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| 1 | Single-center study comparing computed tomography colonography with conventional colonoscopy显示文摘AIM:To compare the results from computed tomography (CT) colonography with conventional colonoscopy in symptomatic patients referred for colonoscopy. METHODS: The study included 227 adult outpatients, mean age 60 years, with appropriate indications for colonoscopy. CT colonography and colonoscopy were performed on the same day in a metropolitan teaching hospital. Colonoscopists were initially blinded to the results of CT colonography but there was segmental unblinding during the procedure. The primary outcome measures were the sensitivity and specificity of CT colonography for the identification of polyps seen at colonoscopy (i.e. analysis by polyp). Secondary outcome measures included an analysis by patient, extracolonic findings at CT colonography, adverse events with both procedures and patient acceptance and preference. RESULTS: Twenty-five patients (11%) were excluded from the analysis because of incomplete colonoscopy or poor bowel preparation that affected either CT colonography, colonoscopy or both procedures. Polyps and masses (usually cancers) were detected at colonoscopy and CT colonography in 35% and 42% of patients, respectively. Of nine patients with a finaldiagnosis of cancer, eight (89%) were identified by CT colonography as masses (5) or polyps (3). For polyps analyzed according to polyp, the overall sensitivity of CT colonography was 50% (95% CI, 39%-61%) but this increased to 71% (95% CI, 52%-85%) for polyps ≥ 6 mm in size. Similarly, specificity for all polyps was 48% (95% CI, 39%-58%) increasing to 67% (95% CI, 56%-76%) for polyps ≥ 6 mm. Adverse events were uncommon but included one colonic perforation at colonoscopy. Patient acceptance was high for both procedures but preference favoured CT colonography. CONCLUSION: Although CT colonography was more sensitive in this study than in some previous studies, the procedure is not yet sensitive enough for widespread application in symptomatic patients. | Ian C Roberts-Thomson Graeme R Tucker Peter J Hewett Peter Cheung Ruben A Sebben EE Win Khoo Julie D Marker Wayne K Clapton | 2008 | World Journal of Gastroenterology2008，14，3： | 4 |
| 2 | Inhibition of the epidermal growth factor receptor increases expression of genes that stimulate inflammation,apoptosis,and cell attachment显示文摘 | Woodworth CD Michael E Marker D | 2005 | Mol Cancer Ther2005，4，4： | 1 |
| 3 | BMP5 and the molecular,skeletal,and soft-tissue alterations in short ear mice显示文摘 | KINGSLEY D M KING J A MARKER P C | 1994 | Dev Biol1994，166，： | 1 |
| 4 | Organization of small area estimators using a generalized linear regression framework 显示文摘 | Marker D A | 1999 | Journal of Official Statistics1999，，15： | 1 |
| 5 | Inhibition of the epidelraal growth factor receptor increases expression of genes that stimulate in- flammation, apoptosis, and cell attachment 显示文摘 | Woodworth C D Michael E Marker D | 2005 | Mol Cancer Ther2005，4，4： | 1 |
| 6 | Surface precision of optical membranes with curvature 显示文摘 | Marker D K Jenkins C H | 1997 | Optics Express1997，1，11： | 1 |
| 7 | Inhibition of the epi dermal growth factor receptor increases expression of genes that stimulate inflammation, apoptosis, and cell attachment 显示文摘 | Woodworth CD Michael E Marker D | 2005 | Mol Cancer Ther2005，4，： | 1 |
| 8 | A novel candidate gene for mouse and human preaxial polydactyly with altered expression in limbs of Hemimelic extra-toes mutant mice显示文摘 | Clark R M Marker P C Kingsley D M | 2000 | Genomics2000，67，1： | 1 |
| 9 | Surface precision of optical membranes with curvature显示文摘 | MARKER D K JENKINS C H | 1997 | Optics Express1997，1，11： | 1 |
| 10 | Inhibition of the epidermal growth factor receptor increases expression of genes that stimulate inflammation, apoptosis, and cell attachment显示文摘 | Woodworth CD Micheal E Marker D | 2005 | Mol Cancer Ther2005，4，4： | 1 |
| 11 | Functional problems and arthrofibrosis following total knee arthroplasty 显示文摘 | Seyler T M Marker D R Bhave A | 2007 | J Bone Joint Surg Am2007，89，3： | 1 |
| 12 | Inte- gration of rapid signaling events with steroid hormone receptor action in breast and prostate cancer显示文摘 | Lange C A Gioeli D Hammes S R Marker P C | 2007 | Ann Rev Physiol2007，69，： | 1 |
| 13 | Inhibition of the epidermal growth factor receptor increases expression of genes that stimulate inflammation,apoptosis,and cell attachment显示文摘 | Woodworth CD Miehael E Marker D | | 0，，04： | 1 |
| 14 | A novel candidate gene for mouse and human preaxial polydactyly with altered expression in limbs of Hemimelic extra-toes mutant mice 显示文摘 | Marker P C Kingsley D M | 2000 | Genomics2000，67，： | 1 |
| 15 | Surface precision of optical membranes with curvature 显示文摘 | Marker D K Jenkins C H | 1997 | Optics Express(S 1094-4087)1997，1，11： | 1 |
| 16 | Progress toward large-aperture membrane mirrors 显示文摘 | Rotge J R Marker D K | 2000 | Proc of SPIE(S0277-786X)2000，4091，： | 1 |
| 17 | Inhibition of the epidermal growth factor receptor increases expression of genes that stimulate inflammation, apoptosis, and cell attachment显示文摘 | Woodworth CD Michael E Marker D | 2005 | Mol Cancer Ther2005，4，4： | 1 |
| 18 | The natural history of untreated asymptomatic osteonecrosis of the femoral head: a systematic literature review显示文摘 | Mont M A Zywiel M G Marker D R | 2010 | J Bone Joint Surg Am2010，92，： | 1 |
| 19 | Fuzzy logic control for an optical membrane mirror显示文摘 | CARRERAS R A MARKER D K LUTZ B J | 2005 | Intelligent Automation and Soft Computing2005，11，1： | 1 |
| 20 | A novel candidate gene for mouse and human preaxial polydactyly with altered expression in limbs of Hemimelic extra- toes mutant mice 显示文摘 | Clark R M Marker P C Kingsley D M | 2000 | Genomies2000，67，： | 1 |
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