|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Cell biology of CML cells显示文摘 | Gordon M Y Dazzi F Marley S B | 1999 | Leukemia1999，13，1： | 1 |
| 3 | Fatigue Reassessment Applications:State-of-the-Art Paper显示文摘 | WILLIAM G B MARLEY M J MOHAMMADI J JIELSEN R J SARKANI S | 1997 | Journal of Structural Engineering1997，123，3： | 1 |
| 4 | Treatment with interferon-α preferentially reduces the capacity for amplification of granulocyte-macrophage progenitors (CFUGM) from patients with chronic myeloid leukemia but spares normal CFU-GM显示文摘 | GORDON M Y MARLEY S B LEWIS J L | 1998 | J Clin Invest1998，102，4： | 1 |
| 5 | Treatment with interferona preferentially reduces the capacity for amplification of granulocytemacrophage progenitors (CFU-GM) from patients with chronic myeloid leukemia but spares normal CFU-GM 显示文摘 | Gordon M Y Marley S B Lewis J L | 1998 | J Clin Invest1998，102，4： | 1 |
| 6 | Peripheral blood progenitor cell mobilization alters myeloid,but not erythroid, progenitor cell self-renewal kinetics 显示文摘 | Lewis JL Zheng B | 2001 | Bone Marrow Transplant2001，27，3： | 1 |
| 7 | Resistance of spark channe 显示文摘 | Raul M Marley B Vernon C | 2006 | IEEE Transactions on Plasma Science2006，34，5： | 1 |
| 8 | Peripheral blood progvnitor cell mobilisation alters myeloid, but not erythroid, progenitor cell self-renewal kinetics 显示文摘 | Marley SB Lewis JL Zheng B | 2001 | Bone Marrow Transplant2001，27，3： | 1 |
| 9 | Decision-maker's preferences modeling in the stochastic goal programming显示文摘 | Aouni B Abdelaziz F B Marlei J M | 2005 | European Journal of Operational Research2005，162，： | 1 |
| 10 | Resistance of spark channe显示文摘 | Raul M Marley B Vernon C | 2006 | IEEE Transactions on Plasma Science2006，34，5： | 1 |
| 11 | Resistance of spark channe 显示文摘 | Raul M Marley B Vernon C | 2006 | IEEE Transaction Plasma Science2006，34，5： | 1 |
| 12 | Targeting primary human leukaemia cells with RNA interference: Bcr-Abl targeting inhibits myeloid progenitor self-renewal in chronic myeloid leukaemia cells显示文摘 | Withey J M Marley S B Kaeda J | 2005 | Br J Haematol2005，129，3： | 1 |
| 13 | Ferric ion promoted photodecomposition of triazines显示文摘 | Larson R A Schlauch M B Marley K A | 1991 | Journal of Agricultural and Food Chemistry1991，39，11： | 1 |
| 14 | The effect of chlorhexidine gluconate as an endodontic irrigant on the apicalseal: long-term results显示文摘 | Ferguson D B Marley J T Hartwell G R | 2003 | J Endod2003，29，2： | 1 |
| 15 | Chromogranin A:secretion of processed products from the stimulated retrogradely perfused bovine adrenal gland显示文摘 | Helle K B Marley P D Angeletti R H | 1993 | Neuroendocrinology1993，5，4： | 1 |
| 16 | Triggers and barriers to financial inclusion:The use of ICT-based branchless banking in an Amazon county显示文摘 | EDUARDO D RENE B MARLEI P | 2012 | Electronic Commerce Research and Applications2012，11，5： | 1 |
| 17 | Mexico City aerosol analysis during MILAGRO using high resolution aerosol mass spectrometry at the urban supersite (T0)-Part 1:Fine particle composition and organic source apportionment显示文摘 | Aiken A C Salcedo D Cubison M J Huffman J A DeCarlo P F Ulbrich I M Docherty K S Sueper D Kimmel J R Worsnop D R Trimborn A Northway M Stone E A Schauer J J Volkamer R M Fortner E de Foy B Wang J Laskin A Shutthanandan V Zheng J Zhang R Gaffney J Marley N | | 0，，17： | 1 |
| 18 | Acute cholestasis - induced renal failure: effects of antioxidants and ligands for the thromboxane A2 receptor显示文摘 | Holt S Marley R Fernando B | 1999 | Kidney Int1999，55，1： | 1 |
| 19 | Treatment with interferona preferentially reduces the capacity for amplifi- cation of granulocyte - macrophage progenitors ( CFU - GM) from patients with chronic myeloid leukemia but spares normal CFU - GM 显示文摘 | Gordon M Y Marley S B Lewis J L | 2010 | J Clin Invest2010，102，： | 1 |
| 20 | Ferric ion promoted pho- todecomposition of triazines 显示文摘 | Larson R A Schlauch M B Marley K A | 1991 | Journal of Agricultural and Food Chemistry1991，39，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员