 美国医学会杂志(中文版)2006，25，5： | 18 |
| 2 | AHA/ACC Guidelines for Secondary Prevention for Patients With Coronary and Other Atherosclerotic Vascular Disease: 2006 Update: Endorsed by the National Heart, Lung, and Blood Institute显示文摘 | Sidney C. Smith Jerilyn Allen Steven N. Blair Robert O. Bonow Lawrence M. Brass Gregg C. Fonarow Scott M. Grundy Loren Hiratzka Daniel Jones Harlan M. Krumholz Lori Mosca Richard C. Pasternak Thomas Pearson Marc A. Pfeffer Kathryn A. Taubert | 2006 | Circulation2006，，19： | 4 |
| 3 | Karrikin and Cyanohydrin Smoke Signals Provide Clues to New Endogenous Plant Signaling Compounds显示文摘表明混合物的二种新类型由于他们刺激种子萌芽的能力在野火烟被发现了。第一发现了是 karrikins,它与植物荷尔蒙的 strigolactone 类分享某结构的类似,并且两个都通过普通 F 盒子蛋白质发信号。然而, karrikins 和 strigolactones 通过不那样不同的发信号的小径操作,各由特定的 / hydrolase 蛋白质区分了。基因分析建议植物包含通过 karrikin 小径明确地发信号的内长的混合物。在烟发现的另外的活跃混合物是在水解作用之上释放刺激萌芽的氰化物的氰醇。氰醇在植物广泛地发生并且在内长的氰化物发信号对另外的有机体,而是一个另外的角色在防卫有一个角色现在应该也被考虑。 | Gavin R. Flematti Mark T. Waters Adrian Scaffidi David J. Merritt Emilio L. Ghisalberti' Kingsley W.Dixon Steven M. Smith | 2013 | Molecular Plant2013，6，1： | 3 |
| 4 | The Combination of Ribavirin and Peginterferon Is Superior to Peginterferon and Placebo for Children and Adolescents With Chronic Hepatitis C显示文摘 | Kathleen B. Schwarz Regino P. Gonzalez–Peralta Karen F. Murray Jean P. Molleston Barbara A. Haber Maureen M. Jonas Philip Rosenthal Parvathi Mohan William F. Balistreri Michael R. Narkewicz Lesley Smith Steven J. Lobritto Stephen Rossi Alexandra Valsamaki | 2011 | Gastroenterology2011，，2： | 2 |
| 5 | Risk of Thromboembolism Following Acute Intracerebral Hemorrhage显示文摘 | Joshua N. Goldstein Louis E. Fazen Lauren Wendell Yuchiao Chang Natalia S. Rost Ryan Snider Kristin Schwab Rishi Chanderraj Christopher Kabrhel Catherine Kinnecom Emilie FitzMaurice Eric E. Smith Steven M. Greenberg Jonathan Rosand | 2009 | Neurocritical Care2009，，1： | 1 |
| 6 | 2009 Focused Updates: ACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction (Updating the 2004 Guideline and 2007 Focused Update) and ACC/AHA/SCAI Guidelines on Percutaneous Coronary Intervention (Updating the 2005 Guid显示文摘 | Frederick G. Kushner Mary Hand Sidney C. Smith Spencer B. King Jeffrey L. Anderson Elliott M. Antman Steven R. Bailey Eric R. Bates James C. Blankenship Donald E. Casey Lee A. Green Judith S. Hochman Alice K. Jacobs Harlan M. Krumholz Douglass A. Morrison | 2009 | Circulation2009，，22： | 1 |
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| 10 | Comparison of Hematoma Shape and Volume Estimates in Warfarin Versus Non-Warfarin-Related Intracerebral Hemorrhage显示文摘 | Kevin N. Sheth Tracy A. Cushing Lauren Wendell Michael H. Lev Javier M. Romero Kristin Schwab Eric E. Smith Steven M. Greenberg Jonathan Rosand Joshua N. Goldstein | 2010 | Neurocritical Care2010，，1： | 1 |
| 11 | Prediction of Functional Outcome in Patients With Primary Intracerebral Hemorrhage: The FUNC Score显示文摘 | Natalia S. Rost Eric E. Smith Yuchiao Chang Ryan W. Snider Rishi Chanderraj Kristin Schwab Emily FitzMaurice Lauren Wendell Joshua N. Goldstein Steven M. Greenberg Jonathan Rosand | 2008 | Stroke2008，，8： | 1 |
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| 13 | Structural and Functional Consequences of Mitochondrial Biogenesis in Human Adipocytes in Vitro显示文摘 | Iwona Bogacka Barbara Ukropcova Michele McNeil Jeffrey M. Gimble Steven R. Smith | 2005 | The Journal of Clinical Endocrinology & Metabolism2005，，12： | 1 |
| 14 | Global Warming Potentials: 1. Climatic Implications of Emissions Reductions显示文摘 | Steven J. Smith M. L. Wigley | 2000 | Climatic Change2000，，4： | 1 |
| 15 | AHA/ACC Guidelines for Secondary Prevention for Patients With Coronary and Other Atherosclerotic Vascular Disease: 2006 Update显示文摘 | Sidney C. Smith Jerilyn Allen Steven N. Blair Robert O. Bonow Lawrence M. Brass Gregg C. Fonarow Scott M. Grundy Loren Hiratzka Daniel Jones Harlan M. Krumholz Lori Mosca Richard C. Pasternak Thomas Pearson Marc A. Pfeffer Kathryn A. Taubert | 2006 | Journal of the American College of Cardiology2006，，10： | 1 |
| 16 | Anatomic Pattern of Intracerebral Hemorrhage Expansion: Relation to CT Angiography Spot Sign and Hematoma Center显示文摘 | Grégoire Boulouis Andrew Dumas Rebecca A. Betensky H. Bart Brouwers Panagiotis Fotiadis Anastasia Vashkevich Alison Ayres Kristin Schwab Javier M. Romero Eric E. Smith Anand Viswanathan Joshua N. Goldstein Jonathan Rosand M. Edip Gurol Steven M. Greenberg | 2014 | Stroke2014，，： | 1 |
| 17 | Clinical Value of Combined Positron Emission Tomography/Computed Tomography Imaging in the Interpretation of 2-Deoxy-2-[F-18]fluoro-d-glucose–Positron Emission Tomography Studies in Cancer Patients显示文摘 | Henry W. D. Yeung MD Heiko Sch?der MD Alex Smith MS Mithat Gonen PhD Steven M. Larson MD | 2005 | Molecular Imaging and Biology2005，，3： | 1 |
| 18 | Safety and efficacy of endoscopic spray cryotherapy for Barrett’s esophagus with high-grade dysplasia显示文摘 | Nicholas J. Shaheen Bruce D. Greenwald Anne F. Peery John A. Dumot Norman S. Nishioka Herbert C. Wolfsen J. Steven Burdick Julian A. Abrams Kenneth K. Wang Damien Mallat Mark H. Johnston Alvin M. Zfass Jenny O. Smith James S. Barthel Charles J. Lightdale | 2010 | Gastrointestinal Endoscopy2010，，4： | 1 |
| 19 | Myostatin maps to the interval containing the bovine mh locus显示文摘 | Timothy P.L. Smith Nestor L. Lopez-Corrales Steven M. Kappes Tad S. Sonstegard | 1997 | Mammalian Genome1997，，10： | 1 |
| 20 | Genetic Predictors and Remodeling of Dilated Cardiomyopathy in Muscular Dystrophy显示文摘 | John L. Jefferies Benjamin W. Eidem John W. Belmont William J. Craigen Stephanie M. Ware Susan D. Fernbach Steven R. Neish E O’Brian Smith Jeffrey A. Towbin | 2005 | Circulation2005，，： | 1 |
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