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| 1 | Alcoholic pancreatitis:New insights into the pathogenesisand treatment显示文摘Acute pancreatitis is a necro-inflammatory disease of the exocrine pancreas that is characterized by inappropriate activation of zymogens, infiltration of the pancreas by inflammatory cells, and destruction of the pancreatic exocrine cells. Acute pancreatitis can progress to a severe life-threatening disease. Currently there is no pharmacotherapy to prevent or treat acute pancreatitis. One of the more common factors associated with acute pancreatitis is alcohol abuse. Although commonly associated with pancreatitis alcohol alone is unable to cause pancreatitis. Instead, it appears that alcohol and its metabolic by-products predispose the pancreas to damage from agents that normally do not cause pancreatitis, or to more severe disease from agents that normally cause mild pancreatic damage. Over the last 10 to 20 years, a tremendous amount of work has defined a number of alcohol-mediated biochemical changes in pancreatic cells. Among these changes are: Sustained levels of intracellular calcium, activation of the mitochondrial permeability transition pore, endoplasmic reticulum stress, impairment in autophagy, alteration in the activity of transcriptional activators, and colocalization of lysosomal and pancreatic digestive enzymes. Elucidation of these changes has led to a deeper understanding of the mechanisms by which ethanol predisposes acinar cells to damage. This greater understanding has revealed a number of promising targets for therapeutic intervention. It is hoped that further investigation of these targets will lead to the development of pharmacotherapy that is effective in treating and preventing the progression of acute pancreatitis. | Dahn L Clemens Katrina J Schneider Christopher K Arkfeld Jaclyn R Grode Mark A Wells Shailender Singh | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，1： | 10 |
| 2 | 感应热矫平--薄钢板焊接变形矫平方法显示文摘在造船行业中,只要用到薄钢板,船甲板就将产生扭曲变形,而这种变形将无法完全消除,这种认识已经被广泛的接受。然而,当发现产生变形的根本原因后,我们发现一种最具有经济效益和管理效益的Terac热矫平方法。过去由于缺乏薄板热矫平知识或加热过程控制手段, | Mark Wells | 2009 | 船舶工程2009，31，4： | 4 |
| 3 | c-Met Is a Marker of Pancreatic Cancer Stem Cells and Therapeutic Target显示文摘 | Chenwei Li Jing–Jiang Wu Mark Hynes Joseph Dosch Bedabrata Sarkar Theodore H. Welling Marina Pasca di Magliano Diane M. Simeone | 2011 | Gastroenterology2011，，6： | 3 |
| 4 | 船甲板焊接变形矫正新方法显示文摘在造船行业中,只要用到薄钢板,船甲板就将产生扭曲变形,而这种变形将无法完全消除。但是,当发现产生变形的根本原因后,我们发现一种最有经济效益和管理效益的Terac热矫正方法。过去由于缺乏薄板热矫正知识或加热过程控制手段,有些情况下将导致薄板上的筋板热变形更加严重,而对于Terac感应加热系统的应用进行评估发现,这种方法大大减少了矫正时间。 | Mark Wells 王正(译) 赵亚涛(译) | 2009 | 金属加工(热加工)2009，，20： | 3 |
| 5 | In vitro antagonism of Trichoderma species against six fungal plant pathogens显示文摘 | Bell DK Wells HD Mark han CR | 1982 | Phytopathology1982，，： | 1 |
| 6 | Cocirculation of avian H9N2 and contemporary 'human' H3N2 influenza A viruses in pigs in southeastern China:potential for genetic reas-sortment?显示文摘 | PEIRIS J S GUAN Y MARK WELL D | 2001 | J Virol2001，75，20： | 1 |
| 7 | Customer perception of switch-feel in luxury sports utility vehieles显示文摘 | Wellings Tom Williams Mark A and Pitts Matthew | 2008 | Food Quality and Preference2008，19，8： | 1 |
| 8 | Fatty Acid -Induced Insulin Resistance in Adipocytes显示文摘 | MARK VAN EPPS-FUNG JODIE WILLIFORD ALAN WELLS | 1997 | Endocrinology1997，138，10： | 1 |
| 9 | The distribution of colloidal and particulate bioactive metals in Narragansett Bay, RI显示文摘 | Mark L Wells Geoffrey J Smith K.W Bruland | 2000 | Marine Chemistry2000，，1： | 1 |
| 10 | Travoprost 0.004% With and Without Benzalkonium Chloride: A Comparison of Safety and Efficacy显示文摘 | Richard A. Lewis Gregory J. Katz Mark J. Weiss Theresa A. Landry Jaime E. Dickerson John E. James Steven Y. Hua E. Kenneth Sullivan Dawnelle B. Montgomery David T. Wells and Michael V. W. Bergamini | 2007 | Journal of Glaucoma2007，，1： | 1 |
| 11 | Postconcussive Symptoms Are Associated With Compensatory Cortical Recruitment During a Working Memory Task显示文摘 | Jamie E Pardini Dustin A Pardini James T Becker Kathryn L Dunfee William F Eddy Mark R Lovell Joel S Welling | 2010 | Neurosurgery2010，，4： | 1 |
| 12 | The Changing Market forHeritage Tourism: A Case Study of Visits :to Historic Houses in England 显示文摘 | Mark well S Bennett M Ravens croft N | 1997 | International Journal of Heritage Studies1997，，3： | 1 |
| 13 | A pilot study of a system for grading of drainage blebs after glaucoma surgery 显示文摘 | Wells AP Crowston JG Marks J Kirwan JF Smith G Clarke JC | 2004 | J Glaucoma2004，13，5： | 1 |
| 14 | Role of all-trans-retinoic acid (ATRA) in the consolidation therapy of acute promyelocytic leukaemia (APL)显示文摘 | Vikas Gupta Qi-long Yi Joseph Brandwein Jeffrey H. Lipton Hans A. Messner Andre C. Schuh Richard A. Wells Mark D. Minden | 2004 | Leukemia Research2004，，1： | 1 |
| 15 | Eyewitness Identification Procedures: Recommendations for Lineups and Photospreads显示文摘 | Gary L. Wells Mark Small Steven Penrod Roy S. Malpass Solomon M. Fulero C. A. E. Brimacombe | 1998 | Law and Human Behavior1998，，6： | 1 |
| 16 | Customer Perception of Switch - Feel in Luxury Sports Utility Vehicles 显示文摘 | Tom Wellings Mark A Williams Matthew Pitts | 2008 | Food Quality and Preference2008，19，8： | 1 |
| 17 | Nature:大规模研究揭示生命所必需的基因显示文摘在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中,来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature期刊上,论文标题为“High—throughput discovery of novel developmental phenotypes”。 | Dickinson, Mary E. Flenniken, Ann M. Ji, Xiao Teboul, Lydia Wong, Michael D. White, Jacqueline K. Meehan, Terrence F. Weninger, Wolfgang J. Westerberg, Henrik Adissu, Hibret Baker, Candice N. Bower, Lynette Brown, James M. Caddle, L. Brianna Chiani, Francesco Clary, Dave Cleak, James Daly, Mark J. Denegre, James M. Doe, Brendan Dolan, Mary E. Edie, Sarah M. Fuchs, Helmut Gailus-Durner, Valerie Galli, Antonella Gambadoro, Alessia Gallegos, Juan Guo, Shiying Horner, Neil R. Hsu, Chih-Wei Johnson, Sara J. Kalaga, Sowmya Keith, Lance C. Lanoue, Louise Lawson, Thomas N. Lek, Monkol Mark, Manuel Arschall, Susan M. Mason, Jeremy McElwee, Melissa L. Newbigging, Susan Nutter, Lauryl M. J. Peterson, Kevin A. Ramirez-Solis, Ramiro Rowland, Douglas J. Ryder, Edward Samocha, Kaitlin E. Seavitt, John R. Selloum, Mohammed Szoke-Kovacs, Zsombor Tamura, Masaru Trainor, Amanda G. Tudose, Ilinca Wakana, Shigeharu Warren, Jonathan Wendling, Olivia West, David B. Wong, Leeyean Yoshiki, Atsushi MacArthur, Daniel G. Tocchini-Valentini, Glauco P. Gao, Xiang Flicek, Paul Bradley, Allan Skarnes, William C. Justice, Monica J. Parkinson, Helen E. Moore, Mark Wells, Sara Braun, Robert E. Svenson, Karen L. de Angelis, Martin Hrabe Herault, Yann Mohun, Tim Mallon, Ann-Marie Henkelman, R. Mark Brown, Steve D. M. Adams, David J. Lloyd, K. C. Kent McKerlie, Colin Beaudet, Arthur L. Bucan, Maja Murray, Stephen A. | 2016 | 现代生物医学进展2016，16，31： | 1 |
| 18 | A pilot study of a sys-tem for grading of drainage blebs after glaucoma surgery 显示文摘 | Wells AP Crewston JG Marks J et aL | 2004 | jGlaucoma2004，13，： | 1 |
| 19 | Anemia Is Associated with Poor Outcomes in Patients with Less Severe Ischemic Stroke显示文摘 | Jason J. Sico John Concato Carolyn K. Wells Albert C. Lo Steven E. Nadeau Linda S. Williams Aldo J. Peixoto Mark Gorman John L. Boice Dawn M. Bravata | 2011 | Journal of Stroke and Cerebrovascular Diseases2011，，： | 1 |
| 20 | Eyewitness Identification Procedures: Recommendations for Lineups and Photospreads显示文摘 | Gary L. Wells Mark Small Steven Penrod Roy S. Malpass Solomon M. Fulero C. A. E. Brimacombe | 1998 | Law and Human Behavior1998，，6： | 1 |
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